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Structure and Activity of Largazole, a Potent Antiproliferative Agent from the Floridian Marine Cyanobacterium Symploca sp.

https://doi.org/10.1021/ja7110064
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Marine peptides in breast cancer: Therapeutic and mechanistic understanding
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.114165openalex-snapshot
Marine life as a source for breast cancer treatment: A comprehensive review
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.115989openalex-snapshot
Bioactive substances of cyanobacteria and microalgae: Sources, metabolism, and anticancer mechanism insights
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2011.03.001openalex-snapshot
Bio-mining the microbial treasures of the ocean: New natural products
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2013.02.006openalex-snapshot
Recent advances in marine drug research
inferred← citeshttps://doi.org/10.1016/j.bmc.2011.02.024openalex-snapshot
Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability
inferred← citeshttps://doi.org/10.1016/j.bmc.2014.06.029openalex-snapshot
RETRACTED: Design and synthesis of CHAP31, trapoxin B and HC-toxin based bicyclic tetrapeptides disulfide as potent histone deacetylase inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmc.2015.03.063openalex-snapshot
Modular synthesis and biological activity of pyridyl-based analogs of the potent Class I Histone Deacetylase Inhibitor Largazole
inferred← citeshttps://doi.org/10.1016/j.bmc.2015.10.004openalex-snapshot
New macrocyclic analogs of the natural histone deacetylase inhibitor FK228; design, synthesis and preliminary biological evaluation
inferred← citeshttps://doi.org/10.1016/j.bmc.2016.08.040openalex-snapshot
Synthesis and biological evaluation of santacruzamate A analogues for anti-proliferative and immunomodulatory activity
inferred← citeshttps://doi.org/10.1016/j.bmc.2017.03.071openalex-snapshot
Synthesis and biological evaluation of largazole zinc-binding group analogs
inferred← citeshttps://doi.org/10.1016/j.bmc.2021.116510openalex-snapshot
From natural products to HDAC inhibitors: An overview of drug discovery and design strategy
inferred← citeshttps://doi.org/10.1016/j.bmcl.2013.06.012openalex-snapshot
Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs
inferred← citeshttps://doi.org/10.1016/j.bmcl.2014.07.006openalex-snapshot
Evaluation of class I HDAC isoform selectivity of largazole analogues
inferred← citeshttps://doi.org/10.1016/j.bmcl.2016.07.010openalex-snapshot
Design, synthesis and antimalarial evaluation of novel thiazole derivatives
inferred← citeshttps://doi.org/10.1016/j.bmcl.2020.127023openalex-snapshot
Structural determinants of affinity and selectivity in the binding of inhibitors to histone deacetylase 6
inferred← citeshttps://doi.org/10.1016/j.canlet.2014.06.005openalex-snapshot
Epigenetic modulators from “The Big Blue”: A treasure to fight against cancer
inferred← citeshttps://doi.org/10.1016/j.cclet.2025.111131openalex-snapshot
Photocatalyzed hydrogen transfer enabled three-component radical cascade reactions: Direct access to thioesters from primary alcohols, elemental sulfur and alkenes
inferred← citeshttps://doi.org/10.1016/j.chphi.2023.100187openalex-snapshot
Investigation on the growth, characterization and computational analysis of 2-Amino-2-thiazoline single crystals
inferred← citeshttps://doi.org/10.1016/j.copbio.2010.09.019openalex-snapshot
Biologically active secondary metabolites from marine cyanobacteria
inferred← citeshttps://doi.org/10.1016/j.cplett.2022.139408openalex-snapshot
Synthesis, molecular docking, antimicrobial, antioxidant and anticonvulsant assessment of novel S and C-linker thiazole derivatives
inferred← citeshttps://doi.org/10.1016/j.drudis.2013.05.010openalex-snapshot
Pharmaceutical agents from filamentous marine cyanobacteria
inferred← citeshttps://doi.org/10.1016/j.ejmech.2011.08.010openalex-snapshot
Synthesis and antioxidant activity of oxazolyl/thiazolylsulfonylmethyl pyrazoles and isoxazoles
inferred← citeshttps://doi.org/10.1016/j.ejmech.2012.01.008openalex-snapshot
Design, synthesis of some new (2-aminothiazol-4-yl)methylester derivatives as possible antimicrobial and antitubercular agents
inferred← citeshttps://doi.org/10.1016/j.ejmech.2013.10.008openalex-snapshot
Synthesis, physicochemical characterization, cytotoxicity, antimicrobial, anti-inflammatory and psychotropic activity of new N-[1,3-(benzo)thiazol-2-yl]-ω-[3,4-dihydroisoquinolin-2(1H)-yl]alkanamides
inferred← citeshttps://doi.org/10.1016/j.ejmech.2014.09.009openalex-snapshot
Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups
inferred← citeshttps://doi.org/10.1016/j.ejmech.2014.10.058openalex-snapshot
Bioactive thiazole and benzothiazole derivatives
inferred← citeshttps://doi.org/10.1016/j.ejmech.2016.02.003openalex-snapshot
Design, synthesis and biological evaluation of bisthiazole-based trifluoromethyl ketone derivatives as potent HDAC inhibitors with improved cellular efficacy
inferred← citeshttps://doi.org/10.1016/j.ejmech.2018.08.073openalex-snapshot
HDAC as onco target: Reviewing the synthetic approaches with SAR study of their inhibitors
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.111672openalex-snapshot
A fluorine scan on the Zn2+-binding thiolate side chain of HDAC inhibitor largazole: Synthesis, biological evaluation, and molecular modeling
inferred← citeshttps://doi.org/10.1016/j.ejmech.2021.113934openalex-snapshot
NO-HDAC dual inhibitors
inferred← citeshttps://doi.org/10.1016/j.ejphar.2014.06.019openalex-snapshot
Largazole, an inhibitor of class I histone deacetylases, attenuates inflammatory corneal neovascularization
inferred← citeshttps://doi.org/10.1016/j.fitote.2015.04.012openalex-snapshot
Insights into drug discovery from natural products through structural modification
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2012.12.019openalex-snapshot
Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2–ARE pathway
inferred← citeshttps://doi.org/10.1016/j.mib.2009.05.002openalex-snapshot
Chasing the treasures of the sea — bacterial marine natural products
inferred← citeshttps://doi.org/10.1016/j.molstruc.2014.05.009openalex-snapshot
Synthesis, characterization and density functional theory study of some new 2-anilinothiazoles
inferred← citeshttps://doi.org/10.1016/j.molstruc.2015.12.033openalex-snapshot
Synthesis, antimicrobial evaluation and theoretical prediction of NMR chemical shifts of thiazole and selenazole derivatives with high antifungal activity against Candida spp.
