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Synthesis, Biological Evaluation, and Molecular Modeling of Donepezil and N-[(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine Hybrids as New Multipotent Cholinesterase/Monoamine Oxidase Inhibitors for the Treatment of Alzheimer’s Disease
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Outgoing claims: the papers this work cites, builds on, or argues with.
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A Small Molecule Targeting the Multifactorial Nature of Alzheimer's Disease
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Alzheimer's Disease: From Pathology to Therapeutic Approaches
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Development and testing of a general amber force field
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Comparison of multiple Amber force fields and development of improved protein backbone parameters
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Implications of co-morbidity for etiology and treatment of neurodegenerative diseases with multifunctional neuroprotective-neurorescue drugs; ladostigil
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Reactive oxygen species production by monoamine oxidases in intact cells
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A new and rapid colorimetric determination of acetylcholinesterase activity
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Some observations upon a new inhibitor of monoamine oxidase in brain tissue
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Concentration dependence of the oxidation of tyramine by the two forms of rat liver mitochondrial monoamine oxidase
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Determination of monoamine oxidase concentrations in rat liver by inhibitor binding
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The kinetics of monoamine oxidase inhibition by three 2-indolylmethylamine derivatives
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Dérivés acétyléniques et alléniques de la 2-(5-méthoxy-indolyl) méthylamine: synthèse et évaluation comme inhibiteurs sélectifs des monoamines oxydases A et B
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Imino 1,2,3,4-tetrahydrocyclopent[b]indole carbamates as dual inhibitors of acetylcholinesterase and monoamine oxidase
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Cognitive dysfunction in neuropsychiatric disorders: Selected serotonin receptor subtypes as therapeutic targets
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Design, synthesis, and structure–activity relationships of potent GPIIb/IIIa antagonists: discovery of FK419
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Design and synthesis of N-benzylpiperidine–purine derivatives as new dual inhibitors of acetyl- and butyrylcholinesterase
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Structure–activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action
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Depression and Alzheimer's disease: Neurobiological links and common pharmacological targets
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Automatic atom type and bond type perception in molecular mechanical calculations
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Cholinergic–serotonergic imbalance contributes to cognitive and behavioral symptoms in Alzheimer’s disease
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Acetylcholinesterase inhibitors: novel activities of old molecules
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Multi-functional drugs for various CNS targets in the treatment of neurodegenerative disorders
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β-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies
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Acetylcholinesterase in Alzheimer's disease
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Monoamine Oxidase-B Inhibition in Alzheimer's Disease
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Alzheimer's disease: more than a ‘cholinergic disorder' — evidence that cholinergic–monoaminergic interactions contribute to EEG slowing and dementia
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Selective dopaminergic vulnerability: 3,4-dihydroxyphenylacetaldehyde targets mitochondria
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Acetylcholinesterase Accelerates Assembly of Amyloid-β-Peptides into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the Enzyme
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Structure of acetylcholinesterase complexed with E2020 (Aricept®): implications for the design of new anti-Alzheimer drugs
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A Structural Motif of Acetylcholinesterase That Promotes Amyloid β-Peptide Fibril Formation
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3D Structure of Torpedo californica Acetylcholinesterase Complexed with Huprine X at 2.1 Å Resolution: Kinetic and Molecular Dynamic Correlates,
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Site-Activated Chelators Targeting Acetylcholinesterase and Monoamine Oxidase for Alzheimer’s Therapy
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Optimized Radii for Poisson−Boltzmann Calculations with the AMBER Force Field
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A well-behaved electrostatic potential based method using charge restraints for deriving atomic charges: the RESP model
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Rapid and Accurate Prediction of Binding Free Energies for Saquinavir-Bound HIV-1 Proteases
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Aging of Cholinesterases Phosphylated by Tabun Proceeds through O-Dealkylation
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Continuum Solvent Studies of the Stability of DNA, RNA, and Phosphoramidate−DNA Helices
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Partial GABAA Receptor Agonists. Synthesis and in Vitro Pharmacology of a Series of Nonannulated Analogs of 4,5,6,7-Tetrahydroisoxazolo[4,5-c]pyridin-3-ol
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N-Substituted dibenzoxazepines as analgesic PGE2 antagonists
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Design, Synthesis, and Structure−Activity Relationships of a Series of 3-[2-(1-Benzylpiperidin-4-yl)ethylamino]pyridazine Derivatives as Acetylcholinesterase Inhibitors
