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Synthesis and Biological Evaluation of Derivatives of 2-{2-Fluoro-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic Acid: Nonsteroidal Anti-Inflammatory Drugs with Low Gastric Ulcerogenic Activity

https://doi.org/10.1021/jm300049g
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jama.286.8.954openalex-snapshot
Risk of Cardiovascular Events Associated With Selective COX-2 Inhibitors
inferredcites →https://doi.org/10.1002/jhet.5570370442openalex-snapshot
The synthesis of new 2,4‐diaminofuro[2,3‐ d ]pyrimidines with 5‐biphenyl, phenoxyphenyl and tricyclic substitutions as dihydrofolate reductase inhibitors
inferredcites →https://doi.org/10.1016/0006-2952(91)90242-wopenalex-snapshot
Inhibition of prostaglandin production in the inflammatory tissue by loxoprofen-Na, an anti-inflammatory prodrug
inferredcites →https://doi.org/10.1016/j.bbrc.2004.08.205openalex-snapshot
Membrane permeabilization by non-steroidal anti-inflammatory drugs
inferredcites →https://doi.org/10.1016/j.bcp.2003.09.020openalex-snapshot
Role of direct cytotoxic effects of NSAIDs in the induction of gastric lesions
inferredcites →https://doi.org/10.1016/j.bmc.2007.11.025openalex-snapshot
Conception of myeloperoxidase inhibitors derived from flufenamic acid by computational docking and structure modification
inferredcites →https://doi.org/10.1016/j.bmc.2011.04.050openalex-snapshot
Synthesis and biological evaluation of loxoprofen derivatives
inferredcites →https://doi.org/10.1016/j.bmcl.2003.11.034openalex-snapshot
Manipulation of kinetic profiles in 2-aryl propionic acid cyclooxygenase inhibitors
inferredcites →https://doi.org/10.1016/j.tetlet.2003.11.018openalex-snapshot
Negishi-type coupling of bromoarenes with dimethylzinc
inferredcites →https://doi.org/10.1016/s0006-2952(02)00842-0openalex-snapshot
Selective cyclooxygenase-2 (COX-2) inhibitors and potential risk of cardiovascular events
inferredcites →https://doi.org/10.1016/s0021-9258(18)98774-0openalex-snapshot
TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue
inferredcites →https://doi.org/10.1021/jm101116sopenalex-snapshot
Properties and Synthesis of 2-{2-Fluoro (or Bromo)-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic Acid: Nonsteroidal Anti-inflammatory Drugs with Low Membrane Permeabilizing and Gastric Lesion-Producing Activities
inferredcites →https://doi.org/10.1021/ol702291ropenalex-snapshot
Simple Palladium(II) Precatalyst for Suzuki−Miyaura Couplings: Efficient Reactions of Benzylic, Aryl, Heteroaryl, and Vinyl Coupling Partners
inferredcites →https://doi.org/10.1038/384644a0openalex-snapshot
Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
inferredcites →https://doi.org/10.1038/nsb1196-927openalex-snapshot
Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2
inferredcites →https://doi.org/10.1053/gast.2000.9561openalex-snapshot
Nonsteroidal anti-inflammatory drug gastropathy
inferredcites →https://doi.org/10.1056/nejm200108093450607openalex-snapshot
The Coxibs, Selective Inhibitors of Cyclooxygenase-2
inferredcites →https://doi.org/10.1073/pnas.88.7.2692openalex-snapshot
Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.
inferredcites →https://doi.org/10.1073/pnas.96.1.272openalex-snapshot
Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: The human pharmacology of a selective inhibitor of COX-2
inferredcites →https://doi.org/10.1093/oxfordjournals.aje.a117469openalex-snapshot
Nonsteroidal Anti-inflammatory Drugs and the Incidence of Hospitalizations for Peptic Ulcer Disease in Elderly Persons
inferredcites →https://doi.org/10.1111/j.1440-1746.1995.tb01053.xopenalex-snapshot
Effects of loxoprofen sodium, a newly synthesized non‐steroidal anti‐inflammatory drug, and indomethacin on gastric mucosal haemodynamics in the human
inferredcites →https://doi.org/10.1124/jpet.104.076877openalex-snapshot
Valdecoxib: Assessment of Cyclooxygenase-2 Potency and Selectivity
inferredcites →https://doi.org/10.1161/01.cir.102.8.840openalex-snapshot
Cyclooxygenase-1 and -2–Dependent Prostacyclin Formation in Patients With Atherosclerosis
inferredcites →https://doi.org/10.1186/1471-2474-9-15openalex-snapshot
Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model
inferredcites →https://doi.org/10.1248/bpb.33.398openalex-snapshot
Low Direct Cytotoxicity of Loxoprofen on Gastric Mucosal Cells

