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Discovery, Synthesis, and Biological Evaluation of Orally Active Pyrrolidone Derivatives as Novel Inhibitors of p53–MDM2 Protein–Protein Interaction
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/anie.200462316openalex-snapshot
Terphenyl‐Based Helical Mimetics That Disrupt the p53/HDM2 Interaction
inferredcites →https://doi.org/10.1002/bies.950151008openalex-snapshot
What the papers say: The p53‐mdm2 autoregulatory feedback loop: A paradigm for the regulation of growth control by p53?
inferredcites →https://doi.org/10.1002/bip.20608openalex-snapshot
Protein–protein interactions as targets for small molecule drug discovery
inferredcites →https://doi.org/10.1002/ddr.20261openalex-snapshot
New developments in small molecules targeting p53 pathways in anticancer therapy
inferredcites →https://doi.org/10.1002/jcc.20267openalex-snapshot
A fast, scalable method for the parallel evaluation of distance‐limited pairwise particle interactions
inferredcites →https://doi.org/10.1002/prot.10465openalex-snapshot
Improved protein–ligand docking using GOLD
inferredcites →https://doi.org/10.1006/jmbi.1996.0897openalex-snapshot
Development and validation of a genetic algorithm for flexible docking 1 1Edited by F. E. Cohen
inferredcites →https://doi.org/10.1016/b978-0-12-380916-2.00003-6openalex-snapshot
MDM2 and MDMX in Cancer and Development
inferredcites →https://doi.org/10.1016/j.ejca.2010.01.015openalex-snapshot
MDM2 inhibitor MI-319 in combination with cisplatin is an effective treatment for pancreatic cancer independent of p53 function
inferredcites →https://doi.org/10.1016/j.ejmech.2011.09.043openalex-snapshot
Synthesis and biological evaluation of thio-benzodiazepines as novel small molecule inhibitors of the p53–MDM2 protein–protein interaction
inferredcites →https://doi.org/10.1016/s0065-230x(08)60785-xopenalex-snapshot
p53 and Human Cancer: The First Ten Thousand Mutations
inferredcites →https://doi.org/10.1016/s0092-8674(00)81871-1openalex-snapshot
p53, the Cellular Gatekeeper for Growth and Division
inferredcites →https://doi.org/10.1016/s1074-5521(00)00106-xopenalex-snapshot
Antagonists of protein–protein interactions
inferredcites →https://doi.org/10.1016/s1367-5931(01)00262-9openalex-snapshot
Protein–protein interfaces: mimics and inhibitors
inferredcites →https://doi.org/10.1021/bi000930vopenalex-snapshot
Chalcone Derivatives Antagonize Interactions between the Human Oncoprotein MDM2 and p53
inferredcites →https://doi.org/10.1021/ja002940popenalex-snapshot
Isolation and Structure Elucidation of Chlorofusin, a Novel p53-MDM2 Antagonist from a Fusarium sp.
