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Ascorbate Tumor Chemotherapy by An Iron-Engineered Nanomedicine-Catalyzed Tumor-Specific Pro-Oxidation

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/adhm.201700720openalex-snapshot
Coordination‐Accelerated “Iron Extraction” Enables Fast Biodegradation of Mesoporous Silica‐Based Hollow Nanoparticles
inferredcites →https://doi.org/10.1002/adhm.201800268openalex-snapshot
Exogenous/Endogenous‐Triggered Mesoporous Silica Cancer Nanomedicine
inferredcites →https://doi.org/10.1002/anie.202004317openalex-snapshot
Developing New Cancer Nanomedicines by Repurposing Old Drugs
inferredcites →https://doi.org/10.1007/978-3-0348-9074-8_11openalex-snapshot
Ascorbate radical: A valuable marker of oxidative stress
inferredcites →https://doi.org/10.1016/0165-022x(88)90100-5openalex-snapshot
In the absence of catalytic metals ascorbate does not autoxidize at pH 7: ascorbate as a test for catalytic metals
inferredcites →https://doi.org/10.1016/0891-5849(93)90508-ropenalex-snapshot
Ascorbate free radical as a marker of oxidative stress: An EPR study
inferredcites →https://doi.org/10.1016/0891-5849(94)90019-1openalex-snapshot
The redox couple between glutathione and ascorbic acid: A chemical and physiological perspective
inferredcites →https://doi.org/10.1016/0891-5849(94)90107-4openalex-snapshot
Ascorbyl radical as natural indicator of oxidative stress: quantitative regularities
inferredcites →https://doi.org/10.1016/j.ccell.2017.02.018openalex-snapshot
O2⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2005.01.001openalex-snapshot
Regulation of apoptosis by glutathione redox state in PC12 cells exposed simultaneously to iron and ascorbic acid
inferredcites →https://doi.org/10.1016/j.jhazmat.2016.01.031openalex-snapshot
Ascorbic acid enhanced activation of oxygen by ferrous iron: A case of aerobic degradation of rhodamine B
inferredcites →https://doi.org/10.1016/j.mser.2019.01.001openalex-snapshot
Mesoporous silica/organosilica nanoparticles: Synthesis, biological effect and biomedical application
inferredcites →https://doi.org/10.1016/s0300-483x(00)00231-6openalex-snapshot
The Haber–Weiss reaction and mechanisms of toxicity
inferredcites →https://doi.org/10.1016/s8755-9668(86)80021-7openalex-snapshot
The antioxidant role of vitamin C
inferredcites →https://doi.org/10.1021/acs.chemrev.8b00626openalex-snapshot
Reactive Oxygen Species (ROS)-Based Nanomedicine
inferredcites →https://doi.org/10.1021/cr60036a002openalex-snapshot
Auto-oxidation.
inferredcites →https://doi.org/10.1021/ja00839a013openalex-snapshot
Interrelation of bond dissociation energies and contributing bond energies
inferredcites →https://doi.org/10.1021/ja00992a036openalex-snapshot
Metal ion and metal chelate catalyzed oxidation of ascorbic acid by molecular oxygen. I. Cupric and ferric ion catalyzed oxidation
inferredcites →https://doi.org/10.1021/ja01002a046openalex-snapshot
Metal ion and metal chelate catalyzed oxidation of ascorbic acid by molecular oxygen. II. Cupric and ferric chelate catalyzed oxidation
inferredcites →https://doi.org/10.1021/ja01233a011openalex-snapshot
Oxidation Processes. XVII.1 The Autoxidation of Ascorbic Acid in the Presence of Copper
inferredcites →https://doi.org/10.1021/ja01246a053openalex-snapshot
The Autoxidation of Ascorbic Acid1
inferredcites →https://doi.org/10.1021/ja01250a038openalex-snapshot
Oxidation Processes. XVI.1 The Autoxidation of Ascorbic Acid
inferredcites →https://doi.org/10.1021/ja01865a070openalex-snapshot
Oxidation of Ascorbic Acid by Oxygen with Cupric Ion as Catalyst
inferredcites →https://doi.org/10.1038/275073a0openalex-snapshot
Haem exposure as the determinate of oxidation–reduction potential of haem proteins
inferredcites →https://doi.org/10.1038/natrevmats.2016.14openalex-snapshot
Analysis of nanoparticle delivery to tumours
inferredcites →https://doi.org/10.1038/nchembio.85openalex-snapshot
Reconciling the chemistry and biology of reactive oxygen species
inferredcites →https://doi.org/10.1042/bj0221387openalex-snapshot
Observations on the function of peroxidase systems and the chemistry of the adrenal cortex
inferredcites →https://doi.org/10.1042/bj0301446openalex-snapshot
Some relations between ascorbic acid and glutathione
inferredcites →https://doi.org/10.1071/ch9821133openalex-snapshot
Outer-sphere electron-transfer reactions of ascorbate anions
inferredcites →https://doi.org/10.1073/pnas.0506390102openalex-snapshot
Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues
inferredcites →https://doi.org/10.1073/pnas.0702854104openalex-snapshot
Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo
inferredcites →https://doi.org/10.1073/pnas.0804226105openalex-snapshot
Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice
inferredcites →https://doi.org/10.1073/pnas.73.10.3685openalex-snapshot
Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer.
