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Fragment-Based Prediction of the Clinical Occurrence of Long QT Syndrome and Torsade de Pointes

https://doi.org/10.1021/ci900116q
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/047002142xopenalex-snapshot
The hERG Cardiac Potassium Channel: Structure, Function and Long QT Syndrome
inferredcites →https://doi.org/10.1002/1439-7633(20020503)3:5<455::aid-cbic455>3.0.co;2-lopenalex-snapshot
A Virtual Screening Method for Prediction of the hERG Potassium Channel Liability of Compound Libraries
inferredcites →https://doi.org/10.1002/pds.885openalex-snapshot
Disproportionality analysis using empirical Bayes data mining: a tool for the evaluation of drug interactions in the post‐marketing setting
inferredcites →https://doi.org/10.1002/qsar.19930120205openalex-snapshot
The Probability of Chance Correlation Using Partial Least Squares (PLS)
inferredcites →https://doi.org/10.1007/978-1-59259-884-7openalex-snapshot
Cardiac safety of noncardiac drugs : practical guidelines for clinical research and drug development
inferredcites →https://doi.org/10.1007/bf03256733openalex-snapshot
Comparison of Sensitivity and Timing of Early Signal Detection of Four Frequently Used Signal Detection Methods
inferredcites →https://doi.org/10.1007/s00228-007-0279-3openalex-snapshot
Illusions of objectivity and a recommendation for reporting data mining results
inferredcites →https://doi.org/10.1016/0092-8674(95)90340-2openalex-snapshot
A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel
inferredcites →https://doi.org/10.1016/0160-9327(86)90116-xopenalex-snapshot
Molecular connectivity in structure-activity analysis
inferredcites →https://doi.org/10.1016/j.bmc.2004.02.003openalex-snapshot
A model for identifying HERG K+ channel blockers
inferredcites →https://doi.org/10.1016/j.pbiomolbio.2003.09.001openalex-snapshot
HERG binding specificity and binding site structure: evidence from a fragment-based evolutionary computing SAR study
inferredcites →https://doi.org/10.1016/j.pharmthera.2008.02.013openalex-snapshot
Assessing QT prolongation in conscious dogs: Validation of a beat-to-beat method
inferredcites →https://doi.org/10.1016/j.vascn.2008.03.001openalex-snapshot
Temporal variability of QT interval and changes in T wave morphology in dogs as markers of the clinical risk of drug-induced proarrhythmia
inferredcites →https://doi.org/10.1016/s0006-2952(02)01074-2openalex-snapshot
Predicting plasma protein binding of drugs: a new approach
inferredcites →https://doi.org/10.1016/s0011-393x(01)80071-0openalex-snapshot
Some US Food and Drug Administration perspectives on data mining for pediatric safety Assessment
inferredcites →https://doi.org/10.1016/s0960-894x(03)00196-3openalex-snapshot
Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches
inferredcites →https://doi.org/10.1016/s0960-894x(03)00492-xopenalex-snapshot
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods
inferredcites →https://doi.org/10.1021/ci000327jopenalex-snapshot
Evaluation of Descriptors and Mini-Fingerprints for the Identification of Molecules with Similar Activity
inferredcites →https://doi.org/10.1021/ci049744copenalex-snapshot
Generalized Fragment-Substructure Based Property Prediction Method
inferredcites →https://doi.org/10.1021/ci050308fopenalex-snapshot
Development and Evaluation of an in Silico Model for hERG Binding
inferredcites →https://doi.org/10.1021/ci8000887openalex-snapshot
Toward an Improved Clustering of Large Data Sets Using Maximum Common Substructures and Topological Fingerprints
inferredcites →https://doi.org/10.1021/ja993663topenalex-snapshot
Prediction of Properties from Simulations: Free Energies of Solvation in Hexadecane, Octanol, and Water
inferredcites →https://doi.org/10.1021/jm0208875openalex-snapshot
Toward a Pharmacophore for Drugs Inducing the Long QT Syndrome: Insights from a CoMFA Study of HERG K+ Channel Blockers
inferredcites →https://doi.org/10.1046/j.1365-2125.2002.01627.xopenalex-snapshot
The significance of QT interval in drug development
inferredcites →https://doi.org/10.1073/pnas.210244497openalex-snapshot
A structural basis for drug-induced long QT syndrome
inferredcites →https://doi.org/10.1080/00031305.1999.10474456openalex-snapshot
Bayesian Data Mining in Large Frequency Tables, with an Application to the FDA Spontaneous Reporting System
