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Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications

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inferredcites →https://doi.org/10.1002/ana.22665openalex-snapshot
A channelopathy contributes to cerebellar dysfunction in a model of multiple sclerosis
inferredcites →https://doi.org/10.1002/ana.23725openalex-snapshot
Neuropathy‐associated NaV1.7 variant I228M impairs integrity of dorsal root ganglion neuron axons
inferredcites →https://doi.org/10.1002/anie.201308235openalex-snapshot
Saxitoxin
inferredcites →https://doi.org/10.1002/asia.201402202openalex-snapshot
Synthesis of 5‐ and 8‐Deoxytetrodotoxin
inferredcites →https://doi.org/10.1002/bip.22368openalex-snapshot
Re‐engineering the μ‐conotoxin SIIIA scaffold
inferredcites →https://doi.org/10.1002/cmdc.201190057openalex-snapshot
Cover Picture: Understanding of Molecular Substructures that Contribute to hERG K+ Channel Blockade: Synthesis and Biological Evaluation of E‐4031 Analogues (ChemMedChem 1/2012)
inferredcites →https://doi.org/10.1002/cne.21701openalex-snapshot
Tetrodotoxin‐resistant voltage‐gated sodium channels Nav1.8 and Nav1.9 are expressed in the retina
inferredcites →https://doi.org/10.1002/ejp.567openalex-snapshot
A systematic review of therapeutic interventions to reduce acute and chronic post‐surgical pain after amputation, thoracotomy or mastectomy
inferredcites →https://doi.org/10.1002/humu.21325openalex-snapshot
Congenital insensitivity to pain: novel SCN9A missense and in-frame deletion mutations
inferredcites →https://doi.org/10.1002/ijc.28890openalex-snapshot
The sodium channel β1 subunit mediates outgrowth of neurite‐like processes on breast cancer cells and promotes tumour growth and metastasis
inferredcites →https://doi.org/10.1007/978-3-642-41588-3openalex-snapshot
Voltage Gated Sodium Channels
inferredcites →https://doi.org/10.1007/978-3-642-41588-3_1openalex-snapshot
Introduction to Sodium Channels
inferredcites →https://doi.org/10.1007/978-3-642-41588-3_5openalex-snapshot
Altered Sodium Channel Gating as Molecular Basis for Pain: Contribution of Activation, Inactivation, and Resurgent Currents
inferredcites →https://doi.org/10.1007/978-3-642-41588-3_7openalex-snapshot
The Role of Late I Na in Development of Cardiac Arrhythmias
inferredcites →https://doi.org/10.1007/bfb0000612openalex-snapshot
Effects of veratridine on sodium currents and fluxes
inferredcites →https://doi.org/10.1007/s00018-003-2354-xopenalex-snapshot
Isolation and characterization of hainantoxin-IV, a novel antagonist of tetrodotoxin-sensitive sodium channels from the Chinese bird spider Selenocosmia hainana
inferredcites →https://doi.org/10.1007/s00408-013-9533-xopenalex-snapshot
Targeting Voltage Gated Sodium Channels NaV1.7, NaV1.8, and NaV1.9 for Treatment of Pathological Cough
inferredcites →https://doi.org/10.1007/s00424-010-0814-4openalex-snapshot
Sodium channelopathies of skeletal muscle result from gain or loss of function
inferredcites →https://doi.org/10.1007/s10549-012-2102-9openalex-snapshot
Therapeutic potential for phenytoin: targeting Nav1.5 sodium channels to reduce migration and invasion in metastatic breast cancer
inferredcites →https://doi.org/10.1007/s10989-013-9389-1openalex-snapshot
Roles of Individual Disulfide Bridges in the Conformation and Activity of μ-Conotoxin GIIIA, a Peptide Blocker of Muscle Sodium Channels
inferredcites →https://doi.org/10.1007/s11095-010-0052-7openalex-snapshot
In Vitro and In Vivo Effects of Water Extract of White Cocoa Tea (Camellia ptilophylla) Against Human Prostate Cancer
inferredcites →https://doi.org/10.1007/s12017-013-8220-7openalex-snapshot
Neurotoxicity and Reactive Astrogliosis in the Anterior Cingulate Cortex in Acute Ciguatera Poisoning
inferredcites →https://doi.org/10.1007/s12640-013-9429-9openalex-snapshot
Neuroprotective Effects of Rosmarinic Acid on Ciguatoxin in Primary Human Neurons
inferredcites →https://doi.org/10.1016/j.ajhg.2013.09.016openalex-snapshot
Gain-of-Function Mutations in SCN11A Cause Familial Episodic Pain
inferredcites →https://doi.org/10.1016/j.bbrc.2014.02.115openalex-snapshot
Mechanism of tetrodotoxin block and resistance in sodium channels
inferredcites →https://doi.org/10.1016/j.bcp.2008.03.019openalex-snapshot
Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels NaV1.2, 1.6 and 1.7
inferredcites →https://doi.org/10.1016/j.bmc.2012.03.034openalex-snapshot
Solution NMR analysis of the binding mechanism of DIVS6 model peptides of voltage-gated sodium channels and the lipid soluble alkaloid veratridine
inferredcites →https://doi.org/10.1016/j.bmcl.2013.06.086openalex-snapshot
De novo design and synthesis of a μ-conotoxin KIIIA peptidomimetic
inferredcites →https://doi.org/10.1016/j.bmcl.2014.08.017openalex-snapshot
The discovery of benzenesulfonamide-based potent and selective inhibitors of voltage-gated sodium channel Nav1.7
inferredcites →https://doi.org/10.1016/j.bpj.2013.04.035openalex-snapshot
The Mechanism of Na+/K+ Selectivity in Mammalian Voltage-Gated Sodium Channels Based on Molecular Dynamics Simulation
inferredcites →https://doi.org/10.1016/j.cell.2014.03.064openalex-snapshot
RETRACTED: A Monoclonal Antibody that Targets a NaV1.7 Channel Voltage Sensor for Pain and Itch Relief
inferredcites →https://doi.org/10.1016/j.ejca.2013.03.016openalex-snapshot
Ovarian cancer: Ion channel and aquaporin expression as novel targets of clinical potential
inferredcites →https://doi.org/10.1016/j.ejmech.2013.04.041openalex-snapshot
Expanding chemical diversity of conotoxins: Peptoid–peptide chimeras of the sodium channel blocker μ-KIIIA and its selenopeptide analogues
inferredcites →https://doi.org/10.1016/j.genhosppsych.2008.12.006openalex-snapshot
Pharmacotherapy of chronic pain: a synthesis of recommendations from systematic reviews
inferredcites →https://doi.org/10.1016/j.jacc.2014.04.032openalex-snapshot
Mutations in SCN10A Are Responsible for a Large Fraction of Cases of Brugada Syndrome
inferredcites →https://doi.org/10.1016/j.jmb.2013.06.036openalex-snapshot
Two Alternative Conformations of a Voltage-Gated Sodium Channel
inferredcites →https://doi.org/10.1016/j.jmb.2013.10.010openalex-snapshot
Structure of a Prokaryotic Sodium Channel Pore Reveals Essential Gating Elements and an Outer Ion Binding Site Common to Eukaryotic Channels
inferredcites →https://doi.org/10.1016/j.jpain.2012.03.009openalex-snapshot
The Economic Costs of Pain in the United States
inferredcites →https://doi.org/10.1016/j.molmed.2014.06.003openalex-snapshot
Channelopathies, painful neuropathy, and diabetes: which way does the causal arrow point?
