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Molecular Effects of Baicalein in Hct116 Cells and Caenorhabditis elegans: Activation of the Nrf2 Signaling Pathway and Prolongation of Lifespan

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s00204-007-0215-4openalex-snapshot

Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF-16 in the model organism Caenorhabditis elegans

inferredcites →https://doi.org/10.1007/s00894-010-0942-yopenalex-snapshot

Mechanistic study of the structure–activity relationship for the free radical scavenging activity of baicalein

inferredcites →https://doi.org/10.1007/s11418-008-0230-7openalex-snapshot

Comparison of the major flavonoid content of S. baicalensis, S. lateriflora, and their commercial products

inferredcites →https://doi.org/10.1016/0031-9422(95)00200-qopenalex-snapshot

Two flavone 2′-glucosides from Scutellaria baicalensis

inferredcites →https://doi.org/10.1016/j.ab.2011.10.028openalex-snapshot

Screening for natural chemoprevention agents that modify human Keap1

inferredcites →https://doi.org/10.1016/j.canlet.2006.01.011openalex-snapshot

Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell

inferredcites →https://doi.org/10.1016/j.cbpb.2007.10.004openalex-snapshot

Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin

inferredcites →https://doi.org/10.1016/j.etap.2010.11.002openalex-snapshot

Mitochondria protection of baicalein against oxidative damage via induction of manganese superoxide dismutase

inferredcites →https://doi.org/10.1016/j.jchromb.2004.06.045openalex-snapshot

Separation methods used for Scutellaria baicalensis active components

inferredcites →https://doi.org/10.1016/j.jchromb.2006.10.061openalex-snapshot

Characterization of flavonoids in the traditional Chinese herbal medicine-Huangqin by liquid chromatography coupled with electrospray ionization mass spectrometry

inferredcites →https://doi.org/10.1016/j.jep.2006.09.036openalex-snapshot

Comparative pharmacokinetics of baicalin after oral administration of pure baicalin, Radix scutellariae extract and Huang-Lian-Jie-Du-Tang to rats

inferredcites →https://doi.org/10.1016/j.jep.2011.12.046openalex-snapshot

Gene expression profiling and pathway network analysis of hepatic metabolic enzymes targeted by baicalein

inferredcites →https://doi.org/10.1016/j.jnutbio.2010.03.008openalex-snapshot

Protocatechuic acid induces antioxidant/detoxifying enzyme expression through JNK-mediated Nrf2 activation in murine macrophages

inferredcites →https://doi.org/10.1016/j.jpba.2010.11.019openalex-snapshot

Evaluation of quality control strategies in Scutellaria herbal medicines

inferredcites →https://doi.org/10.1016/j.mad.2007.07.007openalex-snapshot

Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans

inferredcites →https://doi.org/10.1016/j.mad.2011.07.008openalex-snapshot

Curcumin-mediated lifespan extension in Caenorhabditis elegans

inferredcites →https://doi.org/10.1016/j.taap.2009.03.005openalex-snapshot

Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents

inferredcites →https://doi.org/10.1016/j.tox.2007.02.006openalex-snapshot

Investigations of protective effects of the flavonoids quercetin and rutin on stress resistance in the model organism Caenorhabditis elegans

inferredcites →https://doi.org/10.1021/jf104217gopenalex-snapshot

Use of Saccharomyces cerevisiae and Caenorhabditis elegans as Model Organisms To Study the Effect of Cocoa Polyphenols in the Resistance to Oxidative Stress

inferredcites →https://doi.org/10.1021/jf301511mopenalex-snapshot

Baicalein Protects against 6-OHDA-Induced Neurotoxicity through Activation of Keap1/Nrf2/HO-1 and Involving PKCα and PI3K/AKT Signaling Pathways

inferredcites →https://doi.org/10.1073/pnas.94.10.5361openalex-snapshot

Functional antioxidant responsive elements

inferredcites →https://doi.org/10.1093/gerona/glp165openalex-snapshot

Disruption of the mGsta4 Gene Increases Life Span of C57BL Mice

inferredcites →https://doi.org/10.1097/mco.0b013e32834136f2openalex-snapshot

The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation

inferredcites →https://doi.org/10.1111/j.1365-2443.2010.01473.xopenalex-snapshot

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

inferredcites →https://doi.org/10.1111/j.1474-9726.2006.00192.xopenalex-snapshot

Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans

inferredcites →https://doi.org/10.1124/mol.105.018374openalex-snapshot

Involvement of Nrf2, p38, B-Raf, and Nuclear Factor-κB, but Not Phosphatidylinositol 3-Kinase, in Induction of Hemeoxygenase-1 by Dietary Polyphenols

inferredcites →https://doi.org/10.1146/annurev.pharmtox.43.100901.140229openalex-snapshot