inferredcites →https://doi.org/10.1073/pnas.86.16.6377openalex-snapshot
Ascorbate is an outstanding antioxidant in human blood plasma.
inferredcites →https://doi.org/10.1111/j.1432-1033.1983.tb07804.xopenalex-snapshot
On the cytotoxicity of vitamin C and metal ions
inferredcites →https://doi.org/10.1111/j.1742-4658.2006.05607.xopenalex-snapshot
Vitamin C
inferredcites →https://doi.org/10.1111/j.1751-1097.1978.tb06989.xopenalex-snapshot
THE HABER‐WEISS CYCLE
inferredcites →https://doi.org/10.2307/3579270openalex-snapshot
Fenton Chemistry: An Introduction
inferredcites →https://doi.org/10.3109/10715768609051638openalex-snapshot
Ascorbate Autoxidation in the Presence of Iron and Copper Chelates

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1002/9783527845347.ch1openalex-snapshot
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Dual Enzyme Mimics Based on Metal–Ligand Cross‐Linking Strategy for Accelerating Ascorbate Oxidation and Enhancing Tumor Therapy
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inferred← citeshttps://doi.org/10.1002/adhm.202502490openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/adma.202104223openalex-snapshot
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Defect Engineering in Biomedical Sciences
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Doping Engineering to Modulate Lattice and Electronic Structure for Enhanced Piezocatalytic Therapy and Ferroptosis
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Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects
inferred← citeshttps://doi.org/10.1002/advs.202308632openalex-snapshot
Nanomaterials‐Induced Redox Imbalance: Challenged and Opportunities for Nanomaterials in Cancer Therapy
inferred← citeshttps://doi.org/10.1002/anbr.202300069openalex-snapshot
A Brief Review on Manipulation of Essential Metal Ions as Nanomedicine for Cancer Therapy
inferred← citeshttps://doi.org/10.1002/ange.202110832openalex-snapshot
Harnessing GLUT1‐Targeted Pro‐oxidant Ascorbate for Synergistic Phototherapeutics
inferred← citeshttps://doi.org/10.1002/ange.202115247openalex-snapshot
Ferroptosis‐Enhanced Cancer Immunity by a Ferrocene‐Appended Iridium(III) Diphosphine Complex
inferred← citeshttps://doi.org/10.1002/ange.202200480openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/ange.202310061openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/anie.202110832openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/anie.202115247openalex-snapshot
Ferroptosis‐Enhanced Cancer Immunity by a Ferrocene‐Appended Iridium(III) Diphosphine Complex
inferred← citeshttps://doi.org/10.1002/anie.202200480openalex-snapshot
Enhancing Tumor Catalytic Therapy by Co‐Catalysis
inferred← citeshttps://doi.org/10.1002/anie.202310061openalex-snapshot
A Nanomedicine‐Enabled Ion‐Exchange Strategy for Enhancing Curcumin‐Based Rheumatoid Arthritis Therapy
inferred← citeshttps://doi.org/10.1002/bmm2.12041openalex-snapshot
Mesoporous polydopamine nanoplatforms loaded with calcium ascorbate for amplified oxidation and photothermal combination cancer therapy
inferred← citeshttps://doi.org/10.1002/chem.202403568openalex-snapshot
Substrate Specificity of Adenine‐Cu‐PO4 Nanozyme: Ascorbic Acid Oxidation and Selective Cytotoxicity
inferred← citeshttps://doi.org/10.1002/slct.202303970openalex-snapshot
Redox Chemistry of “Neglected Copper‐Tris” Complex in Presence of Ascorbic Acid and O 2
inferred← citeshttps://doi.org/10.1002/smll.202101368openalex-snapshot
A Ferrocene‐Functionalized Covalent Organic Framework for Enhancing Chemodynamic Therapy via Redox Dyshomeostasis
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Nanozymes for Prooxidative Therapy
inferred← citeshttps://doi.org/10.1007/s00775-026-02162-zopenalex-snapshot
Iron–ascorbate complex formation and redox behavior in Tris buffer under aerobic and anaerobic conditions: relevance to iron-deficiency anemia
inferred← citeshttps://doi.org/10.1007/s11581-025-06445-4openalex-snapshot
In situ generating poly ionic liquid composite electrolytes supported by mesoporous silica–modified PP separator enabling stable lithium-ion batteries
inferred← citeshttps://doi.org/10.1007/s40843-023-2722-yopenalex-snapshot