inferredcites →https://doi.org/10.1016/j.neuron.2010.08.021openalex-snapshot
Ion Channel Voltage Sensors: Structure, Function, and Pathophysiology
inferredcites →https://doi.org/10.1016/j.neuron.2013.09.012openalex-snapshot
Noncanonical Roles of Voltage-Gated Sodium Channels
inferredcites →https://doi.org/10.1016/j.neuroscience.2007.01.054openalex-snapshot
Small interfering RNA-mediated selective knockdown of NaV1.8 tetrodotoxin-resistant sodium channel reverses mechanical allodynia in neuropathic rats
inferredcites →https://doi.org/10.1016/j.pain.2011.09.008openalex-snapshot
Treatment of Nav1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker
inferredcites →https://doi.org/10.1016/j.pain.2013.03.037openalex-snapshot
The scorpion toxin Amm VIII induces pain hypersensitivity through gain-of-function of TTX-sensitive Na+ channels
inferredcites →https://doi.org/10.1016/j.pain.2014.01.003openalex-snapshot
Letter to the Editor
inferredcites →https://doi.org/10.1016/j.pain.2014.05.006openalex-snapshot
Paroxysmal itch caused by gain-of-function Nav1.7 mutation
inferredcites →https://doi.org/10.1016/j.pupt.2013.07.001openalex-snapshot
Regulation of cough and action potentials by voltage-gated Na channels
inferredcites →https://doi.org/10.1016/j.tips.2013.12.007openalex-snapshot
Therapeutic potential of NaV1.1 activators
inferredcites →https://doi.org/10.1016/j.toxicon.2005.10.008openalex-snapshot
A novel conotoxin from Conus striatus, μ-SIIIA, selectively blocking rat tetrodotoxin-resistant sodium channels
inferredcites →https://doi.org/10.1016/j.toxicon.2006.07.032openalex-snapshot
Species selective resistance of cardiac muscle voltage gated sodium channels: Characterization of brevetoxin and ciguatoxin binding sites in rats and fish
inferredcites →https://doi.org/10.1016/j.toxicon.2009.02.028openalex-snapshot
Sea anemone toxins affecting voltage-gated sodium channels – molecular and evolutionary features
inferredcites →https://doi.org/10.1016/j.toxicon.2012.04.337openalex-snapshot
Spider-venom peptides that target voltage-gated sodium channels: Pharmacological tools and potential therapeutic leads
inferredcites →https://doi.org/10.1016/j.toxicon.2012.11.026openalex-snapshot
The molecular mystique of tetrodotoxin
inferredcites →https://doi.org/10.1016/j.toxicon.2013.01.014openalex-snapshot
The venom of the fishing spider Dolomedes sulfurous contains various neurotoxins acting on voltage-activated ion channels in rat dorsal root ganglion neurons
inferredcites →https://doi.org/10.1016/j.toxicon.2013.05.015openalex-snapshot
Synthesis and biological characterization of synthetic analogs of Huwentoxin-IV (Mu-theraphotoxin-Hh2a), a neuronal tetrodotoxin-sensitive sodium channel inhibitor
inferredcites →https://doi.org/10.1016/j.toxicon.2014.01.006openalex-snapshot
Poor alkaloid sequestration by arrow poison frogs of the genus Phyllobates from Costa Rica
inferredcites →https://doi.org/10.1016/j.toxicon.2014.02.013openalex-snapshot
A purified Palythoa venom fraction delays sodium current inactivation in sympathetic neurons
inferredcites →https://doi.org/10.1016/j.toxicon.2014.05.006openalex-snapshot
Ciguatera fish poisoning in Hong Kong–A 10-year perspective on the class of ciguatoxins
inferredcites →https://doi.org/10.1016/s0021-9258(17)39364-xopenalex-snapshot
Conus geographus toxins that discriminate between neuronal and muscle sodium channels.
inferredcites →https://doi.org/10.1016/s0021-9258(19)45312-xopenalex-snapshot
The saxitoxin receptor of the sodium channel from rat brain. Evidence for two nonidentical beta subunits.
inferredcites →https://doi.org/10.1016/s0022-3565(25)32194-4openalex-snapshot
The potent excitatory effect of a novel polypeptide, anthopleurin-B, isolated from a sea anemone (Anthopleura xanthogrammica) on the frog spinal cord.
