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GPIIb/IIIa Integrin Antagonists with the New Conformational Restriction Unit, Trisubstituted β-Amino Acid Derivatives, and a Substituted Benzamidine Structure

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/bf00124017openalex-snapshot

Pharmacophore refinement of gpIIb/IIIa antagonists based on comparