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Modular Pathway Engineering of Diterpenoid Synthases and the Mevalonic Acid Pathway for Miltiradiene Production
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Diterpene cyclases and the nature of the isoprene fold
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Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering
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Production of geranylgeraniol on overexpression of a prenyl diphosphate synthase fusion gene in Saccharomyces cerevisiae
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Efficient gene disruption in Saccharomyces cerevisiae using marker cassettes with long homologous arms prepared by the restriction-free cloning strategy
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The yeast genome project: what did we learn?
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Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds
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Construction and optimization of synthetic pathways in metabolic engineering
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Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production
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Targeted proteomics for metabolic pathway optimization: Application to terpene production
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Metabolic engineering tanshinone biosynthetic pathway in Salvia miltiorrhiza hairy root cultures
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Metabolic Engineering to Produce Sesquiterpenes in Yeast
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A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights
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Production of the antimalarial drug precursor artemisinic acid in engineered yeast
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Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis
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Stabilized gene duplication enables long-term selection-free heterologous pathway expression
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Synthetic protein scaffolds provide modular control over metabolic flux
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Structure and mechanism of the diterpene cyclase ent-copalyl diphosphate synthase
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Production of isoprenoid pharmaceuticals by engineered microbes
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Saccharomyces cerevisiae contains two functional genes encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
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The Biosynthetic Incorporation of the Intact Leucine Skeleton into Sterol by the Trypanosomatid Leishmania mexicana
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Oligomerization of G-protein-coupled Receptors Shown by Selective Co-immunoprecipitation
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Reversible Compartmentalization of de Novo Purine Biosynthetic Complexes in Living Cells
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inferredcites →https://doi.org/10.1126/science.1191652openalex-snapshot
Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli
inferredcites →https://doi.org/10.1126/science.1193990openalex-snapshot
Manufacturing Molecules Through Metabolic Engineering
inferredcites →https://doi.org/10.1128/aem.00277-09openalex-snapshot
Overproduction of Geranylgeraniol by Metabolically Engineered Saccharomyces cerevisiae
inferredcites →https://doi.org/10.1128/aem.01249-09openalex-snapshot
Metabolic Engineering of Saccharomyces cerevisiae for Astaxanthin Production and Oxidative Stress Tolerance
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inferredcites →https://doi.org/10.1146/annurev.bi.56.070187.000513openalex-snapshot
COMPLEXES OF SEQUENTIAL METABOLIC ENZYMES
inferredcites →https://doi.org/10.1146/annurev.med.48.1.353openalex-snapshot
THE DEVELOPMENT AND CLINICAL UTILITY OF THE TAXANE CLASS OF ANTIMICROTUBULE CHEMOTHERAPY AGENTS
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Direct ethanol production from cellulosic materials using a diploid strain of Saccharomyces cerevisiaewith optimized cellulase expression
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Salvia miltiorrhiza: Chemical and pharmacological review of a medicinal plant
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Incoming claims: where this work appears in other papers’ reference lists and arguments.
