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Characteristic Physical Properties and Structural Fragments of Marketed Oral Drugs
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Molecular Properties That Influence the Oral Bioavailability of Drug Candidates
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A Comparison of Physiochemical Property Profiles of Development and Marketed Oral Drugs
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Polar Molecular Surface as a Dominating Determinant for Oral Absorption and Brain Penetration of Drugs
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Molecular and Pharmacokinetic Properties of 222 Commercially Available Oral Drugs in Humans.
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Examination of the Computed Molecular Properties of Compounds Selected for Clinical Development
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Gastrointestinal behavior of itraconazole in humans – Part 2: The effect of intraluminal dilution on the performance of a cyclodextrin-based solution
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2017.12.041openalex-snapshot
Enhancing the solubility and bioavailability of poorly water-soluble drugs using supercritical antisolvent (SAS) process
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2018.07.046openalex-snapshot
Drug metabolites and their effects on the development of adverse reactions: Revisiting Lipinski’s Rule of Five
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2019.05.064openalex-snapshot
Development of sorafenib loaded nanoparticles to improve oral bioavailability using a quality by design approach
inferred← citeshttps://doi.org/10.1016/j.jchromb.2007.05.024openalex-snapshot
Use of trifluoroacetic acid to quantify small, polar compounds in rat plasma during discovery-phase pharmacokinetic evaluation
inferred← citeshttps://doi.org/10.1016/j.jiec.2017.06.001openalex-snapshot
Nanostructured mucoadhesive microparticles to enhance oral drug bioavailability
inferred← citeshttps://doi.org/10.1016/j.jmgm.2010.04.007openalex-snapshot
Computational identification of bioactive natural products by structure activity relationship
inferred← citeshttps://doi.org/10.1016/j.jmgm.2015.12.001openalex-snapshot
LOX1 inhibition with small molecules
inferred← citeshttps://doi.org/10.1016/j.molcata.2013.10.029openalex-snapshot
Iridium-catalyzed N-alkylation of diamines with glycerol
inferred← citeshttps://doi.org/10.1016/j.molstruc.2022.134097openalex-snapshot
Synthesis, crystal structure and thermal investigation of molecular salts of (R)-1-phenylethanamine combined with quantum chemical studies
inferred← citeshttps://doi.org/10.1016/j.pharma.2023.05.004openalex-snapshot
Comparative assessment of solubility enhancement of itroconazole by solid dispersion and co-crystallization technique: Investigation of simultaneous effect of media composition on drug dissolution
inferred← citeshttps://doi.org/10.1016/j.pt.2004.07.008openalex-snapshot
Genomic filtering: an approach to discovering novel antiparasitics
inferred← citeshttps://doi.org/10.1016/j.tet.2018.05.076openalex-snapshot
Palladium-catalyzed ortho-olefination of 2-arylpyrrolidines: A tool for increasing structural complexity in nitrogen heterocycles
inferred← citeshttps://doi.org/10.1016/j.tetasy.2009.12.025openalex-snapshot
Synthesis of new polysubstituted piperazines and dihydro-2H-pyrazines by selective reduction of 2-oxo-piperazines
inferred← citeshttps://doi.org/10.1016/j.tetasy.2012.11.015openalex-snapshot
Stereoselective cyclopropanation of chiral 5-substituted dihydro-2H-piperazines
inferred← citeshttps://doi.org/10.1016/j.tetlet.2005.06.020openalex-snapshot
Synthesis of novel piperazine based building blocks: 3,7,9-triazabicyclo[3.3.1]nonane, 3,6,8-triazabicyclo[3.2.2]nonane, 3-oxa-7,9-diazabicyclo[3.3.1]nonane and 3-oxa-6,8-diazabicyclo[3.2.2]nonane
inferred← citeshttps://doi.org/10.1016/j.tetlet.2010.06.019openalex-snapshot
Synthesis of substituted 4-pyridones and 4-aminopyridinium salts via a one-pot pyridine synthesis
inferred← citeshttps://doi.org/10.1016/j.tetlet.2014.12.032openalex-snapshot
Rhodium(II)-catalyzed transannulation of 1-sulfonyl-1,2,3-triazoles with 2 H -azirines: a new method to dihydropyrazines
inferred← citeshttps://doi.org/10.1016/j.tetlet.2018.03.071openalex-snapshot
Dehydrogenative etherification homocoupling of heterocyclic N-oxides
inferred← citeshttps://doi.org/10.1016/j.tibtech.2005.07.003openalex-snapshot
Response to Froloff: Probing system structure–effect relationships
inferred← citeshttps://doi.org/10.1016/j.tibtech.2005.07.004openalex-snapshot
Probing drug action using in vitro pharmacological profiles
inferred← citeshttps://doi.org/10.1016/j.xphs.2020.08.008openalex-snapshot
A Retrospective Biopharmaceutical Analysis of >800 Approved Oral Drug Products: Are Drug Properties of Solid Dispersions and Lipid-Based Formulations Distinctive?
