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Synthesis and Preliminary Characterization of a Novel Antiarrhythmic Compound (KB130015) with an Improved Toxicity Profile Compared with Amiodarone

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Lysosomotropic agents
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The binding of [3H]nitrendipine to receptors for calcium channel antagonists in the heart, cerebral cortex, and ileum of rats
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Plasmid-encoded hygromycin B resistance: the sequence of hygromycin B phosphotransferase gene and its expression in Escherichia coli and Saccharomyces cerevisiae
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Secreted placental alkaline phosphatase: a powerful new quantitative indicator of gene expression in eukaryotic cells
inferredcites →https://doi.org/10.1016/0960-0760(91)90077-iopenalex-snapshot
High level expression of functional full length human thyroid hormone receptor β1 in insect cells using a recombinant baculovirus
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Clinical organ toxicity of antiarrhythmic compounds: ocular and pulmonary manifestations
inferredcites →https://doi.org/10.1016/s0008-6363(97)00114-4openalex-snapshot
Cellular electropharmacology of amiodarone
inferredcites →https://doi.org/10.1016/s0021-9258(18)99192-1openalex-snapshot
High level expression of functional full length and truncated glucocorticoid receptor in Chinese hamster ovary cells. Demonstration of ligand-induced down-regulation of expressed receptor mRNA and protein
inferredcites →https://doi.org/10.1097/00005344-198609000-00025openalex-snapshot
Allosteric Modulation of [3H]Nitrendipine Binding to Cardiac and Cerebral Cortex Membranes by Amiodarone
inferredcites →https://doi.org/10.1111/j.1540-8167.1999.tb00674.xopenalex-snapshot
Current Antiarrhythmic Drugs
inferredcites →https://doi.org/10.1124/mol.54.1.105openalex-snapshot
Differential Response of Estrogen Receptor α and Estrogen Receptor β to Partial Estrogen Agonists/Antagonists
inferredcites →https://doi.org/10.1172/jci113874openalex-snapshot
Antagonism of thyroid hormone action by amiodarone in rat pituitary tumor cells.
inferredcites →https://doi.org/10.7326/0003-4819-121-7-199410010-00009openalex-snapshot
Amiodarone-associated Proarrhythmic Effects: A Review with Special Reference to Torsade de Pointes Tachycardia
inferredcites →https://doi.org/10.7326/0003-4819-68-1-269_2openalex-snapshot
Handbook of Experimental Pharmacology

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Thyroid Hormones and Thyromimetics
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First Heterogeneous Ligand‐ and Salt‐Free Larock Indole Synthesis
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Phase‐Transfer‐Catalyzed Intramolecular Cyclization of ortho‐Alkynyl Phenyl Ether Derivatives for Synthesis of 2,3‐Disubstituted Benzo[b]furans
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Palladium‐Catalyzed Synthesis of 2,3‐Disubstituted Benzofurans: An Approach Towards the Synthesis of Deuterium Labeled Compounds
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Cobalt(III)‐Catalyzed Construction of Benzofurans, Benzofuranones and One‐Pot Orthogonal C−H Functionalizations to Access Polysubstituted Benzofurans
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Cobalt‐katalysierte Negishi‐Kreuzkupplungen von (Hetero)Arylzinkreagentien mit primären und sekundären Alkylbromiden und ‐iodiden
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Palladium‐Catalyzed Synthesis of Benzofurans and Coumarins from Phenols and Olefins
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Cobalt‐Catalyzed Negishi Cross‐Coupling Reactions of (Hetero)Arylzinc Reagents with Primary and Secondary Alkyl Bromides and Iodides
