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Discovery of Small-Molecule Inhibitors of Bcl-2 through Structure-Based Computer Screening
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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A Model Binding Site for Testing Scoring Functions in Molecular Docking
inferred← citeshttps://doi.org/10.1016/s0065-230x(02)85007-2openalex-snapshot
Mitochondria and apoptosis: New therapeutic targets
inferred← citeshttps://doi.org/10.1016/s0065-7743(02)37013-1openalex-snapshot
Chapter 12. Intracellular signaling targets for cancer chemosensitization
inferred← citeshttps://doi.org/10.1016/s0065-7743(04)39020-2openalex-snapshot
Comparative Protein Structure Modeling and its Applications to Drug Discovery
inferred← citeshttps://doi.org/10.1016/s0065-7743(05)40016-0openalex-snapshot
Inhibitors of Anti-apoptotic Proteins for Cancer Therapy
inferred← citeshttps://doi.org/10.1016/s0161-5890(02)00252-3openalex-snapshot
The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions
inferred← citeshttps://doi.org/10.1016/s1074-5521(02)00247-8openalex-snapshot
The Chemical Biology of Apoptosis
inferred← citeshttps://doi.org/10.1016/s1359-6446(00)01506-3openalex-snapshot
Monitor: molecules and profiles
inferred← citeshttps://doi.org/10.1016/s1359-6446(02)02198-0openalex-snapshot
Monitor: molecules and profiles
inferred← citeshttps://doi.org/10.1016/s1359-6446(02)02233-xopenalex-snapshot
Structure-based screening and design in drug discovery
inferred← citeshttps://doi.org/10.1016/s1359-6446(02)02563-1openalex-snapshot
Anticancer drugs of tomorrow: apoptotic pathways as targets for drug design
inferred← citeshttps://doi.org/10.1016/s1367-5931(02)00339-3openalex-snapshot
Lead discovery using molecular docking
inferred← citeshttps://doi.org/10.1016/s1367-5931(02)00352-6openalex-snapshot
A view to a kill: ligands for Bcl-2 family proteins
inferred← citeshttps://doi.org/10.1016/s1574-1400(06)02011-1openalex-snapshot
Chapter 11 Recent Advances in Design of Small-Molecule Ligands to Target Protein–Protein Interactions
inferred← citeshttps://doi.org/10.1016/s1875-5364(15)30063-7openalex-snapshot
Isochamaejasmin induces apoptosis in leukemia cells through inhibiting Bcl-2 family proteins
inferred← citeshttps://doi.org/10.1017/cbo9780511663543.002openalex-snapshot
Apoptosis in health, disease, and therapy: overview and methodology
inferred← citeshttps://doi.org/10.1017/cbo9780511730412.009openalex-snapshot
Docking: a domesday report
inferred← citeshttps://doi.org/10.1017/cbo9781139021500.025openalex-snapshot
Computational Approach for Drug Target Identification
inferred← citeshttps://doi.org/10.1021/acs.jafc.9b01203openalex-snapshot
Characterization and Inception of a Triterpenoid Astrakurkurol, as a Cytotoxic Molecule on Human Hepatocellular Carcinoma Cells, Hep3B
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b02008openalex-snapshot
Docking Screens for Novel Ligands Conferring New Biology
inferred← citeshttps://doi.org/10.1021/acs.orglett.0c00122openalex-snapshot
Cross-Coupling Strategy for the Synthesis of Diazocines
inferred← citeshttps://doi.org/10.1021/acs.orglett.6c03473openalex-snapshot
Direct C1–H Amination of Free NH Carbazoles Enabled by the Catellani Reaction
inferred← citeshttps://doi.org/10.1021/acsomega.1c02524openalex-snapshot
Substituted Dibenzodiazocines: Rapid Synthesis and Photochemical Properties
inferred← citeshttps://doi.org/10.1021/bi501505yopenalex-snapshot
Mapping the BH3 Binding Interface of Bcl-xL, Bcl-2, and Mcl-1 Using Split-Luciferase Reassembly
inferred← citeshttps://doi.org/10.1021/cb200439zopenalex-snapshot
Identification of Influenza Endonuclease Inhibitors Using a Novel Fluorescence Polarization Assay
inferred← citeshttps://doi.org/10.1021/cb300555nopenalex-snapshot
Identification of Novel Host-Targeted Compounds That Protect from Anthrax Lethal Toxin-Induced Cell Death
inferred← citeshttps://doi.org/10.1021/cc700153zopenalex-snapshot
Exploration of Structure−Activity Relationships among Foldamer Ligands for a Specific Protein Binding Site via Parallel and Split-and-Mix Library Synthesis
inferred← citeshttps://doi.org/10.1021/ci020055fopenalex-snapshot
Consideration of Molecular Weight during Compound Selection in Virtual Target-Based Database Screening
inferred← citeshttps://doi.org/10.1021/ci100501dopenalex-snapshot
Rational Design of New Class of BH3-Mimetics As Inhibitors of the Bcl-xL Protein
