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Design, Synthesis, and Qualitative Structure–Activity Evaluations of Novel β-Secretase Inhibitors as Potential Alzheimer’s Drug Leads
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Design and Synthesis of 2,3,5‐Substituted Imidazolidin‐4‐one Inhibitors of BACE‐1
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Surflex-Dock 2.1: Robust performance from ligand energetic modeling, ring flexibility, and knowledge-based search
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Bias, reporting, and sharing: computational evaluations of docking methods
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Effects of protein conformation in docking: improved pose prediction through protein pocket adaptation
inferredcites →https://doi.org/10.1016/j.bmcl.2007.10.053openalex-snapshot
Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor
inferredcites →https://doi.org/10.1016/j.bmcl.2007.10.116openalex-snapshot
Potent pyrrolidine- and piperidine-based BACE-1 inhibitors
inferredcites →https://doi.org/10.1016/j.bmcl.2007.12.019openalex-snapshot
BACE-1 inhibitors part 2: Identification of hydroxy ethylamines (HEAs) with reduced peptidic character
inferredcites →https://doi.org/10.1016/j.bmcl.2009.03.149openalex-snapshot
Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics
inferredcites →https://doi.org/10.1016/j.bmcl.2009.03.150openalex-snapshot
Second generation of BACE-1 inhibitors part 2: Optimisation of the non-prime side substituent
inferredcites →https://doi.org/10.1016/j.bmcl.2009.03.165openalex-snapshot
Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics
inferredcites →https://doi.org/10.1016/j.bmcl.2010.03.050openalex-snapshot
Piperazine sulfonamide BACE1 inhibitors: Design, synthesis, and in vivo characterization
inferredcites →https://doi.org/10.1016/j.ejmech.2011.02.051openalex-snapshot
Design, synthesis and in vitro antimicrobial evaluation of novel Imidazo[1,2-a]pyridine and imidazo[2,1-b][1,3]benzothiazole motifs
inferredcites →https://doi.org/10.1016/j.jalz.2009.03.001openalex-snapshot
2009 Alzheimer's disease facts and figures
inferredcites →https://doi.org/10.1016/j.jalz.2009.04.202openalex-snapshot
P1‐196: Dementia in Malta: Experiences of dementia patients and their caregivers
inferredcites →https://doi.org/10.1016/j.tips.2003.12.001openalex-snapshot
Possible involvement of the endocannabinoid system in the actions of three clinically used drugs
inferredcites →https://doi.org/10.1016/j.tips.2003.12.004openalex-snapshot
β-Secretase inhibition for the treatment of Alzheimer's disease – promise and challenge
inferredcites →https://doi.org/10.1016/s0166-2236(96)20020-7openalex-snapshot
Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype?
inferredcites →https://doi.org/10.1016/s1044-7431(03)00227-6openalex-snapshot
BACE1 (β-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes
inferredcites →https://doi.org/10.1016/s1359-6446(99)01451-8openalex-snapshot
Computational methods for the prediction of ‘drug-likeness’
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Surflex: Fully Automatic Flexible Molecular Docking Using a Molecular Similarity-Based Search Engine
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Parameter Estimation for Scoring Protein−Ligand Interactions Using Negative Training Data
inferredcites →https://doi.org/10.1021/jm060884iopenalex-snapshot
Macrocyclic Inhibitors of β-Secretase: Functional Activity in an Animal Model
inferredcites →https://doi.org/10.1021/jm061197uopenalex-snapshot
Application of Fragment Screening by X-ray Crystallography to the Discovery of Aminopyridines as Inhibitors of β-Secretase
inferredcites →https://doi.org/10.1021/jm9006752openalex-snapshot
Aminoimidazoles as Potent and Selective Human β-Secretase (BACE1) Inhibitors
inferredcites →https://doi.org/10.1021/jm9008482openalex-snapshot
Rational Design and Synthesis of Potent Dibenzazepine Motifs as β-Secretase Inhibitors
inferredcites →https://doi.org/10.1021/jm901408popenalex-snapshot
Discovery of Cyclic Acylguanidines as Highly Potent and Selective β-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I—Inhibitor Design and Validation
inferredcites →https://doi.org/10.1021/jm901414eopenalex-snapshot
Design and Synthesis of 5,5′-Disubstituted Aminohydantoins as Potent and Selective Human β-Secretase (BACE1) Inhibitors
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Protease Inhibitors: Current Status and Future Prospects
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Polar Molecular Surface as a Dominating Determinant for Oral Absorption and Brain Penetration of Drugs
inferredcites →https://doi.org/10.1038/359322a0openalex-snapshot
Amyloid β-peptide is produced by cultured cells during normal metabolism
