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Total Synthesis of Vinblastine, Vincristine, Related Natural Products, and Key Structural Analogues
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Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/anie.200503024openalex-snapshot
Total Synthesis of (−)‐ and ent‐(+)‐Vindorosine: Tandem Intramolecular Diels–Alder/1,3‐Dipolar Cycloaddition of 1,3,4‐Oxadiazoles
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Alkaloids From Catharanthus Roseus 1H NMR Study of 20′S‐Deoxyvinblastine and its N‐2′ Borane Complex
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Total Synthesis of Indole and Dihydroindole Alkaloids. VIII. Studies on the synthesis of bisindole alkaloids in the vinblastine‐vincristine series. The chloroindolenine approach
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Total Synthesis of Indole and Dihydroindole Alkaloids. IX Studies on the synthesis of bisindole alkaloids in the vinblastine‐ vincristine series. The biogenetic approach
inferredcites →https://doi.org/10.1002/jps.2600531023openalex-snapshot
Alkaloids of Vinca rosea Linn. (Catharantbus roseus G. Don) XXIV
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A Note on the Alkaloids of Vinca rosea Linn. (Catharanthus roseus G. Don.) II.**Lilly Research Laboratories and Organic Chemical Development, Eli Lilly and Co., Indianapolis, Ind.
inferredcites →https://doi.org/10.1002/jps.3030481115openalex-snapshot
Alkaloids of Vinca rosea Linn. (Catharanthus roseus G. Don.) V.**Organic Chemical Development and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, Ind.
inferredcites →https://doi.org/10.1007/bf01924654openalex-snapshot
Vinca alkaloids XXXV. Desacetoxyvinblastine a new minor alkaloid fromVinca rosea L. (Catharanthus roseus G. Don)
inferredcites →https://doi.org/10.1016/0031-9422(88)80430-8openalex-snapshot
Extraction of 3′,4′-anhydrovinblastine from Catharanthus roseus
inferredcites →https://doi.org/10.1016/0040-4020(79)87036-2openalex-snapshot
5'-Nor anhydrovinblastine
inferredcites →https://doi.org/10.1016/0040-4020(80)88032-xopenalex-snapshot
Composés antitumoraux du groupe de la vinblastine: nouvelle méthode de préparation
inferredcites →https://doi.org/10.1016/0277-5379(91)90391-popenalex-snapshot
Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine: Evidence for a vascular mechanism
inferredcites →https://doi.org/10.1016/0959-8049(93)90082-qopenalex-snapshot
Vinca alkaloids: Anti-vascular effects in a murine tumour
inferredcites →https://doi.org/10.1016/j.tet.2008.10.064openalex-snapshot
Laccase-catalyzed coupling of catharanthine and vindoline: an efficient approach to the bisindole alkaloid anhydrovinblastine
inferredcites →https://doi.org/10.1016/s0020-1693(98)00090-5openalex-snapshot
Catalytic oxygenation of olefin with dioxygen and tetra-t-butylphthalocyanine complexes in the presence of sodium borohydride
inferredcites →https://doi.org/10.1016/s0040-4020(01)85824-5openalex-snapshot
Production of 3', 4'-anhydrovinblastine: a unique chemical synthesis
inferredcites →https://doi.org/10.1016/s0040-4020(01)86383-3openalex-snapshot
Synthesis of vinca alkaloids and related compounds. Part LVI. 15′,20′-Anhydrovinblastine borane complex. Structural investigations using NMR methods.
inferredcites →https://doi.org/10.1016/s0040-4020(01)86863-0openalex-snapshot
Eine neue synthese von vinblastin- derivaten iv.
inferredcites →https://doi.org/10.1016/s0040-4020(01)88140-0openalex-snapshot
Mechanistic aspects of the formation of anhydrovinblastine by Potier-Polonovski oxidative coupling of catharanthine and vindoline. Spectroscopic observation and chemical reactions of intermediates
inferredcites →https://doi.org/10.1016/s0040-4020(01)88619-1openalex-snapshot
Conversion of anhydrovinblastine to vinblastine by cell-free homogenates of catharanthus roseus cell suspension cultures
inferredcites →https://doi.org/10.1016/s0040-4020(98)00289-0openalex-snapshot
Synthesis and oxidative fragmentation of catharanthine analogs. Comparison to the fragmentation — Coupling of catharanthine and vindoline
inferredcites →https://doi.org/10.1016/s0040-4039(00)79362-2openalex-snapshot
Borane complexes of vinblastine type diindole derivatives
inferredcites →https://doi.org/10.1016/s0040-4039(01)93949-8openalex-snapshot
A new oxidative rearrangement of vindoline
inferredcites →https://doi.org/10.1016/s0040-4039(01)98852-5openalex-snapshot
Vinca alkaloids. XXX. Chemistry of the deoxyvinblastines (deoxy-vlb), leurosine (vlr), and pleurosine, dimeric alkaloids from linn. ( G. Don)
inferredcites →https://doi.org/10.1016/s0099-9598(08)60097-8openalex-snapshot
Chapter 6 Therapeutic Use of Bisindole Alkaloids from Catharanthus
inferredcites →https://doi.org/10.1016/s0959-8049(98)00416-xopenalex-snapshot
Superior in vivo experimental antitumour activity of vinflunine, relative to vinorelbine, in a panel of human tumour xenografts
inferredcites →https://doi.org/10.1021/ar00034a007openalex-snapshot
Plant cell culture combined with chemistry: a powerful route to complex natural products
inferredcites →https://doi.org/10.1021/ic00105a009openalex-snapshot
Chemistry of Borohydride Reduction of Iron(II) and Iron(III) Ions in Aqueous and Nonaqueous Media. Formation of Nanoscale Fe, FeB, and Fe2B Powders
