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Antineoplastic Agents. 379. Synthesis of Phenstatin Phosphate1a,

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Design, synthesis and anticancer properties of 5-arylbenzoxepins as conformationally restricted iso combretastatin A-4 analogs

inferred← citeshttps://doi.org/10.1016/j.ejmech.2013.01.016openalex-snapshot

Synthesis and biochemical activities of antiproliferative amino acid and phosphate derivatives of microtubule-disrupting β-lactam combretastatins

inferred← citeshttps://doi.org/10.1016/j.ejmech.2014.02.061openalex-snapshot

Antimitotic and vascular disrupting agents: 2-Hydroxy-3,4,5-trimethoxybenzophenones

inferred← citeshttps://doi.org/10.1016/j.ejmech.2014.03.018openalex-snapshot

Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids

inferred← citeshttps://doi.org/10.1016/j.ejmech.2014.08.005openalex-snapshot

Chalcone based azacarboline analogues as novel antitubulin agents: Design, synthesis, biological evaluation and molecular modelling studies

inferred← citeshttps://doi.org/10.1016/j.ejmech.2014.12.050openalex-snapshot

Synthesis, anticancer activity and molecular docking studies on a series of heterocyclic trans-cyanocombretastatin analogues as antitubulin agents

inferred← citeshttps://doi.org/10.1016/j.ejmech.2015.05.047openalex-snapshot

Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para-nitrogen substituted isocombretastatins

inferred← citeshttps://doi.org/10.1016/j.ejmech.2016.03.050openalex-snapshot

Triazole tethered C 5 -curcuminoid-coumarin based molecular hybrids as novel antitubulin agents: Design, synthesis, biological investigation and docking studies

inferred← citeshttps://doi.org/10.1016/j.ejmech.2017.08.018openalex-snapshot

Synthesis and biological evaluation of N-substituted 3-oxo-1,2,3,4-tetrahydro-quinoxaline-6-carboxylic acid derivatives as tubulin polymerization inhibitors

inferred← citeshttps://doi.org/10.1016/j.ejmech.2018.11.070openalex-snapshot

Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site

inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.111894openalex-snapshot

Activated carbon/Brønsted acid-promoted aerobic benzylic oxidation under “on-water” condition: Green and efficient synthesis of 3-benzoylquinoxalinones as potent tubulin inhibitors

inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112050openalex-snapshot

β-Lactams with antiproliferative and antiapoptotic activity in breast and chemoresistant colon cancer cells

inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112110openalex-snapshot

Developments of isoCombretastatin A-4 derivatives as highly cytotoxic agents

inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112308openalex-snapshot

Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors

inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112933openalex-snapshot

Methylsulfanylpyridine based diheteroaryl isocombretastatin analogs as potent anti-proliferative agents

inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114112openalex-snapshot

Synthesis and biological evaluation of novel hybrids of phenylsulfonyl furoxan and phenstatin derivatives as potent anti-tumor agents

inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114583openalex-snapshot

Discovery of N-benzylarylamide derivatives as novel tubulin polymerization inhibitors capable of activating the Hippo pathway

inferred← citeshttps://doi.org/10.1016/j.ejmech.2023.115284openalex-snapshot

Design, synthesis, and biological evaluation of diaryl heterocyclic derivatives targeting tubulin polymerization with potent anticancer activities

inferred← citeshttps://doi.org/10.1016/j.ejmech.2025.118191openalex-snapshot

Tubulin-based dual-target compounds and protein degraders for cancer therapy—An updated review (2021-present)

inferred← citeshttps://doi.org/10.1016/j.ejmech.2025.118554openalex-snapshot

2-Naphthyl tetrazoles are potent antiproliferative and apoptotic inducers with different tubulin polymerization dynamics inhibitory activity

inferred← citeshttps://doi.org/10.1016/j.ejmech.2026.118742openalex-snapshot

Who's who in the field of combretastatin A4 analogues: ?

