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Synthesis and muscarinic activities of 1,2,4-thiadiazoles

https://doi.org/10.1021/jm00169a041
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Design, Synthesis and Biological Evaluation of 1,2,3-Triazole Incorporated 1,2,4-Thiadiazole Fused Benzofuran Derivatives as Anticancer Agents
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Muscarinic Agonists as Insecticides and Acaricides
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Thiadiazoles
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ChemInform Abstract: Synthesis and Muscarinic Activities of 1,2,4‐Thiadiazoles.
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Synthesis of Functionalized Nitrogen Heterocycles by Radical Decarboxylation of β‐ and γ‐Amino Acids
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Building 1,2,4‐Thiadiazole: Ten Years of Progress
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Absolute Configuration of 3‐Substituted 1‐Azabicyclo[2.2.1]heptanes
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An Unexpected Result of the Reaction of Benzothioamide Derivatives with 2‐Aryl‐2‐bromoacetonitriles
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Synthesis and Antimicrobial Activity Evaluation of Novel Oxadiazino/Thiadiazino‐Indole and Oxadiazole/Thiadiazole Derivatives of 2‐Oxo‐2H‐benzopyran
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Mechanism of the formation of 1,2,4‐thiadiazoles by condensation of aromatic thioamides and of N‐substituted thioureas
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Synthesis, Pharmacology, Crystal Properties, and Quantitative Solvation Studies from a Drug Transport Perspective for Three New 1,2,4-thiadiazoles
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Drug discovery
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Purification of 3-ethoxycarbonylquinuclidine and its conversion to 3-quinuclidinecarboxylic acid and 3-quinuclidinylmethanol
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Chiral discrimination by hydrolytic enzymes in the synthesis of optically pure materials
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An Expeditious Ultrasound-Initiated Green Synthesis of 1,2,4-Thiadiazoles in Water
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An Efficient and Simple One-Pot Synthesis of Novel 2-Amino-5-aza-6-(dinitrilomethylene)-4,7,7-trimethylbicyclo[2.2.2]octane-1,3-dicarbo-nitrile and its Crystal Structure
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Polymeric composites of 1,2,4-thiadiazole: solubility, dissolution and permeability assay
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Muscarinic agonists as analgesics. Antinociceptive activity versus M1 activity: SAR of alkylthio-TZTP's and related 1,2,5-thiadiazole analogs
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3-(3-Alkylthio-1,2,5-thiadiazol-4-yl)-1-azabicycles. Structure—activity relationships for antinociception mediated by central muscarinic receptors
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Stereoisomerism and muscarinic receptor agonists: synthesis and effects of the stereoisomers of 3-[5-(3-amino-1,2,4-oxadiazol)yl]-1-azabicyclo[2.2.1]heptane
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Enzymatic preparation of homochiral 2-(n-carbobenzyloxypiperid-4-yl)-1,3-propanediol monoacetate. A facile entry to both enantiomers of 3- hydroxymethylquinuclidine.
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Five-Membered Ring Systems: With N and S (Se) Atoms
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Five-Membered Ring Systems: With N & S (Se) Atoms
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1,2,4-Thiadiazoles
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1,2,4-Thiadiazoles
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1,2,4-Thiadiazoles
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Volume 4 References
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Advances in the synthesis and recent therapeutic applications of 1,2,4-thiadiazole heterocycles
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Cocrystal formation, crystal structure, solubility and permeability studies for novel 1,2,4-thiadiazole derivative as a potent neuroprotector
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The effect of different polymers on the solubility, permeability and distribution of poor soluble 1,2,4-thiadiazole derivative
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Synthesis of β-fluoro-β-proline
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Design and synthesis of diaziridinyl quinone thiadiazole hybrids via nitrile sulfide cycloaddition reaction as a key step
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Synthesis of azanorbornyl-spirodioxolanes related to the muscarinic agonist AF30.