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Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase
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Novel Dual Inhibitors of AChE and MAO Derived from Hydroxy Aminoindan and Phenethylamine as Potential Treatment for Alzheimer's Disease
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Synthesis and Structure−Activity Relationships of Conformationally Constrained Histamine H3 Receptor Agonists
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Prazosin-Related Compounds. Effect of Transforming the Piperazinylquinazoline Moiety into an Aminomethyltetrahydroacridine System on the Affinity for α1-Adrenoreceptors
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Crystal Structures of Monoamine Oxidase B in Complex with Four Inhibitors of the N -Propargylaminoindan Class
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Design, Synthesis, and Biological Evaluation of Dual Binding Site Acetylcholinesterase Inhibitors: New Disease-Modifying Agents for Alzheimer's Disease
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Binding of Rasagiline-Related Inhibitors to Human Monoamine Oxidases: A Kinetic and Crystallographic Analysis
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Complexes of Alkylene-Linked Tacrine Dimers with Torpedo californica Acetylcholinesterase: Binding of Bis(5)-tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge
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Novel Multipotent Tacrine−Dihydropyridine Hybrids with Improved Acetylcholinesterase Inhibitory and Neuroprotective Activities as Potential Drugs for the Treatment of Alzheimer's Disease
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Novel Class of Quinone-Bearing Polyamines as Multi-Target-Directed Ligands To Combat Alzheimer's Disease
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First Gallamine−Tacrine Hybrid: Design and Characterization at Cholinesterases and the M2 Muscarinic Receptor
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Structural Optimization and Biological Evaluation of Substituted Bisphenol A Derivatives as β-Amyloid Peptide Aggregation Inhibitors
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Synthesis and Biological Evaluation of Novel Thiazolidinedione Analogues as 15-Hydroxyprostaglandin Dehydrogenase Inhibitors
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Multi-target-Directed Ligands To Combat Neurodegenerative Diseases
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Synthesis and Biological Evaluation of NO-Donor-Tacrine Hybrids as Hepatoprotective Anti-Alzheimer Drug Candidates
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Structure−Activity Relationships of Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone. 4. Further Investigation on the Inner Spacer
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Site-Activated Multifunctional Chelator with Acetylcholinesterase and Neuroprotective−Neurorestorative Moieties for Alzheimer’s Therapy
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Pyrano[3,2-c]quinoline−6-Chlorotacrine Hybrids as a Novel Family of Acetylcholinesterase- and β-Amyloid-Directed Anti-Alzheimer Compounds
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Molecular Determinants of MAO Selectivity in a Series of Indolylmethylamine Derivatives: Biological Activities, 3D-QSAR/CoMFA Analysis, and Computational Simulation of Ligand Recognition
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Molecular Basis of Neuroprotective Activities of Rasagiline and the Anti-Alzheimer Drug TV3326 [lpar;N-Propargyl-(3R) Aminoindan-5-YL)-Ethyl Methyl Carbamate]
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Validation of an empirical RNA-ligand scoring function for fast flexible docking using RiboDock®
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The therapeutic potential of monoamine oxidase inhibitors
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Relevance of benzyloxy group in 2‐indolyl methylamines in the selective MAO‐B inhibition
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A gorge-spanning, high-affinity cholinesterase inhibitor to explore β-amyloid plaques
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Comparison of simple potential functions for simulating liquid water
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Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation
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Three-dimensional structure of human monoamine oxidase A (MAO A): Relation to the structures of rat MAO A and human MAO B
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Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer β-amyloid peptide in rodent
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Structure of human monoamine oxidase A at 2.2-Å resolution: The control of opening the entry for substrates/inhibitors
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Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.
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A multifunctional, neuroprotective drug, ladostigil (TV3326), regulates holo‐APP translation and processing
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Crystallization and X-ray structure of full-length recombinant human butyrylcholinesterase
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CHANGES IN BRAIN CHOLINESTERASES IN SENILE DEMENTIA OF ALZHEIMER TYPE
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Monoamine Oxidase Activity and Monoamine Metabolism in Brains of Parkinsonian Patients Treated with l‐Deprenyl
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Tissue Distribution of Human Monoamine Oxidase A and B mRNA
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A Century of Alzheimer's Disease
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Oxidative Stress, Glutamate, and Neurodegenerative Disorders
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Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.
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A New Therapeutic Target in Alzheimer's Disease Treatment: Attention to Butyrylcholinesterase
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Amyloid-β-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the Aβ peptide. Implications for the pathogenesis of Alzheimer's disease
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Synthesis of New Cardioselective M2 Muscarinic Receptor Antagonists.
