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2-Amino-3,4-dihydroquinazolines as Inhibitors of BACE-1 (β-Site APP Cleaving Enzyme): Use of Structure Based Design to Convert a Micromolar Hit into a Nanomolar Lead
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Apo and Inhibitor Complex Structures of BACE (β-secretase)
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Facile stereoselective synthesis of γ-substituted γ-amino acids from the corresponding α-amino acids
inferredcites →https://doi.org/10.1016/s0896-6273(03)00810-9openalex-snapshot
BACE1 Deficiency Rescues Memory Deficits and Cholinergic Dysfunction in a Mouse Model of Alzheimer's Disease
inferredcites →https://doi.org/10.1016/s1046-5928(02)00516-8openalex-snapshot
Recombinant insect cell expression and purification of human β-secretase (BACE-1) for X-ray crystallography
inferredcites →https://doi.org/10.1021/jm030247hopenalex-snapshot
Human β-Secretase (BACE) and BACE Inhibitors
inferredcites →https://doi.org/10.1021/jm051221oopenalex-snapshot
Heparin Derivatives as Inhibitors of BACE-1, the Alzheimer's β-Secretase, with Reduced Activity against Factor Xa and Other Proteases
inferredcites →https://doi.org/10.1021/jm060154aopenalex-snapshot
Structure-Based Design and Synthesis of Macroheterocyclic Peptidomimetic Inhibitors of the Aspartic Protease β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE)
inferredcites →https://doi.org/10.1021/jm061046ropenalex-snapshot
Discovery of Oxadiazoyl Tertiary Carbinamine Inhibitors of β-Secretase (BACE-1)
inferredcites →https://doi.org/10.1021/jm0611962openalex-snapshot
Application of Fragment Screening by X-ray Crystallography to β-Secretase
inferredcites →https://doi.org/10.1021/jm061197uopenalex-snapshot
Application of Fragment Screening by X-ray Crystallography to the Discovery of Aminopyridines as Inhibitors of β-Secretase
inferredcites →https://doi.org/10.1021/jm061242yopenalex-snapshot
Design, Synthesis, and Crystal Structure of Hydroxyethyl Secondary Amine-Based Peptidomimetic Inhibitors of Human β-Secretase
inferredcites →https://doi.org/10.1021/jo00361a019openalex-snapshot
The chemistry of .alpha.-silyl carbonyl compounds. 12. A synthesis of 4-oxo carboxylic acids, 4-oxo aldehydes, and 1,4-diketones from .gamma.-lactones
inferredcites →https://doi.org/10.1111/j.1471-4159.2005.03576.xopenalex-snapshot
The novel β‐secretase inhibitor KMI‐429 reduces amyloid β peptide production in amyloid precursor protein transgenic and wild‐type mice
inferredcites →https://doi.org/10.1111/j.1471-4159.2006.04260.xopenalex-snapshot
Oral administration of a potent and selective non‐peptidic BACE‐1 inhibitor decreases β‐cleavage of amyloid precursor protein and amyloid‐β production in vivo
inferredcites →https://doi.org/10.1126/science.1132813openalex-snapshot
100 Years and Counting: Prospects for Defeating Alzheimer's Disease
inferredcites →https://doi.org/10.1126/science.1132814openalex-snapshot
A Century of Alzheimer's Disease
inferredcites →https://doi.org/10.1523/jneurosci.2766-05.2005openalex-snapshot
BACE1, a Major Determinant of Selective Vulnerability of the Brain to Amyloid-β Amyloidogenesis, is Essential for Cognitive, Emotional, and Synaptic Functions
inferredcites →https://doi.org/10.2174/156802606776743039openalex-snapshot
Approaches to Palliative Therapies for Alzheimers Disease
inferredcites →https://doi.org/10.2174/156802606776743057openalex-snapshot
Tau Therapeutic Strategies for the Treatment of Alzheimers Disease
inferredcites →https://doi.org/10.2174/156802606776743066openalex-snapshot
The Role of Amyloid-Beta Derived Diffusible Ligands (ADDLs) in Alzheimers Disease
inferredcites →https://doi.org/10.2174/156802606776743084openalex-snapshot
Human β-secretase (BACE) and BACE Inhibitors: Progress Report
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Approaches to Amyloid Therapies for the Treatment of Alzheimer's Disease
inferred← citeshttps://doi.org/10.1002/9780470594087.ch6openalex-snapshot
Structure‐Based Design of BACE Inhibitors: Technical and Practical Aspects of Preparation, 3‐Dimensional Structure, and Computational Analysis
