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Antineoplastic Agents. 445. Synthesis and Evaluation of Structural Modifications of (Z)- and (E)-Combretastatin A-4
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Semiempirical studies of ring twisting in cis-stilbene and related biomolecules
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Synthesis of Lipid Derivatives of Colchicine
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Intramolecular nucleophilic cyclization of 3‐substituted pyridylalkylamines onto the 2‐position of the pyridine ring
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Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4
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Differential cytotoxicity of Combretastatins A1 and A4 in two daunorubicin-resistant P388 cell lines
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Steganacin: An inhibitor of HeLa cell growth and microtubule assembly
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Quantitative Structure–Activity Relationship Analysis of Combretastatins: A Class of Novel Antimitotic Agents
inferredcites →https://doi.org/10.1038/bjc.1995.138openalex-snapshot
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Effects of stilbene components of the roots of Polygonum cuspidatum Sieb. et Zucc. on lipid metabolism.
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Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Pt(IV) prodrugs containing microtubule inhibitors displayed potent antitumor activity and ability to overcome cisplatin resistance
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.111949openalex-snapshot
Microtubule inhibitors containing immunostimulatory agents promote cancer immunochemotherapy by inhibiting tubulin polymerization and tryptophan-2,3-dioxygenase
inferred← citeshttps://doi.org/10.1016/j.ejmech.2021.113275openalex-snapshot
Combretastatin A-4 sulfur-containing heterocyclic derivatives: Synthesis, antiproliferative activities and molecular docking studies
inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114573openalex-snapshot
Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors
inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.116497openalex-snapshot
Design, synthesis of combretastatin A-4 piperazine derivatives as potential antitumor agents by inhibiting tubulin polymerization and inducing autophagy in HCT116 cells
inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.116692openalex-snapshot
Candida antarctica Lipase B mediated kinetic resolution: A sustainable method for chiral synthesis of antiproliferative β-lactams
inferred← citeshttps://doi.org/10.1016/j.ejmech.2026.118742openalex-snapshot
Who's who in the field of combretastatin A4 analogues: ?
inferred← citeshttps://doi.org/10.1016/j.euus.2005.09.007openalex-snapshot
Novel Experimental Therapeutic Approaches for Prostate Cancer
inferred← citeshttps://doi.org/10.1016/j.mencom.2019.03.015openalex-snapshot
A convenient synthesis of cis-restricted combretastatin analogues with pyrazole and isoxazole cores
inferred← citeshttps://doi.org/10.1016/j.molcata.2011.09.025openalex-snapshot
An efficient synthesis of functional stilbenes in Hiyama coupling reaction catalysed by H-spirophosphorane palladium complex
inferred← citeshttps://doi.org/10.1016/j.molstruc.2022.134437openalex-snapshot
Design, synthesis, characterization, antioxidant, antiproliferative activity and molecular docking studies of new transition metal complexes of 1,2,4-triazole as combretastatin A-4 analogues
inferred← citeshttps://doi.org/10.1016/j.taap.2015.05.020openalex-snapshot
Structural modification of resveratrol leads to increased anti-tumor activity, but causes profound changes in the mode of action