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Access to 2,3‐Disubstituted Benzofurans through One‐Pot Acid‐Catalyzed Nucleophilic Substitution/TBAF‐Mediated Oxacycloisomerization
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Synthesis and antimicrobial evaluation of some 1,2,4‐triazole, 1,3,4‐oxa(thia)diazole, and 1,2,4‐triazolo[3,4‐b]‐1,3,4‐thiadiazine derivatives
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Synthesis of Arylated Benzofurans by RegioselectiveSuzuki–Miyaura Cross‐Coupling Reactions of 2,3‐Dibromobenzofurans‐ and 2,3,5‐Tribromobenzofurans
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Benzofuran‐2‐acetic esters as a new class of natural‐like herbicides
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Discovery of novel benzofuran scaffold as 4‐hydroxyphenylpyruvate dioxygenase inhibitors
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Inhibition des muskarinergen Kaliumionenstroms durch das neue Klasse-III-Antiarrhythmikum KB130015 im Vergleich zu Ibutilide
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The class III anti-arrhythmic agent, amiodarone, inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells
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Solution-phase photochemical transformation of 2-aroylbenzofurans: addition–elimination mechanism
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Antiarrhythmics
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Furans and their Benzo Derivatives: Reactivity
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Synthesis and evaluation of the permeability transition inhibitory characteristics of paramagnetic and diamagnetic amiodarone derivatives
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Novel thyroid hormone receptor antagonists with an N-alkylated diphenylamine skeleton
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Structure-based design of novel THR-β agonists and mechanism of activation research by molecular dynamics simulations
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Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta
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A new class of high affinity thyromimetics containing a phenyl-naphthylene core
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Thyroid receptor ligands. Part 5: Novel bicyclic agonist ligands selective for the thyroid hormone receptor β
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Thyroid receptor ligands. Part 7: Indirect antagonists of the thyroid hormone receptor with improved affinity
inferred← citeshttps://doi.org/10.1016/j.bmcl.2007.05.049openalex-snapshot
Thyroid receptor ligands. Part 8: Thyromimetics derived from N-acylated-α-amino acid derivatives displaying modulated pharmacological selectivity compared with KB-141
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Selective thyroid hormone agonists: A strategy for treating metabolic syndrome
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Synthesis and cytotoxicity properties of amiodarone analogues
inferred← citeshttps://doi.org/10.1016/j.ejmech.2009.02.020openalex-snapshot
Convenient synthesis and antimicrobial evaluation of some novel 2-substituted-3-methylbenzofuran derivatives
inferred← citeshttps://doi.org/10.1016/j.ejmech.2009.09.002openalex-snapshot
Stereoselective synthesis and antimicrobial activity of benzofuran-based (1E)-1-(piperidin-1-yl)-N2-arylamidrazones
inferred← citeshttps://doi.org/10.1016/j.ejmech.2013.12.061openalex-snapshot
Synthesis, structure–activity relationship of iodinated-4-aryloxymethyl-coumarins as potential anti-cancer and anti-mycobacterial agents