inferredcites →https://doi.org/10.1021/ja00052a020openalex-snapshot
Nonoxidative coupling methodology for the synthesis of the antitumor bisindole alkaloid vinblastine and a lower-half analog: solvent effect on the stereochemistry of the crucial C-15/C-18' bond
inferredcites →https://doi.org/10.1021/ja00178a079openalex-snapshot
Synthesis of the antitumor bisindole alkaloid vinblastine: diastereoselectivity and solvent effect on the stereochemistry of the crucial C-15-C-18' bond
inferredcites →https://doi.org/10.1021/ja00438a046openalex-snapshot
Application of a modification of the Polonovski reaction to the synthesis of vinblastine-type alkaloids
inferredcites →https://doi.org/10.1021/ja00472a016openalex-snapshot
Synthetic and mechanistic studies of the reduction of .alpha.,.beta.-unsaturated carbonyl compounds by the binuclear cluster, sodium hydrogen octacarbonyldiferrate
inferredcites →https://doi.org/10.1021/ja00487a060openalex-snapshot
Role of anhydrovinblastine in the biosynthesis of the antitumor dimeric indole alkaloids
inferredcites →https://doi.org/10.1021/ja00502a072openalex-snapshot
Preparation of vinblastine, vincristine, and leurosidine, antitumor alkaloids from Catharanthus species (Apocynaceae)
inferredcites →https://doi.org/10.1021/ja00865a042openalex-snapshot
Vinca Alkaloids. X1. The Structure of Vindoline
inferredcites →https://doi.org/10.1021/ja00949a056openalex-snapshot
Structures of Leurocristine (Vincristine) and Vincaleukoblastine.1 X-Ray Analysis of Leurocristine Methiodide
inferredcites →https://doi.org/10.1021/ja0177049openalex-snapshot
Stereocontrolled Total Synthesis of (+)-Vinblastine
inferredcites →https://doi.org/10.1021/ja027533nopenalex-snapshot
Intramolecular Diels−Alder and Tandem Intramolecular Diels−Alder/1,3-Dipolar Cycloaddition Reactions of 1,3,4-Oxadiazoles
inferredcites →https://doi.org/10.1021/ja0612549openalex-snapshot
Intramolecular Diels−Alder/1,3-Dipolar Cycloaddition Cascade of 1,3,4-Oxadiazoles
inferredcites →https://doi.org/10.1021/ja061256topenalex-snapshot
Total Synthesis of (−)- and ent-(+)-Vindoline and Related Alkaloids
inferredcites →https://doi.org/10.1021/ja066787wopenalex-snapshot
Directed Biosynthesis of Alkaloid Analogs in the Medicinal Plant Catharanthus roseus
inferredcites →https://doi.org/10.1021/ja078192mopenalex-snapshot
Direct Coupling of Catharanthine and Vindoline to Provide Vinblastine: Total Synthesis of (+)- and ent-(−)-Vinblastine
inferredcites →https://doi.org/10.1021/ja971864wopenalex-snapshot
Vinca Alkaloids in Superacidic Media: A Method for Creating a New Family of Antitumor Derivatives
inferredcites →https://doi.org/10.1021/jm00199a016openalex-snapshot
Structure-activity relationships of dimeric Catharanthus alkaloids. 1. Deacetyl vinblastine amide (vindesine) sulfate
inferredcites →https://doi.org/10.1021/jm00213a019openalex-snapshot
Alkaloids of Vinca rosea L. (Catharanthus roseus G. Don). 38. 4'-Dehydrated derivatives
inferredcites →https://doi.org/10.1021/jo00002a008openalex-snapshot
Enantioselective syntheses of vinblastine, leurosidine, vincovaline and 20'-epi-vincovaline
inferredcites →https://doi.org/10.1021/jo00032a029openalex-snapshot
A common intermediate providing syntheses of .PSI.-tabersonine, coronaridine, iboxyphylline, ibophyllidine, vinamidine, and vinblastine
inferredcites →https://doi.org/10.1021/jo00228a035openalex-snapshot
Three routes to the critical C16'-C14' parf relative stereochemistry of vinblastine. Syntheses of 20'-desethyl-20'-deoxyvinblastine, and 20'-desethyl-20'-deoxyvincovaline
inferredcites →https://doi.org/10.1021/jo00407a004openalex-snapshot
Selective reduction of alkenes and alkynes by the reagent lithium aluminum hydride-transition-metal halide
inferredcites →https://doi.org/10.1021/jo01336a006openalex-snapshot
A new class of antitumor compounds: 5'-nor and 5',6'-seco derivatives of vinblastine-type alkaloids
inferredcites →https://doi.org/10.1021/np50007a004openalex-snapshot
Synthesis of the Antitumor Dimeric Indole Alkaloids From Catharanthus Species (Vinblastine Group)
inferredcites →https://doi.org/10.1021/ol0201299openalex-snapshot
Co(III)−Alkyl Complex- and Co(III)−Alkylperoxo Complex-Catalyzed Triethylsilylperoxidation of Alkenes with Molecular Oxygen and Triethylsilane
inferredcites →https://doi.org/10.1021/ol049805sopenalex-snapshot
Termination of Mn(III)-Based Oxidative Cyclizations by Trapping with Azide
inferredcites →https://doi.org/10.1021/ol050017sopenalex-snapshot
Total Synthesis of Natural (−)- and ent-(+)-4-Desacetoxy-6,7-dihydrovindorosine and Natural and ent-Minovine: Oxadiazole Tandem Intramolecular Diels−Alder/1,3-Dipolar Cycloaddition Reaction
inferredcites →https://doi.org/10.1021/ol051975xopenalex-snapshot
Total Synthesis of (−)- and ent-(+)-Vindoline
inferredcites →https://doi.org/10.1021/ol702040yopenalex-snapshot
Synthesis of (+)-Vinblastine and Its Analogues
inferredcites →https://doi.org/10.1039/b209990jopenalex-snapshot
Syntheses and biological evaluation of vinblastine congeners
inferredcites →https://doi.org/10.1039/c39750000670openalex-snapshot
Partial synthesis of vinblastine-type alkaloids
inferredcites →https://doi.org/10.1039/c39780000102openalex-snapshot
Antitumour alkaloids of the vinblastine-type: is leurosine an artefact?
