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Novel Dicationic Imidazo[1,2-a]pyridines and 5,6,7,8-Tetrahydro-imidazo[1,2-a]pyridines as Antiprotozoal Agents

https://doi.org/10.1021/jm0400092
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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/3527601783.ch16openalex-snapshot
Dicationic DNA Minor Groove Binders as Antimicrobial Agents
inferredcites →https://doi.org/10.1016/s0040-4020(02)00585-9openalex-snapshot
Chemistry of bicyclic pyridines containing a ring-junction nitrogen
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A highly catalytic robust palladium catalyzed cyanation of aryl bromides
inferredcites →https://doi.org/10.1021/bi0108453openalex-snapshot
Recognition of ATGA Sequences by the Unfused Aromatic Dication DB293 Forming Stacked Dimers in the DNA Minor Groove
inferredcites →https://doi.org/10.1021/bi952162ropenalex-snapshot
A Crystallographic and Spectroscopic Study of the Complex between d(CGCGAATTCGCG)2 and 2,5-Bis(4-guanylphenyl)furan, an Analogue of Berenil. Structural Origins of Enhanced DNA-Binding Affinity
inferredcites →https://doi.org/10.1021/ja00121a034openalex-snapshot
Analysis of van der Waals and Electrostatic Contributions in the Interactions of Minor Groove Binding Benzimidazoles with DNA
inferredcites →https://doi.org/10.1021/jm00006a009openalex-snapshot
Dicationic Diarylfurans as Anti-Pneumocystis carinii Agents
inferredcites →https://doi.org/10.1021/jm00205a005openalex-snapshot
Diarylamidine derivatives with one or both of the aryl moieties consisting of an indole or indole-like ring. Inhibitors of arginine-specific esteroproteases
inferredcites →https://doi.org/10.1021/jm0302602openalex-snapshot
Synthesis and Antiprotozoal Activity of Aza-Analogues of Furamidine
inferredcites →https://doi.org/10.1021/jm9507946openalex-snapshot
Synthesis and DNA Interactions of Benzimidazole Dications Which Have Activity against Opportunistic Infections
inferredcites →https://doi.org/10.1021/jm9604484openalex-snapshot
Targeting the Minor Groove of DNA: Crystal Structures of Two Complexes between Furan Derivatives of Berenil and the DNA Dodecamer d(CGCGAATTCGCG)2
inferredcites →https://doi.org/10.1021/jm970570iopenalex-snapshot
2,5-Bis[4-(N-alkylamidino)phenyl]furans as Anti-Pneumocystis carinii Agents
inferredcites →https://doi.org/10.1021/jm980230copenalex-snapshot
Extended Aromatic Furan Amidino Derivatives as Anti-Pneumocystis carinii Agents
inferredcites →https://doi.org/10.1021/jm9803368openalex-snapshot
Bis-Cationic Heteroaromatics as Macrofilaricides: Synthesis of Bis-Amidine and Bis-Guanylhydrazone Derivatives of Substituted Imidazo[1,2-a]pyridines
inferredcites →https://doi.org/10.1021/jm9810405openalex-snapshot
2-Amino-3-substituted-6-[(E)-1-phenyl-2-(N-methylcarbamoyl)vinyl]imidazo[1,2-a]pyridines as a Novel Class of Inhibitors of Human Rhinovirus: Stereospecific Synthesis and Antiviral Activity
inferredcites →https://doi.org/10.1021/jm990071copenalex-snapshot
2,4-Diphenyl Furan Diamidines as Novel Anti-Pneumocystis carinii Pneumonia Agents
inferredcites →https://doi.org/10.1021/jo026258kopenalex-snapshot
Concise Preparation of Amino-5,6,7,8-tetrahydroquinolines and Amino-5,6,7,8-tetrahydroisoquinolines via Catalytic Hydrogenation of Acetamidoquinolines and Acetamidoisoquinolines
inferredcites →https://doi.org/10.1128/aac.38.9.1890openalex-snapshot
Selective inhibition of topoisomerases from Pneumocystis carinii compared with that of topoisomerases from mammalian cells

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Synthesis and Potent Antimicrobial Activities of Some Novel Retinoidal Monocationic Benzimidazoles
