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Diastereomeric Spirooxindoles as Highly Potent and Efficacious MDM2 Inhibitors

https://doi.org/10.1021/ja3125417
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Pyrrolidinyl‐Spirooxindole Natural Products as Inspirations for the Development of Potential Therapeutic Agents
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Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization
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Synthesis of spirooxindoles via asymmetric 1,3-dipolar cycloaddition
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Pteropodine and isopteropodine positively modulate the function of rat muscarinic M1 and 5-HT2 receptors expressed in Xenopus oocyte
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The Asymmetric Total Synthesis of (+)- and (−)-Spirotryprostatin B
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Oxidative Transformations of Indole Alkaloids. I. The Preparation of Oxindoles from Yohimbine; the Structures and Partial Syntheses of Mitraphylline, Rhyncophylline and Corynoxeine
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Total synthesis of rhyncophyllol and dl-isorhyncophyllol
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3-Hydroxymethyleneoxindole and its Derivatives
inferredcites →https://doi.org/10.1021/ja045089dopenalex-snapshot
A Library of Spirooxindoles Based on a Stereoselective Three-Component Coupling Reaction
inferredcites →https://doi.org/10.1021/ja051147zopenalex-snapshot
Structure-Based Design of Potent Non-Peptide MDM2 Inhibitors
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Organocatalytic Synthesis of Spiro[pyrrolidin-3,3′-oxindoles] with High Enantiopurity and Structural Diversity
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Total Synthesis of Spirotryprostatin A, Leading to the Discovery of Some Biologically Promising Analogues
inferredcites →https://doi.org/10.1021/jm051122aopenalex-snapshot
Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2−p53 Interaction
inferredcites →https://doi.org/10.1021/jm300354jopenalex-snapshot
Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction
inferredcites →https://doi.org/10.1021/jm901400zopenalex-snapshot
Potent and Orally Active Small-Molecule Inhibitors of the MDM2−p53 Interaction
inferredcites →https://doi.org/10.1021/jm990966popenalex-snapshot
Discovery of Potent Antagonists of the Interaction between Human Double Minute 2 and Tumor Suppressor p53
inferredcites →https://doi.org/10.1038/nchem.730openalex-snapshot
Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products
inferredcites →https://doi.org/10.1039/p29960001931openalex-snapshot
Analysis of the kinetics of isomerization of spiro oxindole alkaloids
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Asymmetric Syntheses of Oxindole and Indole Spirocyclic Alkaloid Natural Products
inferredcites →https://doi.org/10.1073/pnas.0708917105openalex-snapshot
Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
inferredcites →https://doi.org/10.1126/science.1092472openalex-snapshot
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
inferredcites →https://doi.org/10.1139/v60-144openalex-snapshot
THE STRUCTURE AND STEREOISOMERISM OF THREE MITRAGYNA ALKALOIDS
inferredcites →https://doi.org/10.1139/v62-156openalex-snapshot
THE SYSTEM LITHIUM SULPHATE – MAGNESIUM SULPHATE – WATER AT 30 °C

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Discovery of Novel Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2–p53 Interaction
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b01665openalex-snapshot
Discovery of 4-((3′ R ,4′ S ,5′ R )-6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical…
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b01137openalex-snapshot
