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Rational Design of Highly Sensitive Fluorescence Probes for Protease and Glycosidase Based on Precisely Controlled Spirocyclization

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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inferredcites →https://doi.org/10.1002/ijc.1492openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.febslet.2005.03.052openalex-snapshot
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Development of a Highly Specific Rhodamine-Based Fluorescence Probe for Hypochlorous Acid and Its Application to Real-Time Imaging of Phagocytosis
inferredcites →https://doi.org/10.1021/ja204781topenalex-snapshot
β-Galactosidase Fluorescence Probe with Improved Cellular Accumulation Based on a Spirocyclized Rhodol Scaffold
inferredcites →https://doi.org/10.1021/ol702769nopenalex-snapshot
Fluorescence Imaging of Cellular Glutathione Using a Latent Rhodamine
inferredcites →https://doi.org/10.1021/ol800206xopenalex-snapshot
Fluorogenic and Chromogenic Rhodamine Spirolactam Based Probe for Nitric Oxide by Spiro Ring Opening Reaction
inferredcites →https://doi.org/10.1038/ni859openalex-snapshot
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Interferon-γ Can Stimulate Post-proteasomal Trimming of the N Terminus of an Antigenic Peptide by Inducing Leucine Aminopeptidase
inferredcites →https://doi.org/10.1074/jbc.m109.060418openalex-snapshot
Aminopeptidase Fingerprints, an Integrated Approach for Identification of Good Substrates and Optimal Inhibitors
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inferredcites →https://doi.org/10.1136/jcp.17.1.52openalex-snapshot
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Seprase Promotes Rapid Tumor Growth and Increased Microvessel Density in a Mouse Model of Human Breast Cancer
inferredcites →https://doi.org/10.1248/cpb.25.362openalex-snapshot
A new fluorogenic substrate for aminopeptidase.
inferredcites →https://doi.org/10.1517/14728222.11.4.453openalex-snapshot
Essential role of placental leucine aminopeptidase in gynecologic malignancy

What points at this work

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inferred← citeshttps://doi.org/10.1021/acs.analchem.7b02910openalex-snapshot
A Ratiometric Fluorescent Probe for Monitoring Leucine Aminopeptidase in Living Cells and Zebrafish Model
inferred← citeshttps://doi.org/10.1021/acs.analchem.7b03114openalex-snapshot
Development of a Long-Lived Luminescence Probe for Visualizing β-Galactosidase in Ovarian Carcinoma Cells
inferred← citeshttps://doi.org/10.1021/acs.analchem.7b03332openalex-snapshot
Near-Infrared Fluorescent Probe with Remarkable Large Stokes Shift and Favorable Water Solubility for Real-Time Tracking Leucine Aminopeptidase in Living Cells and In Vivo
inferred← citeshttps://doi.org/10.1021/acs.analchem.8b01181openalex-snapshot
Twisted-Intramolecular-Charge-Transfer-Based Turn-On Fluorogenic Nanoprobe for Real-Time Detection of Serum Albumin in Physiological Conditions
inferred← citeshttps://doi.org/10.1021/acs.analchem.9b00107openalex-snapshot
Diagnosing Drug-Induced Liver Injury by Multispectral Optoacoustic Tomography and Fluorescence Imaging Using a Leucine-Aminopeptidase-Activated Probe
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.0c00435openalex-snapshot
Companion Diagnosis for Retinal Neuroprotective Treatment by Real-Time Imaging of Calpain Activation Using a Novel Fluorescent Probe
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.2c00039openalex-snapshot
Rapid Visualization of Deeply Located Tumors In Vivo by Intravenous Administration of a γ-Glutamyltranspeptidase-Activated Fluorescent Probe
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.5b00481openalex-snapshot
Aminopeptidase P Mediated Targeting for Breast Tissue Specific Conjugate Delivery
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.6b00290openalex-snapshot
Fluorescent Probe Encapsulated in SNAP-Tag Protein Cavity To Eliminate Nonspecific Fluorescence and Increase Detection Sensitivity
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.7b00233openalex-snapshot
Development of an Activatable Fluorescent Probe for Prostate Cancer Imaging
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.7b00776openalex-snapshot
