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Discovery of N-[2-[2-[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methyl-4- morpholineacetamide as a Novel and Potent Inhibitor of Inosine Monophosphate Dehydrogenase with Excellent in Vivo Activity

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Methotrexate in rheumatoid arthritis: Studies with animal models
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Cloning and sequence analysis of the human and Chinese hamster inosine-5'-monophosphate dehydrogenase cDNAs.
inferredcites →https://doi.org/10.1016/s0162-3109(00)00193-4openalex-snapshot
The structure of inosine 5′-monophosphate dehydrogenase and the design of novel inhibitors
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Inhibition of IMPDH by Mycophenolic Acid: Dissection of Forward and Reverse Pathways Using Capillary Electrophoresis
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Mycophenolic Acid: A One Hundred Year Odyssey from Antibiotic to Immunosuppressant
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IMP dehydrogenase, an enzyme linked with proliferation and malignancy
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Activation-Induced Ubiquitination of the T Cell Antigen Receptor
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Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule
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Animal Models of Arthritis: Relevance to Human Disease
inferredcites →https://doi.org/10.1517/13543776.11.7.1161openalex-snapshot
Inhibitors of inosine monophosphate dehydrogenase as potential chemotherapeutic agents
inferredcites →https://doi.org/10.2174/092986730607220401122519openalex-snapshot
IMP Dehydrogenase: Mechanism of Action and Inhibition
inferredcites →https://doi.org/10.4049/jimmunol.152.3.984openalex-snapshot
Effects of human T lymphocyte activation on inosine monophosphate dehydrogenase expression.

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Synthesis of 2‐Amino Substituted Oxazoles from α‐Amino Ketones and Isothiocyanates via Sequential Addition and I2‐Mediated Desulfurative Cyclization
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Synthesis of Substituted 2‐Amino‐1,3‐oxazoles via Copper‐Catalyzed Oxidative Cyclization of Enamines and N,N‐Dialkyl Formamides
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Selected Methodologies Convenient for the Synthesis of N,5‐Diaryloxazole‐2‐amine Pharmacophore
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Inosine monophosphate dehydrogenase (IMPDH) as a target in drug discovery
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2‐Aminooxazoles: Synthetic Methodologies and Contributions in Drug Discovery as Anticancer and Antibacterial Agents
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Mycophenolic acid analogs with a modified metabolic profile
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Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylase based on a cinnamic hydroxamic acid core structure
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Quinazolinethiones and quinazolinediones, novel inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure–activity relationships
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Low molecular weight indole fragments as IMPDH inhibitors
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The rational design of a novel potent analogue of the 5′-AMP-activated protein kinase inhibitor compound C with improved selectivity and cellular activity
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IMP dehydrogenase: structural schizophrenia and an unusual base
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Synthesis and antiviral activity of a novel class of (5-oxazolyl)phenyl amines
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Multicomponent synthesis of allomaltol containing 2-aminooxazoles and acid-catalyzed recyclization into substituted furo[3,2-b]pyrans
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Novel guanidine-Based inhibitors of inosine monophosphate dehydrogenase
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Novel amide-based inhibitors of inosine 5′-monophosphate dehydrogenase
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Novel inhibitors of IMPDH
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Quinolone-Based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues
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Identification of novel and potent isoquinoline aminooxazole-Based IMPDH inhibitors
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Novel indole-based inhibitors of IMPDH: introduction of hydrogen bond acceptors at indole C-3
inferred← citeshttps://doi.org/10.1016/s0960-894x(03)00258-0openalex-snapshot
Inhibitors of inosine monophosphate dehydrogenase: SARs about the N-[3-Methoxy-4-(5-oxazolyl)phenyl moiety
inferred← citeshttps://doi.org/10.1016/s0960-894x(03)00757-1openalex-snapshot
3-Cyanoindole-based inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure–Activity relationships
inferred← citeshttps://doi.org/10.1021/acs.orglett.5b01592openalex-snapshot
Facile Gold-Catalyzed Heterocyclization of Terminal Alkynes and Cyanamides Leading to Substituted 2-Amino-1,3-Oxazoles
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Bacillus anthracis Inosine 5′-Monophosphate Dehydrogenase in Action: The First Bacterial Series of Structures of Phosphate Ion-, Substrate-, and Product-Bound Complexes
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IMP Dehydrogenase: Structure, Mechanism, and Inhibition
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Discovery of Ledipasvir (GS-5885): A Potent, Once-Daily Oral NS5A Inhibitor for the Treatment of Hepatitis C Virus Infection
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Syntheses and transformations of α-azido ketones and related derivatives
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Selectively targeting inosine monophosphate dehydrogenase-2 impairs brain metastatic potential while preserving immune cell function
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Inosine-5’-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016)
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A modified approach for the synthesis of biologically relevant 5-substituted-2-N-aryl-1,3-oxazole derivatives in mild conditions
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In Silico Design of Human IMPDH Inhibitors Using Pharmacophore Mapping and Molecular Docking Approaches
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Inosine Monophosphate Dehydrogenase as a Probe in Antiviral Drug Discovery
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Identification of Novel Mt-Guab2 Inhibitor Series Active against M. tuberculosis
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Novel Inhibitors of Inosine Monophosphate Dehydrogenase in Patent Literature of the Last Decade
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Synthesis and Biological Activity of Some [(5-oxazolyl)-phenyl]-thiourea Derivatives
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Design, synthesis and biological evaluation of novel inosine 5′-monophosphate dehydrogenase (IMPDH) inhibitors
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Synthesis of the inosine 5′-monophosphate dehydrogenase (IMPDH) inhibitors
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Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story
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Progress towards Adjuvant Development: Focus on Antiviral Therapy
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A CONVENIENT SYNTHESIS OF 2-MERCAPTO-OXAZOLES VIA β-KETOAZIDE AND ITS APPLICATION TO A KEY INTERMEDIATE OF PI3Kγ INHIBITORS
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