inferred← citeshttps://doi.org/10.1002/9780470594087.ch8openalex-snapshot
Adsorption, Distribution, Metabolism, Excretion (ADME), Efficacy, and Toxicology for BACE Inhibitors
inferred← citeshttps://doi.org/10.1002/9781119708841.ch20openalex-snapshot
Recent Applications of Microwave‐Assisted Cyclizations Promoted by Polyphosphoric Acid Esters to the Synthesis of Nitrogen Heterocycles
inferred← citeshttps://doi.org/10.1002/adsc.201200679openalex-snapshot
Transition Metal‐Free α‐C( sp 3 )H Bond Functionalization of Amines by Oxidative Cross Dehydrogenative Coupling Reaction: Simple and Direct Access to C‐4‐Alkylated 3,4‐Dihydroquinazoline Derivatives
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Gold‐Catalyzed Intermolecular [4+2] Annulation of 2‐Ethynylanilines with Ynamides: An Access to Substituted 2‐Aminoquinolines
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Gold‐katalysierte Synthese von Chinolinen aus Propargylsilylethern und Anthranilen über die Umpolung eines Goldcarben‐Kohlenstoffatoms
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Gold‐Catalyzed Synthesis of Quinolines from Propargyl Silyl Ethers and Anthranils through the Umpolung of a Gold Carbene Carbon
inferred← citeshttps://doi.org/10.1002/ardp.201400322openalex-snapshot
N‐(2‐(Piperazin‐1‐yl)phenyl)arylamide Derivatives as β‐Secretase (BACE1) Inhibitors: Simple Synthesis by Ugi Four‐Component Reaction and Biological Evaluation
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New directions for protease inhibitors directed drug discovery
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A Versatile Approach to CF3‐Containing 2‐Pyrrolidones by Tandem Michael Addition–Cyclization: Exemplification in the Synthesis of Amidine Class BACE1 Inhibitors
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Alzheimer’s Disease: Identification and Development of β‐Secretase (BACE‐1) Binding Fragments and Inhibitors by Dynamic Ligation Screening (DLS)
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Cytotoxic Activity and Structure–Activity Relationship of Triazole‐Containing Bis(Aryl Ether) Macrocycles
inferred← citeshttps://doi.org/10.1002/ddr.20289openalex-snapshot
Progress toward the development of a viable BACE‐1 inhibitor
inferred← citeshttps://doi.org/10.1002/ddr.20291openalex-snapshot
Structure and modeling in the design of β‐ and γ‐secretase inhibitors
inferred← citeshttps://doi.org/10.1002/ejoc.200901474openalex-snapshot
Thermal Rearrangements of (Arylimino)diaziridines by Simultaneous Cascades of Pericyclic Reactions
inferred← citeshttps://doi.org/10.1002/jcc.24839openalex-snapshot
Effect of sampling on BACE-1 ligands binding free energy predictions via MM-PBSA calculations
inferred← citeshttps://doi.org/10.1002/jhet.1953openalex-snapshot
Regioselective Synthesis of 2‐Acylquinazolines and 3H‐1,4‐Benzodiazepin‐3‐ones by a Ugi 4CC/Staudinger/aza‐Wittig Sequence
inferred← citeshttps://doi.org/10.1002/jhet.24openalex-snapshot
Synthetic strategies of nonpeptidic β‐secretase (BACE1) inhibitors
inferred← citeshttps://doi.org/10.1002/jhet.2864openalex-snapshot
Synthesis of Condensed Heterocycles, Containing Partially Saturated Pyrimidine Nuclei, from Aromatic Pyrimidine Derivatives
inferred← citeshttps://doi.org/10.1002/med.20132openalex-snapshot
Boom in the development of non‐peptidic β‐secretase (BACE1) inhibitors for the treatment of Alzheimer's disease
inferred← citeshttps://doi.org/10.1002/prot.23050openalex-snapshot
The role of tyrosine 71 in modulating the flap conformations of BACE1
inferred← citeshttps://doi.org/10.1002/slct.201900620openalex-snapshot
Enantiospecific Synthesis of 2‐Substituted Piperidine‐4‐carboxylic Acids from α‐Amino Acids
inferred← citeshttps://doi.org/10.1002/slct.202506089openalex-snapshot
Structure‐Based In Silico Assessment of Strategically Designed Quinazolinone Derivatives for Multi‐Target Alzheimer's Disease: From ADMET to Molecular Dynamics
inferred← citeshttps://doi.org/10.1007/7355_2016_16openalex-snapshot
The Design, Development, and Evaluation of BACE1 Inhibitors for the Treatment of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1007/978-1-0716-1209-5_11openalex-snapshot
