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Antineoplastic agents. 219. Isolation and structure of the cell growth inhibitory constituents from the western Pacific marine sponge Axinella sp

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Unified, Efficient, and Scalable Synthesis of Halichondrins: Zirconium/Nickel‐Mediated One‐Pot Ketone Synthesis as the Final Coupling Reaction
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PdII‐Catalyzed Spiroketalization of Ketoallylic Diols
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Natural Products as a Foundation for Drug Discovery
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Leucascandrolide A, a New Type of Macrolide: The first powerfully bioactive metabolite of calcareous sponges (Leucascandra caveolata, a new genus from the coral sea)
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Cyclic Heptapeptides Axinastatin 2, 3, and 4: Conformational analysis and evaluation of the biological potential
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Story of Eribulin Mesylate: Development of the Longest Drug Synthesis
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Marine Natural Products and their Synthetic Derivatives for Cancer Therapy
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Natural Product Scaffolds in Cancer Therapy
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Towards the Systematic Discovery of Immunomodulatory Adjuvants
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The NCI In Vitro Anticancer Drug Discovery Screen
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The NCI Human Tumor Cell Line (60-Cell) Screen
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The Discovery of Anticancer Drugs From Natural Sources
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Investigational Anticancer Agents Targeting the Microtubule
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Frontier in Antifungal Treatments Against Major Human Fungal Opportunistic Pathogen Candida Species and Medically Important Fungi
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Marine Sponge and Sponge-Associated Microorganisms as a Potential Drugstore in the Sea
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Marine Sponge Derived Eribulin in Preclinical and Clinical Studies for Cancer
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Cytotoxic Cyclic Peptides from the Marine Sponges
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ABC Transporter Modulatory Drugs from Marine Sources: A New Approach to Overcome Drug Resistance in Cancer
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Marine Organisms and Their Prospective Use in Therapy of Human Diseases
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Typification of Chemical Compounds of Marine Sponge Metabolites
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Natural Products: Drug Discovery and Development
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Plant- and Microbes-Mediated Secondary Metabolites: Remunerative Venture for Discovery and Development
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Sequencing of cyclic peptides by NMR and MS techniques demonstrated on stylissamides A–F
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Biological activity of isomalabaricane compounds from the marine sponge Rhabdastrella globostellata
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Interaction of halichondrin B and homohalichondrin B with bovine brain tubulin
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Isolation of dolastatins 10–15 from the marine mollusc
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Enantioselective synthesis of a halichondrin B C(20)→C(36) precursor
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Synthesis of axinastatins 2 – 5
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Natural products which interact with tubulin in the vinca domain: Maytansine, rhizoxin, phomopsin a, dolastatins 10 and 15 and halichondrin B
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Microtubule Targeting Agents
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Hit and Lead Generation Strategies
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Natural Products as Pharmaceuticals and Sources for Lead Structures**Note: This chapter reflects the opinions of the authors, not necessarily those of the US Government
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galacto-C-Furanosides (I, β-C-Lyxose)
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Oceans
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Anticancer Drugs and Potential Anticancer Leads Inspired by Natural Products
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Structural requirement of tunicamycin V for MraY inhibition
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Stylissamide X, a new proline-rich cyclic octapeptide as an inhibitor of cell migration, from an Indonesian marine sponge of Stylissa sp.
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A survey for biochemical synapomorphies to reveal phylogenetic relationships of halichondrid demosponges (Metazoa: Porifera)
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Eribulin—A review of preclinical and clinical studies
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Bryostatin-I: A dendritic cell stimulator for chemokines induction and a promising adjuvant for a peptide based cancer vaccine
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Selected hybrid natural products as tubulin modulators
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Cytotoxic activities of hexane, ethyl acetate and butanol extracts of marine sponges from Mauritian Waters on human cancer cell lines
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Apoptosis inducing lead compounds isolated from marine organisms of potential relevance in cancer treatment
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A world tour in the name of natural products
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Synthesis, structural aspects and cytotoxicity of the natural cyclopeptides yunnanins A, C and phakellistatins 1, 10
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Synthesis, structure, and biological aspects of cyclopeptides related to marine phakellistatins 7–9
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Application of hydrolytic kinetic resolution (HKR) in the synthesis of bioactive compounds
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General strategy towards chiral methylene bis-pyrans: synthesis of the C2–C16 fragment of phorboxazole A
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A novel natural phenyl alkene with cytotoxic activity
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Stylissatins B–D, cycloheptapeptides from the marine sponge Stylissa massa
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Inhibition of tubulin polymerization by vitilevuamide, a bicyclic marine peptide, at a site distinct from colchicine, the vinca alkaloids, and dolastatin 10
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Hymenamides C ~ E, new cyclic heptapeptides with two proline residues from the okinawan marine sponge hymeniacidon sp.