A review of the REDOX properties of MoS2: From wastewater treatment to tumor therapy
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Tumor-activated Theranostic Probe To Enhance Photodynamic Eradication of Solid Tumors by a Three-Pronged Strategy
inferred← citeshttps://doi.org/10.1016/j.ajps.2021.05.001openalex-snapshot
Iron-doxorubicin prodrug loaded liposome nanogenerator programs multimodal ferroptosis for efficient cancer therapy
inferred← citeshttps://doi.org/10.1016/j.apcatb.2026.126837openalex-snapshot
CoFe–N6 dual-atom sites enables the efficient generation of surface-bound ·OH for Fenton-like H2O2 activation
inferred← citeshttps://doi.org/10.1016/j.apsusc.2022.155671openalex-snapshot
FeC2O4/g-C3N4 self-assemble nanorods regulate stimuli-responsive ferroptosis via photo-fenton mechanism
inferred← citeshttps://doi.org/10.1016/j.arabjc.2023.105240openalex-snapshot
Effect of MoS2-PEG nanozymes on tumor cell multiplication
inferred← citeshttps://doi.org/10.1016/j.bioactmat.2022.01.010openalex-snapshot
Upconversion nanoparticles@AgBiS2 core-shell nanoparticles with cancer-cell-specific cytotoxicity for combined photothermal and photodynamic therapy of cancers
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2021.120962openalex-snapshot
NIR-II reinforced intracellular cyclic reaction to enhance chemodynamic therapy with abundant H2O2 supply
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2023.122386openalex-snapshot
Biomimetic inducer enabled dual ferroptosis of tumor and M2-type macrophages for enhanced tumor immunotherapy
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2026.123988openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bios.2025.117716openalex-snapshot
Ni3-xMnxO4-driven hydrolase-oxidase bienzyme-mimicking cascade-stimulated aminoantipyrine self-coupling for time-resolved sensing of ascorbic acid derivatives
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Cascade-enhanced persistent luminescence for monitoring iron metabolism during ferroptosis-based therapy
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Recent advances in multi-configurable nanomaterials for improved chemodynamic therapy
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Recent advances on modulation of H2O2 in tumor microenvironment for enhanced cancer therapeutic efficacy
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Nanoplatforms derived from iron dextran combined with ascorbic acid for enhanced photothermal-chemodynamic therapy of tumors
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A hollow mesoporous iron oxide nanoparticle to strengthen Fenton reaction and weaken antioxidant defense systems for high efficacy tumor ferroptosis therapy
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Cyclodextrin-based supramolecular nanoparticles break the redox balance in chemodynamic therapy-enhanced chemotherapy
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One-pot fabrication of boric acid assisted N-doped CDs and advanced fluorescence sensing property from yellow to red for Fe3+ in acidic water environment
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Lysosomal aggregation of iron nanoparticles guided by multistage transformation induces potent ferroptosis
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inferred← citeshttps://doi.org/10.1021/acsami.2c21067openalex-snapshot
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Ferrocene-Conjugated Paclitaxel Prodrug for Combined Chemo-Ferroptosis Therapy of Cancer
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inferred← citeshttps://doi.org/10.1021/acsbiomaterials.4c00586openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acsnano.2c08446openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acsnano.5c08353openalex-snapshot
Ascorbic Acid-Derived Supramolecular Gels Induce Immunogenic Ferroptosis in Cancer Cells to Potentiate Tumor Immunotherapy
inferred← citeshttps://doi.org/10.1021/acsnano.5c21425openalex-snapshot
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Vitamin C Drives Reentrant Actin Phase Transition: Biphasic Exocytosis Regulation Revealed by Single-Vesicle Electrochemistry