Regulatory Mechanisms Controlling Gene Expression Mediated by the Antioxidant Response Element

inferredcites →https://doi.org/10.1167/iovs.04-1369openalex-snapshot

Flavonoids Protect Human Retinal Pigment Epithelial Cells from Oxidative-Stress–Induced Death

inferredcites →https://doi.org/10.1271/bbb.50698openalex-snapshot

Antioxidative and Anti-Inflammatory Activities of Polyhydroxyflavonoids ofScutellaria baicalensisGEORGI

inferredcites →https://doi.org/10.1371/journal.pone.0027762openalex-snapshot

FDA-Approved Drugs that Protect Mammalian Neurons from Glucose Toxicity Slow Aging Dependent on Cbp and Protect Against Proteotoxicity

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4635659openalex-extracted

inferred← citeshttps://doi.org/10.1002/mco2.70543openalex-snapshot

Baicalein Enhances Longevity and Healthspan of C. elegans Through the Insulin/IGF‐1 Signaling Pathway

inferred← citeshttps://doi.org/10.1007/978-3-030-20762-5_11openalex-snapshot

Lifespan and Healthspan Extension by Nutraceuticals: An Overview

inferred← citeshttps://doi.org/10.1007/s00394-019-01894-wopenalex-snapshot

Hibiscus sabdariffa L. extract prolongs lifespan and protects against amyloid-β toxicity in Caenorhabditis elegans: involvement of the FoxO and Nrf2 orthologues DAF-16 and SKN-1

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Improvement of Baicalein and Wogonin Yields from Scutellaria baicalensis Georgi Roots Fermented by a Novel Endophytic Fungus Capable of Producing Cellulase and β-Glucosidase

inferred← citeshttps://doi.org/10.1007/s12268-014-0487-1openalex-snapshot

Modulation of stress resistance and related signalling in cell culture and Caenorhabditis elegans by baicalein derivatives

inferred← citeshttps://doi.org/10.1016/b978-0-12-814466-4.00012-4openalex-snapshot

The Flavone Baicalein and Its Use in Gastrointestinal Disease

inferred← citeshttps://doi.org/10.1016/j.aaf.2018.07.003openalex-snapshot

Cloning and expression analysis of the nuclear factor erythroid 2-related factor 2 (Nrf2) gene of grass carp (Ctenopharyngodon idellus) and the dietary effect of Eucommia ulmoides on gene expression

inferred← citeshttps://doi.org/10.1016/j.arr.2023.102181openalex-snapshot

Hormesis determines lifespan

inferred← citeshttps://doi.org/10.1016/j.ejphar.2014.10.013openalex-snapshot

Synthesis and biological evaluation of a novel baicalein glycoside as an anti-inflammatory agent

inferred← citeshttps://doi.org/10.1016/j.ejphar.2024.176660openalex-snapshot

Apigenin and baicalein ameliorate thoracic aortic structural deterioration and cognitive deficit via inhibiting AGEs/RAGE/NF-κB pathway in D-galactose-induced aging rats

inferred← citeshttps://doi.org/10.1016/j.fct.2020.111817openalex-snapshot

Flavonoids targeting NRF2 in neurodegenerative disorders

inferred← citeshttps://doi.org/10.1016/j.fitote.2016.06.018openalex-snapshot

Baicalein modulates stress-resistance and life span in C. elegans via SKN-1 but not DAF-16

inferred← citeshttps://doi.org/10.1016/j.fitote.2025.106441openalex-snapshot

The anti-aging and anti-Alzheimer's disease potential of kinsenoside prepared from Anoectochilus roxburghii

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2018.10.421openalex-snapshot

Baicalein protects human vitiligo melanocytes from oxidative stress through activation of NF-E2-related factor2 (Nrf2) signaling pathway

inferred← citeshttps://doi.org/10.1016/j.jep.2020.113596openalex-snapshot

Investigation on the function tropism of Tiaoqin and Kuqin (different specification of Scutellaria baicalensis) by comparing their curative effect on different febrile disease model

inferred← citeshttps://doi.org/10.1016/j.jff.2017.08.005openalex-snapshot

Baicalein improves insulin resistance via regulating SOCS3 and enhances the effect of acarbose on diabetes prevention

inferred← citeshttps://doi.org/10.1016/j.jff.2022.105253openalex-snapshot

Baicalein targets CD36 to prevent foam cell formation by suppressing the excessive uptake of oxLDL and accelerating ABCA1-mediated cholesterol efflux in oxLDL-induced THP-1 macrophages

inferred← citeshttps://doi.org/10.1017/s0029665116000720openalex-snapshot

A literature review of flavonoids and lifespan in model organisms

inferred← citeshttps://doi.org/10.1017/s0954422423000136openalex-snapshot

Scientific evidence of foods that improve the lifespan and healthspan of different organisms

inferred← citeshttps://doi.org/10.1039/c5fo00463bopenalex-snapshot

Methylated derivatives of myricetin enhance life span in Caenorhabditis elegans dependent on the transcription factor DAF-16