Inhibition of p53-Murine Double Minute 2 (MDM2) Interactions with 3,3′-Spirocyclopentene Oxindole Derivatives
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b00846openalex-snapshot
Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b01451openalex-snapshot
Medicinal Chemistry of Inhibiting RING-Type E3 Ubiquitin Ligases
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.5c01235openalex-snapshot
Mixtures Biotransformation: Multilayer Molecular Networking of Kratom Liver Metabolites
inferred← citeshttps://doi.org/10.1021/acs.joc.2c00863openalex-snapshot
Selective C3-Allylation and Formal [3 + 2]-Annulation of Spiro-Aziridine Oxindoles: Synthesis of 5′-Substituted Spiro[pyrrolidine-3,3′-oxindoles] and Coerulescine
inferred← citeshttps://doi.org/10.1021/acs.joc.2c02391openalex-snapshot
Enantioselective Total Synthesis of Spirotryprostatin A
inferred← citeshttps://doi.org/10.1021/acs.joc.3c02630openalex-snapshot
Synthesis of 1,7-Fused Indolines Tethered with Spiroindolinone Based on C–H Activation Strategy with Air as a Sustainable Oxidant
inferred← citeshttps://doi.org/10.1021/acs.joc.3c02966openalex-snapshot
Precise Synthesis of Diastereomers of Spiro-oxindole Derivatives through Dynamic Covalent Transformation
inferred← citeshttps://doi.org/10.1021/acs.joc.5b01399openalex-snapshot
Regio- and Stereoselective Synthesis of Spiropyrrolizidines and Piperazines through Azomethine Ylide Cycloaddition Reaction
inferred← citeshttps://doi.org/10.1021/acs.joc.5c02588openalex-snapshot
Highly Diastereoselective Hydroxy-Aza-Prins Cyclization: Rapid Access to 4′-Hydroxy Six-Membered Spiro Azacyclic Oxindoles
inferred← citeshttps://doi.org/10.1021/acs.joc.6b02062openalex-snapshot
Regio- and Stereoselective Domino Synthesis of Oxazolo Fused Pyridoindoles and Benzofurooxazolo Pyridines from ortho-Alkynylarylaldehydes
inferred← citeshttps://doi.org/10.1021/acs.joc.9b01226openalex-snapshot
Organocatalytic Domino Reaction of Spiroaziridine Oxindoles and Malononitrile for the Enantiopure Synthesis of Spiro[dihydropyrrole-3,3′-oxindoles]
inferred← citeshttps://doi.org/10.1021/acs.joc.9b01501openalex-snapshot
Protecting Group-Directed Diastereodivergent Synthesis of Chiral Tetrahydronaphthalene-Fused Spirooxindoles via Bifunctional Tertiary Amine Catalysis
inferred← citeshttps://doi.org/10.1021/acs.joc.9b01977openalex-snapshot
Asymmetric Total Syntheses of Rhynchophylline and Isorhynchophylline
inferred← citeshttps://doi.org/10.1021/acs.oprd.2c00192openalex-snapshot
Synthesis of MDM2-p53 Inhibitor BI-0282 via a Dipolar Cycloaddition and Late-Stage Davis–Beirut Reaction
inferred← citeshttps://doi.org/10.1021/acs.oprd.6b00320openalex-snapshot
Practical Synthesis of MDM2 Antagonist RG7388. Part 1: A Cu(II)-Catalyzed Asymmetric [3 + 2] Cycloaddition
inferred← citeshttps://doi.org/10.1021/acs.orglett.1c04063openalex-snapshot
Chemoselective Synthesis of Sulfenylated Spiroindolenines from Indolyl-ynones via Organosulfenyl Chloride-Mediated Dearomatizing Spirocyclization
inferred← citeshttps://doi.org/10.1021/acs.orglett.5c01329openalex-snapshot
A RhII-Catalyzed [4 + 3]-Cycloaddition via the Stereoselective Cyclopropanation of Vinyl Allenes En Route to Oxepino[b]indoles and Subsequent Elaboration to Spirooxindole Frameworks
inferred← citeshttps://doi.org/10.1021/acs.orglett.5c02818openalex-snapshot
Silica Gel-Promoted Tryptamine-Ynamide Cyclization Strategy Enabling Total Synthesis of Elacomine
inferred← citeshttps://doi.org/10.1021/acs.orglett.5c03562openalex-snapshot
Synthesis of Oxindole Spiropyrrolidines Based on [1 + 1 + 1 + 2] Spiroannulation Featuring Release and Reuse of Me 2 NH
inferred← citeshttps://doi.org/10.1021/acs.orglett.6c02293openalex-snapshot
Electrochemical Dearomative ipso -Cyclization of Indolyl-ynones: A Direct Access to Trifluoromethyl/Selenyl-Spirooxindoles