inferredcites →https://doi.org/10.1016/s0041-0101(00)00160-4openalex-snapshot
The cystine knot motif in toxins and implications for drug design
inferredcites →https://doi.org/10.1016/s0041-0101(98)00169-xopenalex-snapshot
Ciguatoxins and brevetoxins, neurotoxic polyether compounds active on sodium channels
inferredcites →https://doi.org/10.1016/s0041-0101(99)00108-7openalex-snapshot
Antillatoxin and kalkitoxin, ichthyotoxins from the tropical cyanobacterium Lyngbya majuscula, induce distinct temporal patterns of NMDA receptor-mediated neurotoxicity
inferredcites →https://doi.org/10.1016/s0300-9084(00)01174-3openalex-snapshot
Molecular mechanisms of neurotoxin action on voltage-gated sodium channels
inferredcites →https://doi.org/10.1016/s0896-6273(00)81133-2openalex-snapshot
From Ionic Currents to Molecular Mechanisms
inferredcites →https://doi.org/10.1016/s1474-4422(14)70024-9openalex-snapshot
Painful and painless channelopathies
inferredcites →https://doi.org/10.1021/bi00427a049openalex-snapshot
A molluskivorous Conus toxin: conserved frameworks in conotoxins
inferredcites →https://doi.org/10.1021/bi026546aopenalex-snapshot
Two Tarantula Peptides Inhibit Activation of Multiple Sodium Channels
inferredcites →https://doi.org/10.1021/bi700797fopenalex-snapshot
Structure and Sodium Channel Activity of an Excitatory I1-Superfamily Conotoxin,
inferredcites →https://doi.org/10.1021/cb400012kopenalex-snapshot
Chemical Engineering and Structural and Pharmacological Characterization of the α-Scorpion Toxin OD1
inferredcites →https://doi.org/10.1021/ja00136a031openalex-snapshot
Antillatoxin: An Exceptionally Ichthyotoxic Cyclic Lipopeptide from the Tropical Cyanobacterium Lyngbya majuscula
inferredcites →https://doi.org/10.1021/ja01079a026openalex-snapshot
Batrachotoxin. The Active Principle of the Colombian Arrow Poison Frog, Phyllobates bicolor
inferredcites →https://doi.org/10.1021/jm200839aopenalex-snapshot
Lactam-Stabilized Helical Analogues of the Analgesic μ-Conotoxin KIIIA
inferredcites →https://doi.org/10.1021/jm500687uopenalex-snapshot
Studies Examining the Relationship between the Chemical Structure of Protoxin II and Its Activity on Voltage Gated Sodium Channels
inferredcites →https://doi.org/10.1021/jo00087a027openalex-snapshot
Conformational Analysis of the Sodium Channel Modulator, Brevetoxin A, Comparison with Brevetoxin B Conformations, and a Hypothesis about the Common Pharmacophore of the "Site 5" Toxins
inferredcites →https://doi.org/10.1021/np401097nopenalex-snapshot
Isolation of 6-Deoxytetrodotoxin from the Pufferfish, Takifugu pardalis , and a Comparison of the Effects of the C-6 and C-11 Hydroxy Groups of Tetrodotoxin on Its Activity
inferredcites →https://doi.org/10.1034/j.1399-3011.1999.00039.xopenalex-snapshot
Purification and characterization of huwentoxin‐II, a neurotoxic peptide from the venom of the Chinese bird spider Selenocosmia huwena
inferredcites →https://doi.org/10.1038/356441a0openalex-snapshot
Calcium channel characteristics conferred on the sodium channel by single mutations
inferredcites →https://doi.org/10.1038/9195openalex-snapshot
The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways
inferredcites →https://doi.org/10.1038/cr.2012.173openalex-snapshot
Analysis of the selectivity filter of the voltage-gated sodium channel NavRh
inferredcites →https://doi.org/10.1038/ejhg.2014.166openalex-snapshot
The phenotype of congenital insensitivity to pain due to the NaV1.9 variant p.L811P
inferredcites →https://doi.org/10.1038/nature05413openalex-snapshot
An SCN9A channelopathy causes congenital inability to experience pain
inferredcites →https://doi.org/10.1038/nature05598openalex-snapshot
Gating pore current in an inherited ion channelopathy
inferredcites →https://doi.org/10.1038/nature09975openalex-snapshot
Loss-of-function mutations in sodium channel Nav1.7 cause anosmia
inferredcites →https://doi.org/10.1038/nature10238openalex-snapshot
The crystal structure of a voltage-gated sodium channel
inferredcites →https://doi.org/10.1038/nature10945openalex-snapshot
De novo mutations revealed by whole-exome sequencing are strongly associated with autism
inferredcites →https://doi.org/10.1038/nature11054openalex-snapshot
Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel
inferredcites →https://doi.org/10.1038/nature11077openalex-snapshot
Crystal structure of a voltage-gated sodium channel in two potentially inactivated states
inferredcites →https://doi.org/10.1038/ncomms1795openalex-snapshot
Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons
inferredcites →https://doi.org/10.1038/ncomms2077openalex-snapshot
Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing
inferredcites →https://doi.org/10.1038/ncomms3465openalex-snapshot
Role of the C-terminal domain in the structure and function of tetrameric sodium channels
inferredcites →https://doi.org/10.1038/ncomms4420openalex-snapshot
Evolutionarily conserved intracellular gate of voltage-dependent sodium channels
inferredcites →https://doi.org/10.1038/ncpneuro0735openalex-snapshot
Mechanisms of Disease: sodium channels and neuroprotection in multiple sclerosis—current status
inferredcites →https://doi.org/10.1038/ng.2767openalex-snapshot
A de novo gain-of-function mutation in SCN11A causes loss of pain perception
inferredcites →https://doi.org/10.1038/nm.2750openalex-snapshot
Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy
inferredcites →https://doi.org/10.1038/nrn3404openalex-snapshot
The NaV1.7 sodium channel: from molecule to man
inferredcites →https://doi.org/10.1042/bj20131275openalex-snapshot
Nedd4-2 (NEDD4L) controls intracellular Na+-mediated activity of voltage-gated sodium channels in primary cortical neurons
inferredcites →https://doi.org/10.1073/pnas.0400368101openalex-snapshot
The structure of zetekitoxin AB, a saxitoxin analog from the Panamanian golden frog Atelopus zeteki : A potent sodium-channel blocker
inferredcites →https://doi.org/10.1073/pnas.0404915101openalex-snapshot
Nociceptor-specific gene deletion reveals a major role for Na v 1.7 (PN1) in acute and inflammatory pain
inferredcites →https://doi.org/10.1073/pnas.0611364104openalex-snapshot
A-803467, a potent and selective Na v 1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
inferredcites →https://doi.org/10.1073/pnas.1106811108openalex-snapshot
Voltage-gated sodium channel (Na V ) protein dissection creates a set of functional pore-only proteins
inferredcites →https://doi.org/10.1073/pnas.1107027108openalex-snapshot
μ-Conotoxins that differentially block sodium channels Na V 1.1 through 1.8 identify those responsible for action potentials in sciatic nerve
inferredcites →https://doi.org/10.1073/pnas.1112320108openalex-snapshot
Mapping the receptor site for α-scorpion toxins on a Na + channel voltage sensor
inferredcites →https://doi.org/10.1073/pnas.1214667110openalex-snapshot
Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel
inferredcites →https://doi.org/10.1073/pnas.1216080109openalex-snapshot
Gain-of-function Na v 1.8 mutations in painful neuropathy
inferredcites →https://doi.org/10.1073/pnas.1220844110openalex-snapshot
Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels
inferredcites →https://doi.org/10.1073/pnas.1306285110openalex-snapshot
Discovery of a selective Na V 1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models
inferredcites →https://doi.org/10.1073/pnas.1309827110openalex-snapshot
Nonfunctional Na V 1.1 familial hemiplegic migraine mutant transformed into gain of function by partial rescue of folding defects
inferredcites →https://doi.org/10.1073/pnas.1320907111openalex-snapshot
Ion conduction and conformational flexibility of a bacterial voltage-gated sodium channel
inferredcites →https://doi.org/10.1073/pnas.1324189111openalex-snapshot
A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ
inferredcites →https://doi.org/10.1073/pnas.1406855111openalex-snapshot
Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism
inferredcites →https://doi.org/10.1073/pnas.75.6.2606openalex-snapshot
Purification of the tetrodotoxin-binding component associated with the voltage-sensitive sodium channel from Electrophorus electricus electroplax membranes.
