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Amino Acid Modified Xanthone Derivatives: Novel, Highly Promising Membrane-Active Antimicrobials for Multidrug-Resistant Gram-Positive Bacterial Infections

https://doi.org/10.1021/jm501285x
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Outgoing claims: the papers this work cites, builds on, or argues with.

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Nontoxic Membrane‐Active Antimicrobial Arylamide Oligomers
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A smooth particle mesh Ewald method
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Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides
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Comparative Mechanistic Studies of Brilacidin, Daptomycin, and the Antimicrobial Peptide LL16
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Acute and repeat-dose toxicity studies of the (6-maleimidocaproyl)hydrazone derivative of doxorubicin (DOXO-EMCH), an albumin-binding prodrug of the anticancer agent doxorubicin
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Potent Activity against Multidrug-Resistant Mycobacterium tuberculosis of α-Mangostin Analogs
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Chemical modifications of a natural xanthone and antimicrobial activity against multidrug resistant Staphylococcus aureus and cytotoxicity against human tumor cell lines
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Antimicrobial Peptides
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Recent Insights into the Biosynthesis and Biological Activities of Natural Xanthones
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The dearth of new antibiotic development: why we should be worried and what we can do about it

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Two Unusual Polycyclic Polyprenylated Acylphloroglucinols, Including a Pair of Enantiomers from Garcinia multiflora
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Multifunctional Antimicrobial Nanofiber Dressings Containing ε-Polylysine for the Eradication of Bacterial Bioburden and Promotion of Wound Healing in Critically Colonized Wounds
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Development of Amphiphilic Coumarin Derivatives as Membrane-Active Antimicrobial Agents with Potent In Vivo Efficacy against Gram-Positive Pathogenic Bacteria
inferred← citeshttps://doi.org/10.1021/acsinfecdis.3c00471openalex-snapshot
Xanthone Derivatives Enhance the Therapeutic Potential of Neomycin against Polymicrobial Gram-Negative Bacterial Infections
inferred← citeshttps://doi.org/10.1021/acsinfecdis.9b00102openalex-snapshot
Protective Action of Linear Polyethylenimine against Staphylococcus aureus Colonization and Exaggerated Inflammation in Vitro and in Vivo
inferred← citeshttps://doi.org/10.1021/acsomega.7b01759openalex-snapshot
Molecular Insights into the Membrane Affinities of Model Hydrophobes
inferred← citeshttps://doi.org/10.1038/s41598-017-12905-3openalex-snapshot
Chlorinated emodin as a natural antibacterial agent against drug-resistant bacteria through dual influence on bacterial cell membranes and DNA
inferred← citeshttps://doi.org/10.1039/c5np00108kopenalex-snapshot
The chemistry and biology of guanidine natural products
inferred← citeshttps://doi.org/10.1039/c5ob00576kopenalex-snapshot
Binaphthyl-1,2,3-triazole peptidomimetics with activity against Clostridium difficile and other pathogenic bacteria
inferred← citeshttps://doi.org/10.1039/c5ra18575kopenalex-snapshot
Retracted Article: Shape-specific silver nanoparticles prepared by microwave-assisted green synthesis using pomegranate juice for bacterial inactivation and removal
inferred← citeshttps://doi.org/10.1039/c6ob00031bopenalex-snapshot
Synthesis and evaluation of membrane permeabilizing properties of cationic amphiphiles derived from the disaccharide trehalose
inferred← citeshttps://doi.org/10.1039/c6tb00406gopenalex-snapshot
A purpurin-peptide derivative for selective killing of Gram-positive bacteria via insertion into cell membrane
inferred← citeshttps://doi.org/10.1039/c7cc07285fopenalex-snapshot
Novel bis-cyclic guanidines as potent membrane-active antibacterial agents with therapeutic potential
inferred← citeshttps://doi.org/10.1039/c7md00209bopenalex-snapshot
Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents
inferred← citeshttps://doi.org/10.1039/c7ob00053gopenalex-snapshot
Amphipathic guanidine-embedded glyoxamide-based peptidomimetics as novel antibacterial agents and biofilm disruptors
inferred← citeshttps://doi.org/10.1039/c8md00257fopenalex-snapshot
Structural optimization and antibacterial evaluation of rhodomyrtosone B analogues against MRSA strains
inferred← citeshttps://doi.org/10.1039/c8ob01699bopenalex-snapshot
Guanidine functionalized anthranilamides as effective antibacterials with biofilm disruption activity
inferred← citeshttps://doi.org/10.1039/c9cc03001hopenalex-snapshot
A novel molecular scaffold resensitizes multidrug-resistant S. aureus to fluoroquinolones
inferred← citeshttps://doi.org/10.1039/c9md00229dopenalex-snapshot
Gramicidin S-inspired antimicrobial cyclodextrin to disrupt gram-negative and gram-positive bacterial membranes