Dynamic Docking Using Multicanonical Molecular Dynamics: Simulating Complex Formation at the Atomistic Level
inferred← citeshttps://doi.org/10.1007/978-1-0716-4232-0_2openalex-snapshot
BACE-1 Inhibition for the Treatment of Neurodegenerative Diseases: Rationale, Assay Methodologies, and Reference Compounds
inferred← citeshttps://doi.org/10.1007/978-3-662-67209-9_24openalex-snapshot
Aspartylprotease-Inhibitoren
inferred← citeshttps://doi.org/10.1007/978-3-662-68998-1_24openalex-snapshot
Aspartic Protease Inhibitors
inferred← citeshttps://doi.org/10.1007/s00216-011-4963-xopenalex-snapshot
Beta-secretase as a target for Alzheimer’s disease drug discovery: an overview of in vitro methods for characterization of inhibitors
inferred← citeshttps://doi.org/10.1007/s00894-013-1821-0openalex-snapshot
Retrospective molecular docking study of WY-25105 ligand to β-secretase and bias of the three-dimensional structure flexibility
inferred← citeshttps://doi.org/10.1007/s00894-017-3396-7openalex-snapshot
Investigation of naphthofuran moiety as potential dual inhibitor against BACE-1 and GSK-3β: molecular dynamics simulations, binding energy, and network analysis to identify first-in-class dual inhibitors against Alzheimer’s disease
inferred← citeshttps://doi.org/10.1007/s00894-022-05051-9openalex-snapshot
In silico screening of potential β-secretase (BACE1) inhibitors from VIETHERB database
inferred← citeshttps://doi.org/10.1007/s10822-019-00232-wopenalex-snapshot
Performance evaluation of molecular docking and free energy calculations protocols using the D3R Grand Challenge 4 dataset
inferred← citeshttps://doi.org/10.1007/s11030-011-9350-1openalex-snapshot
Ionic liquid-supported synthesis of dihydroquinazolines and tetrahydroquinazolines under microwave irradiation
inferred← citeshttps://doi.org/10.1007/s11030-021-10189-4openalex-snapshot
Friedel–Crafts synthesis of bis(trifluoromethylated)-4-aryl-3,4-dihydroquinazolines, bis(trifluoromethylated)-3,4-dihydroquinazoline-4-ols and trifluoromethyl arylketoimines using N-aryltrifluoroacetimidoyl chlorides and benzene derivatives
inferred← citeshttps://doi.org/10.1007/s11164-017-3093-2openalex-snapshot
Sonochemical synthesis of 2,3-dihydro-4(1H)-quinazolinones and 1-amidoalkyl-2-naphthols using magnetic nanoparticle-supported ionic liquid as a heterogeneous catalyst
inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.12291-7openalex-snapshot
Spirocyclic Scaffolds in Drug Discovery
inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.13809-0openalex-snapshot
Targeting β-Secretase (BACE) for the Treatment of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1016/b978-0-12-803959-5.50002-7openalex-snapshot
Challenges in Designing Therapeutic Agents for Treating Alzheimer’s Disease-from Serendipity to Rationality
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Measurement of cellular β-site of APP cleaving enzyme 1 activity and its modulation in neuronal assay systems
inferred← citeshttps://doi.org/10.1016/j.bbrc.2024.149538openalex-snapshot
Rational design of novel diaryl ether-linked benzimidazole derivatives as potent and selective BACE1 inhibitors
inferred← citeshttps://doi.org/10.1016/j.bioorg.2019.103135openalex-snapshot
4-Substituted 2-amino-3,4-dihydroquinazolines with a 3-hairpin turn side chain as novel inhibitors of BACE-1
inferred← citeshttps://doi.org/10.1016/j.bmc.2008.08.012openalex-snapshot
Achiral oligoamines as versatile tool for the development of aspartic protease inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmc.2008.12.067openalex-snapshot
Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and β-secretase
inferred← citeshttps://doi.org/10.1016/j.bmc.2013.01.064openalex-snapshot
Phenylimino-2H-chromen-3-carboxamide derivatives as novel small molecule inhibitors of β-secretase (BACE1)
inferred← citeshttps://doi.org/10.1016/j.bmc.2022.117047openalex-snapshot
Guanidine-based β amyloid precursor protein cleavage enzyme 1 (BACE-1) inhibitors for the Alzheimer's disease (AD): A review
inferred← citeshttps://doi.org/10.1016/j.bmc.2026.118549openalex-snapshot