inferredcites →https://doi.org/10.1039/c39790000582openalex-snapshot
Antitumour alkaloids of the vinblastine-type: air oxidation of anhydrovinblastine
inferredcites →https://doi.org/10.1039/c39930001496openalex-snapshot
Electrochemical synthesis of anhydrovinblastine
inferredcites →https://doi.org/10.1039/np9900700085openalex-snapshot
Biosynthesis and synthesis of indole and bisindole alkaloids in plant cell cultures: a personal overview
inferredcites →https://doi.org/10.1054/drup.2002.0230openalex-snapshot
Anticancer therapy with novel tubulin-interacting drugs
inferredcites →https://doi.org/10.1055/s-1991-20611openalex-snapshot
Plant Cell Cultures and Synthetic Chemistry - A Potentially Powerful Route to Complex Natural Products
inferredcites →https://doi.org/10.1055/s-2007-969701openalex-snapshot
N-Deformyl Vincristine a Bisalkaloid fromCatharanthus roseus
inferredcites →https://doi.org/10.1073/pnas.0401323101openalex-snapshot
Stereocontrolled total synthesis of (+)-vincristine
inferredcites →https://doi.org/10.1080/00397918708057764openalex-snapshot
A Mild, Efficient Reduction of Sulfoxides with Ferric Chloride/Sodium Borohydride
inferredcites →https://doi.org/10.1111/j.1749-6632.1958.tb54906.xopenalex-snapshot
ROLE OF CHANCE OBSERVATIONS IN CHEMOTHERAPY: VINCA ROSEA*
inferredcites →https://doi.org/10.1139/v78-011openalex-snapshot
Total synthesis of indole and dihydroindole alkaloids. XII. Selective functionalization of various bisindoles. Efficient syntheses of leurosine and related bisindole alkaloid derivatives
inferredcites →https://doi.org/10.1182/blood.v94.12.4143openalex-snapshot
Antiangiogenesis Is Produced by Nontoxic Doses of Vinblastine
inferredcites →https://doi.org/10.1200/jco.1999.17.3.1061openalex-snapshot
Mechanisms of Action of and Resistance to Antitubulin Agents: Microtubule Dynamics, Drug Transport, and Cell Death
inferredcites →https://doi.org/10.1246/bcsj.64.2948openalex-snapshot
A Novel and Efficient Method for the Preparation of α-Hydroxyimino Carbonyl Compounds from α,β-Unsaturated Carbonyl Compounds with Butyl Nitrite and Phenylsilane Catalyzed by a Cobalt(II) Complex
inferredcites →https://doi.org/10.1246/cl.1978.1285openalex-snapshot
β-DIALKYLAMINO CONJUGATED ENONES: REDUCTION WITH NaBH4–FeCl3 AND CONVERSION INTO CONJUGATED ENONES
inferredcites →https://doi.org/10.1246/cl.1989.1071openalex-snapshot
A New Method for Preparation of Alcohols from Olefins with Molecular Oxygen and Phenylsilane by the Use of Bis(acetylacetonato)cobalt(II)
inferredcites →https://doi.org/10.1246/cl.1989.449openalex-snapshot
Oxidation-Reduction Hydration of Olefins with Molecular Oxygen and 2-Propanol Catalyzed by Bis(acetylacetonato)cobalt(II)
inferredcites →https://doi.org/10.2174/0929867043455846openalex-snapshot
The Catharanthus Alkaloids:Pharmacognosy and Biotechnology
inferredcites →https://doi.org/10.2174/1381612013397483openalex-snapshot
Modifications in the upper or Velbenamine Part of the Vinca Alkaloids have Major Implications for Tubulin Interacting Activities
inferredcites →https://doi.org/10.2174/1568011023354452openalex-snapshot
Novel Aspects of Natural and Modified Vinca Alkaloids
inferredcites →https://doi.org/10.3987/com-06-s(k)8openalex-snapshot
Total Synthesis of (-)- and ent-(+)-4-Desacetoxy-5-desethylvindoline
inferredcites →https://doi.org/10.3987/com-88-4609openalex-snapshot
Flavine Coenzyme Mediated Photooxidation of 3',4'-Anhydrovinblastine. Further Information on the Later Stages of Bisindole Alkaloid Biosynthesis.