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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RECENT DEVELOPMENTS AND BIOLOGICAL ACTIVITIES OF 5-OXO-IMIDAZOLONES DERIVATIVES: A REVIEW
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Self‐photocatalyzed Homolytic Dehalogenative Alkylation/Cyclization of Unactivated Alkenes Based on the Quinazolinone Skeleton via Energy Transfer
inferred← citeshttps://doi.org/10.1002/ange.201309521openalex-snapshot
SpinPhox/Iridium(I)‐Catalyzed Asymmetric Hydrogenation of Cyclic α‐Alkylidene Carbonyl Compounds
inferred← citeshttps://doi.org/10.1002/anie.201309521openalex-snapshot
SpinPhox/Iridium(I)‐Catalyzed Asymmetric Hydrogenation of Cyclic α‐Alkylidene Carbonyl Compounds
inferred← citeshttps://doi.org/10.1002/cmdc.202000258openalex-snapshot
Polysubstituted Pyrimidines as mPGES‐1 Inhibitors: Discovery of Potent Inhibitors of PGE2 Production with Strong Anti‐inflammatory Effects in Carrageenan‐Induced Rat Paw Edema
inferred← citeshttps://doi.org/10.1002/med.21331openalex-snapshot
Recent Developments in Chimeric NSAIDs as Safer Anti‐Inflammatory Agents
inferred← citeshttps://doi.org/10.1007/s10593-014-1534-zopenalex-snapshot
Catalytic Alkylation of Furans by π-Activated Alcohols (Review)
inferred← citeshttps://doi.org/10.1016/j.bmc.2014.02.032openalex-snapshot
Structure–activity relationship of celecoxib and rofecoxib for the membrane permeabilizing activity
inferred← citeshttps://doi.org/10.1016/j.bmcl.2012.12.101openalex-snapshot
Regioselective synthesis of isoxazole–mercaptobenzimidazole hybrids and their in vivo analgesic and anti-inflammatory activity studies
inferred← citeshttps://doi.org/10.1016/j.ejphar.2018.12.008openalex-snapshot
Antinociception by fluoro-loxoprofen, a novel non-steroidal anti-inflammatory drug with less ulcerogenic effects, in rat models of inflammatory pain
inferred← citeshttps://doi.org/10.1021/acs.jcim.8b00876openalex-snapshot
Classification of Cyclooxygenase-2 Inhibitors Using Support Vector Machine and Random Forest Methods
inferred← citeshttps://doi.org/10.1021/acscatal.0c02414openalex-snapshot
Palladium-Catalyzed anti -Michael Reductive Heck Reaction of α,β-Unsaturated Esters
inferred← citeshttps://doi.org/10.1021/jacs.4c15956openalex-snapshot
Secondary Alkylation of Arenes via the Borono–Catellani Strategy
inferred← citeshttps://doi.org/10.1021/jacsau.5c00919openalex-snapshot
Visible-Light-Mediated Radical Truce–Smiles Rearrangement via Arylazo Sulfones
inferred← citeshttps://doi.org/10.1039/c9cc07477eopenalex-snapshot
Asymmetric synthesis of cyclopentanones through dual Lewis acid-catalysed [3+2]-cycloaddition of donor–acceptor cyclopropanes with ketenes
inferred← citeshttps://doi.org/10.1039/d1qo00201eopenalex-snapshot
A radical [3 + 2]-cycloaddition reaction for the synthesis of difluorocyclopentanones
inferred← citeshttps://doi.org/10.1039/d4ob01313aopenalex-snapshot
Catalytic stereoselective synthesis of cyclopentanones from donor–acceptor cyclopropanes and in situ -generated ketenes
inferred← citeshttps://doi.org/10.1080/1062936x.2018.1513952openalex-snapshot
SAR and QSAR models of cyclooxygenase-1 (COX-1) inhibitors
inferred← citeshttps://doi.org/10.1111/cbdd.12292openalex-snapshot
Lead Optimization on Conventional Non‐Steroidal Anti‐Inflammatory Drugs: An Approach to Reduce Gastrointestinal Toxicity
inferred← citeshttps://doi.org/10.1134/s1070363217100310openalex-snapshot
Synthesis of isomerically pure δ-chloro-γ-vinylketones
inferred← citeshttps://doi.org/10.1134/s1070428018030193openalex-snapshot
Iron-Catalyzed Synthesis of 2-[(2E)-Hex-2-en-1-yl]cyclopentanone
inferred← citeshttps://doi.org/10.17795/jjnpp-25421openalex-snapshot
Evaluation of Apoptosis Induced by Celecoxib Loaded Liposomes in Isolated Rat Hepatocytes
inferred← citeshttps://doi.org/10.3390/molecules171012262openalex-snapshot
Design, Synthesis and in Vivo Anti-inflammatory Activities of 2,4-Diaryl-5-4H-imidazolone Derivatives
inferred← citeshttps://doi.org/10.3390/molecules26134029openalex-snapshot
The Role of Organic Small Molecules in Pain Management
inferred← citeshttps://doi.org/10.6060/tcct.2017604.5499openalex-snapshot
SYNTHESIS OF (E)- AND (Z)-ISOMERS OF 2-(3-CHLOROPROP-2-EN-1-YL)CYCLOPENTANONE
inferred← citeshttps://doi.org/10.9734/jpri/2021/v33i45a32746openalex-snapshot
Recent Developments and Biological Activities of 5-Oxo-Imidazolones Derivatives: A Review
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