Structure-activity relationship study of a new class of 2-amino-3,4-dihydroquinazolines as antitubercular agents
inferred← citeshttps://doi.org/10.1016/j.bmcl.2007.12.017openalex-snapshot
BACE-1 inhibitors Part 1: Identification of novel hydroxy ethylamines (HEAs)
inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.04.033openalex-snapshot
Discovery of aminoheterocycles as a novel β-secretase inhibitor class: pH dependence on binding activity part 1
inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.07.071openalex-snapshot
A conformational constraint improves a β-secretase inhibitor but for an unexpected reason
inferred← citeshttps://doi.org/10.1016/j.bmcl.2010.03.097openalex-snapshot
Macrocyclic BACE inhibitors: Optimization of a micromolar hit to nanomolar leads
inferred← citeshttps://doi.org/10.1016/j.bmcl.2010.06.089openalex-snapshot
Fragment-based discovery and optimization of BACE1 inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmcl.2010.07.140openalex-snapshot
Identification of a sub-micromolar, non-peptide inhibitor of β-secretase with low neural cytotoxicity through in silico screening
inferred← citeshttps://doi.org/10.1016/j.bmcl.2010.09.029openalex-snapshot
Design and synthesis of aminohydantoins as potent and selective human β-secretase (BACE1) inhibitors with enhanced brain permeability
inferred← citeshttps://doi.org/10.1016/j.bmcl.2011.02.038openalex-snapshot
Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmcl.2011.10.050openalex-snapshot
Rational design and synthesis of aminopiperazinones as β-secretase (BACE) inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmcl.2011.11.024openalex-snapshot
Discovery of pyrrolidine-based β-secretase inhibitors: Lead advancement through conformational design for maintenance of ligand binding efficiency
inferred← citeshttps://doi.org/10.1016/j.bmcl.2012.07.043openalex-snapshot
Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potent β-secretase inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmcl.2015.10.031openalex-snapshot
Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE)
inferred← citeshttps://doi.org/10.1016/j.bmcl.2022.128543openalex-snapshot
Synthesis, radiolabeling, and evaluation of a potent β-site APP cleaving enzyme (BACE1) inhibitor for PET imaging of BACE1 in vivo
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Discovery of pyrazole as C-terminus of selective BACE1 inhibitors
inferred← citeshttps://doi.org/10.1016/j.ejmech.2017.06.040openalex-snapshot
Discovery of imidazopyridines containing isoindoline-1,3-dione framework as a new class of BACE1 inhibitors: Design, synthesis and SAR analysis
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Therapeutic potential of quinazoline derivatives for Alzheimer's disease: A comprehensive review
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Control of Aβ release from human neurons by differentiation status and RET signaling
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Protein aggregation linked to Alzheimer's disease revealed by saturation transfer MRI
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β-Secretase as a Therapeutic Target for Alzheimer's Disease
inferred← citeshttps://doi.org/10.1016/j.rechem.2025.102343openalex-snapshot
Aminoquinazolin-4(3H)-one derivatives as multitargeting therapeutics in Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.tet.2011.03.056openalex-snapshot
New efficient synthesis of 2,3,4-trisubstituted 3,4-dihydroquinazolines by a Ugi 4CC/Staudinger/aza-Wittig sequence
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Iron-catalyzed C–C bond formation via cross dehydrative coupling reaction of N-heterocyclic aminols with electron rich arenes: facile access to C4-aryl-dihydroquinazolines
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A mild method for the regioselective bromination of 2-aminopyridines
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Iron-catalyzed C sp3 C sp3 bond formation via dehydrative cross coupling reaction: Facile access to new hybrid dihydroquinazolines having quinoline, isoquinoline, quinoxaline and azoles
