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Comparative QSAR Study of Tyrosine Kinase Inhibitors

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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The epidermal growth factor.
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Oncogenes and Tumor Suppressor Genes in Human Malignancies
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Signal transduction by receptor tyrosine kinases
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The current state of oncogenes and cancer: Experimental approaches for analyzing oncogenetic events in human cancer
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Cell-signaling targets for antitumour drug development
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Heterodimerization and functional interaction between EGF receptor family members: a new signaling paradigm with implications for breast cancer research
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Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro
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Signal transduction by receptors with tyrosine kinase activity
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Cooperation between oncogenes
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Oncogenes and signal transduction
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Signalling pathways as target for anticancer drug development
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Tyrphostins as molecular tools and potential antiproliferative drugs
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Signalling targets for anticancer drug development
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Design of a potent peptide inhibitor of the epidermal growth factor receptor tyrosine kinase utilizing sequences based on the natural phosphorylation sites of phospholipase C-γ1
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Inhibition of cell signalling pathways
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Epidermal growth factor-related peptides and their receptors in human malignancies
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Biochemical and cellular effects of c-Src kinase-selective pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors
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Identification and biological characterization of an epidermal growth factor-related protein: cripto-1.
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Angiogenesis.
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On the nature of allosteric transitions: A plausible model
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Expression of Transforming Growth Factor-α and the Epidermal Growth Factor Receptor in Human Prostate Tissues
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Tumor Angiogenesis
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[7] Purification of functionally active epidermal growth factor receptor protein using a competitive antagonist monoclonal antibody and competitive elution with epidermal growth factor
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Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis
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Strategies toward the Design of Novel and Selective Protein Tyrosine Kinase Inhibitors
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The Epidermal Growth Factor Receptor and Its Inhibition in Cancer Therapy
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Allosteric Receptors after 30 Years
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Oncoprotein Signalling and Mitosis
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Expression of pp60c-src in human small cell and non-small cell lung carcinomas
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How the extracellular matrix and macrophages contribute to angiogenesis-dependent diseases
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Transgenic mouse models of tumour angiogenesis: the angiogenic switch, its molecular controls, and prospects for preclinical therapeutic models
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Structure-activity relationships of a novel class of Src SH2 inhibitors
inferredcites →https://doi.org/10.1016/s0968-0004(97)01074-8openalex-snapshot
Molecular mechanisms of blood vessel formation
inferredcites →https://doi.org/10.1016/s0968-0896(00)00248-0openalex-snapshot
Searching for allosteric effects via QSARs
inferredcites →https://doi.org/10.1016/s1359-6446(96)10053-2openalex-snapshot
Receptor tyrosine kinases as targets for inhibition of angiogenesis
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Calculating log Poct from structures
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Synthesis and Structure−Activity Relationships of 7-Substituted 3-(2,6-Dichlorophenyl)-1,6-naphthyridin-2(1H)-ones as Selective Inhibitors of pp60c-src
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Tyrosine kinase inhibitors. 7. 7-amino-4-(phenylamino)- and 7-amino-4-[(phenylmethyl)amino]pyrido[4,3-d]pyrimidines: a new class of inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor
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Tyrosine Kinase Inhibitors. 18. 6-Substituted 4-Anilinoquinazolines and 4-Anilinopyrido[3,4-d]pyrimidines as Soluble, Irreversible Inhibitors of the Epidermal Growth Factor Receptor
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Tyrosine Kinase Inhibitors. 8. An Unusually Steep Structure−Activity Relationship for Analogues of 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a Potent Inhibitor of the Epidermal Growth Factor Receptor
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Tyrosine Kinase Inhibitors. 10. Isomeric 4-[(3-Bromophenyl)amino]pyrido[d]- pyrimidines Are Potent ATP Binding Site Inhibitors of the Tyrosine Kinase Function of the Epidermal Growth Factor Receptor
inferredcites →https://doi.org/10.1021/jm970124vopenalex-snapshot
Use of a Pharmacophore Model for the Design of EGF-R Tyrosine Kinase Inhibitors: 4-(Phenylamino)pyrazolo[3,4-d]pyrimidines
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2-Substituted Aminopyrido[2,3-d]pyrimidin-7(8H)-ones. Structure−Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity
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Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors
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Structure−Activity Relationships for 5-Substituted 1-Phenylbenzimidazoles as Selective Inhibitors of the Platelet-Derived Growth Factor Receptor
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Tyrosine Kinase Inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(Phenylamino)pyrido[d]pyrimidine Acrylamides as Irreversible Inhibitors of the ATP Binding Site of the Epidermal Growth Factor Receptor
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Tyrosine Kinase Inhibitors. 16. 6,5,6-Tricyclic Benzothieno[3,2-d]pyrimidines and Pyrimido[5,4-b]- and -[4,5-b]indoles as Potent Inhibitors of the Epidermal Growth Factor Receptor Tyrosine Kinase
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Design, Synthesis, and Evaluations of Substituted 3-[(3- or 4-Carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as Inhibitors of VEGF, FGF, and PDGF Receptor Tyrosine Kinases
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Tyrosine Kinase Inhibitors. 17. Irreversible Inhibitors of the Epidermal Growth Factor Receptor: 4-(Phenylamino)quinazoline- and 4-(Phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides Bearing Additional Solubilizing Functions
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Identification of Substituted 3-[(4,5,6,7-Tetrahydro-1H-indol-2-yl)methylene]- 1,3-dihydroindol-2-ones as Growth Factor Receptor Inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-Rβ Tyrosine Kinases
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Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
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Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system
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Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors
inferredcites →https://doi.org/10.1038/385595a0openalex-snapshot
Three-dimensional structure of the tyrosine kinase c-Src
inferredcites →https://doi.org/10.1038/47260openalex-snapshot
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
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Angiogenesis in cancer, vascular, rheumatoid and other disease
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A secreted FGF-binding protein can serve as the angiogenic switch in human cancer
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Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling
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Tyrosine Phosphorylation: Past, Present and Future
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Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor
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Evidence for the differential expression of a variant EGF receptor protein in human prostate cancer
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Transplacental Carcinogenesis by Stilbestrol
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Increased pp60c-src tyrosyl kinase activity in human neuroblastomas is associated with amino-terminal tyrosine phosphorylation of the src gene product.