inferred← citeshttps://doi.org/10.1039/d0bm00786bopenalex-snapshot
An on-demand nanoplatform for enhanced elimination of drug-resistant bacteria
inferred← citeshttps://doi.org/10.1039/d1ob00470kopenalex-snapshot
An efficient approach for the synthesis of 1,2-dihydroxanthones enabled by one-pot Claisen condensation/cyclization reactions
inferred← citeshttps://doi.org/10.1039/d5md00407aopenalex-snapshot
A review on small molecular mimics of antimicrobial peptides with an emphasis on the structure–activity relationship perspective
inferred← citeshttps://doi.org/10.1039/d5md00760gopenalex-snapshot
Stereoselective design of amino acid bioconjugates: targeting strategies and physicochemical optimization
inferred← citeshttps://doi.org/10.1039/d5ra07267kopenalex-snapshot
A multifaceted review on extraction optimization, nanoformulation, and chemical modification approaches to enhance the yield, bioavailability, and health effects of xanthones
inferred← citeshttps://doi.org/10.1055/s-0036-1591894openalex-snapshot
Efficient Synthesis of 1-Thiomansonones with Anti-MRSA Activity
inferred← citeshttps://doi.org/10.1080/07391102.2025.2521413openalex-snapshot
α-Mangostin conjugated amino acids as estrogen receptor alpha (ERα) inhibitor
inferred← citeshttps://doi.org/10.1080/14786419.2018.1510925openalex-snapshot
Design, synthesis and cholinesterase inhibitory activity of α-mangostin derivatives
inferred← citeshttps://doi.org/10.1098/rsos.211583openalex-snapshot
Multiple roles of ribosomal antimicrobial peptides in tackling global antimicrobial resistance
inferred← citeshttps://doi.org/10.1111/cxo.13125openalex-snapshot
Antimicrobial resistance of ocular microbes and the role of antimicrobial peptides
inferred← citeshttps://doi.org/10.1126/sciadv.adt4723openalex-snapshot
Development of xanthone derivatives as effective broad-spectrum antimicrobials: Disrupting cell wall and inhibiting DNA synthesis
inferred← citeshttps://doi.org/10.1128/mmbr.00037-22openalex-snapshot
Antimicrobial Peptides and Small Molecules Targeting the Cell Membrane of Staphylococcus aureus
inferred← citeshttps://doi.org/10.1155/2021/9985604openalex-snapshot
Novel α-Mangostin Derivatives from Mangosteen (Garcinia mangostana L.) Peel Extract with Antioxidant and Anticancer Potential
inferred← citeshttps://doi.org/10.1177/2472555218812657openalex-snapshot
Addressing Antimicrobial Resistance through New Medicinal and Synthetic Chemistry Strategies
inferred← citeshttps://doi.org/10.12677/jocr.2015.33017openalex-snapshot
The Research Progress about Synthesis and Biological Activities of Xanthones
inferred← citeshttps://doi.org/10.1371/journal.pone.0144094openalex-snapshot
Aryl-Alkyl-Lysines: Agents That Kill Planktonic Cells, Persister Cells, Biofilms of MRSA and Protect Mice from Skin-Infection
inferred← citeshttps://doi.org/10.1371/journal.pone.0145918openalex-snapshot
Insights into the Mechanism of Action of Bactericidal Lipophosphonoxins
inferred← citeshttps://doi.org/10.2174/0109298673312728241014025846openalex-snapshot
Chemical Synthesis and Enzymatic Modification of Mangostins: A Comprehensive Review on Structural Modifications for Drug Discovery
inferred← citeshttps://doi.org/10.2174/0109298673312729250514115343openalex-snapshot
Exploring the Multitarget Therapeutic Potential of Mangostin Derivatives
inferred← citeshttps://doi.org/10.2174/1570159x19666211005145952openalex-snapshot
Computer Aided Drug Design Methodologies with Natural Products in the Drug Research Against Alzheimer’s Disease
inferred← citeshttps://doi.org/10.2174/1573406416666200619114124openalex-snapshot
Xanthone: A Promising Antimycobacterial Scaffold
inferred← citeshttps://doi.org/10.22159/ajpcr.2016.v9s3.14544openalex-snapshot
THE EFFECT OF ALPHA-MANGOSTIN IN BALANCING THE RATIO OF CYTOKINES PRO-AND ANTI-INFLAMMATION-GAMMA (IFN-γ/IL-10) AND SEVERITY OF THE DISEASE IN MICE INFECTED WITH MYCOBACTERIUM TUBERCULOSIS MULTIDRUG-RESISTANT
inferred← citeshttps://doi.org/10.2217/fmb-2015-0015openalex-snapshot
Membrane-Targeting AM-0016 Kills Mycobacterial Persisters and Shows Low Propensity for Resistance Development
inferred← citeshttps://doi.org/10.2306/scienceasia1513-1874.2024.050openalex-snapshot
Antibacterial and antioxidant aromatic butenolide derivatives from the endophytic fungus Aspergillus flavipes XC5-7
inferred← citeshttps://doi.org/10.32657/10356/151399openalex-snapshot
Nature-inspired antimicrobial nanofibers for infection control
inferred← citeshttps://doi.org/10.32657/10356/165631openalex-snapshot
Developing a hollow fiber infection model system to determine the PK/PD of conjugated oligoelectrolytes against clinically relevant pathogens
inferred← citeshttps://doi.org/10.32657/10356/72273openalex-snapshot
Role of biofilm formation, its triggered immune responses and potential new treatments for bacterial eye infections
inferred← citeshttps://doi.org/10.3389/fcimb.2023.1203663openalex-snapshot
Antimicrobial activity of α-mangostin against Staphylococcus species from companion animals in vitro and therapeutic potential of α-mangostin in skin diseases caused by S. pseudintermedius
inferred← citeshttps://doi.org/10.3389/fimmu.2022.915368openalex-snapshot
Antimicrobial Peptide Mimics for Clinical Use: Does Size Matter?