inferred← citeshttps://doi.org/10.1016/j.molstruc.2024.137647openalex-snapshot
Exploring the untapped potential of marine sponge compounds as anticancer agents against ERα of breast cancer
inferred← citeshttps://doi.org/10.1016/j.phrs.2018.03.001openalex-snapshot
Structure-activity relationships of HDAC8 inhibitors: Non-hydroxamates as anticancer agents
inferred← citeshttps://doi.org/10.1016/j.phytochem.2011.08.019openalex-snapshot
Lagunamide C, a cytotoxic cyclodepsipeptide from the marine cyanobacterium Lyngbya majuscula
inferred← citeshttps://doi.org/10.1016/j.rser.2016.11.110openalex-snapshot
Cyanobacterial factories for the production of green energy and value-added products: An integrated approach for economic viability
inferred← citeshttps://doi.org/10.1016/j.sbi.2011.08.004openalex-snapshot
Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes
inferred← citeshttps://doi.org/10.1016/j.taap.2013.04.014openalex-snapshot
Largazole, a class I histone deacetylase inhibitor, enhances TNF-α-induced ICAM-1 and VCAM-1 expression in rheumatoid arthritis synovial fibroblasts
inferred← citeshttps://doi.org/10.1016/j.tet.2010.11.106openalex-snapshot
Revised structure and structure–activity relationship of bisebromoamide and structure of norbisebromoamide from the marine cyanobacterium Lyngbya sp.
inferred← citeshttps://doi.org/10.1016/j.tet.2011.07.016openalex-snapshot
Copper(II)-catalyzed oxidation of 4-carboxythiazolines and 4-carboxyoxazolines to 4-carboxythiazoles and 4-carboxyoxazoles
inferred← citeshttps://doi.org/10.1016/j.tet.2014.05.078openalex-snapshot
Design, synthesis, and biological evaluation of largazole derivatives: alteration of the zinc-binding domain
inferred← citeshttps://doi.org/10.1016/j.tet.2015.05.051openalex-snapshot
Study for diastereoselective aldol reaction in flow: synthesis of (E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid, a key component of cyclodepsipeptide HDAC inhibitors
inferred← citeshttps://doi.org/10.1016/j.tet.2017.12.025openalex-snapshot
Synthesis of the molecular hybrid inspired by Largazole and Psammaplin A
inferred← citeshttps://doi.org/10.1016/j.tetlet.2009.04.005openalex-snapshot
A solid-phase total synthesis of the cyclic depsipeptide HDAC inhibitor spiruchostatin A
inferred← citeshttps://doi.org/10.1016/j.tetlet.2010.01.091openalex-snapshot
Oxidation of 4-carboxylate thiazolines to 4-carboxylate thiazoles by molecular oxygen
inferred← citeshttps://doi.org/10.1016/j.tetlet.2010.11.058openalex-snapshot
Total synthesis and cytotoxicity of bisebromoamide and its analogues
inferred← citeshttps://doi.org/10.1016/j.tibtech.2008.10.005openalex-snapshot
Panning for chemical gold: marine bacteria as a source of new therapeutics
inferred← citeshttps://doi.org/10.1016/j.toxicon.2015.09.030openalex-snapshot
Selective inhibition of cancer cells' proliferation by compounds included in extracts from Baltic Sea cyanobacteria
inferred← citeshttps://doi.org/10.1016/j.ymben.2022.12.002openalex-snapshot
High-yield production of FK228 and new derivatives in a Burkholderia chassis
inferred← citeshttps://doi.org/10.1016/s0959-6380(09)70036-4openalex-snapshot
Chapter 5.5: Five-Membered Ring Systems: With N and S (Se) Atoms
inferred← citeshttps://doi.org/10.1021/acs.biochem.5b00010openalex-snapshot
Variable Active Site Loop Conformations Accommodate the Binding of Macrocyclic Largazole Analogues to HDAC8
inferred← citeshttps://doi.org/10.1021/acs.biochem.5b00536openalex-snapshot
Design, Synthesis, and Evaluation of Polyamine Deacetylase Inhibitors, and High-Resolution Crystal Structures of Their Complexes with Acetylpolyamine Amidohydrolase
inferred← citeshttps://doi.org/10.1021/acs.chemrev.6b00838openalex-snapshot
Orally Absorbed Cyclic Peptides
inferred← citeshttps://doi.org/10.1021/acs.chemrev.7b00522openalex-snapshot
Small Bioactive Peptides for Biomaterials Design and Therapeutics
inferred← citeshttps://doi.org/10.1021/acs.chemrev.8b00504openalex-snapshot
Structural Simplification of Natural Products
inferred← citeshttps://doi.org/10.1021/acs.chemrev.8b00789openalex-snapshot
Heteroaryl Rings in Peptide Macrocycles
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