inferredcites →https://doi.org/10.3987/com-88-4610openalex-snapshot
Biomimetic Chemical Transformation of 3',4'-Anhydrovinblastine to Vinblastine and Related Bisindole Alkaloids
inferredcites →https://doi.org/10.3987/com-88-4611openalex-snapshot
A Highly Efficient and Commercially Important Synthesis of the Antitumor Catharanthus Alkaloids Vinblastine and Leurosidine from Catharanthine and Vindoline
inferredcites →https://doi.org/10.3987/r-1975-08-0639openalex-snapshot
Studies on the Synthesis of Bisindole Alkaloids. II. The Synthesis of 3’,4’-Dehydrovinblastine, 4’-Deoxovinblastine and Related Analogues. The Biogenetic Approach
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The [4 + 2] Cycloaddition of 2‐Pyrone in Total Synthesis
inferred← citeshttps://doi.org/10.1002/cjoc.202100827openalex-snapshot
Cobalt‐Catalyzed Intermolecular Hydroamination of Unactivated Alkenes Using NFSI as Nitrogen Source
inferred← citeshttps://doi.org/10.1002/cmdc.201600334openalex-snapshot
15‐Methylene‐Eburnamonine Kills Leukemic Stem Cells and Reduces Engraftment in a Humanized Bone Marrow Xenograft Mouse Model of Leukemia
inferred← citeshttps://doi.org/10.1002/cmdc.201900477openalex-snapshot
A Novel Class of N‐Sulfonyl and N‐Sulfamoyl Noscapine Derivatives that Promote Mitotic Arrest in Cancer Cells
inferred← citeshttps://doi.org/10.1002/cptc.70190openalex-snapshot
Light‐Driven [2 + 2] Cycloaddition Strategies for the Synthesis of Cyclobuta[ b ]indoles and Their Derivatives
inferred← citeshttps://doi.org/10.1002/ejoc.201500141openalex-snapshot
Diastereoselective Synthesis of Indolindiones by Formal [5+1] Double Michael Cycloaddition to 4‐Cinnamoylpyrrolediones
inferred← citeshttps://doi.org/10.1002/ejoc.201700412openalex-snapshot
Enantioselective Synthesis of trans‐2,3‐Dihydro‐1H‐indoles Through C–H Insertion of α‐Diazocarbonyl Compounds
inferred← citeshttps://doi.org/10.1002/ejoc.201800528openalex-snapshot
Employing Small Polyfunctionalized Molecules for a Diastereoselective Synthesis of Highly Substituted Indolines
inferred← citeshttps://doi.org/10.1002/ejoc.201901613openalex-snapshot
Modular Synthesis of Functionalized Butenolides by Oxidative Furan Fragmentation
inferred← citeshttps://doi.org/10.1002/ejoc.202100215openalex-snapshot
Maleic Acid/Thiourea‐Catalyzed Dearomative ipso‐Friedel–Crafts Reaction of Indoles to Produce Functionalized Spiroindolenines
inferred← citeshttps://doi.org/10.1002/ejoc.202401103openalex-snapshot
Recent Advances in Radical Hydrofunctionalization of Alkenes and Dienes via Reductive Metal‐Hydride Hydrogen Atom Transfer (MHAT)
inferred← citeshttps://doi.org/10.1002/jhet.4564openalex-snapshot
Antioxidant and cytotoxic properties of some new dipeptide‐indole conjugates
inferred← citeshttps://doi.org/10.1002/slct.201701971openalex-snapshot
In Silico Exploration of Vinca Domain Tubulin Inhibitors: A Combination of 3D‐QSAR‐Based Pharmacophore Modeling, Docking and Molecular Dynamics Simulations
inferred← citeshttps://doi.org/10.1002/slct.202003936openalex-snapshot
PPh 3 Catalyzed Post‐Transformation Ugi‐4CR Intramolecular Cyclization Reaction: One‐Pot Synthesis of Functionalized Spiropyrrolidinochromanones
inferred← citeshttps://doi.org/10.1002/tcr.202300207openalex-snapshot
Growing Utilization of Radical Chemistry in the Synthesis of Pharmaceuticals
inferred← citeshttps://doi.org/10.1007/7081_2017_14openalex-snapshot
Radical Cascades in the Total Synthesis of Complex Naturally Occurring Heterocycles
inferred← citeshttps://doi.org/10.1007/978-3-030-74779-4_17openalex-snapshot
Higher Plant Sources of Cancer Chemotherapeutic Agents and the Potential Role of Biotechnological Approaches for Their Supply
inferred← citeshttps://doi.org/10.1007/978-3-319-51620-2_7openalex-snapshot
Catharanthus roseus: The Cancer-Fighting Medicine
inferred← citeshttps://doi.org/10.1007/978-3-319-51620-2_8openalex-snapshot
In Vitro Studies, Biosynthesis of Secondary Metabolites and Pharmacological Utility of Catharanthus roseus (L.) G. Don.: A Review
inferred← citeshttps://doi.org/10.1007/978-3-662-70963-4_3openalex-snapshot
Synthesis and Derivatization of Alkenes and Alkynes
inferred← citeshttps://doi.org/10.1007/978-981-97-2166-5_15openalex-snapshot
Bioengineering Strategy for Production of Plant-Based High-Valued Natural Products
inferred← citeshttps://doi.org/10.1007/s00449-025-03270-xopenalex-snapshot
Comprehensive study of a novel Catharanthus roseus cell line for medicinal alkaloids production
inferred← citeshttps://doi.org/10.1007/s00709-022-01801-xopenalex-snapshot
Identification of a second 16-hydroxytabersonine-O-methyltransferase suggests an evolutionary relationship between alkaloid and flavonoid metabolisms in Catharanthus roseus
inferred← citeshttps://doi.org/10.1007/s00894-018-3611-1openalex-snapshot
Identification of a less toxic vinca alkaloid derivative for use as a chemotherapeutic agent, based on in silico structural insights and metabolic interactions with CYP3A4 and CYP3A5
inferred← citeshttps://doi.org/10.1007/s11030-025-11219-1openalex-snapshot