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inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2021.08.112openalex-snapshot
Targeted mutagenesis of CYP76AK2 and CYP76AK3 in Salvia miltiorrhiza reveals their roles in tanshinones biosynthetic pathway
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.135455openalex-snapshot
Screening and modification of (+)-germacrene A synthase for the production of the anti-tumor drug (−)-β-elemene in engineered Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.1016/j.isci.2020.100879openalex-snapshot
Advanced Strategies for Production of Natural Products in Yeast
inferred← citeshttps://doi.org/10.1016/j.isci.2021.102168openalex-snapshot
Recombination machinery engineering for precise genome editing in methylotrophic yeast Ogataea polymorpha
inferred← citeshttps://doi.org/10.1016/j.jbiosc.2014.07.013openalex-snapshot
Production of squalene by squalene synthases and their truncated mutants in Escherichia coli
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2013.07.030openalex-snapshot
Multivariate modular metabolic engineering of Escherichia coli to produce resveratrol from l-tyrosine
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2019.10.019openalex-snapshot
Enhance production of diterpenoids in yeast by overexpression of the fused enzyme of ERG20 and its mutant mERG20
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2025.06.013openalex-snapshot
Improved methanol utilization of Komagataella phaffii by rebuilding metabolic network based on new alcohol-aldehyde transformation system
inferred← citeshttps://doi.org/10.1016/j.jplph.2019.153006openalex-snapshot
The ethylene response factor SmERF8 regulates the expression of SmKSL1 and is involved in tanshinone biosynthesis in Saliva miltiorrhiza hairy roots
inferred← citeshttps://doi.org/10.1016/j.mec.2020.e00129openalex-snapshot
Protein engineering strategies for microbial production of isoprenoids
inferred← citeshttps://doi.org/10.1016/j.meegid.2020.104378openalex-snapshot
Anti-biofilm effect by the combined action of fluconazole and acetylsalicylic acid against species of Candida parapsilosis complex
inferred← citeshttps://doi.org/10.1016/j.meteno.2016.05.004openalex-snapshot
A genetic screen for increasing metabolic flux in the isoprenoid pathway of Saccharomyces cerevisiae : Isolation of SPT15 mutants using the screen
inferred← citeshttps://doi.org/10.1016/j.pbi.2022.102189openalex-snapshot
Tanshinones: Leading the way into Lamiaceae labdane-related diterpenoid biosynthesis
inferred← citeshttps://doi.org/10.1016/j.pep.2018.06.004openalex-snapshot
Cloning, expression, and functional analysis of lysine decarboxylase in mulberry ( Morus alba L.)
inferred← citeshttps://doi.org/10.1016/j.phytochem.2018.07.009openalex-snapshot
Metabolism of ganoderic acids by a Ganoderma lucidum cytochrome P450 and the 3-keto sterol reductase ERG27 from yeast
inferred← citeshttps://doi.org/10.1016/j.plantsci.2013.05.005openalex-snapshot
Metabolic engineering and in vitro biosynthesis of phytochemicals and non-natural analogues
inferred← citeshttps://doi.org/10.1016/j.plantsci.2019.05.013openalex-snapshot
Analysis of the role of geranylgeranyl diphosphate synthase 8 from Tripterygium wilfordii in diterpenoids biosynthesis
inferred← citeshttps://doi.org/10.1016/j.plantsci.2025.112384openalex-snapshot
New insights of advanced biotechnological engineering strategies for tanshinone biosynthesis in Salvia miltiorrhiza
inferred← citeshttps://doi.org/10.1016/j.plgene.2017.07.001openalex-snapshot
De novo transcriptome sequencing and analysis of Euphorbia pekinensis Rupr. and identification of genes involved in diterpenoid biosynthesis
inferred← citeshttps://doi.org/10.1016/j.plipres.2013.03.001openalex-snapshot
Yeast metabolic engineering – Targeting sterol metabolism and terpenoid formation
inferred← citeshttps://doi.org/10.1016/j.prmcm.2023.100349openalex-snapshot
Nanotherapeutic derived from multiple bioactive ingredients of natural products: A robust tool for the development of traditional medicine