inferred← citeshttps://doi.org/10.1016/j.ejps.2023.106529openalex-snapshot

Design, synthesis and biological evaluation of a novel bioactive indane scaffold 2-(diphenylmethylene)c-2,3-dihydro-1H-inden-1-one with potential anticancer activity

inferred← citeshttps://doi.org/10.1016/j.gresc.2024.04.008openalex-snapshot

Carbonylative transformation of aryl halides and strong bonds via cheap metal catalysts and sustainable technologies

inferred← citeshttps://doi.org/10.1016/j.jsbmb.2013.02.009openalex-snapshot

Synthesis of combretastatin A4 analogues on steroidal framework and their anti-breast cancer activity

inferred← citeshttps://doi.org/10.1016/j.steroids.2012.03.012openalex-snapshot

Gallic acid based steroidal phenstatin analogues for selective targeting of breast cancer cells through inhibiting tubulin polymerization

inferred← citeshttps://doi.org/10.1016/j.taap.2013.06.001openalex-snapshot

(4-Methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone inhibits tubulin polymerization, induces G2/M arrest, and triggers apoptosis in human leukemia HL-60 cells

inferred← citeshttps://doi.org/10.1016/j.tet.2006.09.029openalex-snapshot

Synthesis of 7-hydroxy-2-(2-hydroxybenzoyl)benzo[c]chromen-6-ones by sequential application of domino reactions of 1,3-bis(silyl enol ethers) with benzopyrylium triflates

inferred← citeshttps://doi.org/10.1016/j.tet.2006.09.083openalex-snapshot

Disproportionation reaction of diarylmethylisopropyl ethers: a versatile access to diarylmethanes from diarylcarbinols speeded up by the use of microwave irradiation

inferred← citeshttps://doi.org/10.1016/j.tet.2007.02.062openalex-snapshot

One-pot reactions of 2,4-(dioxobutylidene)phosphoranes. Efficient synthesis of 4-(2-hydroxybenzoyl)salicylic acid derivatives and buta-1,3-diene-1,4-dicarboxylates

inferred← citeshttps://doi.org/10.1016/j.tet.2007.10.116openalex-snapshot

Synthesis of 2-benzoyl-4-(2-hydroxybenzoyl)phenols by catalytic domino ‘Michael–retro-Michael–Mukaiyama-aldol’ reactions of 1-aryl-1,3-bis(silyloxy)buta-1,3-dienes with 3-formylchromones

inferred← citeshttps://doi.org/10.1016/j.tet.2008.10.023openalex-snapshot

Successive Michael reactions on chromone derivatives with dimethyl 1,3-acetonedicarboxylate: one-pot synthesis of functionalized benzophenones, benzo[c]chromones and hydroxybenzoylfuroates

inferred← citeshttps://doi.org/10.1016/j.tet.2019.130885openalex-snapshot

FeCl3 catalyzed 1,6-conjugate addition of phenol C-nucleophiles: Facile synthesis of diarylmethanes

inferred← citeshttps://doi.org/10.1016/j.tetlet.2008.05.082openalex-snapshot

The synthesis of compounds related to the indole–indoline core of the vinca alkaloids (+)-vinblastine and (+)-vincristine

inferred← citeshttps://doi.org/10.1016/j.tetlet.2008.11.125openalex-snapshot

A facile synthesis of 2,3-disubstituted furo[2,3-b]pyridines

inferred← citeshttps://doi.org/10.1016/j.tetlet.2011.03.072openalex-snapshot

Weinreb amide based building blocks for convenient access to 1,1-diarylethenes and isocombretastatin analogues

inferred← citeshttps://doi.org/10.1016/j.tetlet.2015.04.128openalex-snapshot

An unusual formation of diarylmethane scaffolds from 4-(halomethyl)cyclohex-2-enone derivatives

inferred← citeshttps://doi.org/10.1016/j.tiv.2011.08.007openalex-snapshot

Assessment of genotoxic effects of (4-methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone in human lymphocytes

inferred← citeshttps://doi.org/10.1016/s0065-7743(08)60576-xopenalex-snapshot

Chapter 14. Antimitotic Agents

inferred← citeshttps://doi.org/10.1016/s0960-894x(00)00596-5openalex-snapshot

Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers

inferred← citeshttps://doi.org/10.1016/s0960-894x(02)00850-8openalex-snapshot

Structure–activity and crystallographic analysis of benzophenone derivatives—the potential anticancer agents

inferred← citeshttps://doi.org/10.1016/s0968-0896(00)00068-7openalex-snapshot

Comparative molecular field analysis of colchicine inhibition and tubulin polymerization for combretastatins binding to the colchicine binding site on β-tubulin