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The amiodarone derivative 2-methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran (KB130015) opens large-conductance Ca2+-activated K+ channels and relaxes vascular smooth muscle
inferred← citeshttps://doi.org/10.1016/j.ejphar.2010.01.010openalex-snapshot
The amiodarone derivative KB130015 activates hERG1 potassium channels via a novel mechanism
inferred← citeshttps://doi.org/10.1016/j.jcat.2024.115351openalex-snapshot
Copper-catalyzed regioselective C−H alkylation of phenol derivatives with unactivated alkyl chlorides: Manifesting a Cu(I)/Cu(III) pathway
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Prediction of binding affinity and efficacy of thyroid hormone receptor ligands using QSAR and structure-based modeling methods
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Recent advances in the chemistry of 2-(2-oxoalkylidene)tetrahydrofurans
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Regioselective synthesis of ω-bromo-3-ketosulfones, ω-bromo-3-ketonitriles and 2-(ω-bromoalkyl)benzofurans based on a ‘ring-closing/ring-opening’ strategy
inferred← citeshttps://doi.org/10.1016/j.tet.2009.06.049openalex-snapshot
Expeditious synthesis of 2,3-dihydro-2-alkoxy-3-methylenebenzofurans from N-benzofuran-3-ylmethyl N,N,N-trialkylammonium bromides: a new approach to access the natural product, 2-hydroxy-3-methylene-6-methyl-2, 3-dihydrobenzofuran
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Synthesis and optical properties of π-conjugated push–pull dyes incorporating a functionalized benzo[1,2-b:3,4-b′]difuran spacer
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A simple approach to highly functionalized benzo[b]furans from phenols and aryl iodides via aryl propargyl ethers
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Efficient synthesis of functionalized dibenzofurans by domino ‘twofold Heck/6π-electrocyclization’ reactions of 2,3-di- and 2,3,5-tribromobenzofuran
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Site-selective Suzuki cross-coupling reactions of 2,3-dibromobenzofuran
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Metal-free synthesis of 3-chalcogen benzo[b]furans via an iodine-mediated electrophilic cyclisation of 2-alkynylanisoles
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One pot rhodium catalyzed, base and solvent-free synthesis of 2-(bromomethyl)furan derivatives and synthesis of Hashmi phenol through platinum catalyzed cascade cyclization
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Target cum flexibility: simple access to benzofuran conjugated sugar and nucleoside derivatives
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One-pot synthesis of 2,2′-bisbenzofurans using cuprous chloride as a catalyst
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Fluorescent 2-(2′-hydroxybenzofuran)benzoxazole (HBBO) borate complexes: synthesis, optical properties, and theoretical calculations
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Synthesis of substituted benzofurans and indoles by Zn-catalyzed tandem Sonogashira-cyclization strategy
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Pd-catalyzed intramolecular Heck reaction for the synthesis of 2-methylbenzofurans
inferred← citeshttps://doi.org/10.1016/j.theochem.2007.02.042openalex-snapshot
ONIOM study of the 4′-hydroxyl hydrogen bond acceptor/donor group nature in thyromimetics
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Copper and Silver Complexes of o-Ph2PC6H4C(O)N(H)C9H6N: Synthesis and Catalytic Applications of CuI Complexes
inferred← citeshttps://doi.org/10.1021/acs.joc.1c01992openalex-snapshot
Visible-Light-Promoted Oxidative Annulation of Naphthols and Alkynes: Synthesis of Functionalized Naphthofurans
