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17-Imidazolyl, Pyrazolyl, and Isoxazolyl Androstene Derivatives. Novel Steroidal Inhibitors of Human Cytochrome Cl7,20-Lyase (P45017α)
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Outgoing claims: the papers this work cites, builds on, or argues with.
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A phase I trial of CGS 16949a. A new aromatase inhibitor
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17β-(Cyclopropylamino)-androst-5-en-3β-ol, a selective mechanism-based inhibitor of cytochrome P45017α (steroid 17α-hydroxylase/C17–20 lyase)
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The clinical development of a 5α-reductase inhibitor, finasteride
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Structure-activity relationships and binding model of novel aromatase inhibitors
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Pharmacology of novel steroidal inhibitors of cytochrome P45017 (17α-hydroxylase/C17–20 lyase)
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Inhibition of steroid C17(20) lyase with C-17-heteroaryl steroids
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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
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Steroids. CXXXVII.1 Synthesis of a New Class of Potent Cortical Hormones. 6α,9α-Difluoro-16α-hydroxyprednisolone and its Acetonide
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Novel Steroidal Inhibitors of Human Cytochrome P45017.alpha.-Hydroxylase-C17,20-lyase): Potential Agents for the Treatment of Prostatic Cancer
inferredcites →https://doi.org/10.1021/jm00171a019openalex-snapshot
Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis
inferredcites →https://doi.org/10.1021/jm00173a022openalex-snapshot
Inhibition of enzymes of estrogen and androgen biosynthesis by esters of 4-pyridylacetic acid
inferredcites →https://doi.org/10.1021/jm00173a023openalex-snapshot
Inhibitors of the P450 enzymes aromatase and lyase. Crystallographic and molecular modeling studies suggest structural features of pyridylacetic acid derivatives responsible for differences in enzyme inhibitory activity
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Iodide catalysis of oxidations with dimethyl sulfoxide. Convenient two-step synthesis of .alpha. diketones from .alpha.-methylene ketones
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17β-Isoxazolyl and 17β-Pyrazolyl Steroids from 3β-Hydroxy-21-formylpregn-5-en-20-one. Structural Assignments1,2
inferredcites →https://doi.org/10.1021/jo01348a025openalex-snapshot
Selenium Dioxide Oxidation of 5α-Androstane-3,17-dione. The Stereochemistry of Dehydrogenation
inferredcites →https://doi.org/10.1135/cccc19690442openalex-snapshot
Steroid derivatives. LX. Androstane derivatives substituted by pyrazole ring in position 17
inferredcites →https://doi.org/10.1210/jcem-71-6-1552openalex-snapshot
Effect of Finasteride, a 5α-Reductase Inhibitor on Prostate Tissue Androgens and Prostate-Specific Antigen*
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Steroidal 21-Imidazolium Salt Derivatives: Synthesis and Antitumoral Activity
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Synthesis of thiazole, imidazole and oxazole containing amino acids for peptide backbone modification
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Inhibition of CYP 17, a New Strategy for the Treatment of Prostate Cancer
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C16 and C17 Substituted Derivatives of Pregnenolone and Progesterone as Inhibitors of 17α‐Hydroxylase‐C17, 20‐lyase: Synthesis and Biological Evaluation
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Cytochrome P450c17-ExpressingEscherichia colias a First-Step Screening System for 17α-Hydroxylase- C17,20-lyase Inhibitors
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Inhibition of Cytochrome P450 Enzymes
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Inhibition of Cytochrome P450 Enzymes
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Steroidal 1,2-oxazoles. Synthesis and biological activity. (Review)
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Pharmacokinetics of novel inhibitors of androgen synthesis after intravenous administration in mice
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A new approach to the synthesis of 17-pyrazolylandrostane
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The Renaissance of CYP17 Inhibitors for the Treatment of Prostate Cancer
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Dehydroepiandrosterone derived imidazolium salts and their antimicrobial efficacy
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Antiproliferative and antimetastatic characterization of an exo-heterocyclic androstane derivative against human breast cancer cell lines
inferred← citeshttps://doi.org/10.1016/j.bmc.2004.02.007openalex-snapshot
C17,20-Lyase inhibitors I. Structure-based de novo design and SAR study of C17,20-lyase inhibitors
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C17,20-lyase inhibitors. Part 2: Design, synthesis and structure–activity relationships of (2-naphthylmethyl)-1H-imidazoles as novel C17,20-lyase inhibitors
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17,20-Lyase inhibitors. Part 4: Design, synthesis and structure–activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors
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17,20-Lyase inhibitors. Part 3: Design, synthesis, and structure–activity relationships of biphenylylmethylimidazole derivatives as novel 17,20-lyase inhibitors
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inferred← citeshttps://doi.org/10.1016/j.ejmech.2011.05.032openalex-snapshot
Stereoselective synthesis and antimicrobial activity of steroidal C-20 tertiary alcohols with thiazole/pyridine side chain