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Acetylcholinesterase Inhibitors as Disease-Modifying Therapies for Alzheimers Disease
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Targeting Beta-Amyloid Pathogenesis Through Acetylcholinesterase Inhibitors
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Structural Determinants of the Multifunctional Profile of Dual Binding Site Acetylcholinesterase Inhibitors as Anti-Alzheimer Agents
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Virtual Screening in Structure-Based Drug Discovery
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Memory Deficits Correlating with Acetylcholinesterase Splice Shift and Amyloid Burden in Doubly Transgenic Mice
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Propargylamine Containing Compounds as Modulators of Proteolytic Cleavage of Amyloid Protein Precursor: Involvement of MAPK and PKC Activation
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Oxidative stress in Alzheimer disease
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Metal‐Free Aminomethylation of Pyrazolones: Direct Access to 4‐Aminomethylated Pyrazolones
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Multipotente Liganden mit kombinierter Cholinesterase‐ und Monoaminooxidase‐Inhibition sowie Histamin‐H3R‐Antagonismus bei neurodegenerativen Erkrankungen
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Design, synthesis and evaluation of novel indandione derivatives as multifunctional agents with cholinesterase inhibition, anti-β-amyloid aggregation, antioxidant and neuroprotection properties against Alzheimer’s disease
inferred← citeshttps://doi.org/10.1016/j.bmc.2016.06.045openalex-snapshot
Design, synthesis and biological evaluation of N-methyl-N-[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmc.2016.12.013openalex-snapshot
Design, synthesis and biological evaluation of 4′-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.bmc.2016.12.029openalex-snapshot
Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer’s disease treatment
inferred← citeshttps://doi.org/10.1016/j.bmc.2017.03.070openalex-snapshot
Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer’s disease
inferred← citeshttps://doi.org/10.1016/j.bmc.2018.01.030openalex-snapshot
Design, synthesis and evaluation of 4′-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer’s disease treatment
inferred← citeshttps://doi.org/10.1016/j.bmc.2019.01.025openalex-snapshot
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer’s disease (1998–2018)
inferred← citeshttps://doi.org/10.1016/j.bmc.2020.115400openalex-snapshot
Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.bmcl.2012.11.064openalex-snapshot
Synthesis, molecular modeling and evaluation of novel N′-2-(4-benzylpiperidin-/piperazin-1-yl)acylhydrazone derivatives as dual inhibitors for cholinesterases and Aβ aggregation
inferred← citeshttps://doi.org/10.1016/j.bmcl.2012.11.100openalex-snapshot
Additional acetyl cholinesterase inhibitory property of diaryl pyrazoline derivatives
inferred← citeshttps://doi.org/10.1016/j.bmcl.2017.01.050openalex-snapshot
DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer’s therapy
inferred← citeshttps://doi.org/10.1016/j.bmcl.2017.01.085openalex-snapshot
Selective inhibition of monoamine oxidase A by purpurin, an anthraquinone
inferred← citeshttps://doi.org/10.1016/j.bmcl.2017.09.055openalex-snapshot
Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer’s disease
inferred← citeshttps://doi.org/10.1016/j.bmcl.2019.126880openalex-snapshot
Propargylamine-derived multi-target directed ligands for Alzheimer’s disease therapy
inferred← citeshttps://doi.org/10.1016/j.brainresbull.2019.09.001openalex-snapshot
Phosphodiesterase 5 inhibitors as novel agents for the treatment of Alzheimer’s disease
inferred← citeshttps://doi.org/10.1016/j.cbi.2025.111497openalex-snapshot
Cholinesterase-based inhibitors as multitarget small molecules for the therapy of Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.ejmech.2012.06.038openalex-snapshot
Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.ejmech.2012.09.030openalex-snapshot
Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: Synthesis, biological assessment, and molecular modeling
inferred← citeshttps://doi.org/10.1016/j.ejmech.2013.01.039openalex-snapshot
A novel series of tacrine–selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.ejmech.2013.04.050openalex-snapshot
An atom economic synthesis and AChE inhibitory activity of novel dispiro 7-aryltetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole and 4-aryloctahydroindolizine N-methylpiperidin-4-one hybrid heterocycles