inferred← citeshttps://doi.org/10.1021/acs.joc.4c01680openalex-snapshot
Copper-Catalyzed Three-Component Tandem Cyclization for One-Pot Synthesis of Indole-Benzofuran Bis-Heterocycles
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Synthesis of 2-Aryl and 3-Aryl Benzo[b]furan Thioethers Using Aryl Sulfonyl Hydrazides as Sulfenylation Reagents
inferred← citeshttps://doi.org/10.1021/acs.joc.5c03036openalex-snapshot
Synthesis of 3-Chalcogenylated Benzo[ b ]furans Enabled by a Multicomponent Reagent System
inferred← citeshttps://doi.org/10.1021/acs.orglett.0c04134openalex-snapshot
Rhodium-Catalyzed Twofold Unsymmetrical C–H Alkenylation–Annulation/Thiolation Reaction To Access Thiobenzofurans
inferred← citeshttps://doi.org/10.1021/acs.orglett.2c02388openalex-snapshot
Synthesis of Benzofuran Derivates via a Gold-Catalyzed Claisen Rearrangement Cascade
inferred← citeshttps://doi.org/10.1021/acs.orglett.6b01352openalex-snapshot
Metal-Free Oxidative Annulation of 2-Naphthols with Terminal Alkynes Affording 2-Arylnaphtho[2,1-b]furans
inferred← citeshttps://doi.org/10.1021/acs.orglett.7b00980openalex-snapshot
Ag-Catalyzed Oxidative Cyclization Reaction of 1,6-Enynes and Sodium Sulfinate: Access to Sulfonylated Benzofurans
inferred← citeshttps://doi.org/10.1021/acssuschemeng.0c05156openalex-snapshot
Brønsted Acid Ionic Liquid-Catalyzed Ring Opening of 3,3-Disubstituted Oxetanes in Water: Efficient Access to Furans and Benzofurans
inferred← citeshttps://doi.org/10.1021/jacsau.5c00908openalex-snapshot
Unprecedented Copper/Iron-Cocatalyzed Homocoupling of Propargyl Ethers to Conjugated Benzofurans
inferred← citeshttps://doi.org/10.1021/jm021080fopenalex-snapshot
Thyroid Receptor Ligands. 1. Agonist Ligands Selective for the Thyroid Receptor β1
inferred← citeshttps://doi.org/10.1021/jm050004kopenalex-snapshot
Thyroid Receptor Ligands. 3. Design and Synthesis of 3,5-Dihalo-4-alkoxyphenylalkanoic Acids as Indirect Antagonists of the Thyroid Hormone Receptor
inferred← citeshttps://doi.org/10.1021/jm060521iopenalex-snapshot
Thyroid Receptor Ligands. 6. A High Affinity “Direct Antagonist” Selective for the Thyroid Hormone Receptor
inferred← citeshttps://doi.org/10.1021/jo051079zopenalex-snapshot
Synthesis of Benzofurans with Remote Bromide Functionality by Domino “Ring-Cleavage-Deprotection-Cyclization” Reactions of 2-Alkylidenetetrahydrofurans with Boron Tribromide
inferred← citeshttps://doi.org/10.1021/jo051767iopenalex-snapshot
Efficient Synthesis of Furan-2-ylacetates, 7-(Alkoxycarbonyl)benzofurans, and 7-(Alkoxycarbonyl)-2,3-dihydrobenzofurans Based on Cyclization Reactions of Free and Masked Dianions: A “Cyclization/Dehydrogenation” Strategy
inferred← citeshttps://doi.org/10.1021/jo301162xopenalex-snapshot
Iodine(III)-Mediated Tandem Oxidative Cyclization for Construction of 2-Nitrobenzo[b]furans
inferred← citeshttps://doi.org/10.1021/jo701656zopenalex-snapshot
An Efficient Synthesis and Substitution of 3-Aroyl-2-bromobenzo[b]furans
inferred← citeshttps://doi.org/10.1021/ol8028687openalex-snapshot
Palladium-Catalyzed Sequential Oxidative Cyclization/Coupling of 2-Alkynylphenols and Alkenes: A Direct Entry into 3-Alkenylbenzofurans
inferred← citeshttps://doi.org/10.1021/ol902157copenalex-snapshot
Oxidative Aromatic C−O Bond Formation: Synthesis of 3-Functionalized Benzo[ b ]furans by FeCl 3 -Mediated Ring Closure of α-Aryl Ketones
inferred← citeshttps://doi.org/10.1038/sj.bjp.0705379openalex-snapshot
Action potential changes associated with a slowed inactivation of cardiac voltage‐gated sodium channels by KB130015
inferred← citeshttps://doi.org/10.1039/c3sc51489gopenalex-snapshot
Benzofuran synthesis via copper-mediated oxidative annulation of phenols and unactivated internal alkynes
inferred← citeshttps://doi.org/10.1039/c4cc07026gopenalex-snapshot
