On the public citation graph
Maximizing Lipophilic Efficiency: The Use of Free-Wilson Analysis in the Design of Inhibitors of Acetyl-CoA Carboxylase
0 signed · 72 inferred · view as graph
Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.
Is this your work? Sign in with ORCID and put your name on the
claims that are yours.
Reference health. See whether every reference in this work resolves to a
known work and none has been retracted — and get a dated CiteStamped
badge you can embed.
What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1001/jama.289.1.76openalex-snapshot
Prevalence of Obesity, Diabetes, and Obesity-Related Health Risk Factors, 2001
inferredcites →https://doi.org/10.1016/j.bmcl.2008.07.071openalex-snapshot
Physiochemical drug properties associated with in vivo toxicological outcomes
inferredcites →https://doi.org/10.1016/j.bmcl.2008.11.099openalex-snapshot
Synthesis of spiro[chroman-2,4′-piperidin]-4-one derivatives as acetyl-CoA carboxylase inhibitors
inferredcites →https://doi.org/10.1016/j.bmcl.2009.04.091openalex-snapshot
Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2
inferredcites →https://doi.org/10.1016/j.bmcl.2009.10.012openalex-snapshot
(4-Piperidinyl)-piperazine: A new platform for acetyl-CoA carboxylase inhibitors
inferredcites →https://doi.org/10.1016/j.bmcl.2010.04.134openalex-snapshot
Design and synthesis of disubstituted (4-piperidinyl)-piperazine derivatives as potent acetyl-CoA carboxylase inhibitors
inferredcites →https://doi.org/10.1016/s0021-9258(19)42205-9openalex-snapshot
Acetyl Coenzyme A Carboxylase System of Escherichia coli
inferredcites →https://doi.org/10.1016/s0065-7743(10)45006-xopenalex-snapshot
Recent Advances in Acetyl-CoA Carboxylase Inhibitors
inferredcites →https://doi.org/10.1021/jm00334a001openalex-snapshot
A Mathematical Contribution to Structure-Activity Studies
inferredcites →https://doi.org/10.1021/jm801070qopenalex-snapshot
Assessment of Additive/Nonadditive Effects in Structure−Activity Relationships: Implications for Iterative Drug Design
inferredcites →https://doi.org/10.1039/p19850000081openalex-snapshot
Reactions of glyoxals with hydrazones: a new route to 4-hydroxypyrazoles
inferredcites →https://doi.org/10.1074/jbc.m304481200openalex-snapshot
Isozyme-nonselective N-Substituted Bipiperidylcarboxamide Acetyl-CoA Carboxylase Inhibitors Reduce Tissue Malonyl-CoA Concentrations, Inhibit Fatty Acid Synthesis, and Increase Fatty Acid Oxidation in Cultured Cells and in Experimental Animals
inferredcites →https://doi.org/10.1152/physrev.00024.2006openalex-snapshot
Disordered Lipid Metabolism and the Pathogenesis of Insulin Resistance
inferredcites →https://doi.org/10.1172/jci10583openalex-snapshot
Cellular mechanisms of insulin resistance
inferredcites →https://doi.org/10.1172/jci27300openalex-snapshot
Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2
inferredcites →https://doi.org/10.1517/13543770902862180openalex-snapshot
Review of recent acetyl-CoA carboxylase inhibitor patents: mid-2007 – 2008
inferredcites →https://doi.org/10.2174/157489007782418928openalex-snapshot
Inhibitors of Mammalian Acetyl-CoA Carboxylase
inferredcites →https://doi.org/10.2337/db06-0062openalex-snapshot
Increased Malonyl-CoA Levels in Muscle From Obese and Type 2 Diabetic Subjects Lead to Decreased Fatty Acid Oxidation and Increased Lipogenesis; Thiazolidinedione Treatment Reverses These Defects
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/0471266949.bmc274openalex-snapshot
Therapeutic Approaches for Nonalcoholic Steatohepatitis ( NASH )
inferred← citeshttps://doi.org/10.1002/1873-3468.13097openalex-snapshot
Activity and structure of human acetyl‐CoA carboxylase targeted by a specific inhibitor
inferred← citeshttps://doi.org/10.1002/ejoc.201201576openalex-snapshot
A Tandem Strategy for the Synthesis of 1H‐Benzo[g]indazoles and Naphtho[2,1‐d]isoxazoles from o‐Alkynylarene Chalcones
inferred← citeshttps://doi.org/10.1007/s00018-012-1096-0openalex-snapshot
Structure and function of biotin-dependent carboxylases
inferred← citeshttps://doi.org/10.1007/s10822-012-9605-7openalex-snapshot
Composite multi-parameter ranking of real and virtual compounds for design of MC4R agonists: Renaissance of the Free-Wilson methodology
inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.12291-7openalex-snapshot