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Inverse isostere strategies in the development of cholinergic agonists with multiple therapeutic potentials
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Design and synthesis of azabicyclic muscarinic agonists incorporating an oxime ether functionality
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Synthesis and structure-activity relationships of heterocyclic analogues of the functional M1 selective muscarinic agonist hexyloxy-TZTP
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A rationale for the design and synthesis of m1 selective muscarinic agonists.
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2-(Anilinomethyl)imidazolines as α1A Adrenergic Receptor Agonists: 2′-Heteroaryl and 2′-Oxime Ether Series
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Efficient Transamidation of Primary Carboxamides by in Situ Activation with N,N-Dialkylformamide Dimethyl Acetals
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3-Heteroaryl-Substituted Quinuclidin-3-ol and Quinuclidin-2-ene Derivatives as Muscarinic Antagonists. Synthesis and Structure-Activity Relationships
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Novel, Nonpeptidic Cyanamides as Potent and Reversible Inhibitors of Human Cathepsins K and L
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3-Heteroaryl-2-pyridones: Benzodiazepine Site Ligands with Functional Selectivity for α2/α3-Subtypes of Human GABAA Receptor-Ion Channels
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Synthesis, Ligand Binding, and Quantitative Structure−Activity Relationship Study of 3β-(4‘-Substituted phenyl)-2β-heterocyclic Tropanes: Evidence for an Electrostatic Interaction at the 2β-Position
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1,2,5-Thiadiazole Analogues of Aceclidine as Potent m1 Muscarinic Agonists
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Synthesis of 3-Substituted Bicyclic Imidazo[1,2-d][1,2,4]thiadiazoles and Tricyclic Benzo[4,5]imidazo[1,2-d][1,2,4]thiadiazoles
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Novel 1,2,4-Thiadiazole Derivatives: Crystal Structure, Conformational Analysis, Hydrogen Bond Networks, Calculations, and Thermodynamic Characteristics of Crystal Lattices
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Thermodynamic and Structural Aspects of Novel 1,2,4-Thiadiazoles in Solid and Biological Mediums
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Enzymatic Resolution of N-Substituted-β-prolines
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Synthesis of azabicyclic pyrazine derivatives as muscarinic agonists and the preparation of a chloropyrazine analogue with functional selectivity at sub-types of the muscarinic receptor
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The impact of structural modification of 1,2,4-thiadiazole derivatives on thermodynamics of solubility and hydration processes
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Towards the rational design of novel drugs based on solubility, partitioning/distribution, biomimetic permeability and biological activity exemplified by 1,2,4-thiadiazole derivatives
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Novel cocrystals of the potent 1,2,4-thiadiazole-based neuroprotector with carboxylic acids: virtual screening, crystal structures and solubility performance
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Highly Efficient Synthesis of 3,5-Diaryl-1,2,4-thiadiazoles in Water–Wet Paste Conditions
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Tribromo Phloroglucinol as a Novel and Highly Efficient Reagent for the Conversion of Benzothioamides to the Corresponding 1,2,4-Thiadiazoles
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Design, synthesis, and antimicrobial activity of novel spiroisoxazolo[2,3-b][1,2,4]thiadiazole-2,2′-thiazolidine- 4′-ones and spiroisoxazolo[2,3-b][1,2,4]oxadiazole-2, 2′-thiazolidine-4′-ones
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Inhibitory Activity ofDrynariae rhizomaExtracts on Cathepsin Having Bone Resorption Activity
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Computation of the Solubility of 1,2,4-Thiadiazole Derivatives in Supercritical Carbon Dioxide
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Process Optimization
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Characterization of Isomeric 1,2,4-Oxadiazolyl- N -Methylpyridinium Salts by Electrospray Ionization Tandem Mass Spectrometry
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Orthoamide und Iminiumsalze, CV. Umsetzungen von Orthoamiden der Alkincarbonsäuren mit Carbonsäureamiden
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An Efficient One-Pot Synthesis of 5-(substituted amino)-1,2,4-thia- and -oxa-diazoles
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