inferred← citeshttps://doi.org/10.1016/j.tet.2006.03.090openalex-snapshot
Ultrasound-assisted synthesis of Z and E stilbenes by Suzuki cross-coupling reactions of organotellurides with potassium organotrifluoroborate salts
inferred← citeshttps://doi.org/10.1016/j.tet.2013.01.005openalex-snapshot
Synthesis of (Z) isomers of benzoheterocyclic derivatives of combretastatin A-4: a comparative study of several methods
inferred← citeshttps://doi.org/10.1016/j.tet.2023.133365openalex-snapshot
Synthesis of tetraalkoxyaryldihydrobenzo[g]indazoles from metabolites of dill and parsley seeds essential oil
inferred← citeshttps://doi.org/10.1016/j.tetlet.2007.07.151openalex-snapshot
A new synthesis of combretastatins A-4 and AVE-8062A
inferred← citeshttps://doi.org/10.1016/j.tetlet.2007.12.057openalex-snapshot
One-pot hydrosilylation–protodesilylation of functionalized diarylalkynes: a highly selective access to Z-stilbenes. Application to the synthesis of combretastatin A-4
inferred← citeshttps://doi.org/10.1016/j.ultsonch.2010.04.007openalex-snapshot
Ultrasonic activation of Heck type reactions in the presence of Aliquat-336
inferred← citeshttps://doi.org/10.1016/j.vph.2015.05.004openalex-snapshot
Exaggerated hypertensive response to combretastatin A-4 phosphate in hypertensive rats: Effective pharmacological inhibition by diltiazem
inferred← citeshttps://doi.org/10.1016/s1572-5995(08)80025-7openalex-snapshot
Natural stilbenes and analogues as antineoplastic agents
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.6b00353openalex-snapshot
Combretastatin A-4 Analogue: A Dual-Targeting and Tubulin Inhibitor Containing Antitumor Pt(IV) Moiety with a Unique Mode of Action
inferred← citeshttps://doi.org/10.1021/acs.jafc.4c00326openalex-snapshot
Trends in the Potential of Stilbenes to Improve Plant Stress Tolerance: Insights of Plant Defense Mechanisms in Response to Biotic and Abiotic Stressors
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b01086openalex-snapshot
Synthesis and Biochemical Evaluation of 3-Phenoxy-1,4-diarylazetidin-2-ones as Tubulin-Targeting Antitumor Agents
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b01971openalex-snapshot
Far-Red Light-Activatable Prodrug of Paclitaxel for the Combined Effects of Photodynamic Therapy and Site-Specific Paclitaxel Chemotherapy
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.0c00027openalex-snapshot
Synthesis and Cytotoxicity Studies of Stilbene Long-Chain Fatty Acid Conjugates
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.7b01062openalex-snapshot
Synthesis and in Vitro Bioactivity of Polyunsaturated Fatty Acid Conjugates of Combretastatin A-4
inferred← citeshttps://doi.org/10.1021/acs.joc.8b02563openalex-snapshot
One-Pot Synthesis of 2-Styrylindoles from Ortho -Substituted Chloroenynes
inferred← citeshttps://doi.org/10.1021/acs.orglett.5b02262openalex-snapshot
Synthesis, Characterization, and Bioactivity of the Photoisomerizable Tubulin Polymerization Inhibitor azo-Combretastatin A4
inferred← citeshttps://doi.org/10.1021/acscombsci.6b00023openalex-snapshot
Chemoselective and Sequential Palladium-Catalyzed Couplings for the Generation of Stilbene Libraries via Immobilized Substrates
inferred← citeshttps://doi.org/10.1021/acscombsci.8b00113openalex-snapshot
Sea Urchin Embryo Model As a Reliable in Vivo Phenotypic Screen to Characterize Selective Antimitotic Molecules. Comparative evaluation of Combretapyrazoles, -isoxazoles, -1,2,3-triazoles, and -pyrroles as Tubulin-Binding Agents
inferred← citeshttps://doi.org/10.1021/jm0512903openalex-snapshot
Medicinal Chemistry of Combretastatin A4: Present and Future Directions
