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Similarities and Differences in the Structure−Activity Relationships of Capsaicin and Resiniferatoxin Analogues
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/chin.198240108openalex-snapshot
ChemInform Abstract: Selective Deacetylation of Aromatic Acetates by Aminolysis.
inferredcites →https://doi.org/10.1002/ptr.2650030607openalex-snapshot
Structure/activity analysis of resiniferatoxin analogs
inferredcites →https://doi.org/10.1007/bf00914184openalex-snapshot
Investigations into the skin-irritant properties of resiniferonol ortho esters
inferredcites →https://doi.org/10.1016/0306-4522(89)90269-8openalex-snapshot
Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper
inferredcites →https://doi.org/10.1016/0306-4522(93)90021-7openalex-snapshot
Characterization of resiniferatoxin binding sites on sensory neurons: Co-regulation of resiniferatoxin binding and capsaicin sensitivity in adult rat dorsal root ganglia
inferredcites →https://doi.org/10.1016/b978-0-7506-7571-0.x5000-5openalex-snapshot
Purification of Laboratory Chemicals
inferredcites →https://doi.org/10.1016/s0022-328x(00)82974-5openalex-snapshot
Purification of Laboratory Chemicals
inferredcites →https://doi.org/10.1016/s0022-3565(25)38391-6openalex-snapshot
Vanilloid (capsaicin) receptor in the rat: positive cooperativity of resiniferatoxin binding and its modulation by reduction and oxidation.
inferredcites →https://doi.org/10.1016/s0040-4039(00)84275-6openalex-snapshot
Facile conversion of azides to amines
inferredcites →https://doi.org/10.1016/s0040-4039(00)92160-9openalex-snapshot
A novel oxidative azidation of aromatic compounds with hypervalent iodine reagent, phenyliodine(III) bis(trifluoroacetate) (PIFA) and trimethylsilyl azide
inferredcites →https://doi.org/10.1016/s0040-4039(01)83138-5openalex-snapshot
Hexachloroacetone/triphenylphosphine: A reagent for the regio- and stereoselective conversion of allylic alcohols into chlorides
inferredcites →https://doi.org/10.1021/ja00791a043openalex-snapshot
Thallium in organic synthesis. XXXIII. One-step synthesis of methyl arylacetates from acetophenones using thallium(III) nitrate (TTN)
inferredcites →https://doi.org/10.1021/ja00791a044openalex-snapshot
Mechanism of ozonolysis. New route to ozonides
inferredcites →https://doi.org/10.1021/jm00068a014openalex-snapshot
Analogs of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 1. The aromatic "A-region"
inferredcites →https://doi.org/10.1021/jo00408a041openalex-snapshot
Rapid chromatographic technique for preparative separations with moderate resolution
inferredcites →https://doi.org/10.1021/np50021a018openalex-snapshot
Structure-activity Relations of Polyfunctional Diterpenes of the Daphnane Type. I. Revised Structure For Resiniferatoxin and Structure-activity Relations of Resini-feronol and Some of its Esters
inferredcites →https://doi.org/10.1039/p19920001229openalex-snapshot
Synthesis of 2,9,10-trioxatricyclo[4.3.1.0]decane analogues of resiniferatoxin
inferredcites →https://doi.org/10.1046/j.1471-4159.1995.65010301.xopenalex-snapshot
Resiniferatoxin‐Amide and Analogues as Ligands for Protein Kinase C and Vanilloid Receptors and Determination of Their Biological Activities as Vanilloids
inferredcites →https://doi.org/10.1073/pnas.74.12.5764openalex-snapshot
Opiate receptor: cooperativity of binding observed in brain slices.
inferredcites →https://doi.org/10.1248/cpb.27.2259openalex-snapshot
New derivatization of amines for electrochemical detection in liquid chromatography.