inferredcites →https://doi.org/10.1021/ja051147zopenalex-snapshot
Structure-Based Design of Potent Non-Peptide MDM2 Inhibitors
inferredcites →https://doi.org/10.1021/jm030213+openalex-snapshot
Design, Synthesis, and Evaluation of Novel Boronic-Chalcone Derivatives as Antitumor Agents
inferredcites →https://doi.org/10.1021/jm034182uopenalex-snapshot
A Nonpeptidic Sulfonamide Inhibits the p53−mdm2 Interaction and Activates p53-Dependent Transcription in mdm2-Overexpressing Cells
inferredcites →https://doi.org/10.1021/jm049137gopenalex-snapshot
Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells
inferredcites →https://doi.org/10.1021/jm060023+openalex-snapshot
Discovery of a Nanomolar Inhibitor of the Human Murine Double Minute 2 (MDM2)−p53 Interaction through an Integrated, Virtual Database Screening Strategy
inferredcites →https://doi.org/10.1021/jm060193mopenalex-snapshot
From Ligand to Complexes: Inhibition of Human Immunodeficiency Virus Type 1 Integrase by β-Diketo Acid Metal Complexes
inferredcites →https://doi.org/10.1021/jm100838zopenalex-snapshot
Identification of the Spiro(oxindole-3,3′-thiazolidine)-Based Derivatives as Potential p53 Activity Modulators
inferredcites →https://doi.org/10.1021/jm1011929openalex-snapshot
Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein−Protein Interaction: Structure−Activity Studies Leading to Improved Potency
inferredcites →https://doi.org/10.1021/jm101212eopenalex-snapshot
Design, Synthesis, and Structure−Activity Relationship Exploration of 1-Substituted 4-Aroyl-3-hydroxy-5-phenyl-1 H -pyrrol-2(5 H )-one Analogues as Inhibitors of the Annexin A2−S100A10 Protein Interaction
inferredcites →https://doi.org/10.1021/jm300354jopenalex-snapshot
Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction
inferredcites →https://doi.org/10.1021/jm3007068openalex-snapshot
AM-8553: A Novel MDM2 Inhibitor with a Promising Outlook for Potential Clinical Development
inferredcites →https://doi.org/10.1021/jm990396topenalex-snapshot
Synthesis and SAR of 4-Aryl-2-hydroxy-4-oxobut-2-enoic Acids and Esters and 2-Amino-4-aryl-4-oxobut-2-enoic Acids and Esters: Potent Inhibitors of Kynurenine-3-hydroxylase as Potential Neuroprotective Agents
inferredcites →https://doi.org/10.1023/a:1020783623210openalex-snapshot
Simple Three-Component Synthesis of 4-Acyl-1-(2-aminoethyl)-5-aryl-3-hydroxy-2,5-dihydropyrrol-2(1H)-ones
inferredcites →https://doi.org/10.1038/358080a0openalex-snapshot
Amplification of a gene encoding a p53-associated protein in human sarcomas
inferredcites →https://doi.org/10.1038/362857a0openalex-snapshot
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
inferredcites →https://doi.org/10.1038/nature03197openalex-snapshot
Virtual screening of chemical libraries
inferredcites →https://doi.org/10.1038/nrc2012openalex-snapshot
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas
inferredcites →https://doi.org/10.1038/nrc991openalex-snapshot
Inhibiting the p53–MDM2 interaction: an important target for cancer therapy
inferredcites →https://doi.org/10.1063/1.2191489openalex-snapshot
The midpoint method for parallelization of particle simulations
inferredcites →https://doi.org/10.1073/pnas.1008930107openalex-snapshot
D-peptide inhibitors of the p53–MDM2 interaction for targeted molecular therapy of malignant neoplasms
inferredcites →https://doi.org/10.1074/jbc.m605405200openalex-snapshot
Hdmx Modulates the Outcome of P53 Activation in Human Tumor Cells
inferredcites →https://doi.org/10.1101/gad.7.7a.1126openalex-snapshot
The p53-mdm-2 autoregulatory feedback loop.
inferredcites →https://doi.org/10.1126/science.1092472openalex-snapshot
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
inferredcites →https://doi.org/10.1126/science.274.5289.948openalex-snapshot
Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain
inferredcites →https://doi.org/10.1158/1078-0432.ccr-08-1526openalex-snapshot
Structural and Functional Basis for Therapeutic Modulation of p53 Signaling
inferredcites →https://doi.org/10.1158/1541-7786.mcr-08-0423openalex-snapshot
Targeting Mdm2 and Mdmx in Cancer Therapy: Better Living through Medicinal Chemistry?