inferred← citeshttps://doi.org/10.1021/acs.orglett.7b02474openalex-snapshot
Enantiospecific Synthesis of β-Substituted Tryptamines
inferred← citeshttps://doi.org/10.1021/acs.orglett.7b03516openalex-snapshot
Organocatalytic Asymmetric Synthesis of Spiro-oxindole Piperidine Derivatives That Reduce Cancer Cell Proliferation by Inhibiting MDM2–p53 Interaction
inferred← citeshttps://doi.org/10.1021/acs.orglett.9b01373openalex-snapshot
Copper(I)-Catalyzed Intramolecular Asymmetric Double C-Arylation for the Formation of Chiral Spirocyclic Bis-oxindoles
inferred← citeshttps://doi.org/10.1021/acsanm.1c04380openalex-snapshot
Regioselective Ring-Opening of Spiro-Epoxyoxindoles by a Dual-Ligand Zinc-Based Metal–Organic Framework as an Efficient Heterogeneous Catalyst
inferred← citeshttps://doi.org/10.1021/acscombsci.7b00044openalex-snapshot
1,3-Dipolar Cycloaddition Reactions for the Synthesis of Novel Oxindole Derivatives and Their Cytotoxic Properties
inferred← citeshttps://doi.org/10.1021/acsomega.0c03675openalex-snapshot
Stereoselective Synthesis of Spirooxindole Derivatives Using One-Pot Multicomponent Cycloaddition Reaction and Evaluation of Their Antiproliferative Efficacy
inferred← citeshttps://doi.org/10.1021/acsomega.3c05020openalex-snapshot
Semisynthesis of Novel Dispiro-pyrrolizidino/thiopyrrolizidino-oxindolo/indanedione Natural Product Hybrids of Parthenin Followed by Their Cytotoxicity Evaluation
inferred← citeshttps://doi.org/10.1021/bk-2022-1423.ch005openalex-snapshot
Discovery of AMG 232, a Small Molecule Disrupting the p53-MDM2 Protein–Protein Interaction and Development of a Validation-Ready Process for Its Manufacture
inferred← citeshttps://doi.org/10.1021/cb5009469openalex-snapshot
Interfacing Chemical Biology and Drug Discovery: Report from the 50th International Conference on Medicinal Chemistry of the SCT (French Medicinal Chemistry Society), July 2–4, 2014, Rouen, France
inferred← citeshttps://doi.org/10.1021/cr400362ropenalex-snapshot
Dendrimer Space Exploration: An Assessment of Dendrimers/Dendritic Scaffolding as Inhibitors of Protein–Protein Interactions, a Potential New Area of Pharmaceutical Development
inferred← citeshttps://doi.org/10.1021/jacs.0c12911openalex-snapshot
β-Substituted Alkenyl Heteroarenes as Dipolarophiles in the Cu(I)-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Ylides Empowered by a Dual Activation Strategy: Stereoselectivity and Mechanistic Insight
inferred← citeshttps://doi.org/10.1021/jm400487copenalex-snapshot
Discovery of RG7388, a Potent and Selective p53–MDM2 Inhibitor in Clinical Development
inferred← citeshttps://doi.org/10.1021/jm4005708openalex-snapshot
A Potent Small-Molecule Inhibitor of the MDM2–p53 Interaction (MI-888) Achieved Complete and Durable Tumor Regression in Mice
inferred← citeshttps://doi.org/10.1021/jm401911vopenalex-snapshot
Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres
inferred← citeshttps://doi.org/10.1021/jm501541jopenalex-snapshot
Design of Chemically Stable, Potent, and Efficacious MDM2 Inhibitors That Exploit the Retro-Mannich Ring-Opening-Cyclization Reaction Mechanism in Spiro-oxindoles
inferred← citeshttps://doi.org/10.1021/jo4017259openalex-snapshot
Synthesis of Pyrrolo(spiro-[2.3′]-oxindole)-spiro-[4.3″]-oxindole via 1,3-Dipolar Cycloaddition of Azomethine Ylides with 3-Acetonylideneoxindole
inferred← citeshttps://doi.org/10.1021/ml400359zopenalex-snapshot
Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development
inferred← citeshttps://doi.org/10.1021/ol402473mopenalex-snapshot
Metal-Free Oxidative Spirocyclization of Hydroxymethylacrylamide with 1,3-Dicarbonyl Compounds: A New Route to Spirooxindoles
inferred← citeshttps://doi.org/10.1021/ol500033wopenalex-snapshot
Copper(I)-Catalyzed Aryl or Vinyl Addition to Electron-Deficient Alkenes Cascaded by Cationic Cyclization
