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Identification of New Fyn Kinase Inhibitors Using a FLAP-Based Approach

https://doi.org/10.1021/ci4002553
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1 of the 46 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-11): 10.1523/jneurosci.1858-12.2012 (notice 2025-03-12).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/cncr.24879openalex-snapshot
Fyn
inferredcites →https://doi.org/10.1002/ijc.23579openalex-snapshot
Lysophosphatidic acid induces ovarian cancer cell dispersal by activating Fyn kinase associated with p120‐catenin
inferredcites →https://doi.org/10.1002/ijc.24177openalex-snapshot
A signature predictive of disease outcome in breast carcinomas, identified by quantitative immunocytochemical assays
inferredcites →https://doi.org/10.1002/j.1460-2075.1988.tb03269.xopenalex-snapshot
Identification and characterization of p59fyn (a src‐like protein tyrosine kinase) in normal and polyoma virus transformed cells.
inferredcites →https://doi.org/10.1002/prot.10465openalex-snapshot
Improved protein–ligand docking using GOLD
inferredcites →https://doi.org/10.1007/s10822-012-9612-8openalex-snapshot
Ligand-, structure- and pharmacophore-based molecular fingerprints: a case study on adenosine A1, A2A, A2B, and A3 receptor antagonists
inferredcites →https://doi.org/10.1016/j.bbadis.2004.09.002openalex-snapshot
Tau and src family tyrosine kinases
inferredcites →https://doi.org/10.1016/j.bbrc.2006.05.212openalex-snapshot
Structure of human Fyn kinase domain complexed with staurosporine
inferredcites →https://doi.org/10.1016/j.bbrc.2011.02.134openalex-snapshot
Fyn mediates transforming growth factor-beta1-induced down-regulation of E-cadherin in human A549 lung cancer cells
inferredcites →https://doi.org/10.1016/j.bmc.2009.02.054openalex-snapshot
Structure-based virtual screening of Src kinase inhibitors
inferredcites →https://doi.org/10.1016/j.bmc.2010.05.032openalex-snapshot
Discovery of novel purine derivatives with potent and selective inhibitory activity against c-Src tyrosine kinase
inferredcites →https://doi.org/10.1016/j.bmcl.2008.06.040openalex-snapshot
2-Alkenylthieno[2,3-b]pyridine-5-carbonitriles: Potent and selective inhibitors of PKCθ
inferredcites →https://doi.org/10.1016/j.chembiol.2008.09.007openalex-snapshot
Small Molecule Recognition of c-Src via the Imatinib-Binding Conformation
inferredcites →https://doi.org/10.1016/j.molonc.2009.01.002openalex-snapshot
Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530
inferredcites →https://doi.org/10.1016/s0028-3908(03)00313-7openalex-snapshot
Interactions between Src family protein tyrosine kinases and PSD-95
inferredcites →https://doi.org/10.1016/s0304-3940(02)01439-8openalex-snapshot
Tyrosine kinase and tyrosine phosphatase participate in regulation of interactions of NMDA receptor subunit 2A with Src and Fyn mediated by PSD-95 after transient brain ischemia
inferredcites →https://doi.org/10.1021/cb300172eopenalex-snapshot
Development of a Highly Selective c-Src Kinase Inhibitor
inferredcites →https://doi.org/10.1021/ci050301yopenalex-snapshot
Screening for New Antidepressant Leads of Multiple Activities by Support Vector Machines
inferredcites →https://doi.org/10.1021/ci100161zopenalex-snapshot
Protein Kinases: Docking and Homology Modeling Reliability
inferredcites →https://doi.org/10.1021/ci100221gopenalex-snapshot
FLAP: GRID Molecular Interaction Fields in Virtual Screening. Validation using the DUD Data Set
inferredcites →https://doi.org/10.1021/ci300153dopenalex-snapshot
GRID-Based Three-Dimensional Pharmacophores I: FLAPpharm, a Novel Approach for Pharmacophore Elucidation
inferredcites →https://doi.org/10.1021/ci600253eopenalex-snapshot
A Common Reference Framework for Analyzing/Comparing Proteins and Ligands. Fingerprints for Ligands And Proteins (FLAP): Theory and Application
inferredcites →https://doi.org/10.1021/ci8002649openalex-snapshot
Maximum Unbiased Validation (MUV) Data Sets for Virtual Screening Based on PubChem Bioactivity Data
inferredcites →https://doi.org/10.1021/jm060727jopenalex-snapshot