Spirocyclic Scaffolds in Drug Discovery
inferred← citeshttps://doi.org/10.1016/j.aichem.2024.100077openalex-snapshot
Molecular similarity: Theory, applications, and perspectives
inferred← citeshttps://doi.org/10.1016/j.bioorg.2025.108438openalex-snapshot
Discovery of small molecule ACC inhibitors: Potential treatment for excessive sebum secretion
inferred← citeshttps://doi.org/10.1016/j.bmc.2020.115813openalex-snapshot
A brief overview on recent advances in spiro[chromane-2,4′-piperidine]-4(3H)-one-functionalized compounds in medicinal chemistry research
inferred← citeshttps://doi.org/10.1016/j.bmcl.2015.09.035openalex-snapshot
Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase
inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.113036openalex-snapshot
Synthesis and in vitro evaluation of novel spiroketopyrazoles as acetyl-CoA carboxylase inhibitors and potential antitumor agents
inferred← citeshttps://doi.org/10.1016/j.ejmech.2023.115215openalex-snapshot
Novel spiro[chromanone-2,4′-piperidine]-4-one derivatives as potential inhibitors of fatty acid synthesis in pathogens: Design, synthesis, and biological evaluation
inferred← citeshttps://doi.org/10.1016/j.ejmech.2025.118213openalex-snapshot
Piperidine-containing drugs and recently studied analogs – biological activity, mechanism of action and synthetic cascade access to their scaffolds
inferred← citeshttps://doi.org/10.1016/j.jbc.2021.101535openalex-snapshot
New insights into the molecular mechanisms of glutaminase C inhibitors in cancer cells using serial room temperature crystallography
inferred← citeshttps://doi.org/10.1016/j.jcmgh.2019.04.007openalex-snapshot
Metabolic Targets in Nonalcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1016/j.jhep.2023.10.042openalex-snapshot
Pharmacologic inhibition of lipogenesis for the treatment of NAFLD
inferred← citeshttps://doi.org/10.1016/j.mgene.2020.100798openalex-snapshot
Fatty acid synthesis and cancer: Aberrant expression of the ACACA and ACACB genes increases the risk for cancer
inferred← citeshttps://doi.org/10.1016/j.molcatb.2013.03.015openalex-snapshot
Multicomponent synthesis of dihydropyrano[2,3-c]pyrazoles catalyzed by lipase from Aspergillus niger
inferred← citeshttps://doi.org/10.1016/j.tetlet.2012.03.030openalex-snapshot
Complementary α-alkylation approaches for a sterically hindered spiro[pyrazolopyranpiperidine]ketone
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.6b00043openalex-snapshot
Improving Drug Design: An Update on Recent Applications of Efficiency Metrics, Strategies for Replacing Problematic Elements, and Compounds in Nontraditional Drug Space
inferred← citeshttps://doi.org/10.1021/acs.jafc.5c16806openalex-snapshot
Design, Synthesis, Acaricidal Activity, Structure–Activity Relationship, and Molecular Docking of Novel Piperidine Amine Derivatives Containing a Pyrimidine Motif
inferred← citeshttps://doi.org/10.1021/acs.jafc.9b07055openalex-snapshot
Design, Synthesis, and Structure–Activity Relationship of Novel Spiropyrimidinamines as Fungicides against Pseudoperonospora cubensis
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c00640openalex-snapshot
Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c00159openalex-snapshot
Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c00259openalex-snapshot
Identification of Novel Cyclobutane-Based Derivatives as Potent Acetyl-CoA Carboxylase Allosteric Inhibitors for Nonalcoholic Steatohepatitis Drug Discovery
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b01896openalex-snapshot
The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one)
inferred← citeshttps://doi.org/10.1021/acs.joc.3c01374openalex-snapshot
Convergent Syntheses of Isomeric Imidazolospiroketones as Templates for Acetyl-CoA Carboxylase (ACC) Inhibitors
inferred← citeshttps://doi.org/10.1021/acsomega.2c06944openalex-snapshot
Biological Activity Predictions of Ligands Based on Hybrid Molecular Fingerprinting and Ensemble Learning
inferred← citeshttps://doi.org/10.1021/ci4001376openalex-snapshot
Beyond the Scope of Free-Wilson Analysis: Building Interpretable QSAR Models with Machine Learning Algorithms
inferred← citeshttps://doi.org/10.1021/ci500075qopenalex-snapshot
Beyond the Scope of Free-Wilson Analysis. 2: Can Distance Encoded R-Group Fingerprints Provide Interpretable Nonlinear Models?