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Synthesis of novel 17-(4′-formyl)pyrazolylandrosta-5,16-dienes and their derivatives as potent 17α-hydroxylase/C17,20-lyase inhibitors or antiproliferative agents depending on the substitution pattern of the heteroring
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Isoxazole derivatives as anticancer agent: A review on synthetic strategies, mechanism of action and SAR studies
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A-ring-fused pyrazoles of dihydrotestosterone targeting prostate cancer cells via the downregulation of the androgen receptor
inferred← citeshttps://doi.org/10.1016/j.jorganchem.2012.08.013openalex-snapshot
Synthesis of ferrocene-labelled steroid derivatives via homogeneous catalytic methods
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Reversed- and normal-phase liquid chromatography in quantitative structure retention–property relationships of newly synthesized seco-androstene derivatives
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Synthesis of sex hormone-derived modified steroids possessing antiproliferative activity
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Steroidal 5α-reductase and 17α-hydroxylase/17,20-lyase (CYP17) inhibitors useful in the treatment of prostatic diseases
inferred← citeshttps://doi.org/10.1016/j.mencom.2011.07.003openalex-snapshot
Synthesis of 17-(1,2,3-dithiazole) androstene derivatives
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Synthesis, single crystal study, molecular docking, and in vitro anticancer screening of a series of isoxazolone derivatives of 3-chloro-3-phenylacrylaldehydes
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A versatile synthesis of 17-heteroaryl androstenes via palladium-mediated Suzuki cross-coupling with heteroaryl boronic acids
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Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors
inferred← citeshttps://doi.org/10.1016/j.steroids.2008.05.010openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.steroids.2008.06.011openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.steroids.2011.10.007openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.steroids.2012.02.001openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.steroids.2013.02.014openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.steroids.2014.05.009openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.steroids.2016.06.001openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.steroids.2026.109807openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.tetlet.2011.09.119openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/s0039-128x(02)00006-5openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/s0039-128x(03)00082-5openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/s0960-0760(01)00096-6openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/s0960-0760(99)00129-6openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/s0968-0896(00)00076-6openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/s0968-0896(01)00354-6openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/s0968-0896(99)00160-1openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/jm020576uopenalex-snapshot
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inferred← citeshttps://doi.org/10.1021/jm970568ropenalex-snapshot
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inferred← citeshttps://doi.org/10.1021/jm991070nopenalex-snapshot
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inferred← citeshttps://doi.org/10.1021/jo990373mopenalex-snapshot
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inferred← citeshttps://doi.org/10.1039/a815495yopenalex-snapshot
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inferred← citeshttps://doi.org/10.1039/c2np20082aopenalex-snapshot
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inferred← citeshttps://doi.org/10.1039/d6md00076bopenalex-snapshot
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inferred← citeshttps://doi.org/10.1054/bjoc.2000.1136openalex-snapshot
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inferred← citeshttps://doi.org/10.1080/00397910008087379openalex-snapshot
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inferred← citeshttps://doi.org/10.1081/dmr-120001392openalex-snapshot
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inferred← citeshttps://doi.org/10.1134/s1990750815020134openalex-snapshot
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inferred← citeshttps://doi.org/10.1210/en.140.6.2891openalex-snapshot
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inferred← citeshttps://doi.org/10.1556/abiol.66.2015.1.4openalex-snapshot
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inferred← citeshttps://doi.org/10.18097/bmcrm00241openalex-snapshot
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4-Imidazolecarboxaldehyde attenuates virulence and pathogenicity of Pseudomonas aeruginosa by targeting las and rhl systems
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FTIR investigation of solvent-induced carbonyl band shifts of 17β-hydroxy-17α-picolyl-androst-4-en-3-one
inferred← citeshttps://doi.org/10.3390/ijms231911694openalex-snapshot
New Oxazolo[5,4-d]pyrimidines as Potential Anticancer Agents: Their Design, Synthesis, and In Vitro Biological Activity Research
inferred← citeshttps://doi.org/10.3390/ijms232113534openalex-snapshot
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inferred← citeshttps://doi.org/10.3762/bjoc.14.236openalex-snapshot
Microwave-assisted synthesis of biologically relevant steroidal 17-exo-pyrazol-5'-ones from a norpregnene precursor by a side-chain elongation/heterocyclization sequence
inferred← citeshttps://doi.org/10.3987/com-17-13750openalex-snapshot
Synthesis of 17β-N-Phenylpyrazolyl Steroidal Derivatives and Their Inhibitory Effect on Cell Proliferation
inferred← citeshttps://doi.org/10.5772/52290openalex-snapshot
Steroidal CYP17 Inhibitors for Prostate Cancer Treatment: From Concept to Clinic
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