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Hymenamides a and b, new proline-rich cyclic heptapeptides from the okinawan marine sponge hymeniacidon sp.
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The Dolastatins 20. A Convenient Synthetic Route to Dolastatin 15
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Halichondrin B: synthesis of the C(37)–C(54) subunit
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Synthetic studies on halichondrins: A new practical synthesis of the C.1–C.12 segment
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Nairaiamides A and B. two novel di-proline heptapeptides isolated from a fijian Lissoclinum bistratum ascidian.
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Total synthesis of halichondrin b from common sugars: An F-ring intermediate from D-glucose and efficient construction of the C1 to C21 segment
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Total synthesis of halichondrins: Enantioselective construction of a homochiral tetracyclic KLMN-ring intermediate from D-mannitol
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An expeditious synthesis of the C(1)-C(14) subunit of halichondrin B
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Isohomohalichondrin B, a new antitumour polyether macrolide from the New Zealand deep-water sponge Lissodendoryx sp.
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Wainunuamide, a histidine-containing proline-rich cyclic heptapeptide isolated from the Fijian marine sponge Stylotella aurantium
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Synthetic studies on halichondrins: A practical synthesis of the C.1C.13 segment
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A stereoselective one-pot synthesis of perhydro-7a-hydroxy-7-phenylthiofurano[3,2-b]pyran via an Acid-catalysed deprotection/double cyclisation/rearrangement sequence
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The discovery and development of marine compounds with pharmaceutical potential
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The discovery and development of marine compounds with pharmaceutical potential
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Structure–activity relationships of Halichondrin B analogues: modifications at C.30–C.38
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Antineoplastic agents 323. Isolation and structure of phakellistatin 6 from a Chuuk archipelago marine sponge
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Isolation and structure of phakellistatin 2 from the eastern indian ocean marine sponge phakellia carteri
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Isolation and structure of axinastatin 5 from a republic of comoros marine sponge
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Antineoplastic Agents 390. Isolation and Structure of Phakellistatin 12 from a Chuuk Archipelago Marine Sponge
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New anti-HIV derivatives: synthesis and antiviral evaluation
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Eribulin in soft-tissue sarcomas
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Bioactive marine macrolides
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The Role of Natural Product Chemistry in Drug Discovery: Two Decades of Progress and Perspectives
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Unified Synthesis of Right Halves of Halichondrins A–C
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Stereocontrolled Synthesis of Left Halves of Halichondrins
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Gram-Scale Synthesis of the C14–C23 Fragment of Eribulin
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What Does It Take to Develop Structurally Complex Molecules by Total Synthesis? Rapid Process Development and GMP Manufacturing of E7130 Drug Substance for First-in-Human Clinical Study
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Total Synthesis of Eribulin, a Macrocyclic Ketone Analogue of Halichondrin B, via Prins Macrocyclization
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Diaza-anthracene Antibiotics from a Freshwater-Derived Actinomycete with Selective Antibacterial Activity toward Mycobacterium tuberculosis
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The Spongistatins, Potently Cytotoxic Inhibitors of Tubulin Polymerization, Bind in a Distinct Region of the Vinca Domain
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Small Molecule Modulators of Protein–Protein Interactions: Selected Case Studies
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The Halichondrins and E7389
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Total Synthesis of Halichondrin A, the Missing Member in the Halichondrin Class of Natural Products
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New Syntheses of E7389 C14−C35 and Halichondrin C14−C38 Building Blocks: Double-Inversion Approach