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Molecular cloning and expression of an additional epidermal growth factor receptor-related gene.
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Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails.
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Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family.
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Epiregulin
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Topological Analysis of the Integral Membrane Protein, Type 1 Iodothyronine Deiodinase (D1)
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A Raf-independent Epidermal Growth Factor Receptor Autocrine Loop Is Necessary for Ras Transformation of Rat Intestinal Epithelial Cells
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Unliganded Epidermal Growth Factor Receptor Dimerization Induced by Direct Interaction of Quinazolines with the ATP Binding Site
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Critical Role of Calcium- dependent Epidermal Growth Factor Receptor Transactivation in PC12 Cell Membrane Depolarization and Bradykinin Signaling
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Autoregulatory Mechanisms in Protein-tyrosine Kinases
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Expression of transforming growth factor alpha and epidermal growth factor receptor in human bladder cancer
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Activation of Endogenous Thrombin Receptors Causes Clustering and Sensitization of Epidermal Growth Factor Receptors of Swiss 3t3 Cells without Transactivation
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Radiation-induced Release of Transforming Growth Factor α Activates the Epidermal Growth Factor Receptor and Mitogen-activated Protein Kinase Pathway in Carcinoma Cells, Leading to Increased Proliferation and Protection from Radiation-induced Cell Death
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What Is the Evidence That Tumors Are Angiogenesis Dependent?
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Levels of TGF-α and EGFR Protein in Head and Neck Squamous Cell Carcinoma and Patient Survival
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Prevalence of aberrant expression of the epidermal growth factor receptor in human cancers
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The codependence of angiogenesis and chronic inflammation
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The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1
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Angiogenesis: new aspects relating to its initiation and control
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Growth Factors and Cancer
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Fidelity of T Cell Activation Through Multistep T Cell Receptor ζ Phosphorylation
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Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene
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Tyrosine Kinase Inhibition: An Approach to Drug Development
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Betacellulin: a mitogen from pancreatic beta cell tumors
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CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES
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Angiogenesis: A Paradigm for Balanced Extracellular Proteolysis during Cell Migration and Morphogenesis
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src Expression in Small-Cell Lung Carcinoma and Other Neuroendocrine Malignancies
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pp60c-src activation in human colon carcinoma.
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Differential pp60c-src activity in well and poorly differentiated human colon carcinomas and cell lines.
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Protein tyrosine kinases as therapeutic targets in cancer chemotherapy and recent advances in the development of new inhibitors
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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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ChemInform Abstract: Comparative QSAR Study of Tyrosine Kinase Inhibitors
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Synthesis of C‐Nucleosidic ATP Mimics as Potential FGFR3 Inhibitors
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QSAR and 3D QSAR of inhibitors of the epidermal growth factor receptor
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Towards the Revival of Interpretable QSAR Models
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A 2D image-based method for modeling some c-Src tyrosine kinase inhibitors
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Structure-based 3D-QSAR studies on quinazoline derivatives as platelets-derived growth factor (PDGFR) inhibitors
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In silico QSAR studies of anilinoquinolines as EGFR inhibitors
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Possible allosteric interactions of monoindazole-substituted P2 cyclic urea analogues with wild-type and mutant HIV-1 protease
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One-Pot Cascade Heterocyclization of γ- and β-Ketomalononitriles to 2,4-Dichloro-Substituted Pyrano[2,3-d]pyrimidines and Furo[2,3-d]pyrimidines Mediated by Triphosgene and Triphenylphosphine Oxide
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Proteochemometric Recognition of Stable Kinase Inhibition Complexes Using Topological Autocorrelation and Support Vector Machines
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Modified Particle Swarm Optimization Algorithm for Adaptively Configuring Globally Optimal Classification and Regression Trees
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QSAR of aromatic substances: EGFR inhibitory activity of quinazoline analogues
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Quantitative Structure–Activity Relationship Analysis of 4(3H)-Quinazolone Derivatives as Tyrosine Kinase Inhibitors by Multiple Linear Regression
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CNS Anticancer Drug Discovery and Development Conference White Paper
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Design, synthesis, antitumor evaluations and molecular modeling studies of novel 3,5-substituted indolin-2-one derivatives
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Cheminfomatic-based Drug Discovery of Human Tyrosine Kinase Inhibitors
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Reactions of Tetracyanoethylene with Aliphatic and Aromatic Amines and Hydrazines and Chemical Transformations of Tetracyanoethylene Derivatives
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Ligand-based QSAR Studies on the Indolinones Derivatives as Inhibitors of the Protein Tyrosine Kinase of Fibroblast Growth Factor Receptor by CoMFA and CoMSIA
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The Matrix Expression, Topological Index and Atomic Attribute of Molecular Topological Structure
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