Orthogonal selectivity with cinnamic acids in 3-substituted benzofuran synthesis through C–H olefination of phenols
inferred← citeshttps://doi.org/10.1039/c4ob00575aopenalex-snapshot
Palladium-catalyzed tandem reaction of 2-hydroxyarylacetonitriles with sodium sulfinates: one-pot synthesis of 2-arylbenzofurans
inferred← citeshttps://doi.org/10.1039/c4ob02691hopenalex-snapshot
Fluorination of 2-substituted benzo[b]furans with Selectfluor™
inferred← citeshttps://doi.org/10.1039/c4qo00196fopenalex-snapshot
Synthesis of benzofurans via ruthenium-catalyzed redox-neutral C–H functionalization and reaction with alkynes under mild conditions
inferred← citeshttps://doi.org/10.1039/c5ob00577aopenalex-snapshot
Intramolecular oxidative coupling: I 2 /TBHP/NaN 3 -mediated synthesis of benzofuran derivatives
inferred← citeshttps://doi.org/10.1039/c6cc09080jopenalex-snapshot
Palladium-catalyzed synthesis of [60]fullerene-fused benzofurans via heteroannulation of phenols
inferred← citeshttps://doi.org/10.1039/c6qo00112bopenalex-snapshot
Hydrazone–palladium catalyzed annulation of 1-cinnamyloxy-2-ethynylbenzene derivatives
inferred← citeshttps://doi.org/10.1039/c7cc02053hopenalex-snapshot
Palladium-catalyzed benzofuran and indole synthesis by multiple C–H functionalizations
inferred← citeshttps://doi.org/10.1039/c7ob02873copenalex-snapshot
Hydrazone–Pd-catalyzed direct intermolecular reaction of o -alkynylphenols with allylic acetates
inferred← citeshttps://doi.org/10.1039/d0ra03071fopenalex-snapshot
Nickel catalyzed intramolecular oxidative coupling: synthesis of 3-aryl benzofurans
inferred← citeshttps://doi.org/10.1039/d4ob01223bopenalex-snapshot
Switching the regioselectivity of acid-catalyzed reactions of arylnaphtho[2,1- b ]furans via a [1,2]-aryl shift
inferred← citeshttps://doi.org/10.1039/d5ra05084gopenalex-snapshot
7-Methoxybenzofuran-triazole tethered N -phenylacetamides as a promising class of tyrosinase inhibitors: synthesis, biological evaluation and computational analyses against fungal and human tyrosinases
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Effects of Amiodarone and Dronedarone on Voltage‐Dependent Sodium Current in Human Cardiomyocytes
inferred← citeshttps://doi.org/10.1055/a-2642-9128openalex-snapshot
Visible-Light-Induced I2-Mediated Cyclization of ortho-Biarylchalcones of Naphthofuran Series toward Oxa[5]helicenes
inferred← citeshttps://doi.org/10.1055/sos-sd-110-00529openalex-snapshot
10.1 Product Class 1: Benzo[b]furans
inferred← citeshttps://doi.org/10.1080/00397911.2014.907425openalex-snapshot
Reactivity of Benzofuran Derivatives
inferred← citeshttps://doi.org/10.1080/00397911.2019.1611856openalex-snapshot
Facile synthesis of 3-aryl benzofurans, 3-aryl benzothiophenes, 2-aryl indoles and their dimers
inferred← citeshttps://doi.org/10.1097/fjc.0b013e31816c4325openalex-snapshot
Inward Rectifier Potassium Currents as a Target for Atrial Fibrillation Therapy
inferred← citeshttps://doi.org/10.1097/fjc.0b013e31818914b6openalex-snapshot
Amiodarone as Paradigm for Developing New Drugs for Atrial Fibrillation
inferred← citeshttps://doi.org/10.1111/j.1527-3466.2003.tb00117.xopenalex-snapshot
KB130015, A New Amiodarone Derivative with Multiple Effects on Cardiac Ion Channels
inferred← citeshttps://doi.org/10.1111/j.1527-3466.2005.tb00161.xopenalex-snapshot
Development of the Thyroid Hormone Receptor β-Subtype Agonist KB-141 : A Strategy for Body Weight Reduction and Lipid Lowering with Minimal Cardiac Side Effects
inferred← citeshttps://doi.org/10.1124/jpet.102.042218openalex-snapshot
Slowing of the Inactivation of Cardiac Voltage-Dependent Sodium Channels by the Amiodarone Derivative 2-Methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran (KB130015)