inferredcites →https://doi.org/10.1073/pnas.77.1.639openalex-snapshot
Covalent labeling of protein components of the sodium channel with a photoactivable derivative of scorpion toxin.
inferredcites →https://doi.org/10.1073/pnas.78.7.4620openalex-snapshot
Purification of the saxitoxin receptor of the sodium channel from rat brain.
inferredcites →https://doi.org/10.1074/jbc.270.28.16796openalex-snapshot
A New Family of Conotoxins That Blocks Voltage-gated Sodium Channels
inferredcites →https://doi.org/10.1074/jbc.m111.282509openalex-snapshot
Structure-Function Map of the Receptor Site for β-Scorpion Toxins in Domain II of Voltage-gated Sodium Channels
inferredcites →https://doi.org/10.1074/jbc.m112.434266openalex-snapshot
Proton Sensors in the Pore Domain of the Cardiac Voltage-gated Sodium Channel
inferredcites →https://doi.org/10.1074/jbc.m112.445924openalex-snapshot
The Fibroblast Growth Factor 14·Voltage-gated Sodium Channel Complex Is a New Target of Glycogen Synthase Kinase 3 (GSK3)
inferredcites →https://doi.org/10.1074/jbc.m113.462366openalex-snapshot
Molecular Architecture of a Sodium Channel S6 Helix
inferredcites →https://doi.org/10.1074/jbc.m113.527994openalex-snapshot
Crystal Structure and Molecular Imaging of the Nav Channel β3 Subunit Indicates a Trimeric Assembly
inferredcites →https://doi.org/10.1074/jbc.m309576200openalex-snapshot
A δ-Conotoxin from Conus ermineus Venom Inhibits Inactivation in Vertebrate Neuronal Na+ Channels but Not in Skeletal and Cardiac Muscles
inferredcites →https://doi.org/10.1074/jbc.m412552200openalex-snapshot
Differential Phospholipid Binding by Site 3 and Site 4 Toxins
inferredcites →https://doi.org/10.1074/jbc.m704616200openalex-snapshot
Structure/Function Characterization of μ-Conotoxin KIIIA, an Analgesic, Nearly Irreversible Blocker of Mammalian Neuronal Sodium Channels
inferredcites →https://doi.org/10.1074/jbc.m806481200openalex-snapshot
Synthetic Ciguatoxins Selectively Activate Nav1.8-derived Chimeric Sodium Channels Expressed in HEK293 Cells
inferredcites →https://doi.org/10.1085/jgp.201310984openalex-snapshot
Interactions among DIV voltage-sensor movement, fast inactivation, and resurgent Na current induced by the NaVβ4 open-channel blocking peptide
inferredcites →https://doi.org/10.1085/jgp.201311036openalex-snapshot
Asymmetric functional contributions of acidic and aromatic side chains in sodium channel voltage-sensor domains
inferredcites →https://doi.org/10.1085/jgp.201311037openalex-snapshot
Sodium channel selectivity and conduction: Prokaryotes have devised their own molecular strategy
inferredcites →https://doi.org/10.1093/brain/awr143openalex-snapshot
Deletion mutation of sodium channel NaV1.7 in inherited erythromelalgia: enhanced slow inactivation modulates dorsal root ganglion neuron hyperexcitability
inferredcites →https://doi.org/10.1093/brain/aws225openalex-snapshot
Neurological perspectives on voltage-gated sodium channels
inferredcites →https://doi.org/10.1093/brain/awu079openalex-snapshot
Gain-of-function mutations in sodium channel NaV1.9 in painful neuropathy
inferredcites →https://doi.org/10.1098/rstb.2013.0105openalex-snapshot
Regulation of voltage-gated sodium channel expression in cancer: hormones, growth factors and auto-regulation
inferredcites →https://doi.org/10.1111/bph.12051openalex-snapshot
Co‐expression of NaVβ subunits alters the kinetics of inhibition of voltage‐gated sodium channels by pore‐blocking μ‐conotoxins
inferredcites →https://doi.org/10.1111/bph.12119openalex-snapshot
Pharmacological fractionation of tetrodotoxin‐sensitive sodium currents in rat dorsal root ganglion neurons by μ‐conotoxins
inferredcites →https://doi.org/10.1111/j.1749-6632.1999.tb11272.xopenalex-snapshot
Diversity of Mammalian Voltage‐Gated Sodium Channels
inferredcites →https://doi.org/10.1113/expphysiol.1968.sp001951openalex-snapshot
THE FAILURE OF RESPIRATION IN DEATH BY TETRODOTOXIN POISONING
inferredcites →https://doi.org/10.1113/expphysiol.2013.071969openalex-snapshot
Structure and function of voltage‐gated sodium channels at atomic resolution
inferredcites →https://doi.org/10.1113/jphysiol.1952.sp004764openalex-snapshot
A quantitative description of membrane current and its application to conduction and excitation in nerve
inferredcites →https://doi.org/10.1124/jpet.110.178343openalex-snapshot
NaVβ Subunits Modulate the Inhibition of NaV1.8 by the Analgesic Gating Modifier μO-Conotoxin MrVIB
inferredcites →https://doi.org/10.1124/mol.106.022970openalex-snapshot
Potent Modulation of the Voltage-Gated Sodium Channel Nav1.7 by OD1, a Toxin from the Scorpion Odonthobuthus doriae
inferredcites →https://doi.org/10.1124/mol.107.039867openalex-snapshot
The Investigational Anticonvulsant Lacosamide Selectively Enhances Slow Inactivation of Voltage-Gated Sodium Channels
inferredcites →https://doi.org/10.1124/mol.107.041046openalex-snapshot
Inhibition of Sodium Channel Gating by Trapping the Domain II Voltage Sensor with Protoxin II
inferredcites →https://doi.org/10.1124/mol.113.091173openalex-snapshot
Block of Human Cardiac Sodium Channels by Lacosamide: Evidence for Slow Drug Binding along the Activation Pathway
inferredcites →https://doi.org/10.1124/pr.111.005322openalex-snapshot
Conus Venom Peptide Pharmacology
inferredcites →https://doi.org/10.1124/pr.57.4.4openalex-snapshot
International Union of Pharmacology. XLVII. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels
inferredcites →https://doi.org/10.1126/science.1213760openalex-snapshot
The Molecular Basis of Acid Insensitivity in the African Naked Mole-Rat
inferredcites →https://doi.org/10.1126/science.1236451openalex-snapshot
Voltage-Gated Sodium Channel in Grasshopper Mice Defends Against Bark Scorpion Toxin
inferredcites →https://doi.org/10.1126/science.1470919openalex-snapshot
Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
inferredcites →https://doi.org/10.1146/annurev-pharmtox-011112-140232openalex-snapshot
Sodium Channels, Inherited Epilepsy, and Antiepileptic Drugs