inferred← citeshttps://doi.org/10.1021/jm061142sopenalex-snapshot
Highly Potent Triazole-Based Tubulin Polymerization Inhibitors
inferred← citeshttps://doi.org/10.1021/jm101115uopenalex-snapshot
Synthesis and Evaluation of Azetidinone Analogues of Combretastatin A-4 as Tubulin Targeting Agents
inferred← citeshttps://doi.org/10.1021/jm300596sopenalex-snapshot
Synthesis and Biological Evaluation of 1-Benzylidene-3,4-dihydronaphthalen-2-one as a New Class of Microtubule-Targeting Agents
inferred← citeshttps://doi.org/10.1021/jm3015603openalex-snapshot
Endowing Indole-Based Tubulin Inhibitors with an Anchor for Derivatization: Highly Potent 3-Substituted Indolephenstatins and Indoleisocombretastatins
inferred← citeshttps://doi.org/10.1021/jm400139wopenalex-snapshot
Site-Specific and Far-Red-Light-Activatable Prodrug of Combretastatin A-4 Using Photo-Unclick Chemistry
inferred← citeshttps://doi.org/10.1021/jm701362mopenalex-snapshot
Synthesis and Biological Activity of Fluorinated Combretastatin Analogues
inferred← citeshttps://doi.org/10.1021/jo062592vopenalex-snapshot
Cascade Synthesis of Polyoxygenated 6H,11H-[2]Benzopyrano-[4,3-c][1]benzopyran-11-ones
inferred← citeshttps://doi.org/10.1021/jo100247aopenalex-snapshot
Highly Chemo- and Stereoselective Palladium-Catalyzed Transfer Semihydrogenation of Internal Alkynes Affording cis -Alkenes
inferred← citeshttps://doi.org/10.1021/jo502802kopenalex-snapshot
Cu-Catalyzed Consecutive Hydroxylation and Aerobic Oxidative Cycloetherification under Microwave Conditions: Entry to 2-Arylbenzofuran-3-carboxylic Acids
inferred← citeshttps://doi.org/10.1021/np1004278openalex-snapshot
Synthesis of Antimitotic Polyalkoxyphenyl Derivatives of Combretastatin Using Plant Allylpolyalkoxybenzenes
inferred← citeshttps://doi.org/10.1021/np400310mopenalex-snapshot
cis-Restricted 3-Aminopyrazole Analogues of Combretastatins: Synthesis from Plant Polyalkoxybenzenes and Biological Evaluation in the Cytotoxicity and Phenotypic Sea Urchin Embryo Assays
inferred← citeshttps://doi.org/10.1021/np800661ropenalex-snapshot
Development of Synthetic Methodology Suitable for the Radiosynthesis of Combretastatin A-1 (CA1) and Its Corresponding Prodrug CA1P
inferred← citeshttps://doi.org/10.1021/np9002146openalex-snapshot
Antineoplastic Agents. 579. Synthesis and Cancer Cell Growth Evaluation of E-Stilstatin 3: A Resveratrol Structural Modification
inferred← citeshttps://doi.org/10.1039/c2ob26253copenalex-snapshot
Synthesis, biological evaluation, and structure–activity relationships of tri- and tetrasubstituted olefins related to isocombretastatin A-4 as new tubulin inhibitors
inferred← citeshttps://doi.org/10.1039/c3md00357dopenalex-snapshot
Combretastatin A-4 inspired novel 2-aryl-3-arylamino-imidazo-pyridines/pyrazines as tubulin polymerization inhibitors, antimitotic and anticancer agents
inferred← citeshttps://doi.org/10.1039/c7cy01344bopenalex-snapshot
One-pot Suzuki–Heck relay to prepare industrially valuable intermediates using the Pd–Cy*Phine catalyst system
inferred← citeshttps://doi.org/10.1039/c7md00450hopenalex-snapshot
New (3-(1 H -benzo[ d ]imidazol-2-yl))/(3-(3 H -imidazo[4,5- b ]pyridin-2-yl))-(1 H -indol-5-yl)(3,4,5-trimethoxyphenyl)methanone conjugates as tubulin polymerization inhibitors
inferred← citeshttps://doi.org/10.1039/c7ra04314gopenalex-snapshot
Identification of potential tubulin polymerization inhibitors by 3D-QSAR, molecular docking and molecular dynamics
inferred← citeshttps://doi.org/10.1039/c8ra02818dopenalex-snapshot
Diaryl ethers synthesis: nano-catalysts in carbon-oxygen cross-coupling reactions
inferred← citeshttps://doi.org/10.1039/c9ob00558gopenalex-snapshot
