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Importance of Purity Evaluation and the Potential of Quantitative 1H NMR as a Purity Assay

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Structure analytical methods for quantitative reference applications
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Organic structure analysis

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Development of a rapid quantitative method of analysis of carbohydrate fatty acid ester reaction mixtures using 1H qNMR
inferred← citeshttps://doi.org/10.1016/j.cbi.2024.111042openalex-snapshot
Cytotoxicity of acridinium-based ionic liquids: Structure-activity relationship and mechanistic studies
inferred← citeshttps://doi.org/10.1016/j.chroma.2015.11.046openalex-snapshot
The Generally Useful Estimate of Solvent Systems (GUESS) method enables the rapid purification of methylpyridoxine regioisomers by countercurrent chromatography
inferred← citeshttps://doi.org/10.1016/j.clay.2023.106931openalex-snapshot
NHC-heterocycle carbene gold catalyst intercalated in Layered Double Hydroxides as reusable hybrid catalyst in acidic medium
inferred← citeshttps://doi.org/10.1016/j.clinbiochem.2019.11.006openalex-snapshot
An isotope dilution LC-MS/MS based candidate reference method for the quantification of cyclosporine A, tacrolimus, sirolimus and everolimus in human whole blood
inferred← citeshttps://doi.org/10.1016/j.cpan.2026.03.010openalex-snapshot
Quantitative determination of combination of amlodipine besylate and telmisartan in tablets using 1H-qNMR and its comparison to HPLC for further validation
inferred← citeshttps://doi.org/10.1016/j.cplett.2021.139091openalex-snapshot
Heavy atom effect on water-soluble porphyrin photosensitizers for photodynamic therapy
inferred← citeshttps://doi.org/10.1016/j.csbj.2016.10.007openalex-snapshot
Nuclear Magnetic Resonance (NMR) Study for the Detection and Quantitation of Cholesterol in HSV529 Therapeutic Vaccine Candidate
inferred← citeshttps://doi.org/10.1016/j.desal.2024.117643openalex-snapshot
Homopolymers and copolymers with iminodiacetic acid chelating units for scale inhibition
inferred← citeshttps://doi.org/10.1016/j.dib.2020.105313openalex-snapshot
HPLC, quantitative NMR and HRMS spectroscopic data of nusbiarylins as a new class of antimicrobial agents
inferred← citeshttps://doi.org/10.1016/j.dyepig.2017.08.006openalex-snapshot
Elaborated DNA-binding specialities, in vitro medicated apoptosis and restrained malignancy of neotype water-soluble cationic porphyrin acylhydrazone Cu-complex
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.04.021openalex-snapshot
A combinatorial approach for the discovery of drug-like inhibitors of 15-lipoxygenase-1
inferred← citeshttps://doi.org/10.1016/j.ejmech.2023.115496openalex-snapshot
Synthesis and anti-inflammatory activity evaluation of NO-releasing furoxan/1,2,4-triazole hybrid derivatives
inferred← citeshttps://doi.org/10.1016/j.ejmech.2025.117504openalex-snapshot
Macrocyclic dihydropyridine analogs as pan-BET BD2-preferred inhibitors
inferred← citeshttps://doi.org/10.1016/j.ejps.2017.07.034openalex-snapshot
Cytochrome P450 inhibition by three licorice species and fourteen licorice constituents
inferred← citeshttps://doi.org/10.1016/j.electacta.2024.145224openalex-snapshot
Solvent-exchange-assisted activation of Cu-1,4-benzene dicarboxylate metal-organic framework for use as a bifunctional water splitting electrocatalyst
inferred← citeshttps://doi.org/10.1016/j.fct.2023.114202openalex-snapshot
Effects of cationic head group structure on cytotoxicity and mitochondrial actions of amphiphilic ionic liquids
inferred← citeshttps://doi.org/10.1016/j.fitote.2017.04.002openalex-snapshot
Chemotaxonomic and biosynthetic relationships between flavonolignans produced by Silybum marianum populations
inferred← citeshttps://doi.org/10.1016/j.fitote.2019.104467openalex-snapshot
NMR based quantitation of cycloartane triterpenes in black cohosh extracts
inferred← citeshttps://doi.org/10.1016/j.fitote.2021.104878openalex-snapshot
Auto-hydrolysis of red clover as “green” approach to (iso)flavonoid enriched products
inferred← citeshttps://doi.org/10.1016/j.fitote.2026.107364openalex-snapshot
Strategies for quantitative analysis and preparation of hepatoprotective rosmarinic acid of Lycopus lucidus aerial parts
inferred← citeshttps://doi.org/10.1016/j.foodchem.2020.128646openalex-snapshot
Facile NMR approach for profiling curcuminoids present in turmeric
inferred← citeshttps://doi.org/10.1016/j.foodchem.2025.145215openalex-snapshot
Analytical characterization and biological assay of avocado lipids with nematocidal activity
inferred← citeshttps://doi.org/10.1016/j.foodcont.2018.01.022openalex-snapshot
Combined MS-NMR approach for the quality control of food supplements containing amino acids
inferred← citeshttps://doi.org/10.1016/j.foodcont.2019.107053openalex-snapshot
Online monitoring of enzymatic hydrolysis of marine by-products using benchtop nuclear magnetic resonance spectroscopy
inferred← citeshttps://doi.org/10.1016/j.forc.2020.100263openalex-snapshot
Quantification of MDMA in seized tablets using benchtop 1H NMR spectroscopy in the absence of internal standards
inferred← citeshttps://doi.org/10.1016/j.forc.2021.100321openalex-snapshot
Fast & fluorinated – Development and validation of a rapid benchtop NMR approach and other routine screening methods for the detection and quantification of synthesized fluorofentanyl derivatives
inferred← citeshttps://doi.org/10.1016/j.forc.2023.100523openalex-snapshot
Synthesis, characterisation and quantification of the new psychoactive substance 1-(1,3-benzodioxol-5-yl)-2-(propylamino)butan-1-one (bk-PBDB, putylone)
inferred← citeshttps://doi.org/10.1016/j.forc.2025.100687openalex-snapshot
2D NMR detection and quantification of heroin in a street sample
inferred← citeshttps://doi.org/10.1016/j.forsciint.2015.05.003openalex-snapshot
4F-PBP (4′-fluoro-α-pyrrolidinobutyrophenone), a new substance of abuse: Structural characterization and purity NMR profiling
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.134843openalex-snapshot
Lignin and green solvent extracted phenolic compounds from date palm leaves as functional ingredients for the formulation of soy protein isolate biocomposite packaging materials: A circular packaging concept
inferred← citeshttps://doi.org/10.1016/j.indcrop.2015.12.012openalex-snapshot
Silymarin content in Silybum marianum populations growing in Egypt
inferred← citeshttps://doi.org/10.1016/j.indcrop.2022.116138openalex-snapshot
Rosmarinic acid 4′-O-β-glucoside – A compound with prospective medicinal and cosmetological applications - its isolation from callus and root cultures of Eryngium species and biological activity
inferred← citeshttps://doi.org/10.1016/j.jarmap.2022.100434openalex-snapshot
Variation among hemp (Cannabis sativus L.) analytical testing laboratories evinces regulatory and quality control issues for the industry
inferred← citeshttps://doi.org/10.1016/j.jchromb.2020.122230openalex-snapshot
Enhancement of covalent aggregate quantification of protein therapeutics by non-reducing capillary gel electrophoresis using sodium hexadecyl sulfate (CE-SHS)
inferred← citeshttps://doi.org/10.1016/j.jelechem.2025.119097openalex-snapshot
Nuclear magnetic resonance spectroscopy: A comprehensive tool for analyzing liquid products in electrochemical CO2 reduction
inferred← citeshttps://doi.org/10.1016/j.jep.2019.111865openalex-snapshot
Dynamics of the isoflavone metabolome of traditional preparations of Trifolium pratense L.