inferred← citeshttps://doi.org/10.1021/jm3013163openalex-snapshot
Free-Wilson and Structural Approaches to Co-optimizing Human and Rodent Isoform Potency for 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitors
inferred← citeshttps://doi.org/10.1021/jm401033topenalex-snapshot
Spirolactam-Based Acetyl-CoA Carboxylase Inhibitors: Toward Improved Metabolic Stability of a Chromanone Lead Structure
inferred← citeshttps://doi.org/10.1021/jm401601sopenalex-snapshot
Piperazine Oxadiazole Inhibitors of Acetyl-CoA Carboxylase
inferred← citeshttps://doi.org/10.1021/jm500695eopenalex-snapshot
Recent Advances in the Development of Acetyl-CoA Carboxylase (ACC) Inhibitors for the Treatment of Metabolic Disease
inferred← citeshttps://doi.org/10.1021/jm5016022openalex-snapshot
Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes
inferred← citeshttps://doi.org/10.1021/jm501778sopenalex-snapshot
Discovery of AZD3147: A Potent, Selective Dual Inhibitor of mTORC1 and mTORC2
inferred← citeshttps://doi.org/10.1021/jo202377gopenalex-snapshot
Synthesis of 7-Oxo-dihydrospiro[indazole-5,4′-piperidine] Acetyl-CoA Carboxylase Inhibitors
inferred← citeshttps://doi.org/10.1021/jo3014808openalex-snapshot
Synthesis of Spiropiperidine Lactam Acetyl-CoA Carboxylase Inhibitors
inferred← citeshttps://doi.org/10.1021/sc300173zopenalex-snapshot
Amberlyst A21 Catalyzed Chromatography-Free Method for Multicomponent Synthesis of Dihydropyrano[2,3-c]pyrazoles in Ethanol
inferred← citeshttps://doi.org/10.1038/s41467-022-31896-yopenalex-snapshot
NHC-Ni(II)-catalyzed cyclopropene-isocyanide [5 + 1] benzannulation
inferred← citeshttps://doi.org/10.1038/s42255-020-00272-9openalex-snapshot
De novo lipogenesis is essential for platelet production in humans
inferred← citeshttps://doi.org/10.1039/c6ra14531kopenalex-snapshot
Identification of novel pyrazole–rhodanine hybrid scaffolds as potent inhibitors of aldose reductase: design, synthesis, biological evaluation and molecular docking analysis
inferred← citeshttps://doi.org/10.1080/10406638.2021.1915807openalex-snapshot
Synthesis, Biological Evaluation and Molecular Docking of Novel N -Acyl/Aroyl Spiro[Chromane-2,4′-Piperidin]-4(3 H )-One as Potent Anti-Microbial Agents
inferred← citeshttps://doi.org/10.1080/13543784.2019.1657825openalex-snapshot
Acetyl-CoA carboxylase (ACC) as a therapeutic target for metabolic syndrome and recent developments in ACC1/2 inhibitors
inferred← citeshttps://doi.org/10.1101/2021.09.20.461106openalex-snapshot
New Insights into the Mechanisms Used by Inhibitors Targeting Glutamine Metabolism in Cancer Cells
inferred← citeshttps://doi.org/10.1126/scitranslmed.aau8465openalex-snapshot
Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition
inferred← citeshttps://doi.org/10.1134/s1070363223050274openalex-snapshot
Development of Spiro[chromane-2,4′-piperidine]-4(3H)-one Compounds in the Field of Medicinal Chemistry Research (A Review)
inferred← citeshttps://doi.org/10.1371/journal.pone.0169566openalex-snapshot
Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells
inferred← citeshttps://doi.org/10.2174/1573409914666181109110030openalex-snapshot
Virtual Screening Strategy Combined Bayesian Classification Model, Molecular Docking for Acetyl-CoA Carboxylases Inhibitors
inferred← citeshttps://doi.org/10.3390/ijms23158117openalex-snapshot
An Overview of the Biological Evaluation of Selected Nitrogen-Containing Heterocycle Medicinal Chemistry Compounds
inferred← citeshttps://doi.org/10.3390/molecules200916221openalex-snapshot
Synthesis, Biological Evaluation and Molecular Docking Studies of Piperidinylpiperidines and Spirochromanones Possessing Quinoline Moieties as Acetyl-CoA Carboxylase Inhibitors
inferred← citeshttps://doi.org/10.3390/molecules24020296openalex-snapshot
Synthesis of Dihydropyrano[3,2-c]pyrazoles via Double Bond Migration and Ring-Closing Metathesis
inferred← citeshttps://doi.org/10.4155/fmc-2019-0312openalex-snapshot
Recent Development in Acetyl-CoA Carboxylase Inhibitors and their Potential as Novel Drugs
Editorial review for independent work. ICSAC — the Institute for Complexity
Science and Advanced Computing — runs a structured editorial panel for researchers
publishing outside journals, and publishes on CiteStamp rails. Submission is free
and goes through ORCID: icsacinstitute.org/submit.