inferredcites →https://doi.org/10.1093/jac/45.5.557openalex-snapshot
Quinolone-induced QT interval prolongation: a not-so-unexpected class effect
inferredcites →https://doi.org/10.1097/00005344-199501000-00006openalex-snapshot
Terfenadine Increases the QT Interval in Isolated Guinea Pig Heart
inferredcites →https://doi.org/10.1111/j.1747-0285.2006.00379.xopenalex-snapshot
A QSAR Model of hERG Binding Using a Large, Diverse, and Internally Consistent Training Set
inferredcites →https://doi.org/10.1124/jpet.105.093393openalex-snapshot
Comparative Evaluation of HERG Currents and QT Intervals following Challenge with Suspected Torsadogenic and Nontorsadogenic Drugs
inferredcites →https://doi.org/10.1124/jpet.301.2.427openalex-snapshot
Three-Dimensional Quantitative Structure-Activity Relationship for Inhibition of Human Ether-a-Go-Go-Related Gene Potassium Channel
inferredcites →https://doi.org/10.1126/science.272.5262.681openalex-snapshot
Molecular Genetic Insights into Cardiovascular Disease
inferredcites →https://doi.org/10.1186/1471-244x-8-1openalex-snapshot
Postnatal depression in Southern Brazil: prevalence and its demographic and socioeconomic determinants
inferredcites →https://doi.org/10.1186/1471-244x-8-57openalex-snapshot
The Sertindole Safety Survey: A retrospective analysis under a named patient use programme in Europe
inferredcites →https://doi.org/10.1289/ehp.10573openalex-snapshot
Use of Cell Viability Assay Data Improves the Prediction Accuracy of Conventional Quantitative Structure–Activity Relationship Models of Animal Carcinogenicity
inferredcites →https://doi.org/10.1517/14740338.6.6.705openalex-snapshot
Effect of consumer reporting on signal detection: using disproportionality analysis
inferredcites →https://doi.org/10.2165/00002018-199106050-00008openalex-snapshot
Statistical Methods in Pharmacoepidemiology
inferredcites →https://doi.org/10.2165/00002018-200225060-00001openalex-snapshot
Use of Screening Algorithms and Computer Systems to Efficiently Signal Higher-Than-Expected Combinations of Drugs and Events in the US FDA??s Spontaneous Reports Database
inferredcites →https://doi.org/10.2165/00002018-200326050-00001openalex-snapshot
Application of Quantitative Signal Detection in the Dutch Spontaneous Reporting System for Adverse Drug Reactions
inferredcites →https://doi.org/10.2174/1570163043334794openalex-snapshot
Assessment of the Health Effects of Chemicals in Humans: II. Construction of an Adverse Effects Database for QSAR Modeling
inferredcites →https://doi.org/10.2174/157488608784529215openalex-snapshot
Hepatic Effects of Duloxetine – III: Analysis of Hepatic Events Using External Data Sources

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1002/9781118098141.ch2openalex-snapshot
Screening for Safety‐Relevant Off‐Target Activities
inferred← citeshttps://doi.org/10.1002/med.21255openalex-snapshot
Fragment Informatics and Computational Fragment‐Based Drug Design: An Overview and Update
inferred← citeshttps://doi.org/10.1007/128_2011_182openalex-snapshot
Fragment-Based Approaches and Computer-Aided Drug Discovery
inferred← citeshttps://doi.org/10.1007/7653_2015_51openalex-snapshot
Computational Fragment-Based Drug Design
inferred← citeshttps://doi.org/10.1007/978-1-4939-1304-6_7openalex-snapshot
Pharmacometrics in Cardiovascular Safety
inferred← citeshttps://doi.org/10.1016/j.ejmcr.2026.100338openalex-snapshot
Recent advances in computational modelling, artificial intelligence, and in silico strategies for predicting adverse effects in skincare safety: A critical review
inferred← citeshttps://doi.org/10.1038/aps.2014.35openalex-snapshot
Novel Bayesian classification models for predicting compounds blocking hERG potassium channels
inferred← citeshttps://doi.org/10.1093/toxsci/kfr334openalex-snapshot
Application of Data Mining and Visualization Techniques for the Prediction of Drug-Induced Nausea in Man
inferred← citeshttps://doi.org/10.1146/annurev-pharmtox-011112-140248openalex-snapshot
Systems Pharmacology to Predict Drug Toxicity: Integration Across Levels of Biological Organization
inferred← citeshttps://doi.org/10.4155/fmc.10.277openalex-snapshot
Computational Medicinal Chemistry in Fragment-Based Drug Discovery: What, How and When
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