inferred← citeshttps://doi.org/10.1016/s0968-0896(00)00176-0openalex-snapshot

Synthesis and biological evaluation of aryl azide derivatives of combretastatin a-4 as molecular probes for tubulin

inferred← citeshttps://doi.org/10.1016/s1470-2045(00)00224-2openalex-snapshot

Targeting tumour vasculature: the development of combretastatin A4

inferred← citeshttps://doi.org/10.1016/s1572-5995(08)80025-7openalex-snapshot

Natural stilbenes and analogues as antineoplastic agents

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b00101openalex-snapshot

Novel Combretastatin-2-aminoimidazole Analogues as Potent Tubulin Assembly Inhibitors: Exploration of Unique Pharmacophoric Impact of Bridging Skeleton and Aryl Moiety

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b00463openalex-snapshot

Blocking Blood Flow to Solid Tumors by Destabilizing Tubulin: An Approach to Targeting Tumor Growth

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b00551openalex-snapshot

Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization

inferred← citeshttps://doi.org/10.1021/acs.jnatprod.9b00773openalex-snapshot

Bioreductively Activatable Prodrug Conjugates of Combretastatin A‑1 and Combretastatin A‑4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia

inferred← citeshttps://doi.org/10.1021/acs.joc.6b00570openalex-snapshot

Phosphine-Free, Heterogeneous Palladium-Catalyzed Atom-Efficient Carbonylative Cross-Coupling of Triarylbismuths with Aryl Iodides: Synthesis of Biaryl Ketones

inferred← citeshttps://doi.org/10.1021/acs.joc.7b03068openalex-snapshot

Synthesis of Diaryl Ketones through Oxidative Cleavage of the C–C Double Bonds in N-Sulfonyl Enamides

inferred← citeshttps://doi.org/10.1021/acs.joc.8b00806openalex-snapshot

Nickel-Catalyzed Molybdenum-Promoted Carbonylative Synthesis of Benzophenones

inferred← citeshttps://doi.org/10.1021/acs.orglett.3c00792openalex-snapshot

Palladium-Catalyzed Carbonylative Synthesis of Diaryl Ketones from Arenes and Arylboronic Acids through C(sp 2 )–H Thianthrenation

inferred← citeshttps://doi.org/10.1021/acs.orglett.6c00555openalex-snapshot

Nickel-Catalyzed Cross-Coupling of Oxime Esters with Arylboronic Acids

inferred← citeshttps://doi.org/10.1021/acsmedchemlett.5b00208openalex-snapshot

Structural Optimization of Indole Derivatives Acting at Colchicine Binding Site as Potential Anticancer Agents

inferred← citeshttps://doi.org/10.1021/acsomega.8b00996openalex-snapshot

Combretastatin-Inspired Heterocycles as Antitubulin Anticancer Agents

inferred← citeshttps://doi.org/10.1021/jacsau.5c01331openalex-snapshot

Gold-Catalyzed Carbonyl Release and its Adaptation for Prodrug Therapy Using Multivalent Lectin-Directed Artificial Metalloenzymes

inferred← citeshttps://doi.org/10.1021/jm000045aopenalex-snapshot

Antineoplastic Agents. 443. Synthesis of the Cancer Cell Growth Inhibitor Hydroxyphenstatin and Its Sodium Diphosphate Prodrug

inferred← citeshttps://doi.org/10.1021/jm010119yopenalex-snapshot

Antineoplastic Agents. 465. Structural Modification of Resveratrol: Sodium Resverastatin Phosphate

inferred← citeshttps://doi.org/10.1021/jm010365+openalex-snapshot

Synthesis and Structure−Activity Relationship of 2-Aminobenzophenone Derivatives as Antimitotic Agents

inferred← citeshttps://doi.org/10.1021/jm0307685openalex-snapshot

Novel Benzylidene-9(10H)-anthracenones as Highly Active Antimicrotubule Agents. Synthesis, Antiproliferative Activity, and Inhibition of Tubulin Polymerization

inferred← citeshttps://doi.org/10.1021/jm049802lopenalex-snapshot

Concise Synthesis and Structure−Activity Relationships of Combretastatin A-4 Analogues, 1-Aroylindoles and 3-Aroylindoles, as Novel Classes of Potent Antitubulin Agents