inferred← citeshttps://doi.org/10.1124/jpet.103.057646openalex-snapshot
Inhibition of G Protein-Coupled and ATP-Sensitive Potassium Currents by 2-Methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran (KB130015), an Amiodarone Derivative
inferred← citeshttps://doi.org/10.1124/jpet.105.092221openalex-snapshot
The Amiodarone Derivative KB130015 [2-Methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran] Induces an Na+-Dependent Increase of [Ca2+] in Ventricular Myocytes
inferred← citeshttps://doi.org/10.1124/jpet.106.108993openalex-snapshot
Hepatocellular Toxicity and Pharmacological Effect of Amiodarone and Amiodarone Derivatives
inferred← citeshttps://doi.org/10.1124/jpet.106.116152openalex-snapshot
Pharmacological Profile of the Thyroid Hormone Receptor Antagonist NH3 in Rats
inferred← citeshttps://doi.org/10.1128/aac.01184-06openalex-snapshot
Amiodarone and Bepridil Inhibit Anthrax Toxin Entry into Host Cells
inferred← citeshttps://doi.org/10.1134/s1070428023120059openalex-snapshot
Design, Synthesis, and Antiarrhythmic Activity of New Indole-3-carboxamide Derivatives
inferred← citeshttps://doi.org/10.1152/ajplung.00434.2003openalex-snapshot
Effects of metabolites and analogs of amiodarone on alveolar macrophages: structure-activity relationship
inferred← citeshttps://doi.org/10.1210/me.2006-0035openalex-snapshot
Thyroid Hormones Signaling Is Getting More Complex: STORMs Are Coming
inferred← citeshttps://doi.org/10.1517/13543770903567069openalex-snapshot
Thyromimetics: a review of recent reports and patents (2004 – 2009)
inferred← citeshttps://doi.org/10.1517/13543776.14.8.1169openalex-snapshot
Therapeutic thyroid hormone ligand patents 1998 – 2003
inferred← citeshttps://doi.org/10.1517/13543776.2013.801455openalex-snapshot
Benzofuran derivatives: a patent review
inferred← citeshttps://doi.org/10.1517/13543784.13.4.415openalex-snapshot
Dronedarone: an amiodarone analogue
inferred← citeshttps://doi.org/10.1517/13543784.16.2.169openalex-snapshot
Pharmacological therapy of atrial fibrillation
inferred← citeshttps://doi.org/10.1517/14728222.11.9.1161openalex-snapshot
Pharmacologic targets for atrial fibrillation
inferred← citeshttps://doi.org/10.22159/ijpps.2017v9i11.21413openalex-snapshot
IN VITRO ANTIOXIDANT, ANTIMICROBIAL AND ADMET STUDY OF NOVEL FURAN/BENZOFURAN C-2 COUPLED QUINOLINE HYBRIDS
inferred← citeshttps://doi.org/10.24820/ark.5550190.p010.609openalex-snapshot
Microwave promoted Heck and Suzuki coupling reactions of new 3-(5-bromobenzofuranyl)pyrazole in aqueous media
inferred← citeshttps://doi.org/10.25258/ijpqa.14.3.34openalex-snapshot
In-silico and In-vitro Studies on Targeting Tumor Apoptosis by Activating Caspase-3
inferred← citeshttps://doi.org/10.3184/174751917x14839766277170openalex-snapshot
One-pot Synthesis of Novel 2-(Benzofuran-2-yl)-4-Phenylquinoline-3-Carboxylates
inferred← citeshttps://doi.org/10.31857/s0514749223120054openalex-snapshot
Design, synthesis and antiarrhythmic activity of new amide derivatives of indole-3-carboxylic acid
inferred← citeshttps://doi.org/10.32725/jab.2003.027openalex-snapshot
Amiodarone - excellent antiarrhythmic drug? (Happy end after 40 years of problems)
inferred← citeshttps://doi.org/10.3389/fphys.2022.974160openalex-snapshot
Multitargeting nature of muscarinic orthosteric agonists and antagonists
inferred← citeshttps://doi.org/10.3390/molecules22111820openalex-snapshot
Synthesis and 2D-QSAR Study of Active Benzofuran-Based Vasodilators
inferred← citeshttps://doi.org/10.4236/gsc.2011.14025openalex-snapshot
Phase-Transfer-Catalyzed Intramolecular Hydroaryloxylation and Hydroamination of C≡C Triple Bonds: An Efficient Synthesis of Benzo[b]furan and 3-Methyleneisoindoline-1-one Derivatives
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