Synthesis and evaluation of antiproliferative microtubule-destabilising combretastatin A-4 piperazine conjugates
inferred← citeshttps://doi.org/10.1039/d4ra02867hopenalex-snapshot
Medicinal chemistry perspective on the structure–activity relationship of stilbene derivatives
inferred← citeshttps://doi.org/10.1080/00397911.2010.538889openalex-snapshot
Hydroxyl Substitutional Effect on Selective Synthesis of cis, trans Stilbenes and 3-Arylcoumarins Through Perkin Condensation
inferred← citeshttps://doi.org/10.1080/02603594.2022.2140146openalex-snapshot
Aminoethylpiperazine Based Metal Schiff Base Complexes: Catalytic and Biological Activities
inferred← citeshttps://doi.org/10.1080/10406638.2021.1991391openalex-snapshot
Synthesis of Tri-Substituted Olefin Derivatives from 1-Alkene-1,2-Diboronic Esters via Sequential Suzuki-Suzuki Coupling Reaction and Their Biological Activity
inferred← citeshttps://doi.org/10.1080/13543776.2019.1651841openalex-snapshot
Combretastatin-based compounds with therapeutic characteristics: a patent review
inferred← citeshttps://doi.org/10.1107/s0108270109019702openalex-snapshot
1,2,3-Trimethoxy-4-[(E)-2-phenylvinyl]benzene and (E,E)-1,4-bis(2,3,4-trimethoxyphenyl)buta-1,3-diene
inferred← citeshttps://doi.org/10.1107/s205322962001236xopenalex-snapshot
Two new polymorphic forms of combretastatin A-4, an antitumour agent
inferred← citeshttps://doi.org/10.1111/cbdd.12738openalex-snapshot
Synthesis and Biological Evaluation of 1,2,3‐triazole tethered Pyrazoline and Chalcone Derivatives
inferred← citeshttps://doi.org/10.1134/s1070363225608257openalex-snapshot
Synthesis and Study of the Structure and Cytotoxicity of Five-Membered Cyclic Structural Analogs of Combretastatin A4
inferred← citeshttps://doi.org/10.1134/s1070363226601845openalex-snapshot
Development of AVE-8063-Bearing Pt(IV) Prodrug for Dual-Action Light-Controlled Chemotherapy
inferred← citeshttps://doi.org/10.1186/1752-153x-7-179openalex-snapshot
Synthesis and biological evaluation of Combretastatin A-4 derivatives containing a 3’-O-substituted carbonic ether moiety as potential antitumor agents
inferred← citeshttps://doi.org/10.1186/2191-2858-3-3openalex-snapshot
Novel indole-bearing combretastatin analogues as tubulin polymerization inhibitors
inferred← citeshttps://doi.org/10.1186/s13765-019-0434-4openalex-snapshot
Synthesis and anticancer activities of polymethylenedioxy analogues of combretastatin A-2
inferred← citeshttps://doi.org/10.1371/journal.pone.0171806openalex-snapshot
Structurally simplified biphenyl combretastatin A4 derivatives retain in vitro anti-cancer activity dependent on mitotic arrest
inferred← citeshttps://doi.org/10.2174/0113852728314401240613045216openalex-snapshot
Synthesis of Polyoxygenated 4,5-Diarylpyridazines with Antiproliferative and Antitubulin Activity via Inverse Electron-Demand Diels-Alder Reaction of 1,2,4,5- Tetrazine
inferred← citeshttps://doi.org/10.2174/092986711794480221openalex-snapshot
Developments of Combretastatin A-4 Derivatives as Anticancer Agents
inferred← citeshttps://doi.org/10.2174/157340721002141001102524openalex-snapshot
Dietary Polyphenols for Prostate Cancer Therapy
inferred← citeshttps://doi.org/10.2174/1871520615666150819121106openalex-snapshot
Recent Developments on 1,2,4-Triazole Nucleus in Anticancer Compounds: A Review
inferred← citeshttps://doi.org/10.2174/2212796813666190926112807openalex-snapshot
Cytotoxicity Evaluation of Dimethoxy and Trimethoxy Indanonic Spiroisoxazolines Against Cancerous Liver Cells
inferred← citeshttps://doi.org/10.22038/ijbms.2020.40845.9648openalex-snapshot
Synthesis and biological evaluation of oxazinonaphthalene-3-one derivatives as potential anticancer agents and tubulin inhibitors.