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Recifin A, Initial Example of the Tyr-Lock Peptide Structural Family, Is a Selective Allosteric Inhibitor of Tyrosyl-DNA Phosphodiesterase I
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Selective Activation/Coupling of Polyhalogenated Nucleophiles in Ni/Cr-Mediated Reactions: Synthesis of C1–C19 Building Block of Halichondrin Bs
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Unified Synthesis of C1–C19 Building Blocks of Halichondrins via Selective Activation/Coupling of Polyhalogenated Nucleophiles in (Ni)/Cr-Mediated Reactions
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Rescuing Biological Activity from Synthetic Phakellistatin 19
inferred← citeshttps://doi.org/10.1021/jo000140ropenalex-snapshot
Halichondrin B: Synthesis of the C(1)−C(15) Subunit
inferred← citeshttps://doi.org/10.1021/jo020482sopenalex-snapshot
Two Distinct Conformers of the Cyclic Heptapeptide Phakellistatin 2 Isolated from the Fijian Marine Sponge Stylotella aurantium
inferred← citeshttps://doi.org/10.1021/jo051479mopenalex-snapshot
Halichondrin B: Synthesis of the C1−C22 Subunit
inferred← citeshttps://doi.org/10.1021/jo7018152openalex-snapshot
A Second-Generation Total Synthesis of (+)-Phorboxazole A
inferred← citeshttps://doi.org/10.1021/jo701816hopenalex-snapshot
Synthesis and Biological Evaluation of Phorboxazole Congeners Leading to the Discovery and Preparative-Scale Synthesis of (+)-Chlorophorboxazole A Possessing Picomolar Human Solid Tumor Cell Growth Inhibitory Activity
inferred← citeshttps://doi.org/10.1021/jo951877xopenalex-snapshot
Acid-Catalyzed Reactions of Homohalichondrin B, a Marine Sponge-Derived Antitumor Polyether Macrolide
inferred← citeshttps://doi.org/10.1021/jo981181eopenalex-snapshot
An Expeditious Synthesis of the C(38)−C(54) Halichondrin B Subunit
inferred← citeshttps://doi.org/10.1021/jo981342eopenalex-snapshot
Synthesis of a C(22)−C(34) Halichondrin B Precursor via Ring Opening−Double Ring Closing Metathesis
inferred← citeshttps://doi.org/10.1021/jo9818780openalex-snapshot
A Backbone Linker for BOC-Based Peptide Synthesis and On-Resin Cyclization: Synthesis of Stylostatin 1,
inferred← citeshttps://doi.org/10.1021/np0100441openalex-snapshot
Synthesis of Phakellistatin 11: A Micronesia (Chuuk) Marine Sponge Cyclooctapeptide
inferred← citeshttps://doi.org/10.1021/np030336xopenalex-snapshot
Cyclonellin, a New Cyclic Octapeptide from the Marine Sponge Axinella carteri
inferred← citeshttps://doi.org/10.1021/np040031yopenalex-snapshot
Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials
inferred← citeshttps://doi.org/10.1021/np5006778openalex-snapshot
Reniochalistatins A–E, Cyclic Peptides from the Marine Sponge Reniochalina stalagmitis
inferred← citeshttps://doi.org/10.1021/np800568jopenalex-snapshot
Tubulin-Interactive Natural Products as Anticancer Agents
inferred← citeshttps://doi.org/10.1021/np9004135openalex-snapshot
Isolation and Structural Elucidation of Euryjanicins B−D, Proline-Containing Cycloheptapeptides from the Caribbean Marine Sponge Prosuberites laughlini
inferred← citeshttps://doi.org/10.1021/np900664fopenalex-snapshot
Stylissamides E and F, Cyclic Heptapeptides from the Caribbean Sponge Stylissa caribica
inferred← citeshttps://doi.org/10.1021/np9008267openalex-snapshot
Proline-Containing Cyclopeptides from the Marine Sponge Phakellia fusca
inferred← citeshttps://doi.org/10.1021/np9604386openalex-snapshot
Progress in the Discovery of Biosynthetic Anticancer Drugs
inferred← citeshttps://doi.org/10.1021/np980168mopenalex-snapshot
Antineoplastic Agents. 400. Synthesis of the Indian Ocean Marine Sponge Cyclic Heptapeptide Phakellistatin 2,1a
inferred← citeshttps://doi.org/10.1021/ol0269805openalex-snapshot
Asymmetric Ni(II)/Cr(II)-Mediated Coupling Reaction: Stoichiometric Process
inferred← citeshttps://doi.org/10.1021/ol027389aopenalex-snapshot
Halichondrin B: Synthesis of a C1−C14 Model via Desymmetrization of (+)-Conduritol E
inferred← citeshttps://doi.org/10.1021/ol0473400openalex-snapshot
Synthetic Efforts toward the C22−C36 Subunit of Halichondrin B Utilizing Local and Imposed Symmetry
inferred← citeshttps://doi.org/10.1021/ol060014vopenalex-snapshot
Design and Synthesis of a Potent Phorboxazole C(11−15) Acetal Analogue
inferred← citeshttps://doi.org/10.1021/ol063113hopenalex-snapshot
Operationally Simple and Efficient Workup Procedure for TBAF-Mediated Desilylation: Application to Halichondrin Synthesis
inferred← citeshttps://doi.org/10.1021/ol801093popenalex-snapshot
Further Improvement on Sulfonamide-Based Ligand for Catalytic Asymmetric 2-Haloallylation and Allylation
inferred← citeshttps://doi.org/10.1021/ol8027225openalex-snapshot
Attempts To Improve the Overall Stereoselectivity of the Ireland−Claisen Rearrangement
inferred← citeshttps://doi.org/10.1021/ol9016589openalex-snapshot
Second Generation Synthesis of C27−C35 Building Block of E7389, a Synthetic Halichondrin Analogue
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What are the structures of phakellistatin 2 and phakellistatin 4?