inferred← citeshttps://doi.org/10.1021/ci200280mopenalex-snapshot
Discovery of Novel Selective Serotonin Reuptake Inhibitors through Development of a Protein-Based Pharmacophore
inferred← citeshttps://doi.org/10.1021/ci200322sopenalex-snapshot
Hot Spots and Transient Pockets: Predicting the Determinants of Small-Molecule Binding to a Protein–Protein Interface
inferred← citeshttps://doi.org/10.1021/ci800022eopenalex-snapshot
Evaluation of Virtual Screening Performance of Support Vector Machines Trained by Sparsely Distributed Active Compounds
inferred← citeshttps://doi.org/10.1021/ci8000474openalex-snapshot
Web Server To Identify Similarity of Amino Acid Motifs to Compounds (SAAMCO)
inferred← citeshttps://doi.org/10.1021/ci900294xopenalex-snapshot
Discovery of Small Molecule Inhibitors of Protein−Protein Interactions Using Combined Ligand and Target Score Normalization
inferred← citeshttps://doi.org/10.1021/ci9003706openalex-snapshot
Molecular Docking Screens Using Comparative Models of Proteins
inferred← citeshttps://doi.org/10.1021/cn900032uopenalex-snapshot
Receptor-Based Discovery of a Plasmalemmal Monoamine Transporter Inhibitor via High-Throughput Docking and Pharmacophore Modeling
inferred← citeshttps://doi.org/10.1021/ja034508oopenalex-snapshot
Molecular Recognition of Protein Surfaces: High Affinity Ligands for the CBP KIX Domain
inferred← citeshttps://doi.org/10.1021/ja0441211openalex-snapshot
Paralog-Selective Ligands for Bcl-2 Proteins
inferred← citeshttps://doi.org/10.1021/ja0563861openalex-snapshot
Deconvoluting the Structural and Drug-Recognition Complexity of the G-Quadruplex-Forming Region Upstream of the bcl-2 P1 Promoter
inferred← citeshttps://doi.org/10.1021/ja4118945openalex-snapshot
The Major G-Quadruplex Formed in the Human BCL-2 Proximal Promoter Adopts a Parallel Structure with a 13-nt Loop in K+ Solution
inferred← citeshttps://doi.org/10.1021/jm0300330openalex-snapshot
Information Decay in Molecular Docking Screens against Holo, Apo, and Modeled Conformations of Enzymes
inferred← citeshttps://doi.org/10.1021/jm050639jopenalex-snapshot
Novel Human Lipoxygenase Inhibitors Discovered Using Virtual Screening with Homology Models
inferred← citeshttps://doi.org/10.1021/jm060460oopenalex-snapshot
Structure-Based Design of Potent Small-Molecule Inhibitors of Anti-Apoptotic Bcl-2 Proteins
inferred← citeshttps://doi.org/10.1021/jm061400lopenalex-snapshot
Pyrogallol-Based Molecules as Potent Inhibitors of the Antiapoptotic Bcl-2 Proteins
inferred← citeshttps://doi.org/10.1021/jm070383copenalex-snapshot
Structure-Based Design of Flavonoid Compounds As a New Class of Small-Molecule Inhibitors of the Anti-apoptotic Bcl-2 Proteins
inferred← citeshttps://doi.org/10.1021/jm3010306openalex-snapshot
Structure-Based Discovery of BM-957 as a Potent Small-Molecule Inhibitor of Bcl-2 and Bcl-xL Capable of Achieving Complete Tumor Regression
inferred← citeshttps://doi.org/10.1021/jm701358vopenalex-snapshot
Acylpyrogallols as Inhibitors of Antiapoptotic Bcl-2 Proteins
inferred← citeshttps://doi.org/10.1021/jm8005433openalex-snapshot
Structure−Activity Relationship Studies of Phenanthridine-Based Bcl-XL Inhibitors
inferred← citeshttps://doi.org/10.1021/jo0303158openalex-snapshot
Synthesis of Carbazoles via an Intramolecular Cyclization of 2-(6-Substituted 3(Z)-hexen-1,5-diynyl)anilines and Their Related Molecules
inferred← citeshttps://doi.org/10.1021/jo9006249openalex-snapshot
Synthesis of Carbazoles by Intramolecular Arylation of Diarylamide Anions
inferred← citeshttps://doi.org/10.1021/mp7000846openalex-snapshot
Ethyl-2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H- chromene-3-carboxylate (HA 14-1), a Prototype Small-Molecule Antagonist against Antiapoptotic Bcl-2 Proteins, Decomposes To Generate Reactive Oxygen Species That Induce Apoptosis
inferred← citeshttps://doi.org/10.1021/np900192ropenalex-snapshot
Cytotoxic Pentacyclic Triterpenoids from Combretum sundaicum and Lantana camara as Inhibitors of Bcl-xL/BakBH3 Domain Peptide Interaction
inferred← citeshttps://doi.org/10.1023/b:appt.0000045786.98031.1dopenalex-snapshot
Apoptosome dysfunction in human cancer
inferred← citeshttps://doi.org/10.1023/b:jcam.0000022559.72848.1copenalex-snapshot
Molecular dynamics study of peptide segments of the BH3 domain of the proapoptotic proteins Bak, Bax, Bid and Hrk bound to the Bcl-xL and Bcl-2 proteins
inferred← citeshttps://doi.org/10.1038/cdd.2008.37openalex-snapshot
Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy?