Synthesis, anti-tumor evaluation, and mechanistic investigation of 3-indolylpyrazole phenoxyacetamide derivatives against chronic myeloid leukemia cells
inferred← citeshttps://doi.org/10.1007/s11030-026-11617-zopenalex-snapshot
CPA-catalyzed enantioselective synthesis of α,α-bisindoles-assembled triarylmethanes between 3-indolyl[1,4]thiazepines and indoles via ring-opening/friedel–crafts reaction
inferred← citeshttps://doi.org/10.1007/s11172-012-0167-6openalex-snapshot
Synthesis of azecino[5,4-b]indoles and indolo[3,2-e][2]benzazonines via tandem transformation of hydrogenated indoloquinolizines and indolizines
inferred← citeshttps://doi.org/10.1007/s11172-016-1566-xopenalex-snapshot
Cycloaddition chemistry of carbonyl ylides for alkaloid synthesis
inferred← citeshttps://doi.org/10.1007/s11426-016-0032-yopenalex-snapshot
Advances of radical and photo reactions in natural products synthesis
inferred← citeshttps://doi.org/10.1007/s11426-016-0055-0openalex-snapshot
Asymmetric construction of all-carbon quaternary stereocenters in the total synthesis of natural products
inferred← citeshttps://doi.org/10.1007/s12010-024-04902-wopenalex-snapshot
Molecular Identification and Phytochemical Analysis and Bioactivity Assessment of Catharanthus roseus Leaf Extract: Exploring Antioxidant Potential and Antimicrobial Activities
inferred← citeshttps://doi.org/10.1007/s12247-025-10227-wopenalex-snapshot
Isolation and Anti-Cancer Activity of Vinblastine from Colletotrichum siamense, an Endophyte of Catharanthus roseus (L.) G. Don
inferred← citeshttps://doi.org/10.1007/s13205-023-03636-6openalex-snapshot
Vinca alkaloids as a potential cancer therapeutics: recent update and future challenges
inferred← citeshttps://doi.org/10.1007/s13205-025-04562-5openalex-snapshot
Endophytic fungus Epichloe festucae from Catharanthus roseus as a novel source of vinblastine and vincristine with apoptosis-inducing activity
inferred← citeshttps://doi.org/10.1016/b978-0-08-096805-6.00001-2openalex-snapshot
Recent Advances in the Synthesis of Aspidosperma-Type Alkaloids
inferred← citeshttps://doi.org/10.1016/b978-0-08-096805-6.00006-1openalex-snapshot
Five-Membered Ring Systems
inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.14618-9openalex-snapshot
Biosynthesis of Vinblastine
inferred← citeshttps://doi.org/10.1016/b978-0-12-802972-5.00024-xopenalex-snapshot
Recent developments in using plant-derived natural products as tubulin inhibitors for the management of cancer
inferred← citeshttps://doi.org/10.1016/b978-0-12-821277-6.00004-0openalex-snapshot
Vinca Alkaloids as Chemotherapeutic Agents Against Breast Cancer
inferred← citeshttps://doi.org/10.1016/b978-0-443-23754-6.00003-3openalex-snapshot
Natural product–inspired bioactive alkaloids via C–C/C–N coupling reactions: Synthetic developments, current scenario, and future perspectives
inferred← citeshttps://doi.org/10.1016/b978-0-443-40511-2.00006-1openalex-snapshot
FDA-approved plant-based drugs for cancer treatment
inferred← citeshttps://doi.org/10.1016/bs.aihch.2016.03.005openalex-snapshot
Recent Advances of 1,3-Dipolar Cycloaddition Chemistry for Alkaloid Synthesisa
inferred← citeshttps://doi.org/10.1016/bs.alkal.2015.09.001openalex-snapshot
Monoterpenoid Bisindole Alkaloids
inferred← citeshttps://doi.org/10.1016/bs.alkal.2020.02.002openalex-snapshot
Recent applications of the Wittig reaction in alkaloid synthesis
inferred← citeshttps://doi.org/10.1016/j.bioorg.2021.104626openalex-snapshot
Vincamine, a safe natural alkaloid, represents a novel anticancer agent
inferred← citeshttps://doi.org/10.1016/j.bioorg.2025.108676openalex-snapshot
Discovery of novel combretastatin A4 derivatives as a microtubule targeting agent capable of inducing HepG-2 cell apoptosis via the mitochondria and ER stress mediated pathway
inferred← citeshttps://doi.org/10.1016/j.biortech.2026.135370openalex-snapshot
De novo synthesis of large-scale metabolic pathways for natural products and their optimization strategies
inferred← citeshttps://doi.org/10.1016/j.bmcl.2010.09.091openalex-snapshot
Catharanthine C16 substituent effects on the biomimetic coupling with vindoline: Preparation and evaluation of a key series of vinblastine analogues
inferred← citeshttps://doi.org/10.1016/j.bmcl.2013.08.095openalex-snapshot
Synthesis of 15-methylene-eburnamonine from (+)-vincamine, evaluation of anticancer activity, and investigation of mechanism of action by quantitative NMR
inferred← citeshttps://doi.org/10.1016/j.bmcl.2017.05.058openalex-snapshot
Key analogs of a uniquely potent synthetic vinblastine that contain modifications of the C20′ ethyl substituent
inferred← citeshttps://doi.org/10.1016/j.bmcl.2018.02.006openalex-snapshot
High expression of class III β-tubulin has no impact on functional cancer cell growth inhibition of a series of key vinblastine analogs
inferred← citeshttps://doi.org/10.1016/j.bmcl.2019.03.036openalex-snapshot
Ultra-potent vinblastine analogues improve on-target activity of the parent microtubulin-targeting compound
inferred← citeshttps://doi.org/10.1016/j.bmcl.2023.129566openalex-snapshot