inferred← citeshttps://doi.org/10.1016/j.tetlet.2021.153361openalex-snapshot
One-pot, two-step synthesis of 3,4-dihydroquinazoline-2(1H)-thiones from o-azidobenzenealdehydes, aryl amines and carbon disulfide
inferred← citeshttps://doi.org/10.1016/j.ultsonch.2013.05.009openalex-snapshot
Poly(4-vinylpyridine) supported acidic ionic liquid: A novel solid catalyst for the efficient synthesis of 2,3-dihydroquinazolin-4(1H)-ones under ultrasonic irradiation
inferred← citeshttps://doi.org/10.1016/s0079-6468(09)04804-8openalex-snapshot
Progress in the Development of β-secretase Inhibitors for Alzheimer's Disease
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Computer-aided drug design: a practical guide to protein-structure-based modeling
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To Design Scalable Free Energy Perturbation Networks, Optimal Is Not Enough
inferred← citeshttps://doi.org/10.1021/acs.jcim.6b00220openalex-snapshot
Application of Free Energy Perturbation for the Design of BACE1 Inhibitors
inferred← citeshttps://doi.org/10.1021/acs.jctc.7b00885openalex-snapshot
Accurate and Reliable Prediction of the Binding Affinities of Macrocycles to Their Protein Targets
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b01101openalex-snapshot
1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b01558openalex-snapshot
Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b01995openalex-snapshot
Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b01195openalex-snapshot
Active Site Mapping of an Aspartic Protease by Multiple Fragment Crystal Structures: Versatile Warheads To Address a Catalytic Dyad
inferred← citeshttps://doi.org/10.1021/acs.joc.5c00996openalex-snapshot
Tandem Synthesis of Tetrahydropyrroloquinazolines and Related Polyannular Scaffolds
inferred← citeshttps://doi.org/10.1021/acs.jpcb.8b12419openalex-snapshot
Dynamic Docking of a Medium-Sized Molecule to Its Receptor by Multicanonical MD Simulations
inferred← citeshttps://doi.org/10.1021/acsinfecdis.6c00258openalex-snapshot
2-Amino-3,4-Dihydroquinazolines Exhibit Potent Antimalarial Activity by Targeting Plasmepsin X
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.9b00181openalex-snapshot
Evaluation of a Series of β-Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine Warheads
inferred← citeshttps://doi.org/10.1021/acsomega.6b00482openalex-snapshot
Fragment Binding to β-Secretase 1 without Catalytic Aspartate Interactions Identified via Orthogonal Screening Approaches
inferred← citeshttps://doi.org/10.1021/bi901061aopenalex-snapshot
Fragment-Based Discovery of BACE1 Inhibitors Using Functional Assays
inferred← citeshttps://doi.org/10.1021/ci300390hopenalex-snapshot
Protein Flexibility in Virtual Screening: The BACE-1 Case Study
inferred← citeshttps://doi.org/10.1021/jm200544qopenalex-snapshot
From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1)
inferred← citeshttps://doi.org/10.1021/jm201715dopenalex-snapshot
Discovery and Optimization of a Novel Spiropyrrolidine Inhibitor of β-Secretase (BACE1) through Fragment-Based Drug Design
inferred← citeshttps://doi.org/10.1021/jm300069yopenalex-snapshot
Discovery of Cyclic Sulfone Hydroxyethylamines as Potent and Selective β-Site APP-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure-Based Design and in Vivo Reduction of Amyloid β-Peptides
inferred← citeshttps://doi.org/10.1021/jm300598eopenalex-snapshot
Structure- and Property-Based Design of Aminooxazoline Xanthenes as Selective, Orally Efficacious, and CNS Penetrable BACE Inhibitors for the Treatment of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1021/jm3009025openalex-snapshot
Design and Synthesis of β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors with in Vivo Brain Reduction of β-Amyloid Peptides
inferred← citeshttps://doi.org/10.1021/jm300931yopenalex-snapshot
Acyl Guanidine Inhibitors of β-Secretase (BACE-1): Optimization of a Micromolar Hit to a Nanomolar Lead via Iterative Solid- and Solution-Phase Library Synthesis
inferred← citeshttps://doi.org/10.1021/jm301039copenalex-snapshot
Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme-1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation
inferred← citeshttps://doi.org/10.1021/jm301127xopenalex-snapshot
Discovery of Biphenylacetamide-Derived Inhibitors of BACE1 Using de Novo Structure-Based Molecular Design
inferred← citeshttps://doi.org/10.1021/jm301659nopenalex-snapshot
Structure-Based Design of β-Site APP Cleaving Enzyme 1 (BACE1) Inhibitors for the Treatment of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1021/jm500797gopenalex-snapshot
Transition State Mimetics of the Plasmodium Export Element Are Potent Inhibitors of Plasmepsin V from P. falciparum and P. vivax
inferred← citeshttps://doi.org/10.1021/jm5012676openalex-snapshot
Inhibitors of β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1): Identification of (S)-7-(2-Fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5′H-spiro[chromeno[2,3-b]pyridine-5,4′-oxazol]-2′-amine (AMG-8718)
inferred← citeshttps://doi.org/10.1021/jm800138hopenalex-snapshot
Second Generation of Hydroxyethylamine BACE-1 Inhibitors: Optimizing Potency and Oral Bioavailability
inferred← citeshttps://doi.org/10.1021/jm900818sopenalex-snapshot
Molecular Shape and Medicinal Chemistry: A Perspective
inferred← citeshttps://doi.org/10.1021/jm901414eopenalex-snapshot
Design and Synthesis of 5,5′-Disubstituted Aminohydantoins as Potent and Selective Human β-Secretase (BACE1) Inhibitors
inferred← citeshttps://doi.org/10.1021/jm901472uopenalex-snapshot
Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel μM Leads for the Development of nM BACE-1 (β-Site APP Cleaving Enzyme 1) Inhibitors
inferred← citeshttps://doi.org/10.1038/aps.2012.74openalex-snapshot
L655,240, acting as a competitive BACE1 inhibitor, efficiently decreases β-amyloid peptide production in HEK293-APPswe cells
inferred← citeshttps://doi.org/10.1038/s41598-018-24766-5openalex-snapshot
High throughput evaluation of macrocyclization strategies for conformer stabilization
inferred← citeshttps://doi.org/10.1039/c2ob26103kopenalex-snapshot
Optimisation of BACE1 inhibition of tripartite structures by modification of membrane anchors, spacers and pharmacophores – development of potential agents for the treatment of Alzheimer's disease
inferred← citeshttps://doi.org/10.1039/c3cs60460hopenalex-snapshot
BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease
inferred← citeshttps://doi.org/10.1039/c4ra10203gopenalex-snapshot
C–N and C–P bond formation via cross dehydrative coupling reaction: an efficient synthesis of novel 3,4-dihydroquinazolines
inferred← citeshttps://doi.org/10.1039/c7ob01895aopenalex-snapshot
Recent advances in transition-metal-catalyzed reactions of alkynes with isoxazoles
inferred← citeshttps://doi.org/10.1039/c8ob01005fopenalex-snapshot
Palladium-catalyzed selective synthesis of 3,4-dihydroquinazolines from electron-rich arylamines, electron-poor arylamines and glyoxalates
inferred← citeshttps://doi.org/10.1039/c9ob01596eopenalex-snapshot
Triflic anhydride mediated synthesis of 3,4-dihydroquinazolines: a three-component one-pot tandem procedure
inferred← citeshttps://doi.org/10.1039/d2nj00371fopenalex-snapshot
Synthesis and biological evaluation of benzimidazoles/1,3,5-triazine-2,4-diamine hybrid compounds: a new class of multifunctional alzheimer targeting agents
inferred← citeshttps://doi.org/10.1055/a-1786-9881openalex-snapshot
Formal Syntheses of Dictyodendrins B, C, and E by a Multi-Substituted Indole Synthesis
inferred← citeshttps://doi.org/10.1055/s-0037-1611817openalex-snapshot
New Facile Synthesis of 3,4-Dihydroquinazoline-2(1H)-thiones by a Sequential Ugi-Azide/Staudinger/Aza-Wittig/Cyclization Reaction
inferred← citeshttps://doi.org/10.1080/07391102.2015.1022603openalex-snapshot
Molecular docking based virtual screening of natural compounds as potential BACE1 inhibitors: 3D QSAR pharmacophore mapping and molecular dynamics analysis
inferred← citeshttps://doi.org/10.1107/s0907444911047251openalex-snapshot
Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations
inferred← citeshttps://doi.org/10.1109/cec.2010.5585932openalex-snapshot
Simplified chain folding models as metaheuristic benchmark for tuning real protein folding algorithms?