inferred← citeshttps://doi.org/10.1038/cdd.2014.105openalex-snapshot
Elimination of quiescent/slow-proliferating cancer stem cells by Bcl-XL inhibition in non-small cell lung cancer
inferred← citeshttps://doi.org/10.1038/nature03579openalex-snapshot
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
inferred← citeshttps://doi.org/10.1038/nrc1736openalex-snapshot
Promoting apoptosis as a strategy for cancer drug discovery
inferred← citeshttps://doi.org/10.1038/nrc3690openalex-snapshot
Oncogenic protein interfaces: small molecules, big challenges
inferred← citeshttps://doi.org/10.1038/nrd.2016.29openalex-snapshot
Small molecules, big targets: drug discovery faces the protein–protein interaction challenge
inferred← citeshttps://doi.org/10.1038/nrd1343openalex-snapshot
Small-molecule inhibitors of protein–protein interactions: progressing towards the dream
inferred← citeshttps://doi.org/10.1038/nrd1549openalex-snapshot
Docking and scoring in virtual screening for drug discovery: methods and applications
inferred← citeshttps://doi.org/10.1038/nrd2658openalex-snapshot
BCL-2 family antagonists for cancer therapy
inferred← citeshttps://doi.org/10.1038/onc.2008.307openalex-snapshot
Bcl-2 family proteins and cancer
inferred← citeshttps://doi.org/10.1038/onc.2009.39openalex-snapshot
BH3-only proteins in apoptosis and beyond: an overview
inferred← citeshttps://doi.org/10.1038/sj.bjp.0707532openalex-snapshot
Ligand discovery and virtual screening using the program LIDAEUS
inferred← citeshttps://doi.org/10.1038/sj.cdd.4401556openalex-snapshot
Apoptosis-based therapies and drug targets
inferred← citeshttps://doi.org/10.1038/sj.cdd.4401992openalex-snapshot
BCL-2 in the crosshairs: tipping the balance of life and death
inferred← citeshttps://doi.org/10.1038/sj.leu.2403029openalex-snapshot
Recent advances in the development of anticancer agents targeting cell death inhibitors in the Bcl-2 protein family
inferred← citeshttps://doi.org/10.1038/sj.leu.2403102openalex-snapshot
HA14-1 selectively induces apoptosis in Bcl-2-overexpressing leukemia/lymphoma cells, and enhances cytarabine-induced cell death
inferred← citeshttps://doi.org/10.1038/sj.onc.1206454openalex-snapshot
Apoptosis and melanoma chemoresistance
inferred← citeshttps://doi.org/10.1038/sj.onc.1207102openalex-snapshot
The Bcl-2 family: roles in cell survival and oncogenesis
inferred← citeshttps://doi.org/10.1038/sj.onc.1209599openalex-snapshot
Mitochondriotoxic compounds for cancer therapy
inferred← citeshttps://doi.org/10.1038/srep22878openalex-snapshot
Structure-Based Virtual Ligand Screening on the XRCC4/DNA Ligase IV Interface
inferred← citeshttps://doi.org/10.1039/9781849735377-00319openalex-snapshot
Computational Strategies and Challenges for Targeting Protein–Protein Interactions with Small Molecules
inferred← citeshttps://doi.org/10.1039/b608043jopenalex-snapshot
Synthetic non-peptide mimetics of α-helices
inferred← citeshttps://doi.org/10.1039/b808767aopenalex-snapshot
Intermolecular sequential [4 + 2]-cycloaddition–aromatization reaction of aryl-substituted allenes with DMAD affording phenanthrene and naphthalene derivatives
inferred← citeshttps://doi.org/10.1039/c0cc02969fopenalex-snapshot
Profiling small molecule inhibitors against helix–receptor interactions: the Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2
inferred← citeshttps://doi.org/10.1039/c4cc04778hopenalex-snapshot
Indanthrone dye revisited after sixty years
inferred← citeshttps://doi.org/10.1039/c4tb00539bopenalex-snapshot
Double-layered hyaluronic acid/stearic acid-modified polyethyleneimine nanoparticles encapsulating (−)-gossypol: a nanocarrier for chiral anticancer drugs
inferred← citeshttps://doi.org/10.1053/hupa.2003.100openalex-snapshot
Clinical applications of molecular genetic testing in hematologic malignancies: Advantages and limitations
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