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A Targetable Fluorescent Probe for Imaging Hydrogen Peroxide in the Mitochondria of Living Cells

https://doi.org/10.1021/ja802355u
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
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The common biology of cancer and ageing
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Molecular imaging of hydrogen peroxide produced for cell signaling
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Genetically encoded fluorescent indicator for intracellular hydrogen peroxide
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Neurodegenerative diseases and oxidative stress
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Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals?
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ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis
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Mito-DEPMPO synthesized from a novel NH2-reactive DEPMPO spin trap: a new and improved trap for the detection of superoxide
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Investigating Mitochondrial Redox Potential with Redox-sensitive Green Fluorescent Protein Indicators
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Hydrogen Peroxide: A Signaling Messenger
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Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria
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H 2 O 2 , a Necessary Evil for Cell Signaling
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A luminescence-based probe for sensitive detection of hydrogen peroxide in seconds
inferred← citeshttps://doi.org/10.1016/j.aca.2016.11.019openalex-snapshot
A mitochondria-targeted fluorescence probe for ratiometric detection of endogenous hypochlorite in the living cells
inferred← citeshttps://doi.org/10.1016/j.aca.2019.07.008openalex-snapshot
A red-emitting styrylnaphthalimide-based fluorescent probe providing a ratiometric signal change for the precise and quantitative detection of H2O2
inferred← citeshttps://doi.org/10.1016/j.aca.2019.11.024openalex-snapshot
A new mitochondria-targeting fluorescent probe for ratiometric detection of H2O2 in live cells
inferred← citeshttps://doi.org/10.1016/j.aca.2019.12.059openalex-snapshot
Dual-site fluorescent probe for multi-response detection of ClO− and H2O2 and bio-imaging
inferred← citeshttps://doi.org/10.1016/j.aca.2021.338420openalex-snapshot
3D nitrogen-doped carbon nanofoam arrays embedded with PdCu alloy nanoparticles: Assembling on flexible microelectrode for electrochemical detection in cancer cells
inferred← citeshttps://doi.org/10.1016/j.bbadis.2020.165808openalex-snapshot
Mitochondria-targeted drug delivery in cancers
inferred← citeshttps://doi.org/10.1016/j.bbagen.2010.06.001openalex-snapshot
Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: Implications for mitochondria-specific therapies and probes
inferred← citeshttps://doi.org/10.1016/j.bbagen.2013.02.005openalex-snapshot
P-glycoprotein (Mdr1a/1b) and breast cancer resistance protein (Bcrp) decrease the uptake of hydrophobic alkyl triphenylphosphonium cations by the brain
inferred← citeshttps://doi.org/10.1016/j.bbagen.2013.05.026openalex-snapshot
Using exomarkers to assess mitochondrial reactive species in vivo
inferred← citeshttps://doi.org/10.1016/j.bbagen.2016.05.017openalex-snapshot
Live-cell imaging approaches for the investigation of xenobiotic-induced oxidant stress
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2015.02.001openalex-snapshot
Hierarchical targeted hepatocyte mitochondrial multifunctional chitosan nanoparticles for anticancer drug delivery
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2015.04.002openalex-snapshot
Ruthenium(II) polypyridyl complexes as mitochondria-targeted two-photon photodynamic anticancer agents
inferred← citeshttps://doi.org/10.1016/j.bios.2011.07.065openalex-snapshot
Nano polyurethane-assisted ultrasensitive biodetection of H2O2 over immobilized Microperoxidase-11
inferred← citeshttps://doi.org/10.1016/j.bios.2013.12.003openalex-snapshot
Targeted surface-functionalized gold nanoclusters for mitochondrial imaging
inferred← citeshttps://doi.org/10.1016/j.bios.2013.12.065openalex-snapshot
A water-soluble BODIPY derivative as a highly selective “Turn-On” fluorescent sensor for H2O2 sensing in vivo
inferred← citeshttps://doi.org/10.1016/j.bios.2014.02.059openalex-snapshot
A resorufin-based colorimetric and fluorescent probe for live-cell monitoring of hydrazine
inferred← citeshttps://doi.org/10.1016/j.bios.2015.10.061openalex-snapshot
A mitochondria-targeted ratiometric two-photon fluorescent probe for biological zinc ions detection
inferred← citeshttps://doi.org/10.1016/j.bios.2015.12.046openalex-snapshot
A fast responsive two-photon fluorescent probe for imaging H2O2 in lysosomes with a large turn-on fluorescence signal
inferred← citeshttps://doi.org/10.1016/j.bios.2016.03.076openalex-snapshot