inferred← citeshttps://doi.org/10.1016/j.ejmech.2013.06.021openalex-snapshot
Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: New dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.ejmech.2013.12.028openalex-snapshot
Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil–indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.ejmech.2014.02.045openalex-snapshot
Design, synthesis and evaluation of genistein-O-alkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.ejmech.2014.04.078openalex-snapshot
Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.ejmech.2014.05.066openalex-snapshot
7-MEOTA–donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies
inferred← citeshttps://doi.org/10.1016/j.ejmech.2015.03.040openalex-snapshot
Multi-target tacrine-coumarin hybrids: Cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.ejmech.2015.06.007openalex-snapshot
Design, synthesis and characterization of dual inhibitors against new targets FabG4 and HtdX of Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.1016/j.ejmech.2016.03.023openalex-snapshot
Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment
inferred← citeshttps://doi.org/10.1016/j.ejmech.2016.03.084openalex-snapshot
Progress in drug development for Alzheimer's disease: An overview in relation to mitochondrial energy metabolism
inferred← citeshttps://doi.org/10.1016/j.ejmech.2016.08.016openalex-snapshot
Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT 6 receptor antagonists. Design, synthesis and biological evaluation
inferred← citeshttps://doi.org/10.1016/j.ejmech.2016.09.041openalex-snapshot
Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.ejmech.2016.12.009openalex-snapshot
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.ejmech.2017.09.022openalex-snapshot
New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation
inferred← citeshttps://doi.org/10.1016/j.ejmech.2018.08.005openalex-snapshot
Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties
inferred← citeshttps://doi.org/10.1016/j.ejmech.2018.09.031openalex-snapshot
Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.02.076openalex-snapshot
Advancement of multi-target drug discoveries and promising applications in the field of Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.05.020openalex-snapshot
Multi-target design strategies for the improved treatment of Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.05.039openalex-snapshot
Dipropargyl substituted diphenylpyrimidines as dual inhibitors of monoamine oxidase and acetylcholinesterase
inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114464openalex-snapshot
Alzheimer's disease: Updated multi-targets therapeutics are in clinical and in progress
inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114655openalex-snapshot
Monoamine oxidase inhibitors: A concise review with special emphasis on structure activity relationship studies
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2021.01.148openalex-snapshot
Chemical similarity assisted search for acetylcholinesterase inhibitors: Molecular modeling and evaluation of their neuroprotective properties
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2021.10.102openalex-snapshot
Fluoxetine and sertraline based multitarget inhibitors of cholinesterases and monoamine oxidase-A/B for the treatment of Alzheimer's disease: Synthesis, pharmacology and molecular modeling studies
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2021.10.204openalex-snapshot
Deciphering the AChE-binding mechanism with multifunctional tricyclic coumarin anti-Alzheimer's agents using biophysical and bioinformatics approaches and evaluation of their modulating effect on Amyloidogenic peptide assembly
inferred← citeshttps://doi.org/10.1016/j.mcat.2020.110833openalex-snapshot
Zn-promoted Hβ zeolite for gas-phase catalyzed aza-heterocyclic-aromatization of acrolein dimethyl acetal and aniline to quinolines
inferred← citeshttps://doi.org/10.1016/j.molstruc.2024.139854openalex-snapshot
Some heterocycles connected to substituted piperazine by 1,3,4-oxadiazole linker: Design, synthesis, anticholinesterase and antioxidant activity
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2020.108352openalex-snapshot
Efficacy of acetylcholinesterase inhibitors in Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2017.06.034openalex-snapshot
Newly Developed Drugs for Alzheimer’s Disease in Relation to Energy Metabolism, Cholinergic and Monoaminergic Neurotransmission
inferred← citeshttps://doi.org/10.1016/j.pneurobio.2015.12.003openalex-snapshot
