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A Three-Dimensional in Silico Pharmacophore Model for Inhibition of Plasmodium falciparum Cyclin-Dependent Kinases and Discovery of Different Classes of Novel Pfmrk Specific Inhibitors

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Plasmodium falciparum protein kinase 5 and the malarial nuclear division cycles

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Structure-activity relationship study of antimalarial indolo [2,1-b]quinazoline-6,12-diones (tryptanthrins). Three dimensional pharmacophore modeling and identification of new antimalarial candidates

inferredcites →https://doi.org/10.1016/j.jmgm.2003.09.002openalex-snapshot

Characteristics of the Plasmodium falciparum PK5 ATP-binding site: implications for the design of novel antimalarial agents

inferredcites →https://doi.org/10.1016/j.str.2003.09.020openalex-snapshot

Structures of P. falciparum PfPK5 Test the CDK Regulation Paradigm and Suggest Mechanisms of Small Molecule Inhibition

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Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum11Abbreviations: CDK, cyclin-dependent kinase; CDK1, cyclin-dependent kinase 1; and PfPK, Plasmodium falciparum protein kinase.

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Cyclin-dependent kinase homologues of Plasmodium falciparum

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Cyclin-dependent kinases as potential targets to improve stroke outcome

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Chemical Inhibitors of Cyclin-Dependent Kinases

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Properties and Potential Applications of Chemical Inhibitors of Cyclin-Dependent Kinases

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Pharmacological inhibitors of cyclin-dependent kinases

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Cyclin H activation and drug susceptibility of the Pfmrk cyclin dependent protein kinase from Plasmodium falciparum

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Clinical status and implications of antimalarial drug resistance

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A QSAR Study of the Antimalarial Activity of Some Synthetic 1,2,4-Trioxanes

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Oxindole-Based Compounds Are Selective Inhibitors of Plasmodium falciparum Cyclin Dependent Protein Kinases

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Crystal structure of cyclin-dependent kinase 2

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Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

inferredcites →https://doi.org/10.1074/jbc.275.12.8952openalex-snapshot

Activation of a Plasmodium falciparum cdc2-related Kinase by Heterologous p25 and Cyclin H

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Crystallographic Approach to Identification of Cyclin-dependent Kinase 4 (CDK4)-specific Inhibitors by Using CDK4 Mimic CDK2 Protein

inferredcites →https://doi.org/10.1111/j.1432-1033.1997.0518a.xopenalex-snapshot

Inhibition of Cyclin‐Dependent Kinases by Purine Analogues

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Designing Inhibitors of Cyclin-Dependent Kinases

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Cyclin-dependent protein kinases as therapeutic drug targets for antimalarial drug development

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Pharmacophore Modeling and Three-dimensional Database Searching for Drug Design Using Catalyst

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Inhibiting Cyclin-Dependent Kinase / Cyclin Activity for the Treatment of Cancer and Cardiovascular Disease

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A Comparison of Methods for Pharmacophore Generation with the Catalyst Software and their Use for 3D-QSAR Application to a Set of 4-Aminopyridine Thrombin Inhibitors

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The ears of the hippopotamus: manifestations, determinants, and estimates of the malaria burden

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Antimalarials

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Targeting the Malaria Kinome: Discovering Kinase Inhibitors as Novel Antimalarial Agents

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Recent advances in antimalarial drug development

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Beyond QSAR: Lead Hopping to Different Structures

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In Silico Three Dimensional Pharmacophore Models to Aid the Discovery and Design of New Antimalarial Agents

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Malarial Kinases: Novel Targets for In Silico Approaches to Drug Discovery

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Design and tests of prospective property predictions for novel antimalarial 2-aminopropylaminoquinolones

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Pharmacophore Modeling: 2 – Applications

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Applications of Pharmacophore Mapping☆

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Pharmacophore-based virtual screening of large compound databases can aid “big data” problems in drug discovery

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Role of In Silico Stereoelectronic Properties and Pharmacophores in Aid of Discovery of Novel Antimalarials, Antileishmanials, and Insect Repellents

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Targeting malaria protein kinases

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Structure–activity relationship study of oxindole-based inhibitors of cyclin-dependent kinases based on least-squares support vector machines

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QSAR studies of some side chain modified 7-chloro-4-aminoquinolines as antimalarial agents

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Targeting malaria with specific CDK inhibitors

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3D-QSAR studies of 2,2-diphenylpropionates to aid discovery of novel potent muscarinic antagonists

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Evaluation of broad spectrum protein kinase inhibitors to probe the architecture of the malarial cyclin dependent protein kinase Pfmrk

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Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones

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Activity of substituted thiophene sulfonamides against malarial and mammalian cyclin dependent protein kinases

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Design, synthesis, and biological evaluation of (2E)-(2-oxo-1, 2-dihydro-3 H -indol-3-ylidene)acetate derivatives as anti-proliferative agents through ROS-induced cell apoptosis

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Identification of an effector protein and gain-of-function mutants that activate Pfmrk, a malarial cyclin-dependent protein kinase

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Drugging the Plasmodium kinome: the benefits of academia–industry synergy

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1 Finding Protein Kinase Hits using Structural Information

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Plasmodial Kinase Inhibitors: License to Cure?

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Activity of and Initial Mechanistic Studies on a Novel Antileishmanial Agent Identified through in Silico Pharmacophore Development and Database Searching

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Direct Metalation of Heteroaromatic Esters and Nitriles Using a Mixed Lithium−Cadmium Base. Subsequent Conversion to Dipyridopyrimidinones

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In Silico Pharmacophore Model for Tabun-Inhibited Acetylcholinesterase Reactivators: A Study of Their Stereoelectronic Properties

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TiCl 4 /DMAP mediated Z-selective knovenagel condensation of isatins with nitroacetates and related compounds

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The potential of anti-malarial compounds derived from African medicinal plants, part III: an in silico evaluation of drug metabolism and pharmacokinetics profiling

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Development, Selectivity, and Application of Paullones, a Family of CDK Inhibitors

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Correlation between Cyclin Dependent Kinases and Artemisinin-Induced Dormancy in Plasmodium falciparum In Vitro

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In silicothree-dimensional pharmacophores for aiding the discovery of the Pfmrk (Plasmodium cyclin-dependent protein kinases) specific inhibitors for the therapeutic treatment of malaria

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Advances in quantitative structure–activity relationship models of antimalarials

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Proposition of In silico Pharmacophore Models for Malaria: A Review

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In Silico Pharmacophore Modeling on Known Pyridinium Oxime Reactivators of Cyclosarin (GF) Inhibited AChE to Aid Discovery of Potential, More Efficacious Novel Non-Oxime Reactivators

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Several Human Cyclin-Dependent Kinase Inhibitors, Structurally Related to Roscovitine, As New Anti-Malarial Agents

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An Update on Development of Small-Molecule Plasmodial Kinase Inhibitors

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Computer-Assisted and Data Driven Approaches for Surveillance, Drug Discovery, and Vaccine Design for the Zika Virus

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Plasmodium Kinases As Targets For New-Generation Antimalarials

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Difluorocarbene-Enabled Synthesis of 3-Substituted-2-oxoindoles from o-Vinylanilines

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