inferred← citeshttps://doi.org/10.1016/s0065-7743(07)42029-2openalex-snapshot
Chapter 29 Computational Models for ADME
inferred← citeshttps://doi.org/10.1016/s0065-7743(10)45024-1openalex-snapshot
Reducing the Risk of Drug Attrition Associated with Physicochemical Properties
inferred← citeshttps://doi.org/10.1016/s0066-4103(06)60002-1openalex-snapshot
NMR Methods for Characterising Ligand-Receptor and Drug–Membrane Interactions in Pharmaceutical Research
inferred← citeshttps://doi.org/10.1016/s0074-7742(07)82015-0openalex-snapshot
Glia Proinflammatory Cytokine Upregulation as a Therapeutic Target for Neurodegenerative Diseases: Function‐Based and Target‐Based Discovery Approaches
inferred← citeshttps://doi.org/10.1016/s0079-6468(09)04801-2openalex-snapshot
Medicinal Chemistry by the Numbers: The Physicochemistry, Thermodynamics and Kinetics of Modern Drug Design
inferred← citeshttps://doi.org/10.1016/s1359-6446(04)03275-1openalex-snapshot
High-throughput drug discovery: What can we expect from HTS?
inferred← citeshttps://doi.org/10.1016/s1359-6446(05)03386-6openalex-snapshot
Ligand efficiency indices as guideposts for drug discovery
inferred← citeshttps://doi.org/10.1016/s1359-6446(05)03477-xopenalex-snapshot
Kinomics: characterizing the therapeutically validated kinase space
inferred← citeshttps://doi.org/10.1016/s1359-6446(05)03557-9openalex-snapshot
Reengineering the pharmaceutical industry by crash-testing molecules
inferred← citeshttps://doi.org/10.1016/s1574-1400(05)01011-xopenalex-snapshot
Capter 11 Filtering in Drug Discovery
inferred← citeshttps://doi.org/10.1017/cbo9780511730412.005openalex-snapshot
Fragment-based structure-guided drug discovery: strategy, process, and lessons from human protein kinases
inferred← citeshttps://doi.org/10.1017/cbo9780511730412.006openalex-snapshot
NMR in fragment-based drug discovery
inferred← citeshttps://doi.org/10.1017/cbo9780511730412.013openalex-snapshot
Predicting ADME properties in drug discovery
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.6b00043openalex-snapshot
Improving Drug Design: An Update on Recent Applications of Efficiency Metrics, Strategies for Replacing Problematic Elements, and Compounds in Nontraditional Drug Space
inferred← citeshttps://doi.org/10.1021/acs.chemrev.5b00583openalex-snapshot
Experimental Binding Energies in Supramolecular Complexes
inferred← citeshttps://doi.org/10.1021/acs.jcim.6c01285openalex-snapshot
Toward the Engineering of Chameleonicity: Quantum Mechanical Prediction for the Octanol/Water Distributions of Large Flexible Triazine Macrocycles
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.2c00252openalex-snapshot
Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction–Reconstruction and Fragment-Growing Approach
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.2c01147openalex-snapshot
Hydrogen-Bond Donors in Drug Design
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.4c03078openalex-snapshot
Tertiary Alcohol: Reaping the Benefits but Minimizing the Drawbacks of Hydroxy Groups in Drug Discovery
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b00552openalex-snapshot
Effect of Chirality on Common in Vitro Experiments: An Enantiomeric Pair Analysis
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b00412openalex-snapshot
An N , N -Bis(benzimidazolylpicolinoyl)piperazine (BT-11): A Novel Lanthionine Synthetase C-Like 2-Based Therapeutic for Inflammatory Bowel Disease
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b01469openalex-snapshot
CNS Physicochemical Property Space Shaped by a Diverse Set of Molecules with Experimentally Determined Exposure in the Mouse Brain
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b00137openalex-snapshot
Discovery of a Highly Selective Tankyrase Inhibitor Displaying Growth Inhibition Effects against a Diverse Range of Tumor Derived Cell Lines
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b00686openalex-snapshot
Two Decades under the Influence of the Rule of Five and the Changing Properties of Approved Oral Drugs
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b01259openalex-snapshot
Lipophilic Permeability Efficiency Reconciles the Opposing Roles of Lipophilicity in Membrane Permeability and Aqueous Solubility
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.5b00255openalex-snapshot
Analysis of Physicochemical Properties for Drugs of Natural Origin
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.5b00204openalex-snapshot
Augmented Inhibition of CYP3A4 in Human Primary Hepatocytes by Ritonavir Solid Drug Nanoparticles
inferred← citeshttps://doi.org/10.1021/acs.oprd.8b00090openalex-snapshot
Development of an SNAr Reaction: A Practical and Scalable Strategy To Sequester and Remove HF
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.2c00375openalex-snapshot
Advancing New Chemical Modalities into Clinical Studies
inferred← citeshttps://doi.org/10.1021/acsomega.9b00667openalex-snapshot
Revealing Drug Self-Associations into Nano-Entities
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