inferredcites →https://doi.org/10.1152/ajpcell.00070.2007openalex-snapshot
The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Nav1.6voltage-dependent sodium channel
inferredcites →https://doi.org/10.1152/ajpregu.00028.2013openalex-snapshot
Selective inhibition of vagal afferent nerve pathways regulating cough using Nav 1.7 shRNA silencing in guinea pig nodose ganglia
inferredcites →https://doi.org/10.1172/jci40801openalex-snapshot
Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents
inferredcites →https://doi.org/10.1172/jci73140openalex-snapshot
A common genetic variant within SCN10A modulates cardiac SCN5A expression
inferredcites →https://doi.org/10.1186/1471-2350-15-35openalex-snapshot
De novo SCN2A splice site mutation in a boy with Autism spectrum disorder
inferredcites →https://doi.org/10.1186/1744-8069-10-7openalex-snapshot
A Comparison of RNA-Seq and Exon Arrays for Whole Genome Transcription Profiling of the L5 Spinal Nerve Transection Model of Neuropathic Pain in the Rat
inferredcites →https://doi.org/10.1186/1744-8069-7-32openalex-snapshot
Nav1.7 is the Predominant Sodium Channel in Rodent Olfactory Sensory Neurons
inferredcites →https://doi.org/10.1213/ane.0000000000000070openalex-snapshot
The Endocannabinoid Anandamide Inhibits Voltage-Gated Sodium Channels Nav1.2, Nav1.6, Nav1.7, and Nav1.8 in Xenopus Oocytes
inferredcites →https://doi.org/10.1289/ehp.1307196openalex-snapshot
Ciguatera Fish Poisoning and Climate Change: Analysis of National Poison Center Data in the United States, 2001–2011
inferredcites →https://doi.org/10.1371/journal.pone.0093267openalex-snapshot
Mechanism of μ-Conotoxin PIIIA Binding to the Voltage-Gated Na+ Channel NaV1.4
inferredcites →https://doi.org/10.1371/journal.pone.0105895openalex-snapshot
Global Nav1.7 Knockout Mice Recapitulate the Phenotype of Human Congenital Indifference to Pain
inferredcites →https://doi.org/10.1517/13543776.2014.995628openalex-snapshot
Sodium channel blockers: a patent review (2010 – 2014)
inferredcites →https://doi.org/10.1517/14712598.2011.621940openalex-snapshot
Venoms as a platform for human drugs: translating toxins into therapeutics
inferredcites →https://doi.org/10.1517/17460441.2014.942217openalex-snapshot
New strategies in ion channel screening for drug discovery: are there ways to improve its productivity?
inferredcites →https://doi.org/10.1523/jneurosci.18-12-04473.1998openalex-snapshot
μ-Conotoxin PIIIA, a New Peptide for Discriminating among Tetrodotoxin-Sensitive Na Channel Subtypes
inferredcites →https://doi.org/10.1523/jneurosci.20-20-07743.2000openalex-snapshot
Na v 2/NaG Channel Is Involved in Control of Salt-Intake Behavior in the CNS
inferredcites →https://doi.org/10.1523/jneurosci.23-26-08881.2003openalex-snapshot
Upregulation of Sodium Channel Nav1.3 and Functional Involvement in Neuronal Hyperexcitability Associated with Central Neuropathic Pain after Spinal Cord Injury
inferredcites →https://doi.org/10.1523/jneurosci.5011-13.2014openalex-snapshot
Tetrodotoxin-Resistant Sodium Channels in Sensory Neurons Generate Slow Resurgent Currents That Are Enhanced by Inflammatory Mediators
inferredcites →https://doi.org/10.2174/09298665113206660119openalex-snapshot
Analgesic Effects of Huwentoxin-IV on Animal Models of Inflammatory and Neuropathic Pain
inferredcites →https://doi.org/10.2174/1574892811308010066openalex-snapshot
Persistent Current Blockers of Voltage-Gated Sodium Channels: A Clinical Opportunity for Controlling Metastatic Disease
inferredcites →https://doi.org/10.2183/pjab.90.56openalex-snapshot
Chemical construction and structural permutation of neurotoxic natural product, antillatoxin: importance of the three-dimensional structure of the bulky side chain
inferredcites →https://doi.org/10.2337/db13-1562openalex-snapshot
Blockade of Na+ Channels in Pancreatic α-Cells Has Antidiabetic Effects
inferredcites →https://doi.org/10.3389/fgene.2013.00222openalex-snapshot
Channelopathy pathogenesis in autism spectrum disorders
inferredcites →https://doi.org/10.3389/fphar.2011.00053openalex-snapshot
Na+ Channel ? Subunits: Overachievers of the Ion Channel Family
inferredcites →https://doi.org/10.3389/fphar.2012.00005openalex-snapshot
Aldo–Keto Reductase 1B10 and Its Role in Proliferation Capacity of Drug-Resistant Cancers
inferredcites →https://doi.org/10.3389/fphar.2012.00112openalex-snapshot
Pathophysiological Role of Omega Pore Current in Channelopathies
inferredcites →https://doi.org/10.3390/ijms14059779openalex-snapshot
Effects of (−)-Gallocatechin-3-Gallate on Tetrodotoxin-Resistant Voltage-Gated Sodium Channels in Rat Dorsal Root Ganglion Neurons
inferredcites →https://doi.org/10.3390/toxins6030816openalex-snapshot
Characterization of a Novel BmαTX47 Toxin Modulating Sodium Channels: The Crucial Role of Expression Vectors in Toxin Pharmacological Activity
inferredcites →https://doi.org/10.3892/ol.2014.2110openalex-snapshot
Voltage-gated sodium channels were differentially expressed in human normal prostate, benign prostatic hyperplasia and prostate cancer cells
inferredcites →https://doi.org/10.3987/rev-08-sr(d)6openalex-snapshot
Discovery of Batrachotoxin: The Launch of the Frog Alkaloid Program at NIH
inferredcites →https://doi.org/10.4155/ppa.14.39openalex-snapshot
Inhibitors of voltage-gated Sodium Channel Na v 1.7: Patent Applications Since 2010
inferredcites →https://doi.org/10.4161/chan.21910openalex-snapshot
Voltage-gated sodium channels and metastatic disease
inferredcites →https://doi.org/10.4161/chan.28136openalex-snapshot
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inferredcites →https://doi.org/10.4172/2324-9110.1000102openalex-snapshot
Expression of Voltage-Gated Sodium Channel Nav1.8 in Human Prostate Cancer is Associated with High Histological Grade
inferredcites →https://doi.org/10.5740/jaoacint.sgemccallopenalex-snapshot
Development and Utilization of a Fluorescence-Based Receptor-Binding Assay for the Site 5 Voltage-Sensitive Sodium Channel Ligands Brevetoxin and Ciguatoxin