inferred← citeshttps://doi.org/10.1021/jm0512903openalex-snapshot

Medicinal Chemistry of Combretastatin A4: Present and Future Directions

inferred← citeshttps://doi.org/10.1021/jm060355eopenalex-snapshot

Synthesis and Biological Evaluation of 2-Amino-3-(3‘,4‘,5‘-trimethoxybenzoyl)-5-aryl Thiophenes as a New Class of Potent Antitubulin Agents

inferred← citeshttps://doi.org/10.1021/jm060804aopenalex-snapshot

Synthesis and Biological Evaluation of 2-(3‘,4‘,5‘-Trimethoxybenzoyl)-3-Amino 5-Aryl Thiophenes as a New Class of Tubulin Inhibitors

inferred← citeshttps://doi.org/10.1021/jm070050fopenalex-snapshot

Synthesis and Biological Evaluation of 2- and 3-Aminobenzo[b]thiophene Derivatives as Antimitotic Agents and Inhibitors of Tubulin Polymerization

inferred← citeshttps://doi.org/10.1021/jm200488aopenalex-snapshot

Design, Synthesis, Biological Evaluation, and Structure–Activity Relationships of Substituted Phenyl 4-(2-Oxoimidazolidin-1-yl)benzenesulfonates as New Tubulin Inhibitors Mimicking Combretastatin A-4

inferred← citeshttps://doi.org/10.1021/jm3015603openalex-snapshot

Endowing Indole-Based Tubulin Inhibitors with an Anchor for Derivatization: Highly Potent 3-Substituted Indolephenstatins and Indoleisocombretastatins

inferred← citeshttps://doi.org/10.1021/jm500002kopenalex-snapshot

Design, Synthesis, and Biological Evaluation of Novel Pyridine-Bridged Analogues of Combretastatin-A4 as Anticancer Agents

inferred← citeshttps://doi.org/10.1021/jm500764vopenalex-snapshot

Design, Synthesis, and Biological Evaluation of Stable Colchicine Binding Site Tubulin Inhibitors as Potential Anticancer Agents

inferred← citeshttps://doi.org/10.1021/jm5016389openalex-snapshot

Design, Synthesis, and Biological Evaluation of Combretabenzodiazepines: A Novel Class of Anti-Tubulin Agents

inferred← citeshttps://doi.org/10.1021/jm7011547openalex-snapshot

Synthesis and Biological Evaluation of 1-Methyl-2-(3′,4′,5′-trimethoxybenzoyl)-3-aminoindoles as a New Class of Antimitotic Agents and Tubulin Inhibitors

inferred← citeshttps://doi.org/10.1021/jm800150dopenalex-snapshot

Discovery of 4-Amino and 4-Hydroxy-1-aroylindoles as Potent Tubulin Polymerization Inhibitors

inferred← citeshttps://doi.org/10.1021/jm9001692openalex-snapshot

2-Arylamino-4-Amino-5-Aroylthiazoles. “One-Pot” Synthesis and Biological Evaluation of a New Class of Inhibitors of Tubulin Polymerization

inferred← citeshttps://doi.org/10.1021/jm900321uopenalex-snapshot

Isocombretastatins A versus Combretastatins A: The Forgotten isoCA-4 Isomer as a Highly Promising Cytotoxic and Antitubulin Agent

inferred← citeshttps://doi.org/10.1021/jm900685yopenalex-snapshot

5-Amino-2-Aroylquinolines as Highly Potent Tubulin Polymerization Inhibitors

inferred← citeshttps://doi.org/10.1021/jm9807149openalex-snapshot

Antineoplastic Agents. 410. Asymmetric Hydroxylation of trans-Combretastatin A-4

inferred← citeshttps://doi.org/10.1021/jo0004761openalex-snapshot

Preparation of New Anti-Tubulin Ligands through a Dual-Mode, Addition−Elimination Reaction to a Bromo-Substituted α,β-Unsaturated Sulfoxide