inferred← citeshttps://doi.org/10.1016/j.jfluchem.2023.110190openalex-snapshot
Quantitative NMR external standard fit-for-purpose method for fluorine-containing compounds: Expanding the application of aSSICO signal method to 19F nuclei
inferred← citeshttps://doi.org/10.1016/j.jmr.2020.106814openalex-snapshot
Bayesian approach for automated quantitative analysis of benchtop NMR data
inferred← citeshttps://doi.org/10.1016/j.jorganchem.2021.121991openalex-snapshot
Application of Quantitative 1H and 19F NMR to Organometallics
inferred← citeshttps://doi.org/10.1016/j.jpba.2017.01.056openalex-snapshot
Tiered analytics for purity assessment of macrocyclic peptides in drug discovery: Analytical consideration and method development
inferred← citeshttps://doi.org/10.1016/j.jpba.2017.02.055openalex-snapshot
Purity assessment of ginsenoside Rg1 using quantitative 1H nuclear magnetic resonance
inferred← citeshttps://doi.org/10.1016/j.jpba.2019.112915openalex-snapshot
NMR reveals an undeclared constituent in custom synthetic peptides
inferred← citeshttps://doi.org/10.1016/j.jpba.2020.113338openalex-snapshot
Quantitative 1H NMR analysis of a difficult drug substance and its exo-isomer as hydrochloride salts using alkaline deuterated methanol
inferred← citeshttps://doi.org/10.1016/j.jpba.2020.113601openalex-snapshot
Quantum mechanical NMR full spin analysis in pharmaceutical identity testing and quality control
inferred← citeshttps://doi.org/10.1016/j.jpba.2021.114040openalex-snapshot
Rapid and accurate verification of drug identity, purity and quality by 1H-NMR using similarity calculations and differential NMR
inferred← citeshttps://doi.org/10.1016/j.jpba.2021.114376openalex-snapshot
NMR technique and methodology in botanical health product analysis and quality control
inferred← citeshttps://doi.org/10.1016/j.jpba.2021.114553openalex-snapshot
Drug discovery from natural products – Old problems and novel solutions for the treatment of neurodegenerative diseases
inferred← citeshttps://doi.org/10.1016/j.jpba.2022.114585openalex-snapshot
Quantitative 1H NMR method for analyzing primaquine diphosphate in active pharmaceutical ingredients
inferred← citeshttps://doi.org/10.1016/j.jpba.2022.114665openalex-snapshot
Simultaneous relative UV response determination of known liquid drug product degradants by NMR spectroscopy
inferred← citeshttps://doi.org/10.1016/j.jpba.2022.114709openalex-snapshot
Pharmaceutical analysis by NMR can accommodate strict impurity thresholds: The case of choline
inferred← citeshttps://doi.org/10.1016/j.jpba.2022.114798openalex-snapshot
Guilty by dissociation: Part A: Development of a rapid Ultra-High Performance Liquid Chromatography (UHPLC)-MS/MS methodology for the analysis of regioisomeric diphenidine-derived Novel Psychoactive Substances (NPS)
inferred← citeshttps://doi.org/10.1016/j.jpba.2022.115067openalex-snapshot
Validated quantitative 31P NMR spectroscopy for positional isomeric impurity determination in L-α-glycerylphosphorylcholine (L-α-GPC)
inferred← citeshttps://doi.org/10.1016/j.jpba.2022.115073openalex-snapshot
Development and validation of a quantitative proton NMR method for the analysis of pregnenolone
inferred← citeshttps://doi.org/10.1016/j.jpba.2023.115561openalex-snapshot
Application of quantitative NMR in pharmaceutical analysis: Method qualification and potency determination for two new chemical entities in early-stage clinical studies
inferred← citeshttps://doi.org/10.1016/j.jpba.2024.116010openalex-snapshot
Qualitative and quantitative analysis of glutathione and related impurities in pharmaceuticals by qNMR
inferred← citeshttps://doi.org/10.1016/j.jpba.2024.116390openalex-snapshot
Identification by HSQC and quantification by qHNMR innovate pharmaceutical amino acid analysis
inferred← citeshttps://doi.org/10.1016/j.jpba.2025.116776openalex-snapshot
Development of pH-adjusted NMR methodology for quantitation of caffeoylquinic acid derivatives and evaluation of their antimalignant pleural mesothelioma potential
inferred← citeshttps://doi.org/10.1016/j.jpba.2025.117248openalex-snapshot
Key considerations for phosphatidylserine quantification by 31P NMR in pharmaceutical analysis
inferred← citeshttps://doi.org/10.1016/j.jpba.2026.117391openalex-snapshot
