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Identification of Cryptic Products of the Gliotoxin Gene Cluster Using NMR-Based Comparative Metabolomics and a Model for Gliotoxin Biosynthesis

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Stable isotope-resolved metabolomic analysis of lithium effects on glial-neuronal metabolism and interactions
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NMR-spectroscopic analysis of mixtures: from structure to function
inferredcites →https://doi.org/10.1016/j.chembiol.2010.12.022openalex-snapshot
The Role of Glutathione S-Transferase GliG in Gliotoxin Biosynthesis in Aspergillus fumigatus
inferredcites →https://doi.org/10.1016/j.femsle.2005.05.046openalex-snapshot
Bioinformatic and expression analysis of the putative gliotoxin biosynthetic gene cluster ofAspergillus fumigatus
inferredcites →https://doi.org/10.1016/j.ijmm.2007.04.006openalex-snapshot
Gliotoxin production by clinical and environmental Aspergillus fumigatus strains
inferredcites →https://doi.org/10.1016/j.mycres.2007.08.017openalex-snapshot
Biosynthetic gene clusters for epipolythiodioxopiperazines in filamentous fungi
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Novel and facile solution-phase synthesis of 2,5-diketopiperazines and O-glycosylated analogs
inferredcites →https://doi.org/10.1016/s0040-4020(01)97960-8openalex-snapshot
Total synthesis of gliotoxin, dehydrogliotoxin and hyalodendrin
inferredcites →https://doi.org/10.1016/s1460-1567(08)x0001-7openalex-snapshot
High-Resolution NMR Techniques in Organic Chemistry
inferredcites →https://doi.org/10.1021/ac0711586openalex-snapshot
Strategy for Automated Analysis of Dynamic Metabolic Mixtures by NMR. Application to an Insect Venom
inferredcites →https://doi.org/10.1021/bi061845bopenalex-snapshot
GliP, a Multimodular Nonribosomal Peptide Synthetase inAspergillus fumigatus, Makes the Diketopiperazine Scaffold of Gliotoxin
inferredcites →https://doi.org/10.1021/ja047416nopenalex-snapshot
A New Approach to Natural Products Discovery Exemplified by the Identification of Sulfated Nucleosides in Spider Venom
inferredcites →https://doi.org/10.1021/ja053617vopenalex-snapshot
Exploring Uncharted Terrain in Nature's Structure Space Using Capillary NMR Spectroscopy: 13 Steroids from 50 Fireflies
inferredcites →https://doi.org/10.1021/ja103262mopenalex-snapshot
Transannular Disulfide Formation in Gliotoxin Biosynthesis and Its Role in Self-Resistance of the Human Pathogen Aspergillus fumigatus
inferredcites →https://doi.org/10.1021/jm700948zopenalex-snapshot
Genome Mining for Novel Natural Product Discovery
inferredcites →https://doi.org/10.1021/jo01298a024openalex-snapshot
Biosynthesis of gliotoxin. Synthesis of sulfur-bridged dioxopiperazines from N-hydroxyamino acids
inferredcites →https://doi.org/10.1038/nature04332openalex-snapshot
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
inferredcites →https://doi.org/10.1039/j39700000432openalex-snapshot
Sporidesmins. Part X. Synthesis of polysulphides by reaction of dihydrogen disulphide with disulphides and thiols
inferredcites →https://doi.org/10.1039/p19800000119openalex-snapshot
Biosynthesis of bisdethiobis(methylthio)gliotoxin, a new metabolite of Gliocladium deliquescens
inferredcites →https://doi.org/10.1039/p19810000218openalex-snapshot
New piperazinedione metabolites of Gliocladium deliquescens
inferredcites →https://doi.org/10.1039/p19880000301openalex-snapshot
New co-metabolites of gliotoxin in Gliocladium virens
inferredcites →https://doi.org/10.1039/p19910001283openalex-snapshot
Biosynthesis of hyalodendrin and didethiobis(methylthio)hyalodendrin, sulphur-containing 2,5-dioxopiperazines of the 3S,6S series
inferredcites →https://doi.org/10.1073/pnas.0610503104openalex-snapshot
The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis
inferredcites →https://doi.org/10.1073/pnas.0811918106openalex-snapshot
A shortcut to identifying small molecule signals that regulate behavior and development in Caenorhabditis elegans
inferredcites →https://doi.org/10.1080/14786410600906970openalex-snapshot
A new gliotoxin analogue from a marine-derived fungusAspergillus fumigatusFres
inferredcites →https://doi.org/10.1098/rsbl.2007.0338openalex-snapshot
Secondary chemicals protect mould from fungivory
inferredcites →https://doi.org/10.1111/j.1365-2958.2006.05373.xopenalex-snapshot
Deletion of the gliP gene of Aspergillus fumigatus results in loss of gliotoxin production but has no effect on virulence of the fungus in a low‐dose mouse infection model
inferredcites →https://doi.org/10.1128/ec.00049-06openalex-snapshot
Disruption of a Nonribosomal Peptide Synthetase in Aspergillus fumigatus Eliminates Gliotoxin Production
inferredcites →https://doi.org/10.1128/ec.00141-07openalex-snapshot
Gliotoxin Is a Virulence Factor of Aspergillus fumigatus : gliP Deletion Attenuates Virulence in Mice Immunosuppressed with Hydrocortisone
inferredcites →https://doi.org/10.1128/iai.00780-06openalex-snapshot
GliZ, a Transcriptional Regulator of Gliotoxin Biosynthesis, Contributes toAspergillus fumigatusVirulence
inferredcites →https://doi.org/10.1128/iai.73.1.635-637.2005openalex-snapshot
Detection of Gliotoxin in Experimental and Human Aspergillosis
inferredcites →https://doi.org/10.1371/journal.ppat.1000952openalex-snapshot
Self-Protection against Gliotoxin—A Component of the Gliotoxin Biosynthetic Cluster, GliT, Completely Protects Aspergillus fumigatus Against Exogenous Gliotoxin