inferredcites →https://doi.org/10.1523/jneurosci.08-09-03208.1988openalex-snapshot
Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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An Explainable and Accurate Pungency Prediction Model Based on Ensemble Machine Learning Embedded with Quantum Chemistry Knowledge
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Quantitative determination of capsaicin, a transient receptor potential channel vanilloid 1 agonist, by liquid chromatography quadrupole ion trap mass spectrometry: evaluation of in vitro metabolic stability
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Characterization of [6]‐gingerol metabolism in rat by liquid chromatography electrospray tandem mass spectrometry
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Chemical Components of the Dried Latex of Euphorbia resinifera Berg and Its Medicinal Features
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Synthesis and Biological Evaluation of Phorbol‐Resiniferatoxin (RTX) Hybrids
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Facile Orthoester Formation in a Model Compound of the Taxol Oxetane: Are Biologically Active Epoxy Esters, Orthoesters, and Oxetanyl Esters Latent Electrophiles?
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Hot peppers, pain and analgesics
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The Potential Antitumor Effects of Capsaicin
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Role of Capsaicin in Prostate Cancer
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Capsicums and Chilies: An Introduction
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Exploring the Potential of Capsaicin in Cancer Therapy: In Vitro and In Vivo Effects and Their Mechanism of Action
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Biotechnological Approaches for Enhanced Production of Capsaicin
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Les récepteurs vanilloïdes et leurs ligands
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Chemosensory additivity in trigeminal chemoreception as reflected by detection of mixtures
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TRP channels: potential drug target for neuropathic pain
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Biotechnological advances on in vitro capsaicinoids biosynthesis in capsicum: a review
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A Series of Novel Esters of Capsaicin Analogues Catalyzed by Candida antarctica Lipases
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Exploring Nonopioid Analgesic Agents for Intrathecal Use
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Antidiabetic potential of capsaicinoids
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Concluding remarks: Past, present, future
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Some like it hot: The emerging role of spicy food (capsaicin) in autoimmune diseases
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Capsaicin, its clinical significance in patients with painful diabetic neuropathy
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N-[4-(Methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: analysis of structure–activity relationships for the ‘C-Region’
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Structure–activity relationships of simplified resiniferatoxin analogues with potent VR1 agonism elucidates an active conformation of RTX for VR1 binding
inferred← citeshttps://doi.org/10.1016/j.bmc.2004.07.070openalex-snapshot
Natural and synthetic cage compounds incorporating the 2,9,10-trioxatricyclo[4.3.1.03,8]decane type moiety
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N-4-Substituted-benzyl-N′-tert-butylbenzyl thioureas as vanilloid receptor ligands: investigation on the role of methanesulfonamido group in antagonistic activity
inferred← citeshttps://doi.org/10.1016/j.bmcl.2006.09.077openalex-snapshot
Structure–activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): The homovanillyl moiety
inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.11.035openalex-snapshot
Structure–activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): The side chain benzylic methylene
inferred← citeshttps://doi.org/10.1016/j.bmcl.2010.11.012openalex-snapshot
Receptor activity and conformational analysis of 5′-halogenated resiniferatoxin analogs as TRPV1 ligands
inferred← citeshttps://doi.org/10.1016/j.bmcl.2012.08.018openalex-snapshot
Potent and orally efficacious benzothiazole amides as TRPV1 antagonists
inferred← citeshttps://doi.org/10.1016/j.ejmech.2013.05.001openalex-snapshot
Design and synthesis of conformationally restricted capsaicin analogues based in the 1, 3, 4-thiadiazole heterocycle reveal a novel family of transient receptor potential vanilloid 1 (TRPV1) antagonists