inferred← citeshttps://doi.org/10.1021/ol5028128openalex-snapshot
Titanium(IV)-Catalyzed Stereoselective Synthesis of Spirooxindole-1-pyrrolines
inferred← citeshttps://doi.org/10.1038/s41420-019-0157-7openalex-snapshot
Protoporphyrin IX is a dual inhibitor of p53/MDM2 and p53/MDM4 interactions and induces apoptosis in B-cell chronic lymphocytic leukemia cells
inferred← citeshttps://doi.org/10.1038/s41467-023-40409-4openalex-snapshot
Copper(I)-catalyzed asymmetric 1,3-dipolar cycloaddition of 1,3-enynes and azomethine ylides
inferred← citeshttps://doi.org/10.1038/s41598-017-09574-7openalex-snapshot
Development of a novel immunoassay to detect interactions with the transactivation domain of p53: application to screening of new drugs
inferred← citeshttps://doi.org/10.1039/c3cc47767copenalex-snapshot
Counterion effects in the catalytic stereoselective synthesis of 2,3′-pyrrolidinyl spirooxindoles
inferred← citeshttps://doi.org/10.1039/c3md00161jopenalex-snapshot
Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2–p53 and MDMX–p53 protein–protein interactions
inferred← citeshttps://doi.org/10.1039/c4cc06000hopenalex-snapshot
A Mannich/cyclization cascade process for the asymmetric synthesis of spirocyclic thioimidazolidineoxindoles
inferred← citeshttps://doi.org/10.1039/c5cc05798aopenalex-snapshot
Catalytic asymmetric construction of spiro[pyrrolidine-2,3′-oxindole] scaffolds through chiral phosphoric acid-catalyzed 1,3-dipolar cycloaddition involving 3-amino oxindoles
inferred← citeshttps://doi.org/10.1039/c5cc10057gopenalex-snapshot
Asymmetric synthesis of 3,3′-pyrrolidinyl-dispirooxindoles via a one-pot organocatalytic Mannich/deprotection/aza-Michael sequence
inferred← citeshttps://doi.org/10.1039/c5nj03027gopenalex-snapshot
Isatin-based three-component synthesis of new spirooxindoles using magnetic nano-sized copper ferrite
inferred← citeshttps://doi.org/10.1039/c5ra04106fopenalex-snapshot
Silver-catalyzed TEMPO oxidative homocoupling of indoles for the synthesis of 3,3′-biindolin-2-ones
inferred← citeshttps://doi.org/10.1039/c5ra25025kopenalex-snapshot
Organocatalytic construction of spirooxindole naphthoquinones through Michael/hemiketalization using l -proline derived bifunctional thiourea
inferred← citeshttps://doi.org/10.1039/c6ob02104bopenalex-snapshot
Organocatalyzed enantioselective Michael addition/cyclization cascade reaction of 3-isothiocyanato oxindoles with arylidene malonates
inferred← citeshttps://doi.org/10.1039/c6ob02187eopenalex-snapshot
Catalytic enantioselective cascade Michael/cyclization reaction of 3-isothiocyanato oxindoles with exocyclic α,β-unsaturated ketones en route to 3,2′-pyrrolidinyl bispirooxindoles
inferred← citeshttps://doi.org/10.1039/c6qo00852fopenalex-snapshot
Squaramide-catalyzed asymmetric Michael/cyclization cascade reaction of 3-isothiocyanato oxindoles with chalcones for synthesis of pyrrolidinyl spirooxindoles
inferred← citeshttps://doi.org/10.1039/c7ob03051gopenalex-snapshot
Organocatalytic [3 + 2] cycloaddition of oxindole-based azomethine ylides with 3-nitrochromenes: a facile approach to enantioenriched polycyclic spirooxindole-chromane adducts
inferred← citeshttps://doi.org/10.1039/c8cc04732dopenalex-snapshot
Asymmetric synthesis of tetrahydroisoquinoline-fused spirooxindoles as Ras-GTP inhibitors that inhibit colon adenocarcinoma cell proliferation and invasion
inferred← citeshttps://doi.org/10.1039/c8ra02358aopenalex-snapshot
Substituted spirooxindole derivatives as potent anticancer agents through inhibition of phosphodiesterase 1
inferred← citeshttps://doi.org/10.1039/c8ra06710dopenalex-snapshot
Synthesis of six-membered spirooxindoles via a chiral Brønsted acid-catalyzed asymmetric intramolecular Friedel–Crafts reaction
inferred← citeshttps://doi.org/10.1039/c8ra07985dopenalex-snapshot