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Tin(II) Chloride Dihydrate Catalyzed Groebke Condensation: An Efficient Protocol for the Synthesis of 3‐Aminoimidazo[1,2‐a]pyridines
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Antimalarial Cation‐dimers Synthesized in Two Steps from an Inexpensive Starting Material, Isonicotinic Acid
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Highly Efficient and Practical Thiocyanation of Imidazopyridines Using an N ‐Chlorosuccinimide/NaSCN Combination
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An Efficient One‐Pot Four‐Component Synthesis of Functionalized Imidazo[1,2‐a]pyridines
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Solvent and catalyst‐free synthesis of imidazo[1,2‐a]pyridines by grindstone chemistry
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Some nucleophilic substitutions in 2‐cyano‐3‐nitroimidazo[1,2‐a]pyridine
inferred← citeshttps://doi.org/10.1002/jhet.5570440649openalex-snapshot
An alternate approach for the synthesis of 2‐substituted‐arylimidazo[4,5‐b]pyridines and their anti‐bacterial activity
inferred← citeshttps://doi.org/10.1002/jmr.2342openalex-snapshot
Molecular dynamics simulation studies for DNA sequence recognition by reactive metabolites of anticancer compounds
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inferred← citeshttps://doi.org/10.1002/tcr.202100240openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11164-013-1352-4openalex-snapshot
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Imidazo[1,2-a]pyridine: a Highly Potent Therapeutic Agent Clears Piroplasm Infection In Vitro
inferred← citeshttps://doi.org/10.1007/s13738-019-01845-6openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s40009-019-00795-0openalex-snapshot
Cu2O/Nano-CuFe2O4 as a Magnetically Recoverable Catalyst for Ligand-Free Synthesis of Imidazo[1,2-a] Pyridines and 3-Aroylimidazo[1,2-a] Pyridines
inferred← citeshttps://doi.org/10.1007/s42823-023-00603-2openalex-snapshot
Design, synthesis and biological studies of tetrazole fused imidazopyridines
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Advances in the Discovery of New Antimalarials
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Bicyclic 5-6 Systems with One Bridgehead (Ring Junction) Nitrogen Atom: One Extra Heteroatom 1:0
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Polar [3 + 2] cycloaddition of isatin-3-imines with electrophilically activated heteroaromatic N-ylides: Synthesis of spirocyclic imidazo[1,2-a]pyridine and isoquinoline derivatives
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Synthesis, molecular modeling Insights, and anticancer assessment of novel polyfunctionalized Pyridine congeners
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Structure–activity relationship of chalcones and related derivatives as ligands for detecting of β-amyloid plaques in the brain
inferred← citeshttps://doi.org/10.1016/j.bmc.2007.10.042openalex-snapshot
Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines
inferred← citeshttps://doi.org/10.1016/j.bmc.2008.04.051openalex-snapshot
Pyridinium cationic-dimer antimalarials, unlike chloroquine, act selectively between the schizont stage and the ring stage of Plasmodium falciparum
inferred← citeshttps://doi.org/10.1016/j.bmc.2010.01.013openalex-snapshot
Antimalarial and antitubercular nostocarboline and eudistomin derivatives: Synthesis, in vitro and in vivo biological evaluation
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Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: Synthesis and SAR of novel analogs of MBX 1066 and MBX 1090
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Potent and selective antiplasmodial activity of the cyanobacterial alkaloid nostocarboline and its dimers