Silicon Rhodamine-Based Near-Infrared Fluorescent Probe for γ-Glutamyltransferase
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.9b00198openalex-snapshot
Red Fluorescence Probe Targeted to Dipeptidylpeptidase-IV for Highly Sensitive Detection of Esophageal Cancer
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.9b00391openalex-snapshot
Recent Advances of Molecular Optical Probes in Imaging of β-Galactosidase
inferred← citeshttps://doi.org/10.1021/acs.chemrev.2c00304openalex-snapshot
Enlightening the Path to Protein Engineering: Chemoselective Turn-On Probes for High-Throughput Screening of Enzymatic Activity
inferred← citeshttps://doi.org/10.1021/acs.chemrev.3c00612openalex-snapshot
Activity-Based Fluorescence Diagnostics for Cancer
inferred← citeshttps://doi.org/10.1021/acs.chemrev.3c00778openalex-snapshot
Theranostic Fluorescent Probes
inferred← citeshttps://doi.org/10.1021/acs.chemrev.6b00021openalex-snapshot
Development of Ion Chemosensors Based on Porphyrin Analogues
inferred← citeshttps://doi.org/10.1021/acs.chemrev.7b00767openalex-snapshot
Switchable Fluorophores for Single-Molecule Localization Microscopy
inferred← citeshttps://doi.org/10.1021/acs.chemrev.9b00379openalex-snapshot
Small Molecule as Fluorescent Probes for Monitoring Intracellular Enzymatic Transformations
inferred← citeshttps://doi.org/10.1021/acs.jafc.6c00088openalex-snapshot
BODIPY-Glucosinolates for Rapid, High-throughput Screening Compatible Assays of Myrosinase
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c01313openalex-snapshot
Noninvasive NIR Imaging of Senescence via In Situ Labeling
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b01429openalex-snapshot
Chagas Disease Drug Discovery: Multiparametric Lead Optimization against Trypanosoma cruzi in Acylaminobenzothiazole Series
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b02058openalex-snapshot
Azo-PROTAC: Novel Light-Controlled Small-Molecule Tool for Protein Knockdown
inferred← citeshttps://doi.org/10.1021/acs.joc.5b00077openalex-snapshot
Aminobenzofuran-Fused Rhodamine Dyes with Deep-Red to Near-Infrared Emission for Biological Applications
inferred← citeshttps://doi.org/10.1021/acs.jpcb.1c03193openalex-snapshot
Silinanyl Rhodamines and Silinanyl Fluoresceins for Super-Resolution Microscopy
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.7b00822openalex-snapshot
Optimization of a Protease Activated Probe for Optical Surgical Navigation
inferred← citeshttps://doi.org/10.1021/acsami.6b10238openalex-snapshot
In Situ Ratiometric Quantitative Tracing of Intracellular Leucine Aminopeptidase Activity via an Activatable Near-Infrared Fluorescent Probe
inferred← citeshttps://doi.org/10.1021/acscentsci.0c01189openalex-snapshot
Rapid and Accurate Visualization of Breast Tumors with a Fluorescent Probe Targeting α‑Mannosidase 2C1
inferred← citeshttps://doi.org/10.1021/acscentsci.0c01439openalex-snapshot
Finding the Sweet Spot for Breast Cancer Detection
inferred← citeshttps://doi.org/10.1021/acscentsci.2c00387openalex-snapshot
A Molecular Logic Gate for Developing “AND” Logic Probes and the Application in Hepatopathy Differentiation
inferred← citeshttps://doi.org/10.1021/acschembio.5b00792openalex-snapshot
Environmentally Robust Rhodamine Reporters for Probe-based Cellular Detection of the Cancer-linked Oxidoreductase hNQO1
inferred← citeshttps://doi.org/10.1021/acsomega.0c04303openalex-snapshot
Photooxidation Activity Control of Dimethylaminophenyl-tris-( N -methyl-4-pridinio)porphyrin by pH
inferred← citeshttps://doi.org/10.1021/acsomega.1c05290openalex-snapshot
Aminothiazole-Linked Metal Chelates: Synthesis, Density Functional Theory, and Antimicrobial Studies with Antioxidant Correlations
inferred← citeshttps://doi.org/10.1021/acsomega.7b02084openalex-snapshot
Deciphering Design Principles of Forster Resonance Energy Transfer-Based Protease Substrates: Thermolysin-Like Protease from Geobacillus stearothermophilus as a Test Case
inferred← citeshttps://doi.org/10.1021/acssensors.3c00470openalex-snapshot
Rational Design of pH-Independent and High-Fidelity Near-Infrared Tunable Fluorescent Probes for Tracking Leucine Aminopeptidase In Vivo
inferred← citeshttps://doi.org/10.1021/bc5003289openalex-snapshot