inferred← citeshttps://doi.org/10.1016/j.ejmech.2013.07.042openalex-snapshot
The carbonate analogues of 5′-halogenated resiniferatoxin as TRPV1 ligands
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.111695openalex-snapshot
Design, synthesis and biological evaluation of cinnamic acid derivatives with synergetic neuroprotection and angiogenesis effect
inferred← citeshttps://doi.org/10.1016/j.ejphar.2025.177700openalex-snapshot
Discovery and isolation of novel capsaicinoids and their TRPV1-related activity
inferred← citeshttps://doi.org/10.1016/j.jchromb.2017.01.005openalex-snapshot
Application of time-of-flight mass spectrometry for screening of crude glycerins for toxic phorbol ester contaminants
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2006.12.032openalex-snapshot
Cutoff in detection of eye irritation from vapors of homologous carboxylic acids and aliphatic aldehydes
inferred← citeshttps://doi.org/10.1016/j.phrs.2026.108319openalex-snapshot
Carbamate-based cannabinoids uncover a conserved lipid-sensing pocket in nociceptive TRPA1 and TRPV1 channels
inferred← citeshttps://doi.org/10.1016/j.prenap.2024.100103openalex-snapshot
Capsaicin: A review of its pharmacology in gastrointestinal health and disorders
inferred← citeshttps://doi.org/10.1016/j.surge.2022.09.004openalex-snapshot
The translational implications of the science behind the overactive bladder and the role of OnabotulinumtoxinA
inferred← citeshttps://doi.org/10.1016/j.taap.2005.06.015openalex-snapshot
1,2-Naphthoquinone activates vanilloid receptor 1 through increased protein tyrosine phosphorylation, leading to contraction of guinea pig trachea
inferred← citeshttps://doi.org/10.1016/j.tet.2004.04.016openalex-snapshot
Synthesis of 1-substituted 2,9,10-trioxatricyclo[4.3.1.03,8]decanes
inferred← citeshttps://doi.org/10.1016/j.tips.2012.09.002openalex-snapshot
Multisteric TRPV1 nocisensor: a target for analgesics
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The Cloned Rat Vanilloid Receptor VR1 Mediates Both R-Type Binding and C-Type Calcium Response in Dorsal Root Ganglion Neurons
inferred← citeshttps://doi.org/10.1016/s0031-6997(24)01403-0openalex-snapshot
Vanilloid (Capsaicin) Receptors and Mechanisms
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Solid-phase synthesis of γ-lactams, γ-lactones and cyclobutane derivatives from common resin-bound intermediates
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Anandamide and the question of its functional role for activation of capsaicin receptors
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Vanilloid receptors: new insights enhance potential as a therapeutic target
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Synthesis of 2-substituted-pyrrolidinethiourea derivatives and their antagonist effect on vanilloid receptor
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Synthesis of N,N′,N″-trisubstituted thiourea derivatives and their antagonist effect on the vanilloid receptor
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3-Acyloxy-2-phenalkylpropyl amides and esters of homovanillic acid as novel vanilloid receptor agonists
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N-(3-acyloxy-2-benzylpropyl)-N′-(4-hydroxy-3-methoxybenzyl)thiourea derivatives as potent vanilloid receptor agonists and analgesics
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Phenolic Modification as an Approach to Improve the Pharmacology of the 3-Acyloxy-2-benzylpropyl Homovanillic Amides and Thioureas, a Promising Class of Vanilloid Receptor Agonists and Analgesics
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3-D-QSAR Analysis of N-(3-Acyloxy-2-benzylpropyl)-N′-dihydroxytetrahydrobenzazepine and Tetrahydroisoquinoline and N-(3-Acyloxy-2-benzylpropyl)-N′-(4-hydroxy-3-methoxybenzyl) Thioureas Analogues as Potent Vanilloid Receptor Ligands
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Conformational studies on resiniferatoxin (RTX), an ultrapotent vanilloid agonist
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Chapter 2 History of Ion Channels in the Pain Sensory System
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Recent Progress on Capsaicin- and Nonivamide-Type Compounds as Agrochemicals and Drugs
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Tricyclic Spirolactones as Modular TRPV1 Synthetic Agonists
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Resiniferatoxin Binds to the Capsaicin Receptor (TRPV1) near the Extracellular Side of the S4 Transmembrane Domain
inferred← citeshttps://doi.org/10.1021/ja972279yopenalex-snapshot
The First Synthesis of a Daphnane Diterpene: The Enantiocontrolled Total Synthesis of (+)-Resiniferatoxin