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.pnpbp.2016.02.012openalex-snapshot
Drugs related to monoamine oxidase activity
inferred← citeshttps://doi.org/10.1016/j.saa.2025.126582openalex-snapshot
Merocyanine derivative for real-time imaging of amyloid-β and inhibition of self-aggregation and MAO-B activity
inferred← citeshttps://doi.org/10.1016/j.tetlet.2021.153230openalex-snapshot
Aminomethylation of imidazopyridines with dichloromethane: A general strategy to construct 3-aminomethlylated imidazoheterocycles
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.0c00519openalex-snapshot
In Silico Prediction of the Toxic Potential of Neuroprotective Bifunctional Molecules Based on Chiral N-Propargyl-1,2-amino Alcohol Derivatives
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c02150openalex-snapshot
Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b01222openalex-snapshot
Design, Synthesis, and Evaluation of Orally Available Clioquinol-Moracin M Hybrids as Multitarget-Directed Ligands for Cognitive Improvement in a Rat Model of Neurodegeneration in Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b00478openalex-snapshot
Gramine Derivatives Targeting Ca2+ Channels and Ser/Thr Phosphatases: A New Dual Strategy for the Treatment of Neurodegenerative Diseases
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b01617openalex-snapshot
Acetylene Group, Friend or Foe in Medicinal Chemistry
inferred← citeshttps://doi.org/10.1021/acs.joc.3c01249openalex-snapshot
Metal- and Photocatalyst-Free, Visible-Light-Initiated C3 α-Aminomethylation of Quinoxalin-2(1 H )-ones via Electron Donor–Acceptor Complexes
inferred← citeshttps://doi.org/10.1021/acs.joc.4c02296openalex-snapshot
Visible Light-Promoted and Catalyst-Controlled α-Aminoalkylation and α-Diaminoalkylation of Morita-Baylis–Hillman Acetates with N-Methyl Arylamines: Divergent Synthesis of N-Containing Alkyl Acrylates and γ,γ-Diaminobutyl Esters
inferred← citeshttps://doi.org/10.1021/acs.joc.4c02350openalex-snapshot
Functionalization of Indoles with 1,3,5-Triazinanes: Chemistry of Aminomethylation vs the Hofmann–Martius-Type Rearrangement
inferred← citeshttps://doi.org/10.1021/acs.orglett.9b04568openalex-snapshot
Multifunctional Building Blocks Compatible with Photoredox-Mediated Alkylation for DNA-Encoded Library Synthesis
inferred← citeshttps://doi.org/10.1021/acscatal.7b01973openalex-snapshot
Aminomethylation of Aryl Halides Using α-Silylamines Enabled by Ni/Photoredox Dual Catalysis
inferred← citeshttps://doi.org/10.1021/acschemneuro.2c00132openalex-snapshot
Design, Synthesis, and Pharmacological Evaluation of N-Propargylated Diphenylpyrimidines as Multitarget Directed Ligands for the Treatment of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1021/acschemneuro.6b00122openalex-snapshot
N-Benzylpiperidine Derivatives as α7 Nicotinic Receptor Antagonists
inferred← citeshttps://doi.org/10.1021/acschemneuro.7b00345openalex-snapshot
Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1021/acschemneuro.8b00203openalex-snapshot
Neuroinflammation Signaling Modulated by ASS234, a Multitarget Small Molecule for Alzheimer’s Disease Therapy
inferred← citeshttps://doi.org/10.1021/acschemneuro.8b00220openalex-snapshot
4,6-Diphenylpyrimidine Derivatives as Dual Inhibitors of Monoamine Oxidase and Acetylcholinesterase for the Treatment of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1021/acschemneuro.8b00530openalex-snapshot
Design, Synthesis, and Evaluation of Novel Ferulic Acid Derivatives as Multi-Target-Directed Ligands for the Treatment of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1021/acsomega.1c06344openalex-snapshot
Design, Synthesis, and Bioevaluation of Indole Core Containing 2-Arylidine Derivatives of Thiazolopyrimidine as Multitarget Inhibitors of Cholinesterases and Monoamine Oxidase A/B for the Treatment of Alzheimer Disease
inferred← citeshttps://doi.org/10.1021/acsomega.3c05883openalex-snapshot
Piperidine: A Versatile Heterocyclic Ring for Developing Monoamine Oxidase Inhibitors
inferred← citeshttps://doi.org/10.1021/ci500574nopenalex-snapshot
Discovery of Multitarget-Directed Ligands against Alzheimer’s Disease through Systematic Prediction of Chemical–Protein Interactions
inferred← citeshttps://doi.org/10.1021/cn300178kopenalex-snapshot
Synthesis, Pharmacological Assessment, and Molecular Modeling of Acetylcholinesterase/Butyrylcholinesterase Inhibitors: Effect against Amyloid-β-Induced Neurotoxicity
inferred← citeshttps://doi.org/10.1021/jacs.1c08157openalex-snapshot
Late-Stage N -Me Selective Arylation of Trialkylamines Enabled by Ni/Photoredox Dual Catalysis