inferredcites →https://doi.org/10.1186/1476-4598-8-115openalex-snapshot
An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals
inferredcites →https://doi.org/10.2174/092986708784872375openalex-snapshot
Small Molecule Inhibitors of the p53-MDM2
inferredcites →https://doi.org/10.2174/138161211795222649openalex-snapshot
Small-Molecule Inhibitors of p53-MDM2 Interaction: the 2006-2010 Update
inferredcites →https://doi.org/10.4161/cc.9.6.10956openalex-snapshot
Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Biologically active γ-lactams: synthesis and natural sources
inferred← citeshttps://doi.org/10.1039/c7cc02921gopenalex-snapshot
Highly enantioselective synthesis of fused bicyclic dihydropyranones via low-loading N-heterocyclic carbene organocatalysis
inferred← citeshttps://doi.org/10.1039/c7md00287dopenalex-snapshot
Environment-sensitive turn-on fluorescent probes for p53–MDM2 protein–protein interaction
inferred← citeshttps://doi.org/10.1039/c7ob02043kopenalex-snapshot
Palladium-catalyzed tandem reaction of 2-chloroquinoline-3-carbaldehydes and isocyanides
inferred← citeshttps://doi.org/10.1039/c7ra00473gopenalex-snapshot
Rapid identification of dual p53-MDM2/MDMX interaction inhibitors through virtual screening and hit-based substructure search
inferred← citeshttps://doi.org/10.1039/c8ob02369gopenalex-snapshot
Oxidative cross-dehydrogenative [2 + 3] annulation of α-amino ketones with α-keto esters: concise synthesis of clausenamide analogues
inferred← citeshttps://doi.org/10.1039/c9ob00419jopenalex-snapshot
Enantioselective synthesis of pyrano[2,3- c ]pyrrole via an organocatalytic [4 + 2] cyclization reaction of dioxopyrrolidines and azlactones
inferred← citeshttps://doi.org/10.1039/d0qo01188fopenalex-snapshot
Photocatalytic intramolecular radical cyclization involved synergistic SET and HAT: synthesis of 3,3-difluoro-γ-lactams
inferred← citeshttps://doi.org/10.1074/jbc.rev119.007060openalex-snapshot
Regulator of G-protein signaling (RGS) proteins as drug targets: Progress and future potentials
inferred← citeshttps://doi.org/10.1098/rsfs.2013.0018openalex-snapshot
A cell-free approach to accelerate the study of protein–protein interactions in vitro
inferred← citeshttps://doi.org/10.1111/cbdd.12434openalex-snapshot
A Fluorescent Probe for Imaging p53– MDM 2 Protein–Protein Interaction
inferred← citeshttps://doi.org/10.1134/s1070363225606283openalex-snapshot
Synthesis of 7a,8-Dihydrobenzo[5,6]chromeno[2,3-b]pyrrol-9(11H)-ones
inferred← citeshttps://doi.org/10.18632/oncotarget.22119openalex-snapshot
Inhibition of HSP90 sensitizes a novel Raf/ERK dual inhibitor CY-9d in triple-negative breast cancer cells
inferred← citeshttps://doi.org/10.18632/oncotarget.2521openalex-snapshot
A novel drug discovery strategy: Mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-κB pathways
inferred← citeshttps://doi.org/10.2139/ssrn.5639204openalex-snapshot
Photo-catalyzed decarboxylative annulation of N-substituted glycines with cyclopropenones: Synthesis of pyrrol-2-ones bearing quaternary centers
inferred← citeshttps://doi.org/10.2174/0118715206358340250121060830openalex-snapshot
Research Progress on Small Molecule Inhibitors of MDM2-p53 Protein-protein Interaction
inferred← citeshttps://doi.org/10.2174/09298673113206660325openalex-snapshot
Targeting MDM2-p53 Interaction for Cancer Therapy: Are We There Yet?