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Design, synthesis and biological evaluation of amide derivatives of isoxazole-imidazo[1,2-a]pyridine as anticancer agents
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Synthesis and biological evaluation of tetrazole fused imidazopyridine derivatives as anticancer agents
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Composés á structure imidazopyridinyl-arylpropénone, nouveaux agents anti-infectieux potentiels
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Modulation of carcinogen metabolizing enzymes by new fused heterocycles pendant to 5,6,7,8-tetrahydronaphthalene derivatives
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Synthesis and structure-activity relationship of novel bisindole amidines active against MDR Gram-positive and Gram-negative bacteria
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The position of imidazopyridine and metabolic activation are pivotal factors in the antimutagenic activity of novel imidazo[1,2-a]pyridine derivatives
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Antiprotozoal agents as water soluble singlet oxygen photosensitizers: Imidazo[1,2-a]pyridine and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridine derivatives
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New fluorescent heterocyclic systems from imidazo[1,2- a ]pyridine: Design, synthesis, spectral studies and quantum-chemical investigations
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Palladium-catalyzed facile synthesis of imidazo[1,2-a]pyridine-flavone hybrids and evaluation of their antiplasmodial activity
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Synthesis, spectroscopic characterization, crystal structure, DFT calculations, anti-cancer activities and Hirshfeld surface analysis of 2-((4-chlorophenyl)amino)-2-oxoethyl 2-ethylimidazo[1,2-a]pyridine-3-carboxylate
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Novel 3-aminoimidazole[1,2-α]pyridine/pyrazine analogues: Synthesis and biological evaluation as anticancer agents
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Imidazo[1,2-a]pyridin-2-ylacetic acid and two pairs of isomorphous ML2(H2O)2 dihydrates (M=Ni, Co and Mn, Cd) based on its anion: Syntheses, crystal structures and properties
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Synthesis, spectroscopic and DFT studies of novel fluorescent dyes: 3-Aminoimidazo[1,2-a]pyridines possessing 4-pyrone moieties
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Efficient synthesis of imidazo[1,2-a]pyridin-3(2H)-ones
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A convenient synthesis of linear pyridinoimidazo[1,2-a]pyridine and pyrroloimidazo[1,2-a]pyridine cores
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Catalyst-free three-component reaction between 2-aminopyridines (or 2-aminothiazoles), aldehydes, and isocyanides in water
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Efficient one-pot synthesis of 1-alkoxy-2-arylaminoimidazolines from N-alkoxy-N-(2-aminoethyl)-2-nitrobenzenesulfonamides and arylisothiocyanates
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Catalyst-free synthesis of 3-(alkylamino)-2-arylimidazo[1,2-a]pyridine-8-carboxylic acids via a three-component condensation
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Iron(III)-catalyzed synthesis of 3-aroylimidazo[1,2-a]pyridines from 2-aminopyridines and ynals
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Chapter 6 Furans and benzo[b]furans
inferred← citeshttps://doi.org/10.1017/s0031182013000292openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acs.cgd.7b00798openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b01448openalex-snapshot