inferred← citeshttps://doi.org/10.1111/cbdd.13456openalex-snapshot
Bennett acceptance ratio method to calculate the binding free energy of BACE1 inhibitors: Theoretical model and design of new ligands of the enzyme
inferred← citeshttps://doi.org/10.1111/j.1471-4159.2011.07476.xopenalex-snapshot
Developing β‐secretase inhibitors for treatment of Alzheimer’s disease
inferred← citeshttps://doi.org/10.1111/j.1747-0285.2011.01087.xopenalex-snapshot
Sequential Virtual Screening Approach to the Identification of Small Organic Molecules as Potential BACE‐1 Inhibitors
inferred← citeshttps://doi.org/10.1111/jnc.14467openalex-snapshot
Reduced Aβ secretion by human neurons under conditions of strongly increased BACE activity
inferred← citeshttps://doi.org/10.1186/1472-6807-12-21openalex-snapshot
Exploring the binding of BACE-1 inhibitors using comparative binding energy analysis (COMBINE)
inferred← citeshttps://doi.org/10.1371/journal.pone.0038086openalex-snapshot
Application of Consensus Scoring and Principal Component Analysis for Virtual Screening against β-Secretase (BACE-1)
inferred← citeshttps://doi.org/10.1517/13543776.2012.681302openalex-snapshot
Small-molecule BACE1 inhibitors: a patent literature review (2006 – 2011)
inferred← citeshttps://doi.org/10.1517/17460440902806377openalex-snapshot
Recent progress in the drug discovery of non-peptidic BACE1 inhibitors
inferred← citeshttps://doi.org/10.1517/17460441.2013.784267openalex-snapshot
Advances in the identification of β-secretase inhibitors
inferred← citeshttps://doi.org/10.1586/ern.09.24openalex-snapshot
Secretase inhibitors and modulators for Alzheimer’s disease treatment
inferred← citeshttps://doi.org/10.21608/rpbs.2021.55758.1087openalex-snapshot
Recent insight into BACE1 as a potential target for treatment of Alzheimer's disease
inferred← citeshttps://doi.org/10.2174/0115701794377405251204134843openalex-snapshot
From 2-Azido Products to Complex Nitrogen Heterocycles: The Versatile Ugi MCR in Modern Synthesis
inferred← citeshttps://doi.org/10.2174/15680266113139990137openalex-snapshot
The Structural Evolution of β-Secretase Inhibitors: A Focus on the Development of Small-Molecule Inhibitors
inferred← citeshttps://doi.org/10.3233/jad-130920openalex-snapshot
Early Molecular Changes in Alzheimer Disease: Can We Catch the Disease in its Presymptomatic Phase?
inferred← citeshttps://doi.org/10.3233/jad-2012-121537openalex-snapshot
Cognitive Enhancers (Nootropics). Part 2: Drugs Interacting with Enzymes
inferred← citeshttps://doi.org/10.3389/fnmol.2017.00291openalex-snapshot
Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer’s Disease-Associated Presenilin 1 Mutation
inferred← citeshttps://doi.org/10.3390/molecules25184152openalex-snapshot
One Pot Synthesis of Micromolar BACE-1 Inhibitors Based on the Dihydropyrimidinone Scaffold and Their Thia and Imino Analogues
inferred← citeshttps://doi.org/10.3762/bjoc.13.145openalex-snapshot
Syntheses of 3,4- and 1,4-dihydroquinazolines from 2-aminobenzylamine
inferred← citeshttps://doi.org/10.3762/bjoc.14.227openalex-snapshot
Synthesis of dihydroquinazolines from 2-aminobenzylamine: N3-aryl derivatives with electron-withdrawing groups
inferred← citeshttps://doi.org/10.5772/53603openalex-snapshot
Dropping the BACE: Beta Secretase (BACE1) as an Alzheimer’s Disease Intervention Target
inferred← citeshttps://doi.org/10.70675/bd16b908zde01z4a9fz9aa5zad9c5670eb37openalex-snapshot
Towards in silico prediction of mutations related to antibiotic resistance
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