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N-Acylvanillamides: Development of an Expeditious Synthesis and Discovery of New Acyl Templates for Powerful Activation of the Vanilloid Receptor
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N-(3-Acyloxy-2-benzylpropyl)-N‘-[4-(methylsulfonylamino)benzyl]thiourea Analogues: Novel Potent and High Affinity Antagonists and Partial Antagonists of the Vanilloid Receptor
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Analogues of Capsaicin with Agonist Activity as Novel Analgesic Agents: Structure−Activity Studies. 4. Potent, Orally Active Analgesics
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Resiniferatoxin‐type phorboid vanilloids display capsaicin‐like selectivity at native vanilloid receptors on rat DRG neurons and at the cloned vanilloid receptor VR1
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Pharmacological differences between the human and rat vanilloid receptor 1 (VR1)
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Chemo- and site-selective derivatizations of natural products enabling biological studies
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Understanding TRPV1 activation by ligands: Insights from the binding modes of capsaicin and resiniferatoxin
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Photochemical gating of heterologous ion channels: Remote control over genetically designated populations of neurons
inferred← citeshttps://doi.org/10.1074/jbc.m201551200openalex-snapshot
Protein Kinase Cα Is Required for Vanilloid Receptor 1 Activation
inferred← citeshttps://doi.org/10.1080/1062936x.2020.1777583openalex-snapshot
Predicting pungency and understanding the pungency mechanism of capsaicinoids using TOPS-MODE approach
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Electrochemical Detection of Capsaicin Using Yttrium Oxide Nanoparticles Modified Graphite Paste Electrode (Y2O3/GPE)
inferred← citeshttps://doi.org/10.1113/jphysiol.2005.087874openalex-snapshot
Activation of transient receptor potential vanilloid 1 (TRPV1) by resiniferatoxin
inferred← citeshttps://doi.org/10.1161/circep.118.006942openalex-snapshot
Cardiac Afferent Denervation Abolishes Ganglionated Plexi and Sympathetic Responses to Apnea
inferred← citeshttps://doi.org/10.1177/1934578x20987949openalex-snapshot
Enhancement of Lipolysis in 3T3-L1 Adipocytes by Nitroarene Capsaicinoid Analogs
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Sleep Apnea and Atrial Fibrillation: Role of the Cardiac Autonomic Nervous System
inferred← citeshttps://doi.org/10.1517/13543776.18.2.159openalex-snapshot
Advances in the design and therapeutic use of capsaicin receptor TRPV1 agonists and antagonists
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Differential Activation and Desensitization of Sensory Neurons by Resiniferatoxin
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New pungent and cooling compounds for use in foods
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Capsaicin Responses in Drosophila: Exploring a Non-Trpv1 Model
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AN OVERVIEW ABOUT VERSATILE MOLECULE CAPSAICIN
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A structural view of ligand-dependent activation in thermoTRP channels
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Chemical and Pharmacological Aspects of Capsaicin
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Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses
inferred← citeshttps://doi.org/10.3390/molecules21080966openalex-snapshot
Harnessing the Therapeutic Potential of Capsaicin and Its Analogues in Pain and Other Diseases
inferred← citeshttps://doi.org/10.3892/mmr.2024.13162openalex-snapshot
Pharmacological activity of capsaicin: Mechanisms and controversies (Review)
inferred← citeshttps://doi.org/10.4236/ajps.2015.619300openalex-snapshot
Anti-Cancer Effects and Mechanisms of Capsaicin in Chili Peppers
inferred← citeshttps://doi.org/10.5059/yukigoseikyokaishi.81.1136openalex-snapshot
Development of Streamlined Processes for Construction of Complex Natural Products: Three Total Syntheses of Resiniferatoxin
inferred← citeshttps://doi.org/10.5772/intechopen.73124openalex-snapshot
Capsaicin and its Human Therapeutic Development
inferred← citeshttps://doi.org/10.5772/intechopen.77317openalex-snapshot
A Matter of Taste: Capsaicinoid Diversity in Chile Peppers and the Importance to Human Food Preference
inferred← citeshttps://doi.org/10.5772/intechopen.91897openalex-snapshot
Anticancer Effect of Capsaicin and Its Analogues
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Ghost Pepper (Capsicum chinense Jacq.) - A Reservoir Plant for Therapeutic Applications: An Overview
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Capsaicin Biosynthesis in Water-stressed Hot Pepper Fruits
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