2-Aminothiazole as a Novel Kinase Inhibitor Template. Structure−Activity Relationship Studies toward the Discovery of N -(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (Dasatinib, BMS-354825) as a Potent pan -Src…
inferredcites →https://doi.org/10.1021/jm8011036openalex-snapshot
Assessment of Chemical Coverage of Kinome Space and Its Implications for Kinase Drug Discovery
inferredcites →https://doi.org/10.1021/jm9002928openalex-snapshot
Hybrid Compound Design To Overcome the Gatekeeper T338M Mutation in cSrc
inferredcites →https://doi.org/10.1038/emboj.2009.289openalex-snapshot
Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn
inferredcites →https://doi.org/10.1038/nn.3178openalex-snapshot
Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons
inferredcites →https://doi.org/10.1042/bj20080909openalex-snapshot
Regulation of microtubule nucleation from membranes by complexes of membrane-bound γ-tubulin with Fyn kinase and phosphoinositide 3-kinase
inferredcites →https://doi.org/10.1074/jbc.271.2.695openalex-snapshot
Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor
inferredcites →https://doi.org/10.1083/jcb.145.6.1209openalex-snapshot
Morphological Differentiation of Oligodendrocytes Requires Activation of Fyn Tyrosine Kinase
inferredcites →https://doi.org/10.1093/carcin/bgr088openalex-snapshot
Fyn requires HnRNPA2B1 and Sam68 to synergistically regulate apoptosis in pancreatic cancer
inferredcites →https://doi.org/10.1093/carcin/bgs109openalex-snapshot
Deficiency of Fyn protein is prerequisite for apoptosis induced by Src family kinase inhibitors in human mesothelioma cells
inferredcites →https://doi.org/10.1111/j.1365-2990.2010.01103.xopenalex-snapshot
Tyrosine phosphorylation of tau accompanies disease progression in transgenic mouse models of tauopathy
inferredcites →https://doi.org/10.1111/j.1464-410x.2008.08009.xopenalex-snapshot
FYN is overexpressed in human prostate cancer
inferredcites →https://doi.org/10.1111/j.1600-065x.2008.00745.xopenalex-snapshot
T‐cell receptor proximal signaling via the Src‐family kinases, Lck and Fyn, influences T‐cell activation, differentiation, and tolerance
inferredcites →https://doi.org/10.1111/j.1755-5949.2012.00357.xopenalex-snapshot
Fyn Kinases Play a Critical Role in Neuronal Apoptosis Induced by Oxygen and Glucose Deprivation or Amyloid‐β Peptide Treatment
inferredcites →https://doi.org/10.1124/jpet.102.038380openalex-snapshot
Inhibition of Human T Cell Activation by Novel Src Kinase Inhibitors Is Dependent upon the Complexity of the Signal Delivered to the Cell
inferredcites →https://doi.org/10.1124/mol.111.077149openalex-snapshot
Fyn Inhibition by Cycloalkane-Fused 1,2-Dithiole-3-thiones Enhances Antioxidant Capacity and Protects Mitochondria from Oxidative Injury
inferredcites →https://doi.org/10.1158/1535-7163.mct-05-0171openalex-snapshot
AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes
inferredcites →https://doi.org/10.1371/journal.pone.0006361openalex-snapshot
Differential Matrix Rigidity Response in Breast Cancer Cell Lines Correlates with the Tissue Tropism
inferredcites →https://doi.org/10.1371/journal.pone.0051611openalex-snapshot
Expression and Activity of Fyn Mediate Proliferation and Blastic Features of Chronic Myelogenous Leukemia
inferredcites →https://doi.org/10.1523/jneurosci.1858-12.2012openalex-snapshot
RETRACTED: The Complex PrPc-Fyn Couples Human Oligomeric Aβ with Pathological Tau Changes in Alzheimer's Disease
inferredcites →https://doi.org/10.1523/jneurosci.4162-03.2004openalex-snapshot
Phosphorylation of Tau by Fyn: Implications for Alzheimer's Disease
inferredcites →https://doi.org/10.2174/092986711796150531openalex-snapshot
Fyn Kinase in Brain Diseases and Cancer: The Search for Inhibitors
inferredcites →https://doi.org/10.2174/138620709787581666openalex-snapshot
Docking-Based Virtual Screening: Recent Developments

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1002/jcp.28224openalex-snapshot
Virtual screening identifies a PIN1 inhibitor with possible antiovarian cancer effects
inferred← citeshttps://doi.org/10.1007/978-3-030-79511-5_11openalex-snapshot