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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N‐Heterocyclization in Gliotoxin Biosynthesis is Catalyzed by a Distinct Cytochrome P450 Monooxygenase
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Fungal Genomics
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Characterization of novel gliotoxin biosynthesis-related genes from deep-sea-derived fungus Geosmithia pallida FS140
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Nidustrin A, cysteine-retained emestrin with a unique 18-membered macrocyclic lactone from the endophytic fungus Aspergillus nidulans
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Reconstitution of the early steps of gliotoxin biosynthesis in Aspergillus nidulans reveals the role of the monooxygenase GliC
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Regulation of Nonribosomal Peptide Synthesis: bis-Thiomethylation Attenuates Gliotoxin Biosynthesis in Aspergillus fumigatus
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Meta-omic characterization of prokaryotic gene clusters for natural product biosynthesis
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Proteomic dissection of the role of GliZ in gliotoxin biosynthesis in Aspergillus fumigatus
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Dysregulated gliotoxin biosynthesis attenuates the production of unrelated biosynthetic gene cluster-encoded metabolites in Aspergillus fumigatus
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DABCO/AgOAc cooperatively catalyzed α-sulfenylation of isocyanoacetates with N-(sulfanyl)succinimides
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Resistance is not futile: gliotoxin biosynthesis, functionality and utility
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Profiling human blood serum metabolites by nuclear magnetic resonance spectroscopy: a comprehensive tool for the evaluation of hemodialysis efficiency
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Emestrins: Anti-Cryptococcus Epipolythiodioxopiperazines from Podospora australis
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Combining Mass Spectrometry and NMR Improves Metabolite Detection and Annotation
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Catalytic Enantioselective Construction of Sulfur-Containing Tetrasubstituted Carbon Stereocenters
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Extensive sequence divergence of non-coding regions between Aspergillus fumigatus , a major fungal pathogen of humans, and its relatives
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Interplay between Gliotoxin Resistance, Secretion, and the Methyl/Methionine Cycle in Aspergillus fumigatus
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Talaromyces marneffei simA Encodes a Fungal Cytochrome P450 Essential for Survival in Macrophages
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RNA-seq reveals the pan-transcriptomic impact of attenuating the gliotoxin self-protection mechanism in Aspergillus fumigatus
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Anthranilate Fluorescence Marks a Calcium-Propagated Necrotic Wave That Promotes Organismal Death in C. elegans
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Induction of Gliotoxin Secretion in Aspergillus fumigatus by Bacteria-Associated Molecules
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The Epipolythiodiketopiperazine Gene Cluster in Claviceps purpurea: Dysfunctional Cytochrome P450 Enzyme Prevents Formation of the Previously Unknown Clapurines
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The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulence
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Aspergillus flavus Secondary Metabolites: More than Just Aflatoxins
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Extensive Non-Coding Sequence Divergence Between the Major Human Pathogen Aspergillus fumigatus and its Relatives
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Perturbations in small molecule synthesis uncovers an iron-responsive secondary metabolite network in Aspergillus fumigatus
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Endogenous cross-talk of fungal metabolites
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A new high-performance heterologous fungal expression system based on regulatory elements from the Aspergillus terreus terrein gene cluster
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Fungal Lactamases: Their Occurrence and Function
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De Novo Transcriptome Sequencing of the Deep-Sea-Derived Fungus Dichotomomyces cejpii and Analysis of Gliotoxin Biosynthesis Genes
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Presence, Mode of Action, and Application of Pathway Specific Transcription Factors in Aspergillus Biosynthetic Gene Clusters
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The Sound of Silence: Activating Silent Biosynthetic Gene Clusters in Marine Microorganisms
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Geospallins A–C: New Thiodiketopiperazines with Inhibitory Activity against Angiotensin-Converting Enzyme from a Deep-Sea-Derived Fungus Geosmithia pallida FS140
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Exploring the Role of Nonribosomal Peptides in the Human Microbiome Through the Oral Commensal Streptococcus mutans, the Probiotic Lactobacillus plantarum, and Crohn’s Disease Associated Faecalibacterium prausnitzii
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