inferredcites →https://doi.org/10.1038/nn1797openalex-snapshot
Bace1 modulates myelination in the central and peripheral nervous system
inferredcites →https://doi.org/10.1038/nrn1495openalex-snapshot
Strategies for disease modification in Alzheimer's disease
inferredcites →https://doi.org/10.1038/nrn2620openalex-snapshot
Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
inferredcites →https://doi.org/10.1074/jbc.m505249200openalex-snapshot
Phenotypic and Biochemical Analyses of BACE1- and BACE2-deficient Mice
inferredcites →https://doi.org/10.1096/fj.08-106666openalex-snapshot
Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves
inferredcites →https://doi.org/10.1111/j.1471-4159.2006.04426.xopenalex-snapshot
Aβ Oligomers – a decade of discovery
inferredcites →https://doi.org/10.1124/jpet.107.130039openalex-snapshot
In Vivo β-Secretase 1 Inhibition Leads to Brain Aβ Lowering and Increased α-Secretase Processing of Amyloid Precursor Protein without Effect on Neuregulin-1
inferredcites →https://doi.org/10.1126/science.1072994openalex-snapshot
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
inferredcites →https://doi.org/10.1142/10574openalex-snapshot
Structure and Mechanism in Protein Science
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Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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inferred← citeshttps://doi.org/10.1002/minf.202200113openalex-snapshot
Artificial neural network models driven novel virtual screening workflow for the identification and biological evaluation of BACE1 inhibitors
inferred← citeshttps://doi.org/10.1007/7653_2018_25openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-12-396492-2.00005-9openalex-snapshot
Secretase Inhibitors and Modulators as a Disease-Modifying Approach Against Alzheimer's Disease
inferred← citeshttps://doi.org/10.1016/b978-0-12-803959-5.50011-8openalex-snapshot
Combining BACE1 Inhibition with Metal Chelation as Possible Therapy for Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1016/j.bbrc.2024.149538openalex-snapshot
Rational design of novel diaryl ether-linked benzimidazole derivatives as potent and selective BACE1 inhibitors
inferred← citeshttps://doi.org/10.1016/j.bioorg.2019.103299openalex-snapshot
Critical evaluation of current Alzheimer’s drug discovery (2018–19) & futuristic Alzheimer drug model approach
inferred← citeshttps://doi.org/10.1016/j.bmc.2012.09.016openalex-snapshot
Design, synthesis, and bioevaluation of benzamides: Novel acetylcholinesterase inhibitors with multi-functions on butylcholinesterase, Aβ aggregation, and β-secretase
inferred← citeshttps://doi.org/10.1016/j.bmc.2013.01.064openalex-snapshot
Phenylimino-2H-chromen-3-carboxamide derivatives as novel small molecule inhibitors of β-secretase (BACE1)
inferred← citeshttps://doi.org/10.1016/j.bmc.2013.03.005openalex-snapshot
Design, synthesis and evaluation of tacrine–flurbiprofen–nitrate trihybrids as novel anti-Alzheimer’s disease agents
inferred← citeshttps://doi.org/10.1016/j.bmc.2014.06.057openalex-snapshot
Syntheses of coumarin–tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Aβ aggregation, and β-secretase
inferred← citeshttps://doi.org/10.1016/j.bmc.2021.116251openalex-snapshot
Discovery of novel class of histone deacetylase inhibitors as potential anticancer agents
inferred← citeshttps://doi.org/10.1016/j.bmcl.2012.02.013openalex-snapshot
Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor
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Design of BBB permeable BACE-1 inhibitor as potential drug candidate for Alzheimer disease: 2D-QSAR, molecular docking, ADMET, molecular dynamics, MMGBSA
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inferred← citeshttps://doi.org/10.1016/j.ejmech.2016.11.021openalex-snapshot
Design, synthesis and SAR analysis of potent BACE1 inhibitors: Possible lead drug candidates for Alzheimer's disease
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Discovery of imidazopyridines containing isoindoline-1,3-dione framework as a new class of BACE1 inhibitors: Design, synthesis and SAR analysis
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Discovery of novel imidazolyl-6,7-dimethoxyisoquinoline derivatives as promising BACE1 inhibitors for management of Alzheimer's disease
inferred← citeshttps://doi.org/10.1021/acs.joc.8b00472openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/ci300331dopenalex-snapshot
Simple Structure-Based Approach for Predicting the Activity of Inhibitors of Beta-Secretase (BACE1) Associated with Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1021/jm300118sopenalex-snapshot
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inferred← citeshttps://doi.org/10.1038/s41392-023-01484-7openalex-snapshot
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