inferred← citeshttps://doi.org/10.1021/jo000705jopenalex-snapshot

A Pinacol Rearrangement/Oxidation Synthetic Route to Hydroxyphenstatin1

inferred← citeshttps://doi.org/10.1021/jo5010185openalex-snapshot

One-Pot Synthesis of Diarylmethanones through Palladium-Catalyzed Sequential Coupling and Aerobic Oxidation of Aryl Bromides with Acetophenone as a Latent Carbonyl Donor

inferred← citeshttps://doi.org/10.1021/np200104topenalex-snapshot

Regioselective Synthesis of Water-Soluble Monophosphate Derivatives of Combretastatin A-1

inferred← citeshttps://doi.org/10.1038/nrc1628openalex-snapshot

Disrupting tumour blood vessels

inferred← citeshttps://doi.org/10.1039/c1ob05931aopenalex-snapshot

3-Methoxalylchromones – versatile reagents for the regioselective synthesis of functionalized 2,4′-dihydroxybenzophenones, potential UV-filters

inferred← citeshttps://doi.org/10.1039/c2ra22391kopenalex-snapshot

On the synthesis and biological properties of isocombretastatins: a case of ketone homologation during Wittig reaction attempts

inferred← citeshttps://doi.org/10.1039/c4ob00432aopenalex-snapshot

Synthesis of 1-amino-2-aroyl/acetylnaphthalenes through a base mediated one pot inter and intramolecular C–C bond formation strategy

inferred← citeshttps://doi.org/10.1039/c4ob02606copenalex-snapshot

Synthesis of phenstatin/isocombretastatin–chalcone conjugates as potent tubulin polymerization inhibitors and mitochondrial apoptotic inducers

inferred← citeshttps://doi.org/10.1039/c6ra16948aopenalex-snapshot

The synthesis and evaluation of new benzophenone derivatives as tubulin polymerization inhibitors

inferred← citeshttps://doi.org/10.1039/c6ra23008copenalex-snapshot

Novel formazan derivatives containing phenylsulfanyl and carbonyl units: synthesis, optical and electrochemical properties

inferred← citeshttps://doi.org/10.1039/c7md00450hopenalex-snapshot

New (3-(1 H -benzo[ d ]imidazol-2-yl))/(3-(3 H -imidazo[4,5- b ]pyridin-2-yl))-(1 H -indol-5-yl)(3,4,5-trimethoxyphenyl)methanone conjugates as tubulin polymerization inhibitors

inferred← citeshttps://doi.org/10.1039/c7ra02720fopenalex-snapshot

Synthesis and antiproliferative activity of 2-aryl-4-(3,4,5-trimethoxybenzoyl)-1,2,3-triazol derivatives as microtubule-destabilizing agents

inferred← citeshttps://doi.org/10.1039/c7ra04314gopenalex-snapshot

Identification of potential tubulin polymerization inhibitors by 3D-QSAR, molecular docking and molecular dynamics

inferred← citeshttps://doi.org/10.1039/c8md00322jopenalex-snapshot

Synthesis of dihydronaphthalene analogues inspired by combretastatin A-4 and their biological evaluation as anticancer agents

inferred← citeshttps://doi.org/10.1039/c9md00458kopenalex-snapshot

Application of triazoles as bioisosteres and linkers in the development of microtubule targeting agents

inferred← citeshttps://doi.org/10.1039/c9ob00558gopenalex-snapshot

Synthesis and evaluation of antiproliferative microtubule-destabilising combretastatin A-4 piperazine conjugates

inferred← citeshttps://doi.org/10.1039/d0ob01558jopenalex-snapshot

Non-hydrogen bond catalyst-mediated diastereoselective conjugate additions of 5 H -oxazol-4-ones to o -hydroxyphenyl-substituted p -quinone methides

inferred← citeshttps://doi.org/10.1039/d3ob01114copenalex-snapshot

Design, synthesis and structure–activity relationship studies on erianin analogues as pyruvate carboxylase inhibitors in hepatocellular carcinoma cells

inferred← citeshttps://doi.org/10.1039/d5md00564gopenalex-snapshot

Targeting tumor-associated hypoxia with bioreductively activatable prodrug conjugates derived from dihydronaphthalene, benzosuberene, and indole-based inhibitors of tubulin polymerization

inferred← citeshttps://doi.org/10.1046/j.1365-2613.2002.00211.xopenalex-snapshot

The biology of the combretastatins as tumour vascular targeting agents

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