inferred← citeshttps://doi.org/10.2174/0929867321666140217104648openalex-snapshot
Updated Research and Applications of Small Molecule Inhibitors of Keap1-Nrf2 Protein-Protein Interaction: a Review
inferred← citeshttps://doi.org/10.2174/0929867330666221114103924openalex-snapshot
Recent Advancements in the Discovery of MDM2/MDM2-p53 Interaction Inhibitors for the Treatment of Cancer
inferred← citeshttps://doi.org/10.2174/1568026618666180604080119openalex-snapshot
An Update on MDMX and Dual MDM2/X Inhibitors
inferred← citeshttps://doi.org/10.2174/1573406415666190621094704openalex-snapshot
p53: An Attractive Therapeutic Target for Cancer
inferred← citeshttps://doi.org/10.23851/mjs.v31i1.743openalex-snapshot
Synthesis and Biological Evaluation of Some Pyrrolidine-2-one Derivatives
inferred← citeshttps://doi.org/10.30684/etj.v38i3b.706openalex-snapshot
Synthesis of Some New Derivatives of Pyrrolidine-2-one and Studying Their Antibacterial Potentials
inferred← citeshttps://doi.org/10.3389/fcell.2022.818744openalex-snapshot
It’s Getting Complicated—A Fresh Look at p53-MDM2-ARF Triangle in Tumorigenesis and Cancer Therapy
inferred← citeshttps://doi.org/10.3390/biom10040635openalex-snapshot
Recent Synthetic Approaches towards Small Molecule Reactivators of p53
inferred← citeshttps://doi.org/10.3390/cells15050473openalex-snapshot
PROTAC-Mediated Targeted Degradation of MDM2 Induces Tumor-Suppressive Signaling in Osteosarcoma Cells
inferred← citeshttps://doi.org/10.3390/ecsoc-22-05864openalex-snapshot
Pyrrolidinodiones in Enol-Ugi, Enol-Passerini, and Anomalous Enol-Passerini Condensations
inferred← citeshttps://doi.org/10.3390/ijms150915741openalex-snapshot
Design, Synthesis and Biological Evaluation of Sulfamide and Triazole Benzodiazepines as Novel p53-MDM2 Inhibitors
inferred← citeshttps://doi.org/10.3390/molecules24162951openalex-snapshot
A Brønsted Acid-Catalyzed Multicomponent Reaction for the Synthesis of Highly Functionalized γ-Lactam Derivatives
inferred← citeshttps://doi.org/10.3390/molecules26237179openalex-snapshot
Amination of 5-Spiro-Substituted 3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones
inferred← citeshttps://doi.org/10.3390/molecules27113624openalex-snapshot
Exploring the Synthetic Potential of γ-Lactam Derivatives Obtained from a Multicomponent Reaction—Applications as Antiproliferative Agents
inferred← citeshttps://doi.org/10.3390/molecules27123721openalex-snapshot
Synthesis and Biological Evaluation of Novel Synthetic Indolone Derivatives as Anti-Tumor Agents Targeting p53-MDM2 and p53-MDMX
inferred← citeshttps://doi.org/10.3390/molecules28031325openalex-snapshot
Synthesis and Biological Evaluation of Novel Dispiro-Indolinones with Anticancer Activity
inferred← citeshttps://doi.org/10.3390/ph14080782openalex-snapshot
A Multicomponent Protocol for the Synthesis of Highly Functionalized γ-Lactam Derivatives and Their Applications as Antiproliferative Agents
inferred← citeshttps://doi.org/10.3390/ph15050511openalex-snapshot
Multicomponent Synthesis of Unsaturated γ-Lactam Derivatives. Applications as Antiproliferative Agents through the Bioisosterism Approach: Carbonyl vs. Phosphoryl Group
inferred← citeshttps://doi.org/10.3390/ph18020274openalex-snapshot
The Therapeutic Potential of Spirooxindoles in Cancer: A Focus on p53–MDM2 Modulation
inferred← citeshttps://doi.org/10.3390/ph9020025openalex-snapshot
Chemical Variations on the p53 Reactivation Theme
inferred← citeshttps://doi.org/10.3390/reactions4010007openalex-snapshot
A Brief Review: Advancement in the Synthesis of Amine through the Leuckart Reaction
inferred← citeshttps://doi.org/10.3390/separations10040225openalex-snapshot
Rational Design, Synthesis, Separation, and Characterization of New Spiroxindoles Combined with Benzimidazole Scaffold as an MDM2 Inhibitor
inferred← citeshttps://doi.org/10.4155/ebo.13.151openalex-snapshot
Chemical library screening approaches to aid the design of protein–protein inhibitors
inferred← citeshttps://doi.org/10.51415/10321/1172openalex-snapshot
Synthesis, spectroscopic properties and cytotoxicity of boron- dipyrromethene fluorescent dyes
inferred← citeshttps://doi.org/10.7555/jbr.27.20130030openalex-snapshot
The MDM2-p53 pathway revisited
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