Heterocyclic Diamidine DNA Ligands as HOXA9 Transcription Factor Inhibitors: Design, Molecular Evaluation, and Cellular Consequences in a HOXA9-Dependant Leukemia Cell Model
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.7b00484openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acs.joc.1c00023openalex-snapshot
I 2 -Catalyzed Three-Component Consecutive Reaction for the Synthesis of 3-Aroylimidazo[1,2- a ]- N -Heterocycles
inferred← citeshttps://doi.org/10.1021/acs.joc.3c00960openalex-snapshot
Rh-Catalyzed Twofold Conjugate Addition of 2-Arylimidazo[1,2- a ]pyridines to p -Quinols To Access Bridged Scaffolds with Three Contiguous Stereocenters
inferred← citeshttps://doi.org/10.1021/acs.joc.7b00750openalex-snapshot
Visible-Light-Induced Regioselective Cyanomethylation of Imidazopyridines and Its Application in Drug Synthesis
inferred← citeshttps://doi.org/10.1021/acs.joc.9b01188openalex-snapshot
Lewis Acid-Catalyzed Intermolecular Annulation: Three-Component Reaction toward Imidazo[1,2-a]pyridine Thiones
inferred← citeshttps://doi.org/10.1021/acs.oprd.9b00511openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acscombsci.7b00173openalex-snapshot
Efficient Access to Imidazo[1,2- a ]pyridines/pyrazines/pyrimidines via Catalyst-Free Annulation Reaction under Microwave Irradiation in Green Solvent
inferred← citeshttps://doi.org/10.1021/ja202006uopenalex-snapshot
Water-Mediated Binding of Agents that Target the DNA Minor Groove
inferred← citeshttps://doi.org/10.1021/jm901178dopenalex-snapshot
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inferred← citeshttps://doi.org/10.1021/jo3021105openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/ol200508xopenalex-snapshot
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inferred← citeshttps://doi.org/10.1038/s41598-018-37486-7openalex-snapshot
Crystal Correlation Of Heterocyclic Imidazo[1,2-a]pyridine Analogues and Their Anticholinesterase Potential Evaluation
inferred← citeshttps://doi.org/10.1039/b505569eopenalex-snapshot
[5C + 1N] Annulation: a novel synthetic strategy for functionalized 2,3-dihydro-4-pyridones
inferred← citeshttps://doi.org/10.1039/b719641eopenalex-snapshot
Regiochemistry of the microwave-assisted reaction between aromatic amines and α-bromoketones to yield substituted 1H-indoles
inferred← citeshttps://doi.org/10.1039/b814930eopenalex-snapshot
Conjugated imines and iminium salts as versatile acceptors of nucleophiles
inferred← citeshttps://doi.org/10.1039/c1ra00242bopenalex-snapshot
Three-component solvent-free synthesis of highly substituted tetra-hydroimidazo[1,2-a]pyridines
inferred← citeshttps://doi.org/10.1039/c3ra43221aopenalex-snapshot
Facile synthesis of imidazo[1,2-a]pyridines via a one-pot three-component reaction under solvent-free mechanochemical ball-milling conditions
inferred← citeshttps://doi.org/10.1039/c3ra45485aopenalex-snapshot
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inferred← citeshttps://doi.org/10.1039/c4ra09196eopenalex-snapshot
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inferred← citeshttps://doi.org/10.1039/c5ra02809dopenalex-snapshot
Ga(OTf) 3 -promoted synthesis of functionalized 2-carbonyl-imidazo[1,2-a]pyridines derived from ethyl α-benzotriazolyl-α-morpholinoacetate
inferred← citeshttps://doi.org/10.1039/c6ra19291bopenalex-snapshot
Transition-metal-free C–C bond cleavage and formation: efficient synthesis of 2,3-diarylimidazo[1,2-α]pyridines from 2-aminopyridines and alkynoates
inferred← citeshttps://doi.org/10.1039/c7ob01384aopenalex-snapshot
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inferred← citeshttps://doi.org/10.1039/c7ob02750hopenalex-snapshot
