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P-glycoprotein Substrate Models Using Support Vector Machines Based on a Comprehensive Data set

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Novel formulation approaches for optimising delivery of anticancer drugs based on P-glycoprotein modulation
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Rational Use of in Vitro P-glycoprotein Assays in Drug Discovery
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Drug Binding Sites on P-Glycoprotein Are Altered by ATP Binding Prior to Nucleotide Hydrolysis
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Prediction of P-Glycoprotein Substrates by a Support Vector Machine Approach
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Classification of Substrates and Inhibitors of P-Glycoprotein Using Unsupervised Machine Learning Approach
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Combinatorial QSAR Modeling of P-Glycoprotein Substrates
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Identifying P-Glycoprotein Substrates Using a Support Vector Machine Optimized by a Particle Swarm
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A Computational Ensemble Pharmacophore Model for Identifying Substrates of P-Glycoprotein
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Computational Models for Identifying Potential P-Glycoprotein Substrates and Inhibitors
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Random Forests
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ABCB1 (MDR1)-Type P-Glycoproteins at the Blood–Brain Barrier Modulate the Activity of the Hypothalamic–Pituitary–Adrenocortical System: Implications for Affective Disorder
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Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.
inferredcites →https://doi.org/10.1074/jbc.270.2.843openalex-snapshot
Membrane Topology of a Cysteine-less Mutant of Human P-glycoprotein
inferredcites →https://doi.org/10.1074/jbc.273.24.14671openalex-snapshot
Superfolding of the Partially Unfolded Core-glycosylated Intermediate of Human P-glycoprotein into the Mature Enzyme Is Promoted by Substrate-induced Transmembrane Domain Interactions
inferredcites →https://doi.org/10.1074/jbc.274.35.24759openalex-snapshot
The Transmembrane Domains of the Human Multidrug Resistance P-glycoprotein Are Sufficient to Mediate Drug Binding and Trafficking to the Cell Surface
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Thirteen Ways to Look at the Correlation Coefficient
inferredcites →https://doi.org/10.1080/10611860310001648248openalex-snapshot
Classification Analysis of P-Glycoprotein Substrate Specificity
inferredcites →https://doi.org/10.1124/jpet.102.037549openalex-snapshot
Interaction of Cytochrome P450 3A Inhibitors with P-Glycoprotein
inferredcites →https://doi.org/10.1124/mol.61.5.964openalex-snapshot
Three-Dimensional Quantitative Structure-Activity Relationships of Inhibitors of P-Glycoprotein
inferredcites →https://doi.org/10.1126/science.1168750openalex-snapshot
Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
inferredcites →https://doi.org/10.1128/mcb.10.4.1652openalex-snapshot
Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities.
inferredcites →https://doi.org/10.1145/1961189.1961199openalex-snapshot
LIBSVM
inferredcites →https://doi.org/10.1162/089976600300015042openalex-snapshot
Bounds on Error Expectation for Support Vector Machines
inferredcites →https://doi.org/10.1172/jci8267openalex-snapshot
Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier
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Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.
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How significant is the role of P-glycoprotein in drug absorption and brain uptake?
inferredcites →https://doi.org/10.5414/cpp38069openalex-snapshot
P-glycoprotein: a defense mechanism limiting oral bioavailability and CNS accumulation of drugs

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Anticancer activity of Hedyotis corymbosa nanoliposomes targeting estrogen receptor-alpha in breast cancer cells: In silico and in vitro studies
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Computational models for predicting drug transport mediated by P-glycoprotein
inferred← citeshttps://doi.org/10.59720/20-036openalex-snapshot
Combating drug resistance in cancer cells: Cooperative effect of green tea and turmeric with chemotherapeutic drug
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