Highly functionalized pyrrolidine analogues: stereoselective synthesis and caspase-dependent apoptotic activity
inferred← citeshttps://doi.org/10.1039/c9cc05916dopenalex-snapshot
Organocatalytic diastereoselective [3+2] cyclization of MBH carbonates with dinucleophiles: synthesis of bicyclic imidazoline derivatives that inhibit MDM2–p53 interaction
inferred← citeshttps://doi.org/10.1039/c9gc01751hopenalex-snapshot
Synthesis of spiro[2,3-dihydrofuran-3,3′-oxindole] derivatives via a multi-component cascade reaction of α-diazo esters, water, isatins and malononitrile/ethyl cyanoacetate
inferred← citeshttps://doi.org/10.1039/c9md00042aopenalex-snapshot
Synthesis of DNA-coupled isoquinolones and pyrrolidines by solid phase ytterbium- and silver-mediated imine chemistry
inferred← citeshttps://doi.org/10.1039/c9nj00994aopenalex-snapshot
A [3+2] cycloaddition reaction for the synthesis of spiro[indoline-3,3′-pyrrolidines] and evaluation of cytotoxicity towards cancer cells
inferred← citeshttps://doi.org/10.1039/c9nj04498aopenalex-snapshot
A regio- and stereocontrolled approach to the synthesis of 4-CF 3 -substituted spiro[chromeno[3,4- c ]pyrrolidine-oxindoles] via reversible [3+2] cycloaddition of azomethine ylides generated from isatins and sarcosine to 3-nitro-2-(trifluoromethyl)-2 H -chromenes
inferred← citeshttps://doi.org/10.1039/c9ob01570aopenalex-snapshot
The one pot asymmetric synthesis of 3,3′-pyrrolidonyl spiroxindoles via a regio- and stereoselective domino reaction
inferred← citeshttps://doi.org/10.1039/d0ob00546kopenalex-snapshot
Copper( i )/Ganphos catalysis: enantioselective synthesis of diverse spirooxindoles using iminoesters and alkyl substituted methyleneindolinones
inferred← citeshttps://doi.org/10.1039/d0ob01858aopenalex-snapshot
A base-catalyzed domino reaction between isoindigos and α-alkylidene succinimides—convenient preparation of highly steric bispirooxindoles
inferred← citeshttps://doi.org/10.1039/d0ob01865aopenalex-snapshot
Lewis acid-mediated synthesis of mono- and tris-indole adducts from chiral aziridines
inferred← citeshttps://doi.org/10.1039/d0ob02321copenalex-snapshot
A three-component [3 + 2]-cycloaddition/elimination cascade for the synthesis of spirooxindole-pyrrolizines
inferred← citeshttps://doi.org/10.1039/d0qo01085eopenalex-snapshot
Stereoselective synthesis and applications of spirocyclic oxindoles
inferred← citeshttps://doi.org/10.1039/d0ra02374dopenalex-snapshot
Synthesis of 1,3-diaryl-spiro[azetidine-2,3′-indoline]-2′,4-diones via the Staudinger reaction: cis - or trans -diastereoselectivity with different addition modes
inferred← citeshttps://doi.org/10.1039/d1qo00220aopenalex-snapshot
Recent advances in organocatalytic asymmetric multicomponent cascade reactions for enantioselective synthesis of spirooxindoles
inferred← citeshttps://doi.org/10.1039/d1qo00551kopenalex-snapshot
Synthesis of 3-spirooxindole 3 H -indoles through Rh( iii )-catalyzed [4 + 1] redox-neutral spirocyclization of N -aryl amidines with diazo oxindoles
inferred← citeshttps://doi.org/10.1039/d1ra01161hopenalex-snapshot
Ring-opening hydrolysis of spiro-epoxyoxindoles using a reusable sulfonic acid functionalized nitrogen rich carbon catalyst
inferred← citeshttps://doi.org/10.1039/d1sc07271dopenalex-snapshot
Stereodivergent synthesis of enantioenriched azepino[3,4,5- cd ]-indoles via cooperative Cu/Ir-catalyzed asymmetric allylic alkylation and intramolecular Friedel–Crafts reaction
inferred← citeshttps://doi.org/10.1039/d2cc00618aopenalex-snapshot
Catalytic asymmetric [3 + 2] cycloaddition of pyrazolone-derived MBH carbonate: highly stereoselective construction of the bispiro-[pyrazolone-dihydropyrrole-oxindole] skeleton
inferred← citeshttps://doi.org/10.1039/d2qo00167eopenalex-snapshot
