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Design, Synthesis, and Biological Evaluation of 1-Phenylpyrazolo[3,4-e]pyrrolo[3,4-g]indolizine-4,6(1H,5H)-diones as New Glycogen Synthase Kinase-3β Inhibitors

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Molecular cloning and expression of glycogen synthase kinase‐3/factor A.
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Potential antitumor agents. III. Synthesis of pyrazolo[3,4‐e]pyrrolo[3,4‐g]indolizine and 1H‐pyrazolo[3,4‐e]indolizine derivatives
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Wnt signalling and the mechanistic basis of tumour development
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Selective Phosphorylation of Adult Tau Isoforms in Mature Hippocampal Neurons Exposed to Fibrillar Aβ
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Unregulated mitochondrial GSK3β activity results in NADH:Ubiquinone oxidoreductase deficiency
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Glycogen synthase kinase 3: A key regulator of cellular fate
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Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathy
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[48] cDNA cloning and properties of glycogen synthase kinase-3
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High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation
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2,5-Diaminopyrimidines and 3,5-disubstituted azapurines as inhibitors of glycogen synthase kinase-3 (GSK-3)
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GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins
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Functional Redundancy of GSK-3α and GSK-3β in Wnt/β-Catenin Signaling Shown by Using an Allelic Series of Embryonic Stem Cell Lines
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Molecular fields in drug discovery: getting old or reaching maturity?
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inferredcites →https://doi.org/10.1021/jm300309aopenalex-snapshot
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inferredcites →https://doi.org/10.1074/jbc.m110.209296openalex-snapshot
Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles
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inferredcites →https://doi.org/10.1074/jbc.m410610200openalex-snapshot
Serine 332 Phosphorylation of Insulin Receptor Substrate-1 by Glycogen Synthase Kinase-3 Attenuates Insulin Signaling
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Glycogen Synthase Kinase‐3 from Rabbit Skeletal Muscle
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inferredcites →https://doi.org/10.1126/science.282.5395.1914openalex-snapshot
Mutation-Specific Functional Impairments in Distinct Tau Isoforms of Hereditary FTDP-17
inferredcites →https://doi.org/10.1212/wnl.42.3.631openalex-snapshot
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
inferredcites →https://doi.org/10.1212/wnl.42.9.1681openalex-snapshot
Distribution of Alzheimer‐type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease
inferredcites →https://doi.org/10.1517/13543776.15.10.1315openalex-snapshot
GSK-3 inhibitors and their potential in the treatment of Alzheimer’s disease
inferredcites →https://doi.org/10.1602/neurorx.2.4.541openalex-snapshot
Medicinal chemical properties of successful central nervous system drugs
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Alzheimer's disease: The amyloid cascade hypothesis: An update and reappraisal
inferredcites →https://doi.org/10.3389/fnmol.2011.00032openalex-snapshot
GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS
inferredcites →https://doi.org/10.3891/acta.chem.scand.06-0667openalex-snapshot
Preparation of Cis- and Trans 2,5-Dimethoxy-2-(acetamidomethyl)-2,5-dihydrofuran, of Cis- and Trans 2,5-Dimethoxy-2-(acetamidomethyl)-tetrahydrofuran and of 1-Phenyl-2-(acetamidomethyl)-pyrrole.

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4761082openalex-extracted
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Computational Modelling of Kinase Inhibitors as Anti-Alzheimer Agents
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Impact of GSK-3β and CK-1δ on Wnt signaling pathway in alzheimer disease: A dual target approach
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inferred← citeshttps://doi.org/10.1016/j.dyepig.2023.111332openalex-snapshot
Fast and efficient one-pot ultrasound-mediated synthesis of solid state (full color tunable) fluorescent indolizine derivatives
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New 1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides inhibit hepatitis C virus replication via suppression of cyclooxygenase-2
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The therapeutic voyage of pyrazole and its analogs: A review
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Glycogen synthase kinase-3 and its inhibitors: Potential target for various therapeutic conditions
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Structure-activity relationship (SAR) studies of synthetic glycogen synthase kinase-3β inhibitors: A critical review
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Fused thiophene as a privileged scaffold: A review on anti-Alzheimer's disease potentials via targeting cholinesterases, monoamine oxidases, glycogen synthase kinase-3, and Aβ aggregation
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Indolizines in focus: Synthetic approaches, biological profiles, and SAR perspectives, a review
inferred← citeshttps://doi.org/10.1016/j.molstruc.2023.136726openalex-snapshot
Experimental and theoretical insights on the photophysical properties of ester-substituted indolizines
inferred← citeshttps://doi.org/10.1016/j.tet.2024.134015openalex-snapshot
I2−catalyzed cascade annulation of 2-(pyridin−2−yl)acetate derivatives with ,−dimethylenamine ketones: Site-selective synthesis of functionalized indolizines
inferred← citeshttps://doi.org/10.1016/j.tetlet.2023.154622openalex-snapshot
1,6-Addition of indolizines to para-quinone methides with indium(III) chloride as catalyst
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inferred← citeshttps://doi.org/10.1021/acs.joc.5b01314openalex-snapshot
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