inferred← citeshttps://doi.org/10.1016/j.synbio.2020.05.002openalex-snapshot
Toward fine-tuned metabolic networks in industrial microorganisms
inferred← citeshttps://doi.org/10.1016/j.synbio.2020.06.005openalex-snapshot
Harnessing sub-organelle metabolism for biosynthesis of isoprenoids in yeast
inferred← citeshttps://doi.org/10.1016/j.synbio.2021.03.001openalex-snapshot
Screening neutral sites for metabolic engineering of methylotrophic yeast Ogataea polymorpha
inferred← citeshttps://doi.org/10.1016/j.synbio.2024.02.001openalex-snapshot
Promoter engineering enables precise metabolic regulation towards efficient β-elemene production in Ogataea polymorpha
inferred← citeshttps://doi.org/10.1016/j.synbio.2024.04.015openalex-snapshot
Engineering a non-model yeast Rhodotorula mucilaginosa for terpenoids synthesis
inferred← citeshttps://doi.org/10.1016/j.synbio.2024.05.002openalex-snapshot
Biochemical synthesis of taxanes from mevalonate
inferred← citeshttps://doi.org/10.1016/j.synbio.2025.02.015openalex-snapshot
Exploration and mutagenesis of the germacrene A synthase from Solidago canadensis to enhance germacrene A production in E. coli
inferred← citeshttps://doi.org/10.1016/j.synbio.2025.04.013openalex-snapshot
Promoter engineering for enhanced 3-hydroxypropionic acid production in Pichia pastoris
inferred← citeshttps://doi.org/10.1016/j.synbio.2025.08.003openalex-snapshot
Engineering robust Saccharomyces cerevisiae cell factory for improving fatty alcohol biosynthesis
inferred← citeshttps://doi.org/10.1016/j.tetlet.2013.09.004openalex-snapshot
Synthesis of isoprenoid chain-contained chemical probes for an investigation of molecular interactions by using quartz crystal microbalance
inferred← citeshttps://doi.org/10.1016/j.tibtech.2014.04.003openalex-snapshot
Engineering redox balance through cofactor systems
inferred← citeshttps://doi.org/10.1016/j.tibtech.2015.04.006openalex-snapshot
Plant diterpene synthases: exploring modularity and metabolic diversity for bioengineering
inferred← citeshttps://doi.org/10.1016/j.tibtech.2015.12.007openalex-snapshot
Production of Useful Terpenoids by Higher-Fungus Cell Factory and Synthetic Biology Approaches
inferred← citeshttps://doi.org/10.1016/j.tibtech.2019.12.008openalex-snapshot
Protein Engineering for Improving and Diversifying Natural Product Biosynthesis
inferred← citeshttps://doi.org/10.1016/j.xplc.2025.101286openalex-snapshot
Three cytochrome P450 enzymes consecutively catalyze the biosynthesis of furanoclerodane precursors in Salvia species
inferred← citeshttps://doi.org/10.1016/j.ymben.2012.11.009openalex-snapshot
Metabolic engineering of Escherichia coli for (2S)-pinocembrin production from glucose by a modular metabolic strategy
inferred← citeshttps://doi.org/10.1016/j.ymben.2013.10.004openalex-snapshot
Metabolic engineering of Saccharomyces cerevisiae for production of ginsenosides
inferred← citeshttps://doi.org/10.1016/j.ymben.2014.10.008openalex-snapshot
Efficient diterpene production in yeast by engineering Erg20p into a geranylgeranyl diphosphate synthase
inferred← citeshttps://doi.org/10.1016/j.ymben.2014.11.007openalex-snapshot
Sequential control of biosynthetic pathways for balanced utilization of metabolic intermediates in Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.1016/j.ymben.2014.12.001openalex-snapshot
Reconstructing the chemical diversity of labdane-type diterpene biosynthesis in yeast
inferred← citeshttps://doi.org/10.1016/j.ymben.2015.02.002openalex-snapshot
Mitochondrial engineering of the TCA cycle for fumarate production
inferred← citeshttps://doi.org/10.1016/j.ymben.2015.07.007openalex-snapshot
Modular optimization of multi-gene pathways for fumarate production
inferred← citeshttps://doi.org/10.1016/j.ymben.2017.09.007openalex-snapshot
Enabling the synthesis of medium chain alkanes and 1-alkenes in yeast
inferred← citeshttps://doi.org/10.1016/j.ymben.2018.04.006openalex-snapshot