Diastereoselective synthesis of 1,1,3,3-tetrasubstituted cyclobutanes enabled by cycloaddition of bicyclo[1.1.0]butanes
inferred← citeshttps://doi.org/10.1039/d2sc00028hopenalex-snapshot
Energetics of a protein disorder–order transition in small molecule recognition
inferred← citeshttps://doi.org/10.1039/d3sc00435jopenalex-snapshot
Electron-rich benzofulvenes as effective dipolarophiles in copper( i )-catalyzed asymmetric 1,3-dipolar cycloaddition of azomethine ylides
inferred← citeshttps://doi.org/10.1039/d4cc02215gopenalex-snapshot
A diastereoselective strategy for dihydrophenanthrene-fused spirooxindoles via [1,2]-phospha-Brook rearrangement
inferred← citeshttps://doi.org/10.1039/d4ob00766bopenalex-snapshot
Recent advances in oxidative dearomatization involving C–H bonds for constructing value-added oxindoles
inferred← citeshttps://doi.org/10.1039/d4qo00833bopenalex-snapshot
A domino [3 + 2] cycloaddition/deamination/imine hydrolysis reaction of cyclopropyl spirooxindoles with thiourea for access to spiro-γ-thiolactone oxindoles
inferred← citeshttps://doi.org/10.1039/d4qo01275eopenalex-snapshot
Direct synthesis of spirooxindoles enabled by palladium-catalyzed allylic alkylation and DBU-mediated cyclization: concept, scope and applications
inferred← citeshttps://doi.org/10.1039/d6ob00849fopenalex-snapshot
Diastereodivergent approaches for the synthesis of spirooxindoles
inferred← citeshttps://doi.org/10.1042/bst20140035openalex-snapshot
Resistance acquisition to MDM2 inhibitors
inferred← citeshttps://doi.org/10.1055/a-2444-0067openalex-snapshot
Asymmetric Synthesis of 3,3′-Pyrrolidonyl Spirooxindole-5′-Carboxylic Ester from l-Tryptophan
inferred← citeshttps://doi.org/10.1080/00268976.2015.1087598openalex-snapshot
Insight into binding modes of p53 and inhibitors to MDM2 based on molecular dynamic simulations and principal component analysis
inferred← citeshttps://doi.org/10.1080/00304948.2022.2151811openalex-snapshot
Efficient Synthesis of trans-3-Amino-1-methylcyclobutan-1-ol
inferred← citeshttps://doi.org/10.1080/10286020.2026.2695175openalex-snapshot
Concise total synthesis of coerulescine by Cu(I)-catalyzed tandem reaction
inferred← citeshttps://doi.org/10.1080/10426507.2020.1723590openalex-snapshot
Synthesis and cytotoxicity of oxindoles dispiro derivatives with thiohydantoin and adamantane fragments
inferred← citeshttps://doi.org/10.1080/10428194.2017.1403600openalex-snapshot
Targeting oncoproteins for degradation by small molecules in myeloid leukemia
inferred← citeshttps://doi.org/10.1080/10428194.2020.1817441openalex-snapshot
The expression of MDM2, MDM4, p53 and p21 in myeloid neoplasms and the effect of MDM2/MDM4 dual inhibitor
inferred← citeshttps://doi.org/10.1080/14786419.2026.2683115openalex-snapshot
Semi-synthesis of novel dispiro hybrids of sesquiterpene lactones by using benzylamines via azomethine ylide cycloaddition
inferred← citeshttps://doi.org/10.1101/cshperspect.a026245openalex-snapshot
Targeting the MDM2–p53 Protein–Protein Interaction for New Cancer Therapy: Progress and Challenges
inferred← citeshttps://doi.org/10.1111/cbdd.12474openalex-snapshot
Searching for Dual Inhibitors of the MDM 2‐p53 and MDMX ‐p53 Protein–Protein Interaction by a Scaffold‐Hopping Approach
inferred← citeshttps://doi.org/10.1124/pharmrev.123.001026openalex-snapshot
MDM2 Inhibitors for Cancer Therapy: The Past, Present, and Future
inferred← citeshttps://doi.org/10.1158/0008-5472.can-14-0799openalex-snapshot
SAR405838: An Optimized Inhibitor of MDM2–p53 Interaction That Induces Complete and Durable Tumor Regression
inferred← citeshttps://doi.org/10.1158/1535-7163.mct-23-0783openalex-snapshot
Discovery and Characterization of Brigimadlin, a Novel and Highly Potent MDM2–p53 Antagonist Suitable for Intermittent Dose Schedules
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