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Synthesis and Antiplasmodial Activity of Bicyclic Dioxanes as Simplified Dihydroplakortin Analogues

https://doi.org/10.1021/jm200686d

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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The Fe 2+ ‐Mediated Decomposition, PfATP6 Binding, and Antimalarial Activities of Artemisone and Other Artemisinins: The Unlikelihood of C‐Centered Radicals as Bioactive Intermediates

inferredcites →https://doi.org/10.1002/cmdc.201000508openalex-snapshot

Reactions of Antimalarial Peroxides with Each of Leucomethylene Blue and Dihydroflavins: Flavin Reductase and the Cofactor Model Exemplified

inferredcites →https://doi.org/10.1016/j.cbpa.2007.05.038openalex-snapshot

Drug discovery for malaria: a very challenging and timely endeavor

inferredcites →https://doi.org/10.1016/j.tetlet.2003.09.033openalex-snapshot

Co(thd)2: a superior catalyst for aerobic epoxidation and hydroperoxysilylation of unactivated alkenes: application to the synthesis of spiro-1,2,4-trioxanes

inferredcites →https://doi.org/10.1016/j.tetlet.2009.07.137openalex-snapshot

Synthetic studies toward 1,2-dioxanes as precursors of potential endoperoxide-containing antimalarials

inferredcites →https://doi.org/10.1016/j.tips.2008.07.004openalex-snapshot

Artemisinins: their growing importance in medicine

inferredcites →https://doi.org/10.1016/s0040-4020(99)00332-4openalex-snapshot

Metabolites from the sponge Plakortis simplex. Determination of absolute stereochemistry of plakortin. Isolation and stereostructure of three plakortin related compounds

inferredcites →https://doi.org/10.1016/s0140-6736(10)61963-0openalex-snapshot

Artemisinin resistance—the clock is ticking

inferredcites →https://doi.org/10.1021/jm060899gopenalex-snapshot

Endoperoxide Derivatives from Marine Organisms: 1,2-Dioxanes of the Plakortin Family as Novel Antimalarial Agents

inferredcites →https://doi.org/10.1021/jo1001559openalex-snapshot

Synthesis of Dihydroplakortin, 6-epi-Dihydroplakortin, and Their C10-Desethyl Analogues

inferredcites →https://doi.org/10.1039/a902202copenalex-snapshot

The influence of natural products upon drug discovery (Antiquity to late 1999)

inferredcites →https://doi.org/10.1039/b918600jopenalex-snapshot

Insight into the mechanism of action of plakortins, simple 1,2-dioxaneantimalarials

inferredcites →https://doi.org/10.1056/nejmoa0808859openalex-snapshot

Artemisinin Resistance in Plasmodium falciparum Malaria

inferredcites →https://doi.org/10.1093/jac/dkg008openalex-snapshot

Activity against Plasmodium falciparum of cycloperoxide compounds obtained from the sponge Plakortis simplex

inferredcites →https://doi.org/10.1126/science.1155165openalex-snapshot

Qinghaosu (Artemisinin): The Price of Success

inferredcites →https://doi.org/10.1186/1475-2875-10-s1-s2openalex-snapshot

How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials?

inferredcites →https://doi.org/10.1371/journal.pone.0009582openalex-snapshot

Artemisinin Directly Targets Malarial Mitochondria through Its Specific Mitochondrial Activation

What points at this work

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Advances in the synthesis of 1,2-dioxolanes and 1,2-dioxanes

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Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II)

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Exploring clotrimazole-based pharmacophore: 3D-QSAR studies and synthesis of novel antiplasmodial agents

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Organocatalytic Enantioselective γ-Elimination: Applications in the Preparation of Chiral Peroxides and Epoxides

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Sc(OTf)3-Catalyzed C–C Bond-Forming Reaction of Cyclic Peroxy Ketals for the Synthesis of Highly Functionalized 1,2-Dioxene Endoperoxides

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Stereoselective Oxidative Cyclization of N -Allyl Benzamides to Oxaz(ol)ines

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One-Carbon Homologation of Pyrrole Carboxaldehyde via Wittig Reaction and Mild Hydrolysis of Vinyl Ether – toward the Synthesis of a Sterically Locked Phytochrome Chromophore

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