inferred← citeshttps://doi.org/10.1021/jacs.4c04840openalex-snapshot
Hybrid Membrane-Camouflaged Biomimetic Immunomodulatory Nanoturrets with Sequential Multidrug Release for Potentiating T Cell-Mediated Anticancer Immunity
inferred← citeshttps://doi.org/10.1038/s41467-023-39848-wopenalex-snapshot
Acidic enol electrooxidation-coupled hydrogen production with ampere-level current density
inferred← citeshttps://doi.org/10.1039/d1cs01022kopenalex-snapshot
Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application
inferred← citeshttps://doi.org/10.1039/d2bm02102aopenalex-snapshot
Selenium-incorporated mesoporous silica nanoparticles for osteosarcoma therapy
inferred← citeshttps://doi.org/10.1039/d2cs00236aopenalex-snapshot
Layered double hydroxide-based nanomaterials for biomedical applications
inferred← citeshttps://doi.org/10.1039/d2qm00230bopenalex-snapshot
Synthesis of CoSnS 2 hollow nanocubes with NIR-enhanced chemodynamic therapy and glutathione depletion for combined cancer therapy
inferred← citeshttps://doi.org/10.1039/d2tb01424fopenalex-snapshot
Boosting immunotherapy of triple negative breast cancer through the synergy of mild PTT and Fe-loaded organosilica nanoparticles
inferred← citeshttps://doi.org/10.1039/d3bm00371jopenalex-snapshot
Iron oxide-EDTA nanoparticles for chelation-enhanced chemodynamic therapy and ion interference therapy
inferred← citeshttps://doi.org/10.1039/d3bm01922eopenalex-snapshot
Copper( ii )-based metal–organic framework delivery of calcium ascorbate for enhanced chemodynamic therapy via H 2 O 2 self-supply and glutathione depletion
inferred← citeshttps://doi.org/10.1039/d3cs00356fopenalex-snapshot
Strategies to engineer various nanocarrier-based hybrid catalysts for enhanced chemodynamic cancer therapy
inferred← citeshttps://doi.org/10.1039/d3nr00431gopenalex-snapshot
Concise nanotherapeutic modality for cancer involving graphene oxide dots in conjunction with ascorbic acid
inferred← citeshttps://doi.org/10.1039/d3tb02840bopenalex-snapshot
Optimized silicate nanozymes with atomically incorporated iron and manganese for intratumoral coordination-enhanced once-for-all catalytic therapy
inferred← citeshttps://doi.org/10.1039/d4cs00404copenalex-snapshot
Nanomaterial-based regulation of redox metabolism for enhancing cancer therapy
inferred← citeshttps://doi.org/10.1039/d5cc02271aopenalex-snapshot
Vitamin C-promoted cell death via nanoparticle-based high-dose delivery
inferred← citeshttps://doi.org/10.1080/10717544.2023.2284684openalex-snapshot
Intricate subcellular journey of nanoparticles to the enigmatic domains of endoplasmic reticulum
inferred← citeshttps://doi.org/10.1080/17425247.2022.2050211openalex-snapshot
Anticancer nanomedicines harnessing tumor microenvironmental components
inferred← citeshttps://doi.org/10.1126/sciadv.adr9196openalex-snapshot
A DNA origami–based enzymatic cascade nanoreactor for chemodynamic cancer therapy and activation of antitumor immunity
inferred← citeshttps://doi.org/10.1186/s12951-024-02354-2openalex-snapshot
Smart responsive Fe/Mn nanovaccine triggers liver cancer immunotherapy via pyroptosis and pyroptosis-boosted cGAS-STING activation
inferred← citeshttps://doi.org/10.1186/s12951-026-04585-xopenalex-snapshot
A self-amplifying responsive nanoplatform for dual inhibition of fibroblast-like synoviocytes in rheumatoid arthritis: coupled regulation of cell cycle arrest and apoptosis
inferred← citeshttps://doi.org/10.15541/jim20230151openalex-snapshot
pH Responsive Copper-Doped Mesoporous Silica Nanocatalyst for Enhanced Chemo-Chemodynamic Tumor Therapy
inferred← citeshttps://doi.org/10.2147/ijn.s321612openalex-snapshot
Dual Targeting of Endoplasmic Reticulum by Redox-Deubiquitination Regulation for Cancer Therapy
inferred← citeshttps://doi.org/10.2147/ijn.s559426openalex-snapshot
A Comprehensive Review of Vitamin C for Cancer Therapy: Anti-Tumor Mechanisms and Nano-Formulation Strategies
inferred← citeshttps://doi.org/10.6084/m9.figshare.26689907openalex-snapshot
Additional file 1 of Smart responsive Fe/Mn nanovaccine triggers liver cancer immunotherapy via pyroptosis and pyroptosis-boosted cGAS-STING activation
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