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Antimicrotubular drugs binding to vinca domain of tubulin
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Drug development from marine natural products
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A landmark in drug discovery based on complex natural product synthesis
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Macromarines: A Selective Account of the Potential of Marine Sponges, Molluscs, Soft Corals and Tunicates as a Source of Therapeutically Important Molecular Structures
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Investigations of the marine flora and fauna of the Islands of Palau
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Natural product mode of action (MOA) studies: a link between natural and synthetic worlds
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Isolation and structure of the remarkable human cancer cell growth inhibitors spongistatins 2 and 3 from an eastern indian ocean Spongia sp.
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Industrial natural product chemistry for drug discovery and development
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Recent advances in deep-sea natural products
inferred← citeshttps://doi.org/10.1039/c7sc04744dopenalex-snapshot
Coupling of sterically demanding peptides by β-thiolactone-mediated native chemical ligation
inferred← citeshttps://doi.org/10.1039/np9971400259openalex-snapshot
Marine natural products
inferred← citeshttps://doi.org/10.1039/p19960002411openalex-snapshot
Synthesis of the cyclic heptapeptides axinastatin 2 and axinastatin 3
inferred← citeshttps://doi.org/10.1051/medsci/20143003021openalex-snapshot
Recherche de substances naturelles à activité thérapeutique (2)
inferred← citeshttps://doi.org/10.1053/j.seminoncol.2006.04.006openalex-snapshot
Novel Agents That Target Tublin and Related Elements
inferred← citeshttps://doi.org/10.1080/10286020.2023.2249825openalex-snapshot
A review on marine source as anticancer agents
inferred← citeshttps://doi.org/10.1111/bph.14876openalex-snapshot
Enriching cancer pharmacology with drugs of marine origin
inferred← citeshttps://doi.org/10.1111/j.1476-5381.2009.00573.xopenalex-snapshot
In vitro and in vivo antineoplastic activity of a novel bromopyrrole and its potential mechanism of action
inferred← citeshttps://doi.org/10.1124/mol.106.026641openalex-snapshot
Comparison of the Activities of the Truncated Halichondrin B Analog NSC 707389 (E7389) with Those of the Parent Compound and a Proposed Binding Site on Tubulin
inferred← citeshttps://doi.org/10.1135/cccc2008181openalex-snapshot
Enantioselective synthesis of structurally intricate and complementary polyoxygenated building blocks of Spongistatin 1 (Altohyrtin A)
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-09-1023openalex-snapshot
Eribulin: Rediscovering Tubulin as an Anticancer Target
inferred← citeshttps://doi.org/10.1186/s13045-017-0466-3openalex-snapshot
Emerging therapies for breast cancer
inferred← citeshttps://doi.org/10.1201/9780203414583-11openalex-snapshot
Development of Enzyme Inhibitors as Drugs
inferred← citeshttps://doi.org/10.1201/9780203414583.ch5openalex-snapshot
Development of Enzyme Inhibitors as Drugs
inferred← citeshttps://doi.org/10.1201/9781420039658.ch13openalex-snapshot
Discovery of E7389, a Fully Synthetic Macrocyclic Ketone Analog of Halichondrin B
inferred← citeshttps://doi.org/10.1246/bcsj.20150003openalex-snapshot
Total Synthesis of Stylissatin A, A Cyclic Peptide That Inhibits Nitric Oxide Production
inferred← citeshttps://doi.org/10.14712/18059694.2019.137openalex-snapshot