inferred← citeshttps://doi.org/10.3109/09637486.2013.832172openalex-snapshot
Pancreatic lipase inhibitory stilbenoids from the roots ofVitis vinifera
inferred← citeshttps://doi.org/10.3109/14756360903169659openalex-snapshot
Lead identification of conformationally restricted benzoxepin type combretastatin analogs: synthesis, antiproliferative activity, and tubulin effects
inferred← citeshttps://doi.org/10.3390/biomedicines4030015openalex-snapshot
Design, Synthesis and Biochemical Evaluation of Novel Selective Estrogen Receptor Ligand Conjugates Incorporating an Endoxifen-Combretastatin Hybrid Scaffold
inferred← citeshttps://doi.org/10.3390/cells9051083openalex-snapshot
Tubulin Resists Degradation by Cereblon-Recruiting PROTACs
inferred← citeshttps://doi.org/10.3390/ijms222011033openalex-snapshot
Synthesis and Investigations of Building Blocks with Dibenzo[b,f] Oxepine for Use in Photopharmacology
inferred← citeshttps://doi.org/10.3390/molecules16086684openalex-snapshot
3D-QSAR Study of Combretastatin A-4 Analogs Based on Molecular Docking
inferred← citeshttps://doi.org/10.3390/molecules21101375openalex-snapshot
Novel Natural Product- and Privileged Scaffold-Based Tubulin Inhibitors Targeting the Colchicine Binding Site
inferred← citeshttps://doi.org/10.3390/molecules24183259openalex-snapshot
Design and Synthesis of Benzimidazole-Chalcone Derivatives as Potential Anticancer Agents
inferred← citeshttps://doi.org/10.3390/molecules27093036openalex-snapshot
A Review on Mechanistic Insight of Plant Derived Anticancer Bioactive Phytocompounds and Their Structure Activity Relationship
inferred← citeshttps://doi.org/10.3390/molecules27175654openalex-snapshot
Transition Metal Catalyzed Hiyama Cross-Coupling: Recent Methodology Developments and Synthetic Applications
inferred← citeshttps://doi.org/10.3390/molecules30020317openalex-snapshot
Synthesis and Biological Evaluation of New cis-Restricted Triazole Analogues of Combretastatin A-4
inferred← citeshttps://doi.org/10.3390/molecules30244788openalex-snapshot
Bromo Analogues of Active 3,4,5,4′-Tetramethoxy-trans-stilbene (DMU-212)—A New Path of Research to Anticancer Agents
inferred← citeshttps://doi.org/10.3390/ph12020056openalex-snapshot
3-Vinylazetidin-2-Ones: Synthesis, Antiproliferative and Tubulin Destabilizing Activity in MCF-7 and MDA-MB-231 Breast Cancer Cells
inferred← citeshttps://doi.org/10.3390/ph13010008openalex-snapshot
Colchicine-Binding Site Inhibitors from Chemistry to Clinic: A Review
inferred← citeshttps://doi.org/10.3892/or.2012.2181openalex-snapshot
Novel cis-restricted β-lactam combretastatin A-4 analogues display anti-vascular and anti-metastatic properties in vitro
inferred← citeshttps://doi.org/10.4155/fmc-2017-0100openalex-snapshot
Tubulin Inhibitors Targeting the Colchicine Binding Site: A Perspective of Privileged Structures
inferred← citeshttps://doi.org/10.5935/1984-6835.20150036openalex-snapshot
Combretastatins and their Analogues: Nature as na Alternative Source for the Therapy of Cancer
inferred← citeshttps://doi.org/10.70675/cb4b0dd4z634bz4299z96a9z469b89375839openalex-snapshot
Étude de la restauration de la réponse immunitaire antitumorale dans un modèle murin de cancer pulmonaire induit par une molécule multicible inhibitrice de HDAC et du splicéosome
inferred← citeshttps://doi.org/10.70675/fadd7eddz5149z43fdza617zc80ad7d39abdopenalex-snapshot
Synthèses et évaluations biologiques d’analogues de la combrétastatine A-4 et d’inhibiteurs de kinases DYRK
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