Fluorescence “turn-on” determination of H2O2 using multilayer porous SiO2/NGQDs and PdAu mimetics enzymatic/oxidative cleavage of single-stranded DNA
inferred← citeshttps://doi.org/10.1016/j.bios.2016.07.026openalex-snapshot
A viscosity sensitive fluorescent dye for real-time monitoring of mitochondria transport in neurons
inferred← citeshttps://doi.org/10.1016/j.bios.2019.04.008openalex-snapshot
A ratiometric fluorescence platform based on boric-acid-functional Eu-MOF for sensitive detection of H2O2 and glucose
inferred← citeshttps://doi.org/10.1016/j.bios.2021.112965openalex-snapshot
Real-time in situ monitoring of Lon and Caspase-3 for assessing the state of cardiomyocytes under hypoxic conditions via a novel Au–Se fluorescent nanoprobe
inferred← citeshttps://doi.org/10.1016/j.bmcl.2008.08.035openalex-snapshot
A red-emitting naphthofluorescein-based fluorescent probe for selective detection of hydrogen peroxide in living cells
inferred← citeshttps://doi.org/10.1016/j.bmcl.2010.05.017openalex-snapshot
Synthesis and properties of fluorescence probe for detection of peroxides in mitochondria
inferred← citeshttps://doi.org/10.1016/j.bmcl.2021.128252openalex-snapshot
A microtubule-localizing activity-based sensing fluorescent probe for imaging hydrogen peroxide in living cells
inferred← citeshttps://doi.org/10.1016/j.bmcl.2023.129262openalex-snapshot
A new hydrocyanine probe for imaging reactive oxygen species in the mitochondria of live cells
inferred← citeshttps://doi.org/10.1016/j.cbpa.2009.10.014openalex-snapshot
Mitochondrial-targeted fluorescent probes for reactive oxygen species
inferred← citeshttps://doi.org/10.1016/j.cbpa.2012.07.014openalex-snapshot
Fluorescent probes for sensing and imaging biological hydrogen sulfide
inferred← citeshttps://doi.org/10.1016/j.cbpa.2013.02.003openalex-snapshot
Methods to detect hydrogen peroxide in living cells: Possibilities and pitfalls
inferred← citeshttps://doi.org/10.1016/j.ccell.2014.12.006openalex-snapshot
Glutamate Dehydrogenase 1 Signals through Antioxidant Glutathione Peroxidase 1 to Regulate Redox Homeostasis and Tumor Growth
inferred← citeshttps://doi.org/10.1016/j.cclet.2014.05.020openalex-snapshot
A two-photon mitotracker based on a naphthalimide fluorophore: Synthesis, photophysical properties and cell imaging
inferred← citeshttps://doi.org/10.1016/j.cclet.2015.10.022openalex-snapshot
Development of a triple channel detection probe for hydrogen peroxide
inferred← citeshttps://doi.org/10.1016/j.cclet.2016.02.001openalex-snapshot
Regulation of oxidative stress inside living cells through polythiophene derivatives
inferred← citeshttps://doi.org/10.1016/j.cclet.2017.07.016openalex-snapshot
Fluorescence imaging mitochondrial copper(II) via photocontrollable fluorogenic probe in live cells
inferred← citeshttps://doi.org/10.1016/j.cclet.2019.07.006openalex-snapshot
Organelle targetable fluorescent probes for hydrogen peroxide
inferred← citeshttps://doi.org/10.1016/j.ccr.2012.03.009openalex-snapshot
Probing oxidative stress: Small molecule fluorescent sensors of metal ions, reactive oxygen species, and thiols
inferred← citeshttps://doi.org/10.1016/j.ccr.2015.11.012openalex-snapshot
Synthetic fluorescent probes to map metallostasis and intracellular fate of zinc and copper
inferred← citeshttps://doi.org/10.1016/j.ccr.2025.216785openalex-snapshot
Small-molecule fluorescent probes for detecting hydrogen peroxide in biological systems
inferred← citeshttps://doi.org/10.1016/j.ccr.2025.217229openalex-snapshot
Recent advances in the mitochondria-targeting small molecule fluorescent probes: from the principal design to biological applications
inferred← citeshttps://doi.org/10.1016/j.ccr.2026.217570openalex-snapshot
Optical imaging probes for mitochondrial metabolism: Mechanism, design and frontier applications
inferred← citeshttps://doi.org/10.1016/j.cej.2020.124127openalex-snapshot
H2O2-responsive smart dressing for visible H2O2 monitoring and accelerating wound healing
inferred← citeshttps://doi.org/10.1016/j.cej.2023.144805openalex-snapshot
Metal-organic framework-derived brain platygyra coral-like porous carbon architectures for real-time monitoring of hydrogen peroxide in biological matrices
inferred← citeshttps://doi.org/10.1016/j.celbio.2024.100001openalex-snapshot
Subcellular targeting strategies: Chemical structure-based design concepts for bioimaging and theranostics
inferred← citeshttps://doi.org/10.1016/j.cellsig.2015.12.011openalex-snapshot
Principles for integrating reactive species into in vivo biological processes: Examples from exercise physiology
inferred← citeshttps://doi.org/10.1016/j.cels.2018.01.008openalex-snapshot
Rare Disease Mechanisms Identified by Genealogical Proteomics of Copper Homeostasis Mutant Pedigrees
inferred← citeshttps://doi.org/10.1016/j.chembiol.2011.07.005openalex-snapshot
A Nuclear-Localized Fluorescent Hydrogen Peroxide Probe for Monitoring Sirtuin-Mediated Oxidative Stress Responses In Vivo