inferred← citeshttps://doi.org/10.1021/jacs.8b12832openalex-snapshot
Asymmetric Counter-Anion-Directed Aminomethylation: Synthesis of Chiral β-Amino Acids via Trapping of an Enol Intermediate
inferred← citeshttps://doi.org/10.1021/jm300106zopenalex-snapshot
Tacrine–Ferulic Acid–Nitric Oxide (NO) Donor Trihybrids as Potent, Multifunctional Acetyl- and Butyrylcholinesterase Inhibitors
inferred← citeshttps://doi.org/10.1021/jm301055gopenalex-snapshot
Identification of Small Molecule Inhibitors of Amyloid β-Induced Neuronal Apoptosis Acting through the Imidazoline I 2 Receptor
inferred← citeshttps://doi.org/10.1021/jm400336xopenalex-snapshot
Dual Targeting of Adenosine A2A Receptors and Monoamine Oxidase B by 4H-3,1-Benzothiazin-4-ones
inferred← citeshttps://doi.org/10.1021/jm400567sopenalex-snapshot
Design, Synthesis, and Evaluation of Multitarget-Directed Resveratrol Derivatives for the Treatment of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1021/jm401047qopenalex-snapshot
Synthesis and Evaluation of Multi-Target-Directed Ligands against Alzheimer’s Disease Based on the Fusion of Donepezil and Ebselen
inferred← citeshttps://doi.org/10.1021/jm5006463openalex-snapshot
Polypharmacology: Challenges and Opportunities in Drug Discovery
inferred← citeshttps://doi.org/10.1021/jm500729aopenalex-snapshot
Indazole- and Indole-5-carboxamides: Selective and Reversible Monoamine Oxidase B Inhibitors with Subnanomolar Potency
inferred← citeshttps://doi.org/10.1021/jm501501aopenalex-snapshot
N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a New Cholinesterase and Monoamine Oxidase Dual Inhibitor
inferred← citeshttps://doi.org/10.1038/s41598-022-26929-xopenalex-snapshot
Introduction of benzyloxy pharmacophore into aryl/heteroaryl chalcone motifs as a new class of monoamine oxidase B inhibitors
inferred← citeshttps://doi.org/10.1039/c3md00376kopenalex-snapshot
Multitarget-directed resveratrol derivatives: anti-cholinesterases, anti-β-amyloid aggregation and monoamine oxidase inhibition properties against Alzheimer's disease
inferred← citeshttps://doi.org/10.1039/c5ra10461kopenalex-snapshot
Regioselective synthesis of novel 2,3,4,4a-tetrahydro-1H-carbazoles and their cholinesterase inhibitory activities
inferred← citeshttps://doi.org/10.1039/c5ra22296fopenalex-snapshot
Synthesis and evaluation of 6-substituted 3-arylcoumarin derivatives as multifunctional acetylcholinesterase/monoamine oxidase B dual inhibitors for the treatment of Alzheimer’s disease
inferred← citeshttps://doi.org/10.1039/c5ra26797hopenalex-snapshot
Design, synthesis and evaluation of clioquinol–ebselen hybrids as multi-target-directed ligands against Alzheimer's disease
inferred← citeshttps://doi.org/10.1039/c6md00053copenalex-snapshot
Synthesis and evaluation of donepezil–ferulic acid hybrids as multi-target-directed ligands against Alzheimer's disease
inferred← citeshttps://doi.org/10.1039/c6ra00302hopenalex-snapshot
Recent developments on the structure–activity relationship studies of MAO inhibitors and their role in different neurological disorders
inferred← citeshttps://doi.org/10.1039/c7md00199aopenalex-snapshot
Synthesis and pharmacological evaluation of multi-functional homoisoflavonoid derivatives as potent inhibitors of monoamine oxidase B and cholinesterase for the treatment of Alzheimer's disease
inferred← citeshttps://doi.org/10.1039/c9md00441fopenalex-snapshot
Chromone and donepezil hybrids as new multipotent cholinesterase and monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease
inferred← citeshttps://doi.org/10.1039/d1cc00093dopenalex-snapshot
Copper-catalyzed borylative aminomethylation of C–C double and triple bonds with N , O -acetal
inferred← citeshttps://doi.org/10.1039/d3ra07035bopenalex-snapshot
Isatin-based benzyloxybenzene derivatives as monoamine oxidase inhibitors with neuroprotective effect targeting neurogenerative disease treatment
inferred← citeshttps://doi.org/10.1055/sos-sd-135-00009openalex-snapshot
35.1.1.5.13 Synthesis by Substitution of Oxygen Functionalities (Update 2014)
inferred← citeshttps://doi.org/10.1080/07391102.2023.2203255openalex-snapshot
Development of quinazolinone and vanillin acrylamide hybrids as multi-target directed ligands against Alzheimer’s disease and mechanistic insights into their binding with acetylcholinesterase
inferred← citeshttps://doi.org/10.1080/14756366.2016.1201814openalex-snapshot
Synthesis and pharmacological evaluation of donepezil-based agents as new cholinesterase/monoamine oxidase inhibitors for the potential application against Alzheimer’s disease
inferred← citeshttps://doi.org/10.1080/14756366.2017.1389920openalex-snapshot