Synthesis, in vitro Α-Glucosidase, and acetylcholinesterase inhibitory activities of novel Indol-Fused Pyrano[2,3-D]Pyrimidine compounds
inferred← citeshttps://doi.org/10.1016/j.copbio.2013.09.009openalex-snapshot
Biochemical strategies for enhancing the in vivo production of natural products with pharmaceutical potential
inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114748openalex-snapshot
Bisindole natural products: A vital source for the development of new anticancer drugs
inferred← citeshttps://doi.org/10.1016/j.ejmech.2025.117249openalex-snapshot
Discovery of novel dual tubulin and MMPs inhibitors for the treatment of lung cancer and overcoming drug resistance
inferred← citeshttps://doi.org/10.1016/j.fitote.2012.03.007openalex-snapshot
Cytotoxic dimeric indole alkaloids from Catharanthus roseus
inferred← citeshttps://doi.org/10.1016/j.indcrop.2025.121048openalex-snapshot
Dynamics of growth and production of indole anti-cancer alkaloids in Catharanthus roseus shoot cultures cultivated in flasks and nutrient sprinkle bioreactor
inferred← citeshttps://doi.org/10.1016/j.jpba.2012.08.019openalex-snapshot
NMR and mass spectrometric characterization of vinblastine, vincristine and some new related impurities – Part I
inferred← citeshttps://doi.org/10.1016/j.jpba.2012.09.008openalex-snapshot
NMR and mass spectrometric characterization of vinblastine, vincristine and some new related impurities—Part II
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2020.107552openalex-snapshot
An overview on anti-tubulin agents for the treatment of lymphoma patients
inferred← citeshttps://doi.org/10.1016/j.phytochem.2025.114556openalex-snapshot
Aspidosperma-type bisindole alkaloids from Melodinus suaveolens and their antiproliferative activities
inferred← citeshttps://doi.org/10.1016/j.phytochem.2026.114817openalex-snapshot
Discovery, stereochemical analysis, and cytotoxicity of C14–C3' linked Aspidosperma-type trimer and dimers from Melodinus yunnanensis
inferred← citeshttps://doi.org/10.1016/j.plantsci.2013.05.005openalex-snapshot
Metabolic engineering and in vitro biosynthesis of phytochemicals and non-natural analogues
inferred← citeshttps://doi.org/10.1016/j.plaphy.2026.111179openalex-snapshot
Heterologous expression of CrMATE1 increases flux of intermediates in monoterpenoid indole alkaloid pathway
inferred← citeshttps://doi.org/10.1016/j.sajb.2018.08.015openalex-snapshot
Effects of fungal extracts on vinblastine and vincristine production and their biosynthesis pathway genes in Catharanthus roseus
inferred← citeshttps://doi.org/10.1016/j.sajb.2023.08.034openalex-snapshot
Biosynthesis, extraction, detection and pharmacological attributes of vinblastine and vincristine, two important chemotherapeutic alkaloids of Catharanthus roseus (L.) G. Don: A review
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2015.12.005openalex-snapshot
Reactivity of vinca alkaloids during water chlorination processes: Identification of their disinfection by-products by high-resolution quadrupole-Orbitrap mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.tet.2011.07.009openalex-snapshot
Intramolecular cycloaddition of carbonyl ylides as a strategy for natural product synthesis
inferred← citeshttps://doi.org/10.1016/j.tet.2014.06.054openalex-snapshot
Advances in dearomatization strategies of indoles
inferred← citeshttps://doi.org/10.1016/j.tet.2014.07.094openalex-snapshot
Total synthesis of (−)-kopsinine and ent-(+)-kopsinine
inferred← citeshttps://doi.org/10.1016/j.tet.2016.03.012openalex-snapshot
Formation and trapping of azafulvene intermediates derived from manganese-mediated oxidative malonate coupling
inferred← citeshttps://doi.org/10.1016/j.tet.2018.11.046openalex-snapshot
Total synthesis of (−)-vindoline
inferred← citeshttps://doi.org/10.1016/j.tet.2021.132117openalex-snapshot
Total synthesis of (−)-4-desacetoxy-1-oxovindoline: Single atom exchange of an embedded core heteroatom in vindoline
inferred← citeshttps://doi.org/10.1016/j.tet.2025.134944openalex-snapshot
Cobalt-catalyzed alkene hydrohalogenation via hydrogen atom transfer
inferred← citeshttps://doi.org/10.1016/j.tetlet.2017.12.043openalex-snapshot
Coupling of thioamides with 4-bromocrotonate esters and subsequent conjugate addition for the rapid one-pot synthesis of functionalized thiazolines
inferred← citeshttps://doi.org/10.1016/j.tetlet.2025.155492openalex-snapshot
Iron phthalocyanine-catalyzed aerobic oxidation of olefins enabled by metal-hydride hydrogen atom transfer
inferred← citeshttps://doi.org/10.1016/j.tibtech.2026.08.011openalex-snapshot
Engineering biosensors to enhance monoterpene indole alkaloid production in yeast
inferred← citeshttps://doi.org/10.1016/s0959-6380(11)22006-3openalex-snapshot
Five-Membered Ring Systems
inferred← citeshttps://doi.org/10.1021/acs.accounts.3c00543openalex-snapshot
Inner- and Outer-Sphere Cross-Coupling of High F sp 3 Fragments
inferred← citeshttps://doi.org/10.1021/acs.accounts.5b00068openalex-snapshot
Amine Functionalization via Oxidative Photoredox Catalysis: Methodology Development and Complex Molecule Synthesis