inferred← citeshttps://doi.org/10.1039/c9fo02237fopenalex-snapshot

Baicalein reduces hepatic fat accumulation by activating AMPK in oleic acid-induced HepG2 cells and high-fat diet-induced non-insulin-resistant mice

inferred← citeshttps://doi.org/10.1039/d3np00021dopenalex-snapshot

The role of Caenorhabditis elegans in the discovery of natural products for healthy aging

inferred← citeshttps://doi.org/10.1042/bst20221363openalex-snapshot

Mitophagy-promoting agents and their ability to promote healthy-aging

inferred← citeshttps://doi.org/10.1080/07391102.2015.1082148openalex-snapshot

Inclusion complexation between baicalein and β-cyclodextrin and the influence of β-cyclodextrin on the binding of baicalein with DNA: a spectroscopic approach

inferred← citeshttps://doi.org/10.1089/ars.2023.0247openalex-snapshot

Polyphenols as Potential Geroprotectors

inferred← citeshttps://doi.org/10.1089/rej.2015.1760openalex-snapshot

A Bioinformatic Approach for the Discovery of Antiaging Effects of Baicalein from Scutellaria baicalensis Georgi

inferred← citeshttps://doi.org/10.1089/rej.2020.2312openalex-snapshot

Astragaloside IV Extends Lifespan of Caenorhabditis elegans by Improving Age-Related Functional Declines and Triggering Antioxidant Responses

inferred← citeshttps://doi.org/10.1134/s1062359019120021openalex-snapshot

The Use of Radioprotective Agents to Prevent Effects Associated with Aging

inferred← citeshttps://doi.org/10.1155/2014/920398openalex-snapshot

Caenorhabditis elegansas Model System in Pharmacology and Toxicology: Effects of Flavonoids on Redox-Sensitive Signalling Pathways and Ageing

inferred← citeshttps://doi.org/10.1155/2015/124357openalex-snapshot

TSG (2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside) from the Chinese HerbPolygonum multiflorumIncreases Life Span and Stress Resistance ofCaenorhabditis elegans

inferred← citeshttps://doi.org/10.1155/2017/4397340openalex-snapshot

Flavonoids as Putative Inducers of the Transcription Factors Nrf2, FoxO, and PPARγ

inferred← citeshttps://doi.org/10.1159/000493714openalex-snapshot

Baicalein Inhibits Proliferation Activity of Human Colorectal Cancer Cells HCT116 Through Downregulation of Ezrin

inferred← citeshttps://doi.org/10.1371/journal.pone.0100256openalex-snapshot

Caffeic Acid Phenethylester Increases Stress Resistance and Enhances Lifespan in Caenorhabditis elegans by Modulation of the Insulin-Like DAF-16 Signalling Pathway

inferred← citeshttps://doi.org/10.15698/mic2020.10.731openalex-snapshot

Plant and fungal products that extend lifespan in Caenorhabditis elegans

inferred← citeshttps://doi.org/10.21203/rs.3.rs-3994070/v1openalex-snapshot

Baicalein Inhibits the Th1 / Th17-Mediated Inflammatory Response by Targeting STAT1/3 in Eae Mice

inferred← citeshttps://doi.org/10.3109/13880209.2015.1104703openalex-snapshot

Modulation of the Nrf2 signalling pathway in Hct116 colon carcinoma cells by baicalein and its methylated derivative negletein

inferred← citeshttps://doi.org/10.3389/fbioe.2021.635768openalex-snapshot

The Review of Anti-aging Mechanism of Polyphenols on Caenorhabditis elegans

inferred← citeshttps://doi.org/10.3389/fphar.2017.00884openalex-snapshot

The Evaluation of Geroprotective Effects of Selected Flavonoids in Drosophila melanogaster and Caenorhabditis elegans

inferred← citeshttps://doi.org/10.3390/ijms140611895openalex-snapshot

Myricetin-Mediated Lifespan Extension in Caenorhabditis elegans Is Modulated by DAF-16

inferred← citeshttps://doi.org/10.3390/molecules26195813openalex-snapshot

Micropropagation of Rare Scutellaria havanensis Jacq. and Preliminary Studies on Antioxidant Capacity and Anti-Cancer Potential

inferred← citeshttps://doi.org/10.3390/molecules26237323openalex-snapshot

Bioactive Phytochemicals with Anti-Aging and Lifespan Extending Potentials in Caenorhabditis elegans

inferred← citeshttps://doi.org/10.3390/molecules27238608openalex-snapshot

Preparation of Dendrobium officinale Flower Anthocyanin and Extended Lifespan in Caenorhabditis elegans

inferred← citeshttps://doi.org/10.3892/ijmm.2016.2460openalex-snapshot

Baicalein protects C6 glial cells against hydrogen peroxide-induced oxidative stress and apoptosis through regulation of the Nrf2 signaling pathway

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