Design, synthesis, and pharmacological evaluation of 2-amino-5-nitrothiazole derived semicarbazones as dual inhibitors of monoamine oxidase and cholinesterase: effect of the size of aryl binding site
inferred← citeshttps://doi.org/10.1080/14756366.2018.1458031openalex-snapshot
Novel hits for acetylcholinesterase inhibition derived by docking-based screening on ZINC database
inferred← citeshttps://doi.org/10.1080/14756366.2018.1545766openalex-snapshot
Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer’s disease therapy
inferred← citeshttps://doi.org/10.1111/bph.13318openalex-snapshot
Neuroprotective effects of multifaceted hybrid agents targeting MAO, cholinesterase, iron and β‐amyloid in ageing and Alzheimer's disease
inferred← citeshttps://doi.org/10.1111/cbdd.12822openalex-snapshot
Evaluation of multifunctional synthetic tetralone derivatives for treatment of Alzheimer's disease
inferred← citeshttps://doi.org/10.1111/cbdd.13355openalex-snapshot
Synthesis and biological evaluation of new tetramethylpyrazine‐based chalcone derivatives as potential anti‐Alzheimer agents
inferred← citeshttps://doi.org/10.1111/cns.12269openalex-snapshot
Wnt Signaling Pathway, a Potential Target for Alzheimer's Disease Treatment, is Activated by a Novel Multitarget Compound ASS 234
inferred← citeshttps://doi.org/10.1111/cns.12590openalex-snapshot
Upregulation of Antioxidant Enzymes by ASS 234, a Multitarget Directed Propargylamine for Alzheimer's Disease Therapy
inferred← citeshttps://doi.org/10.1111/cns.12990openalex-snapshot
In silico assessment of the metabolism and its safety significance of multitarget propargylamine ASS 234
inferred← citeshttps://doi.org/10.1111/jphp.12697openalex-snapshot
In-vitroandin-vivoevaluation of the modulatory effects of the multitarget compound ASS234 on the monoaminergic system
inferred← citeshttps://doi.org/10.1155/2013/768185openalex-snapshot
Scale Alpha and Beta of Quantitative Convergence and Chemical Reactivity Analysis in Dual Cholinesterase/Monoamine Oxidase Inhibitors for the Alzheimer Disease Treatment Using Density Functional Theory (DFT)
inferred← citeshttps://doi.org/10.1186/2047-9158-1-21openalex-snapshot
Current advances in the treatment of Alzheimer's disease: focused on considerations targeting Aβ and tau
inferred← citeshttps://doi.org/10.1186/s40169-017-0181-2openalex-snapshot
A perspective on multi‐target drug discovery and design for complex diseases
inferred← citeshttps://doi.org/10.1248/cpb.c18-00704openalex-snapshot
Design, Synthesis and Insecticide Activity of Novel Acetylcholinesterase Inhibitors: Triazolinone and Phthalimide Heterodimers
inferred← citeshttps://doi.org/10.1503/jpn.150209openalex-snapshot
The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease
inferred← citeshttps://doi.org/10.1517/13543776.2012.701619openalex-snapshot
Cholinesterase inhibitors: a patent review (2007 – 2011)
inferred← citeshttps://doi.org/10.1590/s2175-97902019000418325openalex-snapshot
Donepezil: A review of the recent structural modifications and their impact on anti-Alzheimer activity
inferred← citeshttps://doi.org/10.17863/cam.38293openalex-snapshot
Computer-Aided Design of Ligands at Multiple Protein Targets for Multifactorial Diseases
inferred← citeshttps://doi.org/10.17877/de290r-7363openalex-snapshot
3-Aryl-1-phenyl-1H-pyrazole derivatives as new multitarget directed ligands for the treatment of Alzheimer's disease, with acetylcholinesterase and monoamine oxidase inhibitory properties
inferred← citeshttps://doi.org/10.2147/dddt.s354879openalex-snapshot
Design, Synthesis and Biological Evaluation of New 3,4-Dihydro-2(1H)-Quinolinone-Dithiocarbamate Derivatives as Multifunctional Agents for the Treatment of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.2147/dddt.s432170openalex-snapshot
In vitro and in vivo Biological Evaluation of Newly Tacrine-Selegiline Hybrids as Multi-Target Inhibitors of Cholinesterases and Monoamine Oxidases for Alzheimer’s Disease
inferred← citeshttps://doi.org/10.2147/dddt.s69258openalex-snapshot
Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer’s disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids
inferred← citeshttps://doi.org/10.2174/0929867321666141106122628openalex-snapshot
Recent Development of Multifunctional Agents as Potential Drug Candidates for the Treatment of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.2174/13816128113199990026openalex-snapshot
Effects of Novel Monoamine Oxidases and Cholinesterases Targeting Compounds on Brain Neurotransmitters and Behavior in Rat Model of Vascular Dementia