Temperature as the primary risk factor for sevoflurane degradation: Identification and toxicological risk assessment of novel degradants by nuclear magnetic resonance (NMR) spectroscopy
inferred← citeshttps://doi.org/10.1016/j.jpba.2026.117763openalex-snapshot
An Unusual Phenomenon Observed During Quantitative 1H NMR Analysis Using 1,3,5-Trimethoxybenzene as Internal Standard: H/D Exchange of the Internal Standard in Deuterated Solvents Under Acidic Conditions
inferred← citeshttps://doi.org/10.1016/j.lwt.2025.117850openalex-snapshot
Novelly quantitative analysis on mixtures of food supplements containing amino acids via high-resolution pure shift 1H NMR spectroscopy
inferred← citeshttps://doi.org/10.1016/j.microc.2017.09.001openalex-snapshot
Conduritol F, the discriminant marker between C. wilfordii and C. auriculatum by 1H NMR spectroscopy
inferred← citeshttps://doi.org/10.1016/j.microc.2019.104083openalex-snapshot
Determination of etidronic acid in vegetable-washing water by a simple and validated quantitative 31P nuclear magnetic resonance method
inferred← citeshttps://doi.org/10.1016/j.microc.2022.107315openalex-snapshot
Establishment of metrological traceability for fluoroquinolones measurement in monitoring plan of quality and safety for agro-product in China
inferred← citeshttps://doi.org/10.1016/j.microc.2022.108282openalex-snapshot
Establishment of SI-traceable purity assessment of Fumonisin B1 using a combination of quantitative 1H NMR and mass balance
inferred← citeshttps://doi.org/10.1016/j.molliq.2021.117628openalex-snapshot
Tuning critical solution temperature for CO2 capture by aqueous solution of amine
inferred← citeshttps://doi.org/10.1016/j.molstruc.2022.134819openalex-snapshot
Design, synthesis and evaluation of vascular endothelial growth factor receptor inhibitors for the potential treatment of human cancers
inferred← citeshttps://doi.org/10.1016/j.molstruc.2026.146059openalex-snapshot
The semicarbazones derived from the 7-acetyl substituted 2-arylbenzo[b]furans as potential antihyperglycemic agents with antioxidant and cytotoxic effect
inferred← citeshttps://doi.org/10.1016/j.phytochem.2022.113375openalex-snapshot
Stability of valeriana-type iridoid glycosides from rhizomes of Nardostachys jatamansi and their protection against H2O2-induced oxidative stress in SH-SY5Y cells
inferred← citeshttps://doi.org/10.1016/j.saa.2025.126632openalex-snapshot
Innovative first-order UV and fluorescence spectroscopic methods for the quantification of rufinamide in the presence of its toxic degradant: Application of AGREE tool
inferred← citeshttps://doi.org/10.1016/j.scp.2023.101268openalex-snapshot
Green sustainable assessment of stability indicating first derivative synchronous fluorimetry for determination of anti-diabetic drug with its toxic impurity
inferred← citeshttps://doi.org/10.1016/j.scp.2026.102364openalex-snapshot
Sustainable Passerini and Ugi multicomponent reactions using 5-hydroxymethylfurfural and other biomass-derived feedstocks
inferred← citeshttps://doi.org/10.1016/j.seppur.2020.117102openalex-snapshot
Lignocellulosic waste pretreatment and esterification using green solvents
inferred← citeshttps://doi.org/10.1016/j.seppur.2020.118247openalex-snapshot
Chromatographic recovery and purification of natural phytochemicals from underappreciated willow bark water extracts
inferred← citeshttps://doi.org/10.1016/j.smaim.2022.05.001openalex-snapshot
Citrate-based fluorometric sensor for multi-halide sensing
inferred← citeshttps://doi.org/10.1016/j.talanta.2015.03.004openalex-snapshot
Quantification of caffeine in human saliva by Nuclear Magnetic Resonance as an alternative method for cytochrome CYP1A2 phenotyping
inferred← citeshttps://doi.org/10.1016/j.talanta.2020.121504openalex-snapshot
Novel approach of qNMR workflow by standardization using 2H integral: Application to any intrinsic calibration standard
inferred← citeshttps://doi.org/10.1016/j.talanta.2021.122344openalex-snapshot
Quantitative quadrupolar NMR (qQNMR) using nitrogen-14 for the determination of choline in complex matrixes
inferred← citeshttps://doi.org/10.1016/j.talanta.2026.130223openalex-snapshot
Development of Teduglutide purity certified reference material (GBW09342) through amino acid-based isotope dilution mass spectrometry and sulfur-based isotope dilution inductively coupled plasma mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.tca.2016.12.008openalex-snapshot