The Most Important Microtubule Natural Inhibitors
inferred← citeshttps://doi.org/10.1517/14656566.2016.1146683openalex-snapshot
Review on the clinical use of eribulin mesylate for the treatment of breast cancer
inferred← citeshttps://doi.org/10.2147/bctt.s21741openalex-snapshot
Eribulin (Halaven): a new, effective treatment for women with heavily pretreated metastatic breast cancer
inferred← citeshttps://doi.org/10.21608/ejabf.2020.91650openalex-snapshot
Applying a cultured Brachionus plicatilis crud extract as a novel source of natural medical bioactive compounds
inferred← citeshttps://doi.org/10.2174/092986711796642652openalex-snapshot
From the Sea to Anticancer Therapy
inferred← citeshttps://doi.org/10.2174/1389557520666200729162510openalex-snapshot
The Progress of the Anticancer Agents Related to the Microtubules Target
inferred← citeshttps://doi.org/10.2174/187152009787313800openalex-snapshot
Marine Macrolides, a Promising Source of Antitumor Compounds
inferred← citeshttps://doi.org/10.2174/1871520618666180220120544openalex-snapshot
Guide for Selection of Relevant Cell Lines During the Evaluation of new Anti-Cancer Compounds
inferred← citeshttps://doi.org/10.2217/fon-2017-0461openalex-snapshot
Eribulin Therapy for the Treatment of Patients with Advanced Soft Tissue Sarcoma
inferred← citeshttps://doi.org/10.3184/174751917x14837116219618openalex-snapshot
Efficient and Green Synthesis of 2,2′-(Arylmethylene)Bis-4-Pyrones in an Ionic Liquid [bmim + ][BF 4 – ]
inferred← citeshttps://doi.org/10.32792/utq/utjsci/vol3/1/3openalex-snapshot
Antimicrobial activity test of the crude extracts of some marine Mollusca against selected pathogenic fungi, in vitro
inferred← citeshttps://doi.org/10.3390/md11041126openalex-snapshot
Biological Activities of Ethanolic Extracts from Deep-Sea Antarctic Marine Sponges
inferred← citeshttps://doi.org/10.3390/md13085016openalex-snapshot
Eribulin in Cancer Treatment
inferred← citeshttps://doi.org/10.3390/md14110194openalex-snapshot
Natural Proline-Rich Cyclopolypeptides from Marine Organisms: Chemistry, Synthetic Methodologies and Biological Status
inferred← citeshttps://doi.org/10.3390/md18120619openalex-snapshot
Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes
inferred← citeshttps://doi.org/10.3390/md20080494openalex-snapshot
Antibody-Drug Conjugates Containing Payloads from Marine Origin
inferred← citeshttps://doi.org/10.3390/metabo2020303openalex-snapshot
A Historical Overview of Natural Products in Drug Discovery
inferred← citeshttps://doi.org/10.3892/ijo.30.1.161openalex-snapshot
Effects of Agelas oroides and Petrosia ficiformis crude extracts on human neuroblastoma cell survival
inferred← citeshttps://doi.org/10.4048/jbc.2013.16.1.12openalex-snapshot
Eribulin for Advanced Breast Cancer: A Drug Evaluation
inferred← citeshttps://doi.org/10.4137/bcbcr.s32787openalex-snapshot
Eribulin in the Management of Advanced Breast Cancer: Implications of Current Research Findings
inferred← citeshttps://doi.org/10.70675/425263d8zd580z4f8cz91b7zc6529215823fopenalex-snapshot
Interactions between scatter-hoarding rodents, invertebrates and palms in tropical forests : implications for palm vulnerability
inferred← citeshttps://doi.org/10.70675/76b1d104zaa6az4253z864ez51e50bc9290fopenalex-snapshot
Valorisation de substances naturelles marines de Nouvelle-Calédonie d'intérêt en traitement anticancéreux
inferred← citeshttps://doi.org/10.70675/efb2d03ezcc25z4daazb84bz181aed5306d6openalex-snapshot
Total Synthesis of Microsclerodermin D
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