In Vivo Imaging of Intraperitoneally Disseminated Tumors in Model Mice by Using Activatable Fluorescent Small-Molecular Probes for Activity of Cathepsins
inferred← citeshttps://doi.org/10.1021/cb400938nopenalex-snapshot
The International Chemical Biology Society’s Global Mission Crystallizes in Kyoto
inferred← citeshttps://doi.org/10.1021/ja408792kopenalex-snapshot
Highly Selective Off–On Fluorescent Probe for Imaging Thioredoxin Reductase in Living Cells
inferred← citeshttps://doi.org/10.1021/ja503850bopenalex-snapshot
Self-Assembled Near-Infrared Dye Nanoparticles as a Selective Protein Sensor by Activation of a Dormant Fluorophore
inferred← citeshttps://doi.org/10.1021/ja511014wopenalex-snapshot
New Class of Bioluminogenic Probe Based on Bioluminescent Enzyme-Induced Electron Transfer: BioLeT
inferred← citeshttps://doi.org/10.1021/jacs.0c00451openalex-snapshot
Spontaneously Blinking Fluorophores Based on Nucleophilic Addition/Dissociation of Intracellular Glutathione for Live-Cell Super-resolution Imaging
inferred← citeshttps://doi.org/10.1021/jacs.0c09200openalex-snapshot
Multicolor Activatable Raman Probes for Simultaneous Detection of Plural Enzyme Activities
inferred← citeshttps://doi.org/10.1021/jacs.2c06397openalex-snapshot
General Design Strategy to Precisely Control the Emission of Fluorophores via a Twisted Intramolecular Charge Transfer (TICT) Process
inferred← citeshttps://doi.org/10.1021/jacs.5c04193openalex-snapshot
Design of Antigen-Targeting Fluorogenic Probes Utilizing Intramolecular Addition Reaction of Protein-Dye Hybrids
inferred← citeshttps://doi.org/10.1021/jacs.6b11274openalex-snapshot
Photophysics of Coumarin and Carbostyril-Sensitized Luminescent Lanthanide Complexes: Implications for Complex Design in Multiplex Detection
inferred← citeshttps://doi.org/10.1021/jacs.7b01948openalex-snapshot
Carbohydrate Bis-acetal-Based Substrates as Tunable Fluorescence-Quenched Probes for Monitoring exo -Glycosidase Activity
inferred← citeshttps://doi.org/10.1021/jacs.7b04985openalex-snapshot
An OFF–ON Two-Photon Fluorescent Probe for Tracking Cell Senescence in Vivo
inferred← citeshttps://doi.org/10.1021/jacs.7b11014openalex-snapshot
Establishment of Molecular Design Strategy To Obtain Activatable Fluorescent Probes for Carboxypeptidases
inferred← citeshttps://doi.org/10.1021/nn4054914openalex-snapshot
Self-Assembly-Induced Far-Red/Near-Infrared Fluorescence Light-Up for Detecting and Visualizing Specific Protein–Peptide Interactions
inferred← citeshttps://doi.org/10.1038/nchem.2002openalex-snapshot
A spontaneously blinking fluorophore based on intramolecular spirocyclization for live-cell super-resolution imaging
inferred← citeshttps://doi.org/10.1038/nchem.2648openalex-snapshot
Rational design of reversible fluorescent probes for live-cell imaging and quantification of fast glutathione dynamics
inferred← citeshttps://doi.org/10.1038/nnano.2016.284openalex-snapshot
Single-molecule detection of protein efflux from microorganisms using fluorescent single-walled carbon nanotube sensor arrays
inferred← citeshttps://doi.org/10.1038/s41467-024-54523-4openalex-snapshot
Stereoselective chemical N-glycoconjugation of amines via CO2 incorporation
inferred← citeshttps://doi.org/10.1038/s41551-020-00616-6openalex-snapshot
AND-gate contrast agents for enhanced fluorescence-guided surgery
inferred← citeshttps://doi.org/10.1038/s41598-022-12614-6openalex-snapshot
Development of an intraoperative breast cancer margin assessment method using quantitative fluorescence measurements
inferred← citeshttps://doi.org/10.1038/s42004-019-0194-4openalex-snapshot
Design strategy for germanium-rhodamine based pH-activatable near-infrared fluorescence probes suitable for biological applications
inferred← citeshttps://doi.org/10.1038/s42004-020-0326-xopenalex-snapshot
Molecular design strategy of fluorogenic probes based on quantum chemical prediction of intramolecular spirocyclization
inferred← citeshttps://doi.org/10.1038/s44222-024-00153-wopenalex-snapshot
Artificial urinary biomarker probes for diagnosis
inferred← citeshttps://doi.org/10.1038/srep23190openalex-snapshot
Far-red/near-infrared fluorescence light-up probes for specific in vitro and in vivo imaging of a tumour-related protein