inferred← citeshttps://doi.org/10.1021/acs.accounts.5b00510openalex-snapshot
Tandem Intramolecular Diels–Alder/1,3-Dipolar Cycloaddition Cascade of 1,3,4-Oxadiazoles: Initial Scope and Applications
inferred← citeshttps://doi.org/10.1021/acs.accounts.8b00337openalex-snapshot
The High Chemofidelity of Metal-Catalyzed Hydrogen Atom Transfer
inferred← citeshttps://doi.org/10.1021/acs.chemrev.6b00334openalex-snapshot
Mn-, Fe-, and Co-Catalyzed Radical Hydrofunctionalizations of Olefins
inferred← citeshttps://doi.org/10.1021/acs.chemrev.6b00833openalex-snapshot
Methods Utilizing First-Row Transition Metals in Natural Product Total Synthesis
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b00958openalex-snapshot
Vinblastine 20′ Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.0c01195openalex-snapshot
Biologically Significant and Recently Isolated Alkaloids from Endophytic Fungi
inferred← citeshttps://doi.org/10.1021/acs.joc.0c01580openalex-snapshot
Silver-Catalyzed, Chemo- and Enantioselective Intramolecular Dearomatization of Indoles to Access Sterically Congested Azaspiro Frameworks
inferred← citeshttps://doi.org/10.1021/acs.joc.0c02493openalex-snapshot
Divergent Total Syntheses of (−)-Pseudocopsinine and (−)-Minovincinine
inferred← citeshttps://doi.org/10.1021/acs.joc.1c01054openalex-snapshot
Cascade Reaction of Tryptamine-Derived Isocyanides with Nitrile Oxides: Construction of Oxazine Fused-Spiroindoline Derivatives
inferred← citeshttps://doi.org/10.1021/acs.joc.5b00835openalex-snapshot
Chiral Lewis Acid-Catalyzed Enantioselective Cycloadditions between Indoles and Cyclic Carbonyl Ylides Derived from Diazodiketone or Diazoketoester Derivatives
inferred← citeshttps://doi.org/10.1021/acs.joc.5b01777openalex-snapshot
Indolidenes and Indolidenium Intermediates in the Synthesis of Cyclopent[b]indoles: Mechanistic Studies on Intramolecular Cyclizations
inferred← citeshttps://doi.org/10.1021/acs.joc.5b01954openalex-snapshot
General Approach to Nitrogen-Bridged Bicyclic Frameworks by Rh-Catalyzed Formal Carbenoid Insertion into an Amide C–N Bond
inferred← citeshttps://doi.org/10.1021/acs.joc.5c02315openalex-snapshot
Chiral Borane-Catalyzed Asymmetric Hydrosilylation of 2,3,3-Trisubstituted 3 H -Indoles
inferred← citeshttps://doi.org/10.1021/acs.joc.5c02969openalex-snapshot
Synthesis of Indole-Fused Dioxonanes via Brønsted Acid-Catalyzed (5 + 4) Cycloaddition
inferred← citeshttps://doi.org/10.1021/acs.joc.7b02088openalex-snapshot
The Difference a Single Atom Can Make: Synthesis and Design at the Chemistry–Biology Interface
inferred← citeshttps://doi.org/10.1021/acs.joc.7b02299openalex-snapshot
Synthesis of Quaternary-Substituted Thiazolines via Halocyclization of S-Allyl Thioimidate Salts
inferred← citeshttps://doi.org/10.1021/acs.joc.8b00973openalex-snapshot
Access to C5-Alkylated Indolines/Indoles via Michael-Type Friedel–Crafts Alkylation Using Aryl-Nitroolefins
inferred← citeshttps://doi.org/10.1021/acs.joc.9b00834openalex-snapshot
Inverse Electron Demand Diels–Alder Reactions of Heterocyclic Azadienes, 1-Aza-1,3-Butadienes, Cyclopropenone Ketals, and Related Systems. A Retrospective
inferred← citeshttps://doi.org/10.1021/acs.organomet.5b00087openalex-snapshot
Density Functional Theory Study of the Mechanisms of Iron-Catalyzed Intramolecular C–H Amination [1,2]-Shift Tandem Reactions of Aryl Azides
inferred← citeshttps://doi.org/10.1021/acs.orglett.0c01072openalex-snapshot
Redox Neutral Radical-Relay Cobalt Catalysis toward C–H Fluorination and Amination
inferred← citeshttps://doi.org/10.1021/acs.orglett.0c01872openalex-snapshot
Catalytic Dealkylative Synthesis of Cyclic Carbamates and Ureas via Hydrogen Atom Transfer and Radical-Polar Crossover
inferred← citeshttps://doi.org/10.1021/acs.orglett.3c04243openalex-snapshot
Facile Construction of Benzo[ d ][1,3]oxazocine: Reductive Radical Dearomatization of N -Alkyl Quinoline Quaternary Ammonium Salts
inferred← citeshttps://doi.org/10.1021/acs.orglett.5b01870openalex-snapshot
Cycloadditions of 1,2,3-Triazines Bearing C5-Electron Donating Substituents: Robust Pyrimidine Synthesis
inferred← citeshttps://doi.org/10.1021/acs.orglett.5b02046openalex-snapshot
Total Synthesis of (−)-Conolutinine
inferred← citeshttps://doi.org/10.1021/acs.orglett.5b02818openalex-snapshot
Total Synthesis of (−)-Vindoline and (+)-4- epi -Vindoline Based on a 1,3,4-Oxadiazole Tandem Intramolecular [4 + 2]/[3 + 2] Cycloaddition Cascade Initiated by an Allene Dienophile
inferred← citeshttps://doi.org/10.1021/acs.orglett.5c04558openalex-snapshot
Co-MHAT-Catalyzed Wacker-Type Oxidation of 1,3-Enynes into Ynones
inferred← citeshttps://doi.org/10.1021/acs.orglett.6b01047openalex-snapshot
Synthesis of the Privileged 8-Arylmenthol Class by Radical Arylation of Isopulegol
inferred← citeshttps://doi.org/10.1021/acs.orglett.6b01662openalex-snapshot
Co-Catalyzed Hydroarylation of Unactivated Olefins
inferred← citeshttps://doi.org/10.1021/acs.orglett.7b01543openalex-snapshot
Direct Synthesis of β-Aminoenals through Reaction of 1,2,3-Triazine with Secondary Amines
inferred← citeshttps://doi.org/10.1021/acs.orglett.7b03313openalex-snapshot