Enhancing fructosylated chondroitin production in Escherichia coli K4 by balancing the UDP-precursors
inferred← citeshttps://doi.org/10.1016/j.ymben.2018.05.006openalex-snapshot
Advances and prospects of Bacillus subtilis cellular factories: From rational design to industrial applications
inferred← citeshttps://doi.org/10.1016/j.ymben.2018.10.001openalex-snapshot
Identification of a novel cytochrome P450 enzyme that catalyzes the C-2α hydroxylation of pentacyclic triterpenoids and its application in yeast cell factories
inferred← citeshttps://doi.org/10.1016/j.ymben.2020.03.011openalex-snapshot
Engineering chimeric diterpene synthases and isoprenoid biosynthetic pathways enables high-level production of miltiradiene in yeast
inferred← citeshttps://doi.org/10.1016/j.ymben.2020.08.010openalex-snapshot
Engineering Saccharomyces cerevisiae for high yield production of α-amyrin via synergistic remodeling of α-amyrin synthase and expanding the storage pool
inferred← citeshttps://doi.org/10.1016/j.ymben.2020.09.003openalex-snapshot
Promiscuous phosphoketolase and metabolic rewiring enables novel non-oxidative glycolysis in yeast for high-yield production of acetyl-CoA derived products
inferred← citeshttps://doi.org/10.1016/j.ymben.2021.01.007openalex-snapshot
Transportome-wide engineering of Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.1016/j.ymben.2022.10.004openalex-snapshot
Machine-learning guided elucidation of contribution of individual steps in the mevalonate pathway and construction of a yeast platform strain for terpenoid production
inferred← citeshttps://doi.org/10.1016/j.ymben.2022.11.002openalex-snapshot
Engineering yeast for high-level production of diterpenoid sclareol
inferred← citeshttps://doi.org/10.1016/j.ymben.2023.02.008openalex-snapshot
Global metabolic rewiring of the nonconventional yeast Ogataea polymorpha for biosynthesis of the sesquiterpenoid β-elemene
inferred← citeshttps://doi.org/10.1016/j.ymben.2023.03.012openalex-snapshot
Metabolic flux enhancement from the translational fusion of terpene synthases is linked to terpene synthase accumulation
inferred← citeshttps://doi.org/10.1016/j.ymben.2023.08.003openalex-snapshot
Fine-tuning of p-coumaric acid synthesis to increase (2S)-naringenin production in yeast
inferred← citeshttps://doi.org/10.1016/j.ymben.2024.08.006openalex-snapshot
Engineering yeast for high-level production of β-farnesene from sole methanol
inferred← citeshttps://doi.org/10.1016/s1674-6384(15)60042-9openalex-snapshot
Systems Biology Application in Research on Sustainable Utilization of Chinese Materia Medica Resources
inferred← citeshttps://doi.org/10.1016/s1674-6384(16)60001-1openalex-snapshot
Medicinal Model Plants: Breaking the Traditional Medicine Research Methods
inferred← citeshttps://doi.org/10.1016/s1674-6384(16)60002-3openalex-snapshot
Biosynthesis and Regulation of Active Compounds in Medicinal Model Plant Salvia miltiorrhiza
inferred← citeshttps://doi.org/10.1016/s1875-5364(21)60100-0openalex-snapshot
A review: biosynthesis of plant-derived labdane-related diterpenoids
inferred← citeshttps://doi.org/10.1021/acs.jafc.0c04832openalex-snapshot
Comparative Transcriptome Analysis of Key Reductase Genes Involved in the 1-Deoxynojirimycin Biosynthetic Pathway in Mulberry Leaves and Cloning, Prokaryotic Expression, and Functional Analysis of MaSDR1 and MaSDR2
inferred← citeshttps://doi.org/10.1021/acs.jafc.1c00508openalex-snapshot
Enhancing Geranylgeraniol Production by Metabolic Engineering and Utilization of Isoprenol as a Substrate in Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.1021/acs.jafc.2c01394openalex-snapshot
Global Metabolic Rewiring of Yeast Enables Overproduction of Sesquiterpene (+)-Valencene
inferred← citeshttps://doi.org/10.1021/acs.jafc.4c01203openalex-snapshot
Reprogramming the Metabolism of Yeast for High-Level Production of Miltiradiene
inferred← citeshttps://doi.org/10.1021/acs.jafc.4c02595openalex-snapshot