Iodine–NH 4 OAc mediated regioselective synthesis of 2-aroyl-3-arylimidazo[1,2- a ]pyridines from 1,3-diaryl-prop-2-en-1-ones
inferred← citeshttps://doi.org/10.1039/c8gc03622eopenalex-snapshot
Electrochemically initiated intermolecular C–N formation/cyclization of ketones with 2-aminopyridines: an efficient method for the synthesis of imidazo[1,2- a ]pyridines
inferred← citeshttps://doi.org/10.1039/d1cc04602kopenalex-snapshot
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inferred← citeshttps://doi.org/10.1039/d3gc04062copenalex-snapshot
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inferred← citeshttps://doi.org/10.1039/d3qo01508dopenalex-snapshot
Synthesis of imidazo[1,2- a ]pyridinones via a visible light-photocatalyzed functionalization of alkynes/nitrile insertion/cyclization tandem sequence using micro-flow technology
inferred← citeshttps://doi.org/10.1039/d3ra03531jopenalex-snapshot
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inferred← citeshttps://doi.org/10.1039/d5nj03149dopenalex-snapshot
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inferred← citeshttps://doi.org/10.1039/d6ra02944bopenalex-snapshot
Potassium thiocyanate-promoted four-component alkoxysulfenylation of styrenes with imidazo[1,2- a ]pyridines and alcohols
inferred← citeshttps://doi.org/10.1080/00304948.2025.2453802openalex-snapshot
Application of Fe 3 O 4 @THAM‑CH 2 CH 2 ‑SCH 2 CO 2 H Magnetic Nanoparticles as an Acidic, Recyclable and Green Catalyst for the Synthesis of Hexahydroacridine-1,8-diones, Hexahydroquinolines, and 2-Amino-3-cyanopyridines
inferred← citeshttps://doi.org/10.1080/00397910701862931openalex-snapshot
Rapid Synthesis of 3‐Aminoimidazo[1,2‐a]Pyridines and Pyrazines
inferred← citeshttps://doi.org/10.1080/00397910802573155openalex-snapshot
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inferred← citeshttps://doi.org/10.1080/10406638.2020.1866033openalex-snapshot
Synthesis and Antioxidant Activity of Functionalized Pyridinyl-Methylthiosemicarbazide Derivatives
inferred← citeshttps://doi.org/10.1080/10426507.2010.514683openalex-snapshot
Pd-Catalyzed Heterocyclization During Sonogashira Coupling: Synthesis of 3-Aryl-substituted Imidazo[2,1-b]thiazoles
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New developments in human African trypanosomiasis
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Antimicrobial, Antimalarial, and Antileishmanial Activities of Mono‐ and Bis‐quaternary Pyridinium Compounds
inferred← citeshttps://doi.org/10.1128/aac.00005-07openalex-snapshot
Diphenyl Furans and Aza Analogs: Effects of Structural Modification on In Vitro Activity, DNA Binding, and Accumulation and Distribution in Trypanosomes
inferred← citeshttps://doi.org/10.1128/aac.00422-09openalex-snapshot
In Vivo Investigations of Selected Diamidine Compounds againstTrypanosoma evansiUsing a Mouse Model
inferred← citeshttps://doi.org/10.1128/aac.00811-16openalex-snapshot
Antiprion Activity of DB772 and Related Monothiophene- and Furan-Based Analogs in a Persistently Infected Ovine Microglia Culture System
inferred← citeshttps://doi.org/10.1128/aac.01482-10openalex-snapshot
Novel Diamidines with Activity against Babesia divergens In Vitro and Babesia microti In Vivo
inferred← citeshttps://doi.org/10.1134/s1070428023090208openalex-snapshot
Microwave-Assisted Synthesis of New Schiff Bases from Imidazo[1,2-a]pyridine-3-carbaldehyde and Aromatic Amines in PEG-400 as a Green Approach
inferred← citeshttps://doi.org/10.1155/2013/296792openalex-snapshot
A Convenient Synthesis of C‐3‐Aryloxymethyl Imidazo[1,2‐a]Pyridine Derivatives
inferred← citeshttps://doi.org/10.1177/1747519819893060openalex-snapshot