inferredcites →https://doi.org/10.5740/jaoacint.sgetsumurayaopenalex-snapshot
Preparation of Anti-Ciguatoxin Monoclonal Antibodies Using Synthetic Haptens: Sandwich ELISA Detection of Ciguatoxins

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation
inferred← citeshttps://doi.org/10.1016/j.bmc.2018.10.012openalex-snapshot
Veratridine binding to a transmembrane helix of sodium channel Nav1.4 determined by solid-state NMR
inferred← citeshttps://doi.org/10.1016/j.bmcl.2015.06.033openalex-snapshot
Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1
inferred← citeshttps://doi.org/10.1016/j.bmcl.2015.12.103openalex-snapshot
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The discovery of tetrahydropyridine analogs as hNav1.7 selective inhibitors for analgesia
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Discovery of selective, orally bioavailable, N-linked arylsulfonamide Nav1.7 inhibitors with pain efficacy in mice
inferred← citeshttps://doi.org/10.1016/j.bmcl.2017.04.040openalex-snapshot
Benzoxazolinone aryl sulfonamides as potent, selective Nav1.7 inhibitors with in vivo efficacy in a preclinical pain model
inferred← citeshttps://doi.org/10.1016/j.bmcl.2017.06.054openalex-snapshot
Discovery of a biarylamide series of potent, state-dependent NaV1.7 inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmcl.2017.09.056openalex-snapshot
Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes
inferred← citeshttps://doi.org/10.1016/j.bmcl.2018.01.035openalex-snapshot
Discovery of morpholine-based aryl sulfonamides as Nav1.7 inhibitors
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1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of NaV1.7 inhibition
inferred← citeshttps://doi.org/10.1016/j.bmcl.2018.08.007openalex-snapshot
Nav1.7 inhibitors for the treatment of chronic pain
inferred← citeshttps://doi.org/10.1016/j.bmcl.2018.12.013openalex-snapshot
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A survey of the clinical pipeline in neuroscience
inferred← citeshttps://doi.org/10.1016/j.bmcl.2024.130033openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bmcl.2024.130059openalex-snapshot
Development and characterization of pyridyl carboxamides as potent and highly selective Nav1.8 inhibitors
inferred← citeshttps://doi.org/10.1016/j.bpj.2023.11.785openalex-snapshot
A binding site for phosphoinositide modulation of voltage-gated sodium channels described by multiscale simulations
inferred← citeshttps://doi.org/10.1016/j.brainres.2021.147565openalex-snapshot
The impairment of motor coordination following chronic carbamazepine-levetiracetam combination treatment with evidence of corticocerebellar toxicity in male Wistar rats
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GEO-Nav: A geometric dataset of voltage-gated sodium channels
inferred← citeshttps://doi.org/10.1016/j.cbpa.2017.03.004openalex-snapshot
Progress and challenges in the optimization of toxin peptides for development as pain therapeutics
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Discovery, structure, and chemical synthesis of disulfide-rich peptide toxins and their analogs
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The role of ion channels in the regulation of dendritic cell function
inferred← citeshttps://doi.org/10.1016/j.celrep.2022.110735openalex-snapshot
High-resolution structures of human Nav1.7 reveal gating modulation through α-π helical transition of S6IV
inferred← citeshttps://doi.org/10.1016/j.chembiol.2024.07.008openalex-snapshot
A versatile residue numbering scheme for Nav and Cav channels
inferred← citeshttps://doi.org/10.1016/j.compbiomed.2022.105414openalex-snapshot
PEP-PREDNa+: A web server for prediction of highly specific peptides targeting voltage-gated Na+ channels using machine learning techniques
inferred← citeshttps://doi.org/10.1016/j.compbiomed.2024.108737openalex-snapshot
NaII-Pred: An ensemble-learning framework for the identification and interpretation of sodium ion inhibitors by fusing multiple feature representation
inferred← citeshttps://doi.org/10.1016/j.drudis.2019.05.014openalex-snapshot
Voltage-gated sodium channels: structures, functions, and molecular modeling
inferred← citeshttps://doi.org/10.1016/j.drudis.2021.01.026openalex-snapshot
Sodium ion channels as potential therapeutic targets for cancer metastasis
inferred← citeshttps://doi.org/10.1016/j.ejbas.2017.06.005openalex-snapshot
Dichloro-substituted phenyl amino propanamides exhibit anticonvulsant effect and reduce inward sodium ion current (NaV1.6)
inferred← citeshttps://doi.org/10.1016/j.ejmech.2023.115371openalex-snapshot
Discovery of selective NaV1.8 inhibitors based on 5-chloro-2-(4,4-difluoroazepan-1-yl)-6-methyl nicotinamide scaffold for the treatment of pain
inferred← citeshttps://doi.org/10.1016/j.ejmech.2023.115530openalex-snapshot
New aryl and acylsulfonamides as state-dependent inhibitors of Nav1.3 voltage-gated sodium channel
inferred← citeshttps://doi.org/10.1016/j.ejphar.2018.11.017openalex-snapshot
RhoA and Rho-kinase inhibitors modulate cervical resistance: The possible role of RhoA/Rho-kinase signalling pathway in cervical ripening and contractility
inferred← citeshttps://doi.org/10.1016/j.ejphar.2026.179303openalex-snapshot
Molecular basis of dual-site engagement and selectivity of CcoTx3-synth for hNaV1.5
inferred← citeshttps://doi.org/10.1016/j.eplepsyres.2017.10.017openalex-snapshot
Early-onset epileptic encephalopathy with de novo SCN8A mutation
inferred← citeshttps://doi.org/10.1016/j.gene.2026.150172openalex-snapshot
Hypokalemic periodic paralysis: novel perspectives from genetic mutations to clinical management
inferred← citeshttps://doi.org/10.1016/j.heliyon.2023.e23663openalex-snapshot
SCN4A-related congenital myopathy in a Han Chinese patient: A case report and literature review
inferred← citeshttps://doi.org/10.1016/j.hrthm.2024.06.029openalex-snapshot
New focus on cardiac voltage-gated sodium channel β1 and β1B: Novel targets for treating and understanding arrhythmias?