Solid state investigation of BINOL and BINOL derivatives: A contribution to enantioselective symmetry breaking by crystallization
inferred← citeshttps://doi.org/10.1016/j.tca.2017.10.003openalex-snapshot
The manufacture of organic carbonate-poly(methyl ethylacrylate) nanowebs with thermal buffering effect
inferred← citeshttps://doi.org/10.1016/j.tet.2017.08.005openalex-snapshot
Synthesis of highly substituted 3-arylideneindolin-2-ones
inferred← citeshttps://doi.org/10.1016/j.toxlet.2022.11.018openalex-snapshot
A novel binding site in the nicotinic acetylcholine receptor for MB327 can explain its allosteric modulation relevant for organophosphorus-poisoning treatment
inferred← citeshttps://doi.org/10.1016/j.toxlet.2024.04.003openalex-snapshot
Inhibition kinetics of acetylcholinesterase and butyrylcholinesterase from various species by 2-(2-cresyl)-4H-1,3,2-benzodioxaphosphorin-2-oxide (CBDP)
inferred← citeshttps://doi.org/10.1016/j.toxlet.2024.05.011openalex-snapshot
Synthesis and biological evaluation of novel MB327 analogs as resensitizers for desensitized nicotinic acetylcholine receptors after intoxication with nerve agents
inferred← citeshttps://doi.org/10.1016/j.toxlet.2024.05.013openalex-snapshot
Identification of ligands binding to MB327-PAM-1, a binding pocket relevant for resensitization of nAChRs
inferred← citeshttps://doi.org/10.1021/acs.analchem.0c01756openalex-snapshot
Trace Level Detection and Quantification of Crystalline Silica in an Amorphous Silica Matrix with Natural Abundance 29Si NMR
inferred← citeshttps://doi.org/10.1021/acs.analchem.0c02967openalex-snapshot
Accurate and Precise External Calibration Enhances the Versatility of Quantitative NMR (qNMR)
inferred← citeshttps://doi.org/10.1021/acs.analchem.0c03428openalex-snapshot
13C-Satellite Decoupling Strategies for Improving Accuracy in Quantitative Nuclear Magnetic Resonance
inferred← citeshttps://doi.org/10.1021/acs.analchem.1c00407openalex-snapshot
A Monte Carlo Method for Analyzing Systematic and Random Uncertainty in Quantitative Nuclear Magnetic Resonance Measurements
inferred← citeshttps://doi.org/10.1021/acs.analchem.1c01554openalex-snapshot
Tandem of Countercurrent Separation and qHNMR Enables Gravimetric Analyses: Absolute Quantitation of the Rhodiola rosea Metabolome
inferred← citeshttps://doi.org/10.1021/acs.analchem.2c03276openalex-snapshot
Toward the Development of Rapid, Automated Identification Tests for Neat Organic Liquids Using Benchtop NMR Instrumentation
inferred← citeshttps://doi.org/10.1021/acs.analchem.2c03646openalex-snapshot
Absolute Quantification of Residual Solvent in Mesoporous Silica Drug Formulations Using Magic-Angle Spinning NMR Spectroscopy
inferred← citeshttps://doi.org/10.1021/acs.analchem.3c03689openalex-snapshot
Simple and User-Friendly Methodology for Crystal Water Determination by Quantitative Proton NMR Spectroscopy in Deuterium Oxide
inferred← citeshttps://doi.org/10.1021/acs.analchem.3c05078openalex-snapshot
Coaxial-Tube Quantitative Nuclear Magnetic Resonance for Various Solutions Using SI-Traceable Concentration References
inferred← citeshttps://doi.org/10.1021/acs.analchem.3c05267openalex-snapshot
Quantum Mechanical Quantitative Nuclear Magnetic Resonance Enables Digital Reference Standards at All Magnetic Fields and Enhances qNMR Sustainability
inferred← citeshttps://doi.org/10.1021/acs.analchem.4c00422openalex-snapshot
Quantification of Biopharmaceutically Relevant Nonionic Surfactant Excipients Using Benchtop qNMR
inferred← citeshttps://doi.org/10.1021/acs.analchem.4c01952openalex-snapshot
Tuning and Matching Error-Compensated, Quantitative Solid-State Nuclear Magnetic Resonance
inferred← citeshttps://doi.org/10.1021/acs.analchem.5b04565openalex-snapshot
Quantitative Detection of PEGylated Biomacromolecules in Biological Fluids by NMR
inferred← citeshttps://doi.org/10.1021/acs.analchem.5b04911openalex-snapshot
Improving the Performance of High-Precision qNMR Measurements by a Double Integration Procedure in Practical Cases
inferred← citeshttps://doi.org/10.1021/acs.analchem.5c00109openalex-snapshot
Open Digital Reference Materials Unchain Controlled Substance Analysis
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