A Fe(III)/NaBH4-Promoted Free-Radical Hydroheteroarylation of Alkenes
inferred← citeshttps://doi.org/10.1021/acs.orglett.7b03694openalex-snapshot
Asymmetric Total Syntheses of (−)-Jerantinines A, C, and E, (−)-16-Methoxytabersonine, (−)-Vindoline, and (+)-Vinblastine
inferred← citeshttps://doi.org/10.1021/acs.orglett.9b00263openalex-snapshot
Electrochemical Semipinacol Rearrangements of Allylic Alcohols: Construction of All-Carbon Quaternary Stereocenters
inferred← citeshttps://doi.org/10.1021/acs.orglett.9b01198openalex-snapshot
Asymmetric Formal Synthesis of (+)-Catharanthine via Desymmetrization of Isoquinuclidine
inferred← citeshttps://doi.org/10.1021/acs.orglett.9b01399openalex-snapshot
Construction of Indole Structure on Pyrroloindolines via AgNTf2-Mediated Amination/Cyclization Cascade: Application to Total Synthesis of (+)-Pestalazine B
inferred← citeshttps://doi.org/10.1021/acs.orglett.9b01493openalex-snapshot
Construction of All-Carbon Quaternary Stereocenters by Palladium-Catalyzed Decarboxylative Propargylation
inferred← citeshttps://doi.org/10.1021/acs.orglett.9b03722openalex-snapshot
Lewis-Acid-Mediated Thiocyano Semipinacol Rearrangement of Allylic Alcohols for Construction of α-Quaternary Center β-Thiocyano Carbonyls
inferred← citeshttps://doi.org/10.1021/acscatal.0c05359openalex-snapshot
Catalytic Synthesis of Cyclic Guanidines via Hydrogen Atom Transfer and Radical-Polar Crossover
inferred← citeshttps://doi.org/10.1021/acscatal.9b01691openalex-snapshot
Generation of Carbon Radical from Iron-Hydride/Alkene: Exchange-Enhanced Reactivity Selects the Reactive Spin State
inferred← citeshttps://doi.org/10.1021/acscatal.9b05045openalex-snapshot
Catalytic Direct Cyclization of Alkenyl Thioester
inferred← citeshttps://doi.org/10.1021/acsomega.1c04261openalex-snapshot
Access to Indole-Annulated Medium-Sized Lactams through Protonation/Deuteration-Induced Ring-Opening of Spiroindolines
inferred← citeshttps://doi.org/10.1021/acssuschemeng.1c02193openalex-snapshot
Deep Eutectic Solvent as a Sustainable Medium for C–C Bond Formation Via Multicomponent Radical Conjugate Additions
inferred← citeshttps://doi.org/10.1021/acssynbio.5b00289openalex-snapshot
Engineering of a Nepetalactol-Producing Platform Strain of Saccharomyces cerevisiae for the Production of Plant Seco-Iridoids
inferred← citeshttps://doi.org/10.1021/ar500400wopenalex-snapshot
Total Synthesis of Vinblastine, Related Natural Products, and Key Analogues and Development of Inspired Methodology Suitable for the Systematic Study of Their Structure–Function Properties
inferred← citeshttps://doi.org/10.1021/ja1009458openalex-snapshot
Scalable Total Syntheses of N -Linked Tryptamine Dimers by Direct Indole−Aniline Coupling: Psychotrimine and Kapakahines B and F
inferred← citeshttps://doi.org/10.1021/ja1027748openalex-snapshot
Total Synthesis and Evaluation of a Key Series of C5-Substituted Vinblastine Derivatives
inferred← citeshttps://doi.org/10.1021/ja106284sopenalex-snapshot
Asymmetric Total Synthesis of Vindorosine, Vindoline, and Key Vinblastine Analogues
inferred← citeshttps://doi.org/10.1021/ja204856aopenalex-snapshot
Inverse Electron Demand Diels–Alder Reactions of 1,2,3-Triazines: Pronounced Substituent Effects on Reactivity and Cycloaddition Scope
inferred← citeshttps://doi.org/10.1021/ja306229xopenalex-snapshot
New Insights into the Mechanism and an Expanded Scope of the Fe(III)-Mediated Vinblastine Coupling Reaction
inferred← citeshttps://doi.org/10.1021/ja3063716openalex-snapshot
Fe(III)/NaBH 4 -Mediated Free Radical Hydrofluorination of Unactivated Alkenes
inferred← citeshttps://doi.org/10.1021/ja3113565openalex-snapshot
Iron(II) Bromide-Catalyzed Intramolecular C–H Bond Amination [1,2]-Shift Tandem Reactions of Aryl Azides
inferred← citeshttps://doi.org/10.1021/ja4117632openalex-snapshot
A Practical and Catalytic Reductive Olefin Coupling
inferred← citeshttps://doi.org/10.1021/ja500548eopenalex-snapshot
Total Syntheses of (−)-Kopsifoline D and (−)-Deoxoapodine: Divergent Total Synthesis via Late-Stage Key Strategic Bond Formation
inferred← citeshttps://doi.org/10.1021/ja506170gopenalex-snapshot
Synthesis of (−)-Pseudotabersonine, (−)-Pseudovincadifformine, and (+)-Coronaridine Enabled by Photoredox Catalysis in Flow
inferred← citeshttps://doi.org/10.1021/ja5105602openalex-snapshot
Simple, Chemoselective, Catalytic Olefin Isomerization
inferred← citeshttps://doi.org/10.1021/ja908819qopenalex-snapshot
Total Synthesis of (+)-Fendleridine (Aspidoalbidine) and (+)-1-Acetylaspidoalbidine
inferred← citeshttps://doi.org/10.1021/ja910695eopenalex-snapshot
Asymmetric Total Synthesis of Vindoline
inferred← citeshttps://doi.org/10.1021/jacs.0c05017openalex-snapshot
Catalyst- and Silane-Controlled Enantioselective Hydrofunctionalization of Alkenes by Cobalt-Catalyzed Hydrogen Atom Transfer and Radical-Polar Crossover
inferred← citeshttps://doi.org/10.1021/jacs.0c09544openalex-snapshot
Hydrogenation of Alkenes via Cooperative Hydrogen Atom Transfer
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