inferred← citeshttps://doi.org/10.1016/j.imu.2022.101117openalex-snapshot
In silico study of local anesthetics analogues on sodium channel Nav 1.7 a pharmacological target on inflamed dental pulp
inferred← citeshttps://doi.org/10.1016/j.jacep.2021.12.001openalex-snapshot
Brugada Syndrome
inferred← citeshttps://doi.org/10.1016/j.jacep.2022.02.017openalex-snapshot
Congenital Long QT Syndrome
inferred← citeshttps://doi.org/10.1016/j.jad.2021.04.096openalex-snapshot
Exploring real-world evidence to uncover unknown drug benefits and support the discovery of new treatment targets for depressive and bipolar disorders
inferred← citeshttps://doi.org/10.1016/j.jep.2020.113736openalex-snapshot
Active components of Bupleurum chinense and Angelica biserrata showed analgesic effects in formalin induced pain by acting on Nav1.7
inferred← citeshttps://doi.org/10.1016/j.jep.2025.120129openalex-snapshot
Traditional Chinese medicine treatment for epilepsy: Focusing on voltage-gated ion channels
inferred← citeshttps://doi.org/10.1016/j.jmb.2021.166967openalex-snapshot
Structural Pharmacology of Voltage-Gated Sodium Channels
inferred← citeshttps://doi.org/10.1016/j.jmgm.2018.05.006openalex-snapshot
In silico insight into voltage-gated sodium channel 1.7 inhibition for anti-pain drug discovery
inferred← citeshttps://doi.org/10.1016/j.jpain.2022.12.012openalex-snapshot
NaV1.7 Channel Blocker [Ala5, Phe6, Leu26, Arg28]GpTx-1 Attenuates CFA-induced Inflammatory Hypersensitivity in Rats via Endogenous Enkephalin Mechanism
inferred← citeshttps://doi.org/10.1016/j.nbd.2020.104877openalex-snapshot
Single-cell RNA-seq analysis of the brainstem of mutant SOD1 mice reveals perturbed cell types and pathways of amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1016/j.neulet.2017.05.014openalex-snapshot
Recent advances in epilepsy genetics
inferred← citeshttps://doi.org/10.1016/j.neulet.2018.12.008openalex-snapshot
Fenamates inhibit human sodium channel Nav1.7 and Nav1.8
inferred← citeshttps://doi.org/10.1016/j.neulet.2020.135316openalex-snapshot
Mechanisms of small nerve fiber pathology
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2016.10.013openalex-snapshot
Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2017.04.014openalex-snapshot
The pharmacology of voltage-gated sodium channel activators
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2018.02.016openalex-snapshot
Direct evidence for high affinity blockade of NaV1.6 channel subtype by huwentoxin-IV spider peptide, using multiscale functional approaches
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2022.109057openalex-snapshot
The small molecule compound C65780 alleviates pain by stabilizing voltage-gated sodium channels in the inactivated and slowly-recovering state
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2020.05.032openalex-snapshot
Ion Channels Involvement in Neurodevelopmental Disorders
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2021.10.033openalex-snapshot
Changes in Biophysical Properties of Undifferentiated SH-SY5Y Cells During Long-term Cultures
inferred← citeshttps://doi.org/10.1016/j.nexres.2026.101497openalex-snapshot
Voltage sensitive probes for membrane potential determination in life science
inferred← citeshttps://doi.org/10.1016/j.patter.2020.100091openalex-snapshot
Cell Type-Specific Proteogenomic Signal Diffusion for Integrating Multi-Omics Data Predicts Novel Schizophrenia Risk Genes
inferred← citeshttps://doi.org/10.1016/j.pbiomolbio.2026.04.001openalex-snapshot
Voltage-gated sodium channels in pain: Which channels, which blockers, and where NaV1.7 fits
inferred← citeshttps://doi.org/10.1016/j.peptides.2022.170859openalex-snapshot
The T-1 conotoxin μ-SrVA from the worm hunting marine snail Conus spurius preferentially blocks the human NaV1.5 channel
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2023.108444openalex-snapshot
Acidosis-related pain and its receptors as targets for chronic pain
inferred← citeshttps://doi.org/10.1016/j.phrs.2026.109648openalex-snapshot
Decoding voltage-gated sodium channels structure: Molecular mechanisms linking architecture, function, and disease
inferred← citeshttps://doi.org/10.1016/j.pnpbp.2025.111291openalex-snapshot
Two pores instead of one: Gating pore current and the electrical leak in autism and epilepsy
inferred← citeshttps://doi.org/10.1016/j.prp.2023.154909openalex-snapshot
Voltage-gated sodium channels in cancer and their specific inhibitors
inferred← citeshttps://doi.org/10.1016/j.saa.2024.124462openalex-snapshot
Optical and molecular features of negatively curved surfaces created by POPE lipids: A crucial role of the initial conditions
inferred← citeshttps://doi.org/10.1016/j.sbi.2016.11.022openalex-snapshot
Voltage-gated sodium channels viewed through a structural biology lens
inferred← citeshttps://doi.org/10.1016/j.seizure.2025.11.010openalex-snapshot
Exploration of the mechanism of action of cenobamate
inferred← citeshttps://doi.org/10.1016/j.slasd.2021.11.001openalex-snapshot
An efficient and scalable data analysis solution for automated electrophysiology platforms
inferred← citeshttps://doi.org/10.1016/j.steroids.2026.109793openalex-snapshot
Veratrum-derived steroidal alkaloids: from scaffold to pharmacological leads
inferred← citeshttps://doi.org/10.1016/j.str.2024.07.021openalex-snapshot
Scorpion α-toxin LqhαIT specifically interacts with a glycan at the pore domain of voltage-gated sodium channels
inferred← citeshttps://doi.org/10.1016/j.tins.2015.08.010openalex-snapshot
New Mendelian Disorders of Painlessness
inferred← citeshttps://doi.org/10.1016/j.tins.2018.03.011openalex-snapshot
Progress in Understanding and Treating SCN2A-Mediated Disorders
inferred← citeshttps://doi.org/10.1016/j.toxicon.2015.12.009openalex-snapshot
Molecular determinant for the tarantula toxin Jingzhaotoxin-I slowing the fast inactivation of voltage-gated sodium channels
inferred← citeshttps://doi.org/10.1016/j.toxicon.2020.08.019openalex-snapshot
Neurobiological activity of conotoxins via sodium channel modulation
inferred← citeshttps://doi.org/10.1016/j.toxicon.2022.04.010openalex-snapshot
A potential life-threatening Asian funnel-web spider bite (Macrothele gigas) in central Taiwan
inferred← citeshttps://doi.org/10.1016/j.toxicon.2025.108264openalex-snapshot
Capsaicin preferentially inhibits slow-inactivation sodium currents in insects
inferred← citeshttps://doi.org/10.1016/j.vaa.2017.08.009openalex-snapshot