inferred← citeshttps://doi.org/10.3389/fmicb.2019.00150openalex-snapshot
Deciphering the Antibacterial Mode of Action of Alpha-Mangostin on Staphylococcus epidermidis RP62A Through an Integrated Transcriptomic and Proteomic Approach
inferred← citeshttps://doi.org/10.3389/fmicb.2019.00490openalex-snapshot
Antimicrobial and Synergistic Activity of 2,2′,4-Trihydroxybenzophenone Against Bacterial Pathogens of Poultry
inferred← citeshttps://doi.org/10.3389/fmicb.2019.00490/fullopenalex-snapshot
Antimicrobial and synergistic activity of 2,20,4-trihydroxybenzophenone against bacterial pathogens of poultry
inferred← citeshttps://doi.org/10.3389/fmicb.2019.02489openalex-snapshot
Antibacterial Effect and Mode of Action of Flavonoids From Licorice Against Methicillin-Resistant Staphylococcus aureus
inferred← citeshttps://doi.org/10.3389/fmicb.2024.1385585openalex-snapshot
A membrane-targeting magnolol derivative for the treatment of methicillin-resistant Staphylococcus aureus infections
inferred← citeshttps://doi.org/10.3389/fnins.2017.00073openalex-snapshot
Membrane Active Antimicrobial Peptides: Translating Mechanistic Insights to Design
inferred← citeshttps://doi.org/10.3390/antibiotics12030532openalex-snapshot
Conjugation as a Tool in Therapeutics: Role of Amino Acids/Peptides-Bioactive (Including Heterocycles) Hybrid Molecules in Treating Infectious Diseases
inferred← citeshttps://doi.org/10.3390/antibiotics8020044openalex-snapshot
Short Cationic Peptidomimetic Antimicrobials
inferred← citeshttps://doi.org/10.3390/app14135549openalex-snapshot
Glycine-Conjugated α-Mangostins as Potential Estrogen Receptor Alpha (ERα) Antagonists through Pharmacophore Modeling, Docking Analysis, and Molecular Dynamics Simulations
inferred← citeshttps://doi.org/10.3390/app16189240openalex-snapshot
Natural and Synthetic Xanthones in the Search for New Antimicrobial Agents: From Structural Diversity and In Vitro Activity to Translational Challenges
inferred← citeshttps://doi.org/10.3390/foods10102469openalex-snapshot
Polyphenolic Antibacterials for Food Preservation: Review, Challenges, and Current Applications
inferred← citeshttps://doi.org/10.3390/ijms241210357openalex-snapshot
Synthesis and Anti-Inflammatory Evaluation of a Library of Chiral Derivatives of Xanthones Conjugated with Proteinogenic Amino Acids
inferred← citeshttps://doi.org/10.3390/molecules24020314openalex-snapshot
Chiral Derivatives of Xanthones with Antimicrobial Activity
inferred← citeshttps://doi.org/10.3390/molecules24040791openalex-snapshot
Synthetic Chiral Derivatives of Xanthones: Biological Activities and Enantioselectivity Studies
inferred← citeshttps://doi.org/10.3390/molecules27175519openalex-snapshot
Three New Xanthones from Hypericum scabrum and Their Quorum Sensing Inhibitory Activities against Chromobacterium violaceum
inferred← citeshttps://doi.org/10.3390/molecules27217631openalex-snapshot
Amino-Acid-Conjugated Natural Compounds: Aims, Designs and Results
inferred← citeshttps://doi.org/10.3390/molecules28104009openalex-snapshot
Anticancer Activity of Chalcones and Its Derivatives: Review and In Silico Studies
inferred← citeshttps://doi.org/10.3390/ph14111141openalex-snapshot
Enantioselectivity of Chiral Derivatives of Xanthones in Virulence Effects of Resistant Bacteria
inferred← citeshttps://doi.org/10.3762/bjoc.14.284openalex-snapshot
Repurposing the anticancer drug cisplatin with the aim of developing novel Pseudomonas aeruginosa infection control agents
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