Comprehensive Engineering Strategies for Heterologous Production of Zealexin A1 in Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.1021/acs.jafc.9b02156openalex-snapshot
Combinatorial Engineering of Mevalonate Pathway and Diterpenoid Synthases in Escherichia coli for cis-Abienol Production
inferred← citeshttps://doi.org/10.1021/acs.jafc.9b03727openalex-snapshot
Improved Production of Arachidonic Acid by Combined Pathway Engineering and Synthetic Enzyme Fusion in Yarrowia lipolytica
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.6c00168openalex-snapshot
Mining Cytochrome P450 Enzymes Involved in Casbene Oxidation from Euphorbia fischeriana Steud. and Clarifying Their Substrate Specificity
inferred← citeshttps://doi.org/10.1021/acs.orglett.0c00325openalex-snapshot
Syntheses of Epoxyguaiane Sesquiterpenes (−)-Englerin A, (−)-Oxyphyllol, (+)-Orientalol E, and (+)-Orientalol F: A Synthetic Biology Approach
inferred← citeshttps://doi.org/10.1021/acs.orglett.0c03894openalex-snapshot
Syntheses of the Carotane-type Terpenoids (+)-Schisanwilsonene A and (+)-Tormesol via a Two-Stage Approach
inferred← citeshttps://doi.org/10.1021/acscatal.6b03579openalex-snapshot
Synthetic Cofactor-Linked Metabolic Circuits for Selective Energy Transfer
inferred← citeshttps://doi.org/10.1021/acssuschemeng.3c00410openalex-snapshot
Efficient Bioproduction of 3-Hydroxypropionic Acid from Methanol by a Synthetic Yeast Cell Factory
inferred← citeshttps://doi.org/10.1021/acssuschemeng.5c00924openalex-snapshot
Efficient Biosynthesis of the Plant-Derived Diterpenoid Miltiradiene in Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.1021/acssynbio.0c00136openalex-snapshot
Functional Integration of Two CYP450 Genes Involved in Biosynthesis of Tanshinones for Improved Diterpenoid Production by Synthetic Biology
inferred← citeshttps://doi.org/10.1021/acssynbio.1c00065openalex-snapshot
De Novo Biosynthesis of the Oleanane-Type Triterpenoids of Tunicosaponins in Yeast
inferred← citeshttps://doi.org/10.1021/acssynbio.1c00464openalex-snapshot
Engineering Yeast Yarrowia lipolytica for Methanol Assimilation
inferred← citeshttps://doi.org/10.1021/acssynbio.2c00425openalex-snapshot
Optimization of Pinocembrin Biosynthesis in Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.1021/acssynbio.4c00349openalex-snapshot
Dynamically Regulating Homologous Recombination Enables Precise Genome Editing in Ogataea polymorpha
inferred← citeshttps://doi.org/10.1021/acssynbio.5c00105openalex-snapshot
Heterologous Production of Levopimaradiene in Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.1021/acssynbio.5c00882openalex-snapshot
Elucidation and Reconstitution of the Andrographolide Biosynthetic Pathway in Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.1021/acssynbio.7b00006openalex-snapshot
Obtaining a Panel of Cascade Promoter-5′-UTR Complexes in Escherichia coli
inferred← citeshttps://doi.org/10.1021/acssynbio.7b00338openalex-snapshot
Engineering 1-Alkene Biosynthesis and Secretion by Dynamic Regulation in Yeast
inferred← citeshttps://doi.org/10.1021/acssynbio.8b00176openalex-snapshot
Productive Amyrin Synthases for Efficient α-Amyrin Synthesis in Engineered Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.1021/acssynbio.9b00118openalex-snapshot
FadR-Based Biosensor-Assisted Screening for Genes Enhancing Fatty Acyl-CoA Pools in Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.1021/acssynbio.9b00144openalex-snapshot
Expanding the Dynamic Range of a Transcription Factor-Based Biosensor in Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.1021/acssynbio.9b00477openalex-snapshot
Improvement of cis,cis-Muconic Acid Production in Saccharomyces cerevisiae through Biosensor-Aided Genome Engineering
inferred← citeshttps://doi.org/10.1021/ja307404uopenalex-snapshot
Toward a Biosynthetic Route to Sclareol and Amber Odorants
inferred← citeshttps://doi.org/10.1021/ja512685xopenalex-snapshot
Feasibility of Intramolecular Proton Transfers in Terpene Biosynthesis – Guiding Principles
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