inferred← citeshttps://doi.org/10.2174/1381612825666191008103141openalex-snapshot
Cholinesterase Inhibitors for Alzheimer's Disease: Multitargeting Strategy Based on Anti-Alzheimer's Drugs Repositioning
inferred← citeshttps://doi.org/10.2174/1381612826666200316125517openalex-snapshot
In silico Exploration of Bioactive Phytochemicals Against Neurodegenerative Diseases Via Inhibition of Cholinesterases
inferred← citeshttps://doi.org/10.2174/1386207323666200220115154openalex-snapshot
Vital Role of Monoamine Oxidases and Cholinesterases in Central Nervous System Drug Research: A Sharp Dissection of the Pathophysiology
inferred← citeshttps://doi.org/10.2174/1389557513666131119201353openalex-snapshot
Donepezil: An Important Prototype to the Design of New Drug Candidates for Alzheimer’s Disease
inferred← citeshttps://doi.org/10.2174/15672050113109990151openalex-snapshot
Multipotent, Permeable Drug ASS234 Inhibits Aβ Aggregation, Possesses Antioxidant Properties and Protects from Aβ-induced Apoptosis In Vitro
inferred← citeshttps://doi.org/10.2174/1567205016666190228122956openalex-snapshot
Donepezil Derivatives Targeting Amyloid-β Cascade in Alzheimer's Disease
inferred← citeshttps://doi.org/10.2174/1568026619666190128125912openalex-snapshot
Target Enzyme in Alzheimer’s Disease: Acetylcholinesterase Inhibitors
inferred← citeshttps://doi.org/10.2174/1568026620666200616142753openalex-snapshot
A Multi-layered Variable Selection Strategy for QSAR Modeling of Butyrylcholinesterase Inhibitors
inferred← citeshttps://doi.org/10.2174/1568026623666230719124850openalex-snapshot
1,3-thiazole Derivatives: A Scaffold with Considerable Potential in the Treatment of Neurodegenerative Diseases
inferred← citeshttps://doi.org/10.2174/1570159x113116660047openalex-snapshot
Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer’s Disease
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Multi-Target Directed Drugs: A Modern Approach for Design of New Drugs for the treatment of Alzheimer’s Disease
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Changing Paradigm from one Target one Ligand Towards Multi-target Directed Ligand Design for Key Drug Targets of Alzheimer Disease: An Important Role of In Silico Methods in Multi-target Directed Ligands Design
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From Hybrids to New Scaffolds: The Latest Medicinal Chemistry Goals in Multi-target Directed Ligands for Alzheimer’s Disease
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Rearrangement Reactions for the Synthesis of Some Oxa- and Aza-tricyclic Rings Heterocyclic Compounds
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One for All? Hitting Multiple Alzheimer's Disease Targets with One Drug
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Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease
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Drug Design for CNS Diseases: Polypharmacological Profiling of Compounds Using Cheminformatic, 3D-QSAR and Virtual Screening Methodologies
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ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy
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Key Targets for Multi-Target Ligands Designed to Combat Neurodegeneration
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A Comprehensive Review of Cholinesterase Modeling and Simulation
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Oximes: Inhibitors of Human Recombinant Acetylcholinesterase. A Structure-Activity Relationship (SAR) Study
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Neuroprotective Function of Rasagiline and Selegiline, Inhibitors of Type B Monoamine Oxidase, and Role of Monoamine Oxidases in Synucleinopathies
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The Role of Small Heat Shock Proteins in Protein Misfolding Associated Motoneuron Diseases
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Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta
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Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer’s Disease
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Assessment of Enzyme Inhibition: A Review with Examples from the Development of Monoamine Oxidase and Cholinesterase Inhibitory Drugs
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The Forty-Sixth Euro Congress on Drug Synthesis and Analysis: Snapshot †
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Perspectives for New and More Efficient Multifunctional Ligands for Alzheimer′s Disease Therapy
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