inferred← citeshttps://doi.org/10.1016/j.chembiol.2016.06.012openalex-snapshot
Mitochondrial Chemical Biology: New Probes Elucidate the Secrets of the Powerhouse of the Cell
inferred← citeshttps://doi.org/10.1016/j.chom.2018.10.005openalex-snapshot
Mitochondria-Derived Vesicles Deliver Antimicrobial Reactive Oxygen Species to Control Phagosome-Localized Staphylococcus aureus
inferred← citeshttps://doi.org/10.1016/j.cmet.2011.02.003openalex-snapshot
Measurement of H2O2 within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix
inferred← citeshttps://doi.org/10.1016/j.cmet.2011.03.010openalex-snapshot
Unraveling the Biological Roles of Reactive Oxygen Species
inferred← citeshttps://doi.org/10.1016/j.colsurfb.2019.03.008openalex-snapshot
Facile strategy to prepare a metalloporphyrin-based hydrophilic porous organic polymer with enhanced peroxidase-like activity and high stability for colorimetric detection of H2O2 and glucose
inferred← citeshttps://doi.org/10.1016/j.dyepig.2013.06.019openalex-snapshot
Novel water soluble styrylquinolinium boronic acid as a ratiometric reagent for the rapid detection of hypochlorite ion
inferred← citeshttps://doi.org/10.1016/j.dyepig.2016.09.010openalex-snapshot
An aniline bearing hemicyanine derivative serves as a mitochondria selective probe
inferred← citeshttps://doi.org/10.1016/j.dyepig.2017.01.062openalex-snapshot
Development of organelle-targetable europium complex probes for time-gated luminescence imaging of hypochlorous acid in live cells and animals
inferred← citeshttps://doi.org/10.1016/j.dyepig.2017.12.001openalex-snapshot
Two–photon excitable red fluorophores for imaging living cells
inferred← citeshttps://doi.org/10.1016/j.dyepig.2017.12.028openalex-snapshot
An ESIPT-based mitochondria-targeted ratiometric and NIR-emitting fluorescent probe for hydrogen peroxide and its bioimaging in living cells
inferred← citeshttps://doi.org/10.1016/j.dyepig.2018.02.015openalex-snapshot
A highly sensitive and photo-stable fluorescent probe for endogenous intracellular H2O2 imaging in live cancer cells
inferred← citeshttps://doi.org/10.1016/j.dyepig.2018.03.038openalex-snapshot
A fluorescent probe for imaging hydrogen peroxide in ovarian cancer cells
inferred← citeshttps://doi.org/10.1016/j.dyepig.2019.107561openalex-snapshot
Mitochondria-targetable red-emitting probe for real-time fluorescence monitoring of NAD(P)H in live cells
inferred← citeshttps://doi.org/10.1016/j.dyepig.2020.108954openalex-snapshot
A self-immolative near-infrared probe based on hemi-benzothiazolecyanine for visualizing hydrogen peroxide in living cells and mice
inferred← citeshttps://doi.org/10.1016/j.dyepig.2021.109170openalex-snapshot
Real-time monitoring viscosity variation in carcinogenesis evolution models by a red-emitting rotor
inferred← citeshttps://doi.org/10.1016/j.dyepig.2021.109593openalex-snapshot
A simple chalcone molecular rotor for specific fluorescence imaging of mitochondrial viscosity changes in living cells
inferred← citeshttps://doi.org/10.1016/j.dyepig.2022.110938openalex-snapshot
Fluorescent probe-encapsulated smart nanohydrogel to enhance sensitivity toward hydrogen peroxide in living cells
inferred← citeshttps://doi.org/10.1016/j.dyepig.2025.112756openalex-snapshot
Highly sensitive fluorescence probe for accurate detection of peroxynitrite in mitochondria and imaging inflammation sites
inferred← citeshttps://doi.org/10.1016/j.electacta.2015.12.092openalex-snapshot
Photochemical Green Synthesis of Nanostructured Cobalt Oxides as Hydrogen Peroxide Redox for Bifunctional Sensing Application
inferred← citeshttps://doi.org/10.1016/j.engmed.2024.100009openalex-snapshot
Medical imaging-based companion diagnostics for solid tumors
inferred← citeshttps://doi.org/10.1016/j.foodchem.2025.145286openalex-snapshot
Exploring anthraquinone derivatives for effective peroxide detection in reheated palm oil: Insights and innovations
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2008.10.031openalex-snapshot
HPLC study of oxidation products of hydroethidine in chemical and biological systems: ramifications in superoxide measurements
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2010.03.020openalex-snapshot
Reactive oxygen species: A radical role in development?
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2012.03.008openalex-snapshot
Mitochondrial compartmentalization of redox processes
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2012.05.033openalex-snapshot
A ratiometric fluorescent probe for assessing mitochondrial phospholipid peroxidation within living cells
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2012.09.002openalex-snapshot
Detection of reactive oxygen species derived from the family of NOX NADPH oxidases
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2015.10.404openalex-snapshot
ROS-dependent activation of autophagy is a critical mechanism for the induction of anti-glioma effect of sanguinarine
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