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Design, Synthesis, and Biological Evaluation of Novel 3-Aryl-4-(1H-indole-3yl)-1,5-dihydro-2H-pyrrole-2-ones as Vascular Endothelial Growth Factor Receptor (VEGF-R) Inhibitors
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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ChemInform Abstract: REACTION OF α‐AMINO KETONE HYDROCHLORIDES WITH ORTHO ESTERS: AN OXAZOLE SYNTHESIS
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ChemInform Abstract: A Simple and Convenient Synthesis of 3,4‐Diaryl‐1,5‐dihydro‐2H‐pyrrol‐2‐ones.
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The Gatekeeper: Friend or Foe in Identifying the Next Generation of Kinase Inhibitors
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The platelet-derived growth factor receptor as a therapeutic target
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p38 MAPK inhibition is critically involved in VEGFR-2-mediated endothelial cell survival
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Staurosporine and ent-Staurosporine: The First Total Syntheses, Prospects for a Regioselective Approach, and Activity Profiles1
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Profile and Molecular Modeling of 3-(Indole-3-yl)-4-(3,4,5-trimethoxyphenyl)-1H-pyrrole-2,5dione (1) as a Highly Selective VEGF-R2/3 Inhibitor
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inferredcites →https://doi.org/10.1055/s-1999-3383openalex-snapshot
Complete Regioselectivity in Staurosporine Chromophore Formation
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N-{(Z)-2-[1-(Triisopropylsilyl)-1H-indol-3-yl]-2-(triisopropylsilyloxy)vinyl}-2-(3,4,5-trimethoxyphenyl)acetamide
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inferredcites →https://doi.org/10.1200/jco.2005.06.081openalex-snapshot
Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis
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VEGF/VEGFR signalling as a target for inhibiting angiogenesis
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Virtual Screening for Kinase Targets
inferredcites →https://doi.org/10.2174/092986707782023622openalex-snapshot
Antiangiogenic Agents: an Update on Small Molecule VEGFR Inhibitors
inferredcites →https://doi.org/10.2174/1381612033391487openalex-snapshot
Small-molecule Inhibitors of Fibroblast Growth Factor Receptor (FGFR) Tyrosine Kinases (TK)
inferredcites →https://doi.org/10.2174/1381612053507611openalex-snapshot
Receptor Tyrosine Kinases and Anticancer Therapy
inferredcites →https://doi.org/10.5483/bmbrep.2006.39.5.469openalex-snapshot
Differential Roles of Vascular Endothelial Growth Factor Receptor-1 and Receptor-2 in Angiogenesis
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Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Photo-catalyzed decarboxylative annulation of N-substituted glycines with cyclopropenones: Synthesis of pyrrol-2-ones bearing quaternary centers
inferred← citeshttps://doi.org/10.2174/13862073113166660063openalex-snapshot
Classification of Aurora B Kinase Inhibitors Using Computational Models
inferred← citeshttps://doi.org/10.2174/1573406417666210604103135openalex-snapshot
Utility of Certain 2-Furanone Derivatives for Synthesis of Different Heterocyclic Compounds and Testing their Anti-Cancer Activity
inferred← citeshttps://doi.org/10.2174/1871520622666220607143040openalex-snapshot
Recent Updates on Indole Derivatives as Kinase Inhibitors in the Treatment of Cancer
inferred← citeshttps://doi.org/10.2298/jsc180720006mopenalex-snapshot
Glutamic acid as green and bio-based α-amino acid catalyst promoted one-pot access to polyfunctionalized dihydro-2-oxypyrroles
inferred← citeshttps://doi.org/10.3109/14756366.2010.513331openalex-snapshot
Molecular modelling studies on d-annulated benzazepinones as VEGF-R2 kinase inhibitors using docking and 3D-QSAR
inferred← citeshttps://doi.org/10.3184/174751912x13547952669204openalex-snapshot
A One-pot Multi-component Synthesis of N-aryl-3-aminodihydropyrrol-2-one-4-carboxylates Catalysed by Oxalic Acid Dihydrate
inferred← citeshttps://doi.org/10.3390/cryst10070606openalex-snapshot
The Solid-State Structures of Cyclic NH Carboximides
inferred← citeshttps://doi.org/10.3390/ecsoc-22-05864openalex-snapshot
Pyrrolidinodiones in Enol-Ugi, Enol-Passerini, and Anomalous Enol-Passerini Condensations
inferred← citeshttps://doi.org/10.3390/md11093209openalex-snapshot
Marine Derived Hamacanthins as Lead for the Development of Novel PDGFRβ Protein Kinase Inhibitors
inferred← citeshttps://doi.org/10.3390/molecules24162951openalex-snapshot
A Brønsted Acid-Catalyzed Multicomponent Reaction for the Synthesis of Highly Functionalized γ-Lactam Derivatives
inferred← citeshttps://doi.org/10.3390/molecules26226937openalex-snapshot
A Focused Review of Synthetic Applications of Lawesson’s Reagent in Organic Synthesis
inferred← citeshttps://doi.org/10.3390/molecules27113624openalex-snapshot
Exploring the Synthetic Potential of γ-Lactam Derivatives Obtained from a Multicomponent Reaction—Applications as Antiproliferative Agents
inferred← citeshttps://doi.org/10.3390/ph10030062openalex-snapshot
Synthesis and Antiproliferative Activity of Novel Heterocyclic Indole-Trimethoxyphenyl Conjugates
inferred← citeshttps://doi.org/10.3390/ph14080782openalex-snapshot
A Multicomponent Protocol for the Synthesis of Highly Functionalized γ-Lactam Derivatives and Their Applications as Antiproliferative Agents
inferred← citeshttps://doi.org/10.3390/ph15050511openalex-snapshot
Multicomponent Synthesis of Unsaturated γ-Lactam Derivatives. Applications as Antiproliferative Agents through the Bioisosterism Approach: Carbonyl vs. Phosphoryl Group
inferred← citeshttps://doi.org/10.4155/fmc-2023-0121openalex-snapshot
Novel Antimicrobial Iodo-Dihydro-Pyrrole-2-One Compounds
inferred← citeshttps://doi.org/10.4314/bcse.v33i1.15openalex-snapshot
Caffeine as a naturally green and biodegradable catalyst promoted convenient and expedient synthetic route for the synthesis of polysubstituted dihydro-2-oxypyrroles
inferred← citeshttps://doi.org/10.70675/9ed5459ezb72fz4f5dzae3czd833f8973087openalex-snapshot
Selective catalytic C(sp²)–H and C(sp³)–H bond functionalizations for the synthesis of phosphorus and nitrogen containing molecules
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