Carbonic Anhydrase Inhibitors: Identifying Therapeutic Cancer Agents Through Virtual Screening
inferred← citeshttps://doi.org/10.1007/s11030-024-10905-wopenalex-snapshot
In silico screening of Fyn kinase inhibitors using classification-based QSAR model, molecular docking, molecular dynamics and ADME study
inferred← citeshttps://doi.org/10.1007/s12035-024-04286-2openalex-snapshot
Fyn Kinase in Alzheimer’s Disease: Unraveling Molecular Mechanisms and Therapeutic Implications
inferred← citeshttps://doi.org/10.1016/bs.apcsb.2014.06.001openalex-snapshot
The Interplay Between Molecular Modeling and Chemoinformatics to Characterize Protein–Ligand and Protein–Protein Interactions Landscapes for Drug Discovery
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b00140openalex-snapshot
Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors
inferred← citeshttps://doi.org/10.1021/acschemneuro.0c00304openalex-snapshot
Focus on Human Monoamine Transporter Selectivity. New Human DAT and NET Models, Experimental Validation, and SERT Affinity Exploration
inferred← citeshttps://doi.org/10.1021/ci500424nopenalex-snapshot
Extensive Consensus Docking Evaluation for Ligand Pose Prediction and Virtual Screening Studies
inferred← citeshttps://doi.org/10.1021/ci5006806openalex-snapshot
Application of a FLAP-Consensus Docking Mixed Strategy for the Identification of New Fatty Acid Amide Hydrolase Inhibitors
inferred← citeshttps://doi.org/10.1039/d1na00036eopenalex-snapshot
Carbon dots for cancer nanomedicine: a bright future
inferred← citeshttps://doi.org/10.1080/07391102.2025.2606809openalex-snapshot
Structure-based virtual screening and post-docking analysis of a D-amino acid oxidase inhibitor targeting the molecular surface
inferred← citeshttps://doi.org/10.1080/14756366.2016.1193736openalex-snapshot
Reliability analysis and optimization of the consensus docking approach for the development of virtual screening studies
inferred← citeshttps://doi.org/10.1080/14756366.2018.1469017openalex-snapshot
Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors
inferred← citeshttps://doi.org/10.1080/14756366.2019.1571271openalex-snapshot
Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors
inferred← citeshttps://doi.org/10.2174/0929867329666211221153719openalex-snapshot
Role of Fyn Kinase Inhibitors in Switching Neuroinflammatory Pathways
inferred← citeshttps://doi.org/10.2174/1573406417666210511001241openalex-snapshot
From Anti-infective Agents to Cancer Therapy: A Drug Repositioning Study Revealed a New Use for Nitrofuran Derivatives
inferred← citeshttps://doi.org/10.2174/1573407214666181023114820openalex-snapshot
Consensus Docking in Drug Discovery
inferred← citeshttps://doi.org/10.3109/14756366.2014.959946openalex-snapshot
Receptor-based virtual screening evaluation for the identification of estrogen receptorβligands
inferred← citeshttps://doi.org/10.3233/jad-230828openalex-snapshot
Unveiling Phytoconstituents with Inhibitory Potential Against Tyrosine-Protein Kinase Fyn: A Comprehensive Virtual Screening Approach Targeting Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3390/ijms22169098openalex-snapshot
GSK-3β, FYN, and DYRK1A: Master Regulators in Neurodegenerative Pathways
inferred← citeshttps://doi.org/10.3390/molecules20058772openalex-snapshot
Development and Validation of a Docking-Based Virtual Screening Platform for the Identification of New Lactate Dehydrogenase Inhibitors
inferred← citeshttps://doi.org/10.3390/molecules23040777openalex-snapshot
Polymer-Mediated Delivery of siRNAs to Hepatocellular Carcinoma: Variables Affecting Specificity and Effectiveness
inferred← citeshttps://doi.org/10.3390/molecules25081971openalex-snapshot
Application of MM-PBSA Methods in Virtual Screening
inferred← citeshttps://doi.org/10.4161/21565562.2014.979113openalex-snapshot
Kinases as targets for chemical modulators: Structural aspects and their role in spermatogenesis
inferred← citeshttps://doi.org/10.6026/97320630015419openalex-snapshot
Identification of novel inhibitor targeting Fyn kinase using molecular docking analysis
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