3-(Hydroxyimino)imidazo[1,2- a ]pyridin-2(3 H )-ylidene)-1-arylethanones as new red heterocyclic dyes: Synthesis, spectral studies, quantum-chemical investigations, and antibacterial activities
inferred← citeshttps://doi.org/10.1186/s13065-025-01412-6openalex-snapshot
Synthesis and biological activities of 3-aminoimidazo[1,2-α]pyridine compounds
inferred← citeshttps://doi.org/10.1371/journal.pone.0069982openalex-snapshot
Design, Synthesis, Evaluation and Thermodynamics of 1-Substituted Pyridylimidazo[1,5-a]Pyridine Derivatives as Cysteine Protease Inhibitors
inferred← citeshttps://doi.org/10.1371/journal.pone.0091660openalex-snapshot
Novel Potent Imidazo[1,2-a]pyridine-N-Glycinyl-Hydrazone Inhibitors of TNF-α Production: In Vitro and In Vivo Studies
inferred← citeshttps://doi.org/10.1517/13543776.15.9.1241openalex-snapshot
Recent advances in antitrypanosomal chemotherapy: patent literature 2002 – 2004
inferred← citeshttps://doi.org/10.1517/13543784.14.8.939openalex-snapshot
Novel antitrypanosomal agents
inferred← citeshttps://doi.org/10.1517/13543784.14.8.957openalex-snapshot
Aromatic diamidines as antiparasitic agents
inferred← citeshttps://doi.org/10.2174/0113852728264863231017071522openalex-snapshot
Energy-efficient Approach to Multicomponent Reaction for the Synthesis of Therapeutically Relevant Heterocycles
inferred← citeshttps://doi.org/10.2174/0113852728367154250617095504openalex-snapshot
Exploring Synthesis and Functionalization of Imidazo[1,2˗a]pyridines: A Promising Heterocyclic Framework
inferred← citeshttps://doi.org/10.2174/0118715265274067240223040333openalex-snapshot
Imidazo[1,2-A]Pyridine: Potent Biological Activity, SAR and Docking Investigations (2017-2022)
inferred← citeshttps://doi.org/10.2174/1385272823666191029114830openalex-snapshot
A Review of Cationic Arylfurans and Their Isosteres: Synthesis and Biological Importance
inferred← citeshttps://doi.org/10.2174/1570178620666221116093457openalex-snapshot
Acemannan from Aloe vera Extract: A Catalyst-Free, Approach for the Access of Imidazole-Fused Nitrogen-Bridgehead Heterocycles
inferred← citeshttps://doi.org/10.3184/030823409x401844openalex-snapshot
An Efficient, Catalyst- and Solvent-Free Synthesis of imidazo[1,2- a ]pyridines and 2,4-disubstituted thiazoles on Grinding
inferred← citeshttps://doi.org/10.3184/174751916x14683327937934openalex-snapshot
Solvent- and catalyst-free synthesis of imidazo[1,2-a]pyridines under microwave irradiation
inferred← citeshttps://doi.org/10.3184/174751917x14873588907684openalex-snapshot
Synthesis of New Dyes from Imidazo[1,2-a]Pyridine: Tautomerism, Spectroscopic Characterisation, DFT/TD-DFT Calculations, Atoms in Molecules Analyses and Antibacterial Activities
inferred← citeshttps://doi.org/10.3390/inorganics12050139openalex-snapshot
Supramolecular Assemblies in Mn(II) and Zn(II) Metal–Organic Compounds Involving Phenanthroline and Benzoate: Experimental and Theoretical Studies
inferred← citeshttps://doi.org/10.3390/molecules24050946openalex-snapshot
A New Generation of Minor-Groove-Binding—Heterocyclic Diamidines That Recognize G·C Base Pairs in an AT Sequence Context
inferred← citeshttps://doi.org/10.3987/com-10-12074openalex-snapshot
Heck Reactions in 2,6-Diaryl-3,5-dibromo-4-pyrones in the Presence of N,N’-Dibutylbenzimidazolium Bromide
inferred← citeshttps://doi.org/10.3987/rev-12-726openalex-snapshot
Synthesis of Nitrogen-Containing Heterocycles Using Conjugate Addition Reactions of Nucleophiles to α,β-Unsaturated Imines
inferred← citeshttps://doi.org/10.4018/979-8-3693-7267-8.ch011openalex-snapshot
Imidazo-Pyridines
inferred← citeshttps://doi.org/10.4155/fmc-2019-0244openalex-snapshot
Discovery of Novel 2-aminonicotinonitrile Derivatives With New Potential Autophagy Activity
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