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Poorly Soluble Marketed Drugs Display Solvation Limited Solubility

https://doi.org/10.1021/jm0706416
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Outgoing claims: the papers this work cites, builds on, or argues with.

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The Effects of Food on the Dissolution of Poorly Soluble Drugs in Human and in Model Small Intestinal Fluids
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Contribution of solid-state properties to the aqueous solubility of drugs
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
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Predicting aqueous solubility from structure
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Estimation of Aqueous Solubility for a Diverse Set of Organic Compounds Based on Molecular Topology
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Prediction of Aqueous Solubility of a Diverse Set of Compounds Using Quantitative Structure−Property Relationships
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Evaluation of Various Dissolution Media for Predicting In Vivo Performance of Class I and II Drugs

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Solvent Free Fabrication of Micro and Nanostructured Drug Coatings by Thermal Evaporation for Controlled Release and Increased Effects
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Development of a Discriminating In Vitro Dissolution Method for the Poorly Soluble Drug Rimonabant: Effect of Formulation Variables on Dosage Form Release Profiles
inferred← citeshttps://doi.org/10.14227/dt210214p31openalex-snapshot
Development of a Discriminative Intrinsic Dissolution Method for Efavirenz
inferred← citeshttps://doi.org/10.1517/17460441.2014.960839openalex-snapshot
Novel tactics for designing water-soluble molecules in drug discovery
inferred← citeshttps://doi.org/10.17760/d20321213openalex-snapshot
Reoptimization of human kinase inhibitors for the treatment of neglected tropical diseases
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3544641/v1openalex-snapshot
Machine Learning for Solubility Prediction
inferred← citeshttps://doi.org/10.2147/ijn.s34365openalex-snapshot
Effect of particle size on solubility, dissolution rate, and oral bioavailability: evaluation using coenzyme Q10 as naked nanocrystals
inferred← citeshttps://doi.org/10.2147/ijn.s55144openalex-snapshot
Nanostructured lipid carriers as a novel oral delivery system for triptolide: induced changes in pharmacokinetics profile associated with reduced toxicity in male rats
inferred← citeshttps://doi.org/10.2174/1568009618666180629150927openalex-snapshot
Formulation, Pharmacokinetic Evaluation and Cytotoxicity of an Enhanced- penetration Paclitaxel Nanosuspension
inferred← citeshttps://doi.org/10.2174/1570180816666181108114706openalex-snapshot
Synthesis, Formulation and Analytical Method Validation of Rutin Derivative
inferred← citeshttps://doi.org/10.2174/157341309789378177openalex-snapshot
Formulation of Nanosuspensions as a New Approach for the Delivery of Poorly Soluble Drugs
inferred← citeshttps://doi.org/10.2174/2468187312666211222123307openalex-snapshot
The Emerging Role of Nanosuspensions for Drug Delivery and Stability
inferred← citeshttps://doi.org/10.22159/ajpcr.2019.v12i4.31657openalex-snapshot
BIOAVAILABILITY AND DISSOLUTION ENHANCEMENT OF GLYBURIDE NANOSUSPENSION
inferred← citeshttps://doi.org/10.22270/jddt.v15i2.6982openalex-snapshot
Nanocrystal System: A Comprehensive Review of Method of Preparation and their Characterization, Patents and Marketed Products
inferred← citeshttps://doi.org/10.30574/wjbphs.2023.16.1.0438openalex-snapshot
Exploring the super-disintegrating properties of fenugreek seed mucilage for fast-dissolving amlodipine tablets
inferred← citeshttps://doi.org/10.3109/03639045.2011.643895openalex-snapshot
Formulation andin vitroevaluation of self-emulsifying formulations of Cinnarizine
inferred← citeshttps://doi.org/10.3109/10837450.2013.871027openalex-snapshot
Effect of pH, polymer concentration and molecular weight on the physical state properties of tolfenamic acid
inferred← citeshttps://doi.org/10.3389/fonc.2020.00121openalex-snapshot
Improved Prediction of Aqueous Solubility of Novel Compounds by Going Deeper With Deep Learning
inferred← citeshttps://doi.org/10.3390/molecules191016381openalex-snapshot
Biopharmaceutical Profiling of New Antitumor Pyrazole Derivatives
inferred← citeshttps://doi.org/10.3390/pharmaceutics13010097openalex-snapshot
Amorphous Solid Dispersions and the Contribution of Nanoparticles to In Vitro Dissolution and In Vivo Testing: Niclosamide as a Case Study
inferred← citeshttps://doi.org/10.3390/pharmaceutics13071061openalex-snapshot
Repositioning of Tamoxifen in Surface-Modified Nanocapsules as a Promising Oral Treatment for Visceral Leishmaniasis
inferred← citeshttps://doi.org/10.3390/pharmaceutics15010071openalex-snapshot
Regularities of Encapsulation of Tolfenamic Acid and Some Other Non-Steroidal Anti-Inflammatory Drugs in Metal-Organic Framework Based on γ-Cyclodextrin
inferred← citeshttps://doi.org/10.3390/pharmaceutics16040560openalex-snapshot
Host–Guest Complexation of Itraconazole with Cyclodextrins for Bioavailability Enhancement
inferred← citeshttps://doi.org/10.3390/pharmaceutics4030430openalex-snapshot
Influence of the Efavirenz Micronization on Tableting and Dissolution
inferred← citeshttps://doi.org/10.48730/pbyr-j110openalex-snapshot
Novel experimental techniques for biopharmaceutical analysis
inferred← citeshttps://doi.org/10.5599/admet.686openalex-snapshot
Perspectives in solubility measurement and interpretation
inferred← citeshttps://doi.org/10.5599/admet.766openalex-snapshot
Prediction of aqueous intrinsic solubility of druglike molecules using Random Forest regression trained with Wiki-pS0 database
inferred← citeshttps://doi.org/10.63620/mk.jcmrrr.2025.1020openalex-snapshot
inferred← citeshttps://doi.org/10.70675/563e46dbzaf26z4578z979cz54fef1584d33openalex-snapshot
Microparticules hybrides à base d'huiles végétales réticulées par procédé sol-gel : synthèse et évaluation de leur capacité de libération contrôlée de principes actifs peu hydrosolubles
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