inferred← citeshttps://doi.org/10.1039/c3cc46824kopenalex-snapshot
PET-dependent fluorescence sensing of enzyme reactions using the large and tunable pKa shift of aliphatic amines
inferred← citeshttps://doi.org/10.1039/c3cc47624copenalex-snapshot
A fluorogenic peptide probe developed by in vitro selection using tRNA carrying a fluorogenic amino acid
inferred← citeshttps://doi.org/10.1039/c3nj01086dopenalex-snapshot
Fluorescent organic nanoparticles (FONs) of rhodamine-appended dipodal derivative: highly sensitive fluorescent sensor for the detection of Hg2+ in aqueous media
inferred← citeshttps://doi.org/10.1039/c3ra43928copenalex-snapshot
A novel strategy to design latent ratiometric fluorescent pH probes based on self-assembled SNARF derivatives
inferred← citeshttps://doi.org/10.1039/c5an00585jopenalex-snapshot
Discrimination between streptavidin and avidin with fluorescent affinity-based probes
inferred← citeshttps://doi.org/10.1039/c5cc02793dopenalex-snapshot
Recent advances in the development of synthetic chemical probes for glycosidase enzymes
inferred← citeshttps://doi.org/10.1039/c5sc01330eopenalex-snapshot
Near-infrared fluorescence activation probes based on disassembly-induced emission cyanine dye
inferred← citeshttps://doi.org/10.1039/c5sc02808fopenalex-snapshot
Protein sensing in living cells by molecular rotor-based fluorescence-switchable chemical probes
inferred← citeshttps://doi.org/10.1039/c5sc03600copenalex-snapshot
Leucine aminopeptidase may contribute to the intrinsic resistance of cancer cells toward cisplatin as revealed by an ultrasensitive fluorescent probe
inferred← citeshttps://doi.org/10.1039/c6cc04373aopenalex-snapshot
A versatile two-photon fluorescent probe for ratiometric imaging E. coli β-galactosidase in live cells and in vivo
inferred← citeshttps://doi.org/10.1039/c6cc08306dopenalex-snapshot
Efficacious fluorescence turn-on probe for high-contrast imaging of human cells overexpressing quinone reductase activity
inferred← citeshttps://doi.org/10.1039/c6cc09302gopenalex-snapshot
Rotaxane probes for protease detection by 129 Xe hyperCEST NMR
inferred← citeshttps://doi.org/10.1039/c7bm00270jopenalex-snapshot
A specific environment-sensitive near-infrared fluorescent turn-on probe for synergistic enhancement of anticancer activity of a chemo-drug
inferred← citeshttps://doi.org/10.1039/c7cc00249aopenalex-snapshot
A selective and light-up fluorescent probe for β-galactosidase activity detection and imaging in living cells based on an AIE tetraphenylethylene derivative
inferred← citeshttps://doi.org/10.1039/c7cc07783aopenalex-snapshot
A green-light-emitting, spontaneously blinking fluorophore based on intramolecular spirocyclization for dual-colour super-resolution imaging
inferred← citeshttps://doi.org/10.1039/c7cs00862gopenalex-snapshot
Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging
inferred← citeshttps://doi.org/10.1039/c7cs00907kopenalex-snapshot
Fluorogenic probes for disease-relevant enzymes
inferred← citeshttps://doi.org/10.1039/c7sc04014hopenalex-snapshot
Target-activated streptavidin–biotin controlled binding probe
inferred← citeshttps://doi.org/10.1039/c7tb02657aopenalex-snapshot
Eu/Tb luminescence for alkaline phosphatase and β-galactosidase assay in hydrogels and on paper devices
inferred← citeshttps://doi.org/10.1039/c7tb03303fopenalex-snapshot
A novel fibroblast activation protein-targeted near-infrared fluorescent off–on probe for cancer cell detection, in vitro and in vivo imaging
inferred← citeshttps://doi.org/10.1039/c8an02182aopenalex-snapshot
Detection of leucine aminopeptidase activity in serum using surface-enhanced Raman spectroscopy
inferred← citeshttps://doi.org/10.1039/c9cc03018bopenalex-snapshot
Development of a red absorbing Se-rhodamine photosensitizer and its application for bio-orthogonally activatable photodynamic therapy
inferred← citeshttps://doi.org/10.1039/c9cc09158kopenalex-snapshot
Imaging of ovarian cancers using enzyme activatable probes with second near-infrared window emission
inferred← citeshttps://doi.org/10.1039/c9cc09666copenalex-snapshot
Asymmetric Si-rhodamine scaffolds: rational design of pH-durable protease-activated NIR probes in vivo
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