Lack of postexposure analgesic efficacy of low concentrations of eugenol in zebrafish
inferred← citeshttps://doi.org/10.1016/j.virol.2023.109865openalex-snapshot
Molnupiravir, a ribonucleoside antiviral prodrug against SARS-CoV-2, alters the voltage-gated sodium current and causes adverse events
inferred← citeshttps://doi.org/10.1017/s0033583524000210openalex-snapshot
From resting potential to dynamics: advances in membrane voltage indicators and imaging techniques
inferred← citeshttps://doi.org/10.1021/acs.biochem.4c00664openalex-snapshot
Role of Hydration and Amino Acid Interactions on the Ion Permeation Mechanism in the hNaV1.5 Channel
inferred← citeshttps://doi.org/10.1021/acs.cgd.8b01776openalex-snapshot
Substituent Effects on the Patterns of Intermolecular Interactions of 3-Alkyl and 3-Cycloalkyl Derivatives of Phenytoin: A Crystallographic and Quantum-Chemical Study
inferred← citeshttps://doi.org/10.1021/acs.chemrev.7b00723openalex-snapshot
Restoring Vision to the Blind with Chemical Photoswitches
inferred← citeshttps://doi.org/10.1021/acs.jcim.5c02124openalex-snapshot
NavDB: A Comprehensive Database for Voltage-Gated Sodium Channels Modulators and Targets
inferred← citeshttps://doi.org/10.1021/acs.jctc.2c00990openalex-snapshot
Molecular Dynamics Simulations of Ion Permeation in Human Voltage-Gated Sodium Channels
inferred← citeshttps://doi.org/10.1021/acs.jctc.6c00391openalex-snapshot
Hydration Free Energies of Alkali Metal and Halide Ions from Data-Driven Many-Body Potentials
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c00361openalex-snapshot
Discovery of Potent, Selective, and State-Dependent NaV1.7 Inhibitors with Robust Oral Efficacy in Pain Models: Structure–Activity Relationship and Optimization of Chroman and Indane Aryl Sulfonamides
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c00531openalex-snapshot
Design, Synthesis, and Pharmacological Evaluation of Analogues Derived from the PLEV Tetrapeptide as Protein–Protein Interaction Modulators of Voltage-Gated Sodium Channel 1.6
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c01107openalex-snapshot
Two for the Price of One: Heterobivalent Ligand Design Targeting Two Binding Sites on Voltage-Gated Sodium Channels Slows Ligand Dissociation and Enhances Potency
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c01304openalex-snapshot
Drug Development in Channelopathies: Allosteric Modulation of Ligand-Gated and Voltage-Gated Ion Channels
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c00802openalex-snapshot
Discovery of Methylene Thioacetal-Incorporated α-RgIA Analogues as Potent and Stable Antagonists of the Human α9α10 Nicotinic Acetylcholine Receptor for the Treatment of Neuropathic Pain
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c01570openalex-snapshot
Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Nav1.7 for the Treatment of Pain
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b01947openalex-snapshot
Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx-1
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c02093openalex-snapshot
Novel 3-Methoxypropanamide Derivatives as Potential Antiseizure and Antinociceptive Agents: Experimental Evidence from In Vitro and In Vivo Studies
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b00063openalex-snapshot
Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b00425openalex-snapshot
Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective Na V 1.7 Inhibitors
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b01850openalex-snapshot
Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b01851openalex-snapshot
Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b01918openalex-snapshot
Development of New Benzenesulfonamides As Potent and Selective Na v 1.7 Inhibitors for the Treatment of Pain
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6c00199openalex-snapshot
From Scaffold Optimization to a Promising Lead: Discovery of a Novel Roemerine Analogue, a Multichannel Antiarrhythmic with Low hERG Liability and Functional Restoration Capacity
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b00598openalex-snapshot
Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b01826openalex-snapshot
Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification ofN-([1,2,4]Triazolo[4,3-a]pyridin-3-yl)methane-sulfonamides as Potent and SelectivehNaV1.7 Inhibitors for the Treatment of Pain
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b00736openalex-snapshot
Discovery of Tarantula Venom-Derived NaV1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b01550openalex-snapshot
Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b01621openalex-snapshot
Identification of Selective Acyl Sulfonamide–Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (Na V ) 1.7 with Potent Analgesic Activity
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b01032openalex-snapshot
Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.1c00104openalex-snapshot
Functional Characterization of the Nemertide α Family of Peptide Toxins
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.1c01001openalex-snapshot
Antillatoxin-Stimulated Neurite Outgrowth Involves the Brain-Derived Neurotrophic Factor (BDNF) - Tropomyosin Related Kinase B (TrkB) Signaling Pathway
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.5c00978openalex-snapshot
Discovery of Na v 1.7 Inhibitors through the Screening of Marine Natural Product Extracts
inferred← citeshttps://doi.org/10.1021/acs.joc.3c00365openalex-snapshot
Enantioselective Total Syntheses of Grayanane Diterpenoids and (+)-Kalmanol: Evolution of the Bridgehead Carbocation-Based Cyclization and Late-Stage Functional Group Manipulation Strategies
inferred← citeshttps://doi.org/10.1021/acs.joc.3c00580openalex-snapshot
Approaches to Construction of the Medium-Sized Ring Structure in Zetekitoxin AB by Ring-Closing Metathesis
inferred← citeshttps://doi.org/10.1021/acs.jpcb.2c08431openalex-snapshot
Voltage-Dependent FTIR and 2D Infrared Spectroscopies within the Electric Double Layer Using a Plasmonic and Conductive Electrode
inferred← citeshttps://doi.org/10.1021/acs.jpcb.6c02473openalex-snapshot
Modeling Ion Transport and Selectivity via a Lennard-Jones Modified Poisson-Nernst–Planck Approach
inferred← citeshttps://doi.org/10.1021/acs.jproteome.9b00121openalex-snapshot
Analysis of Single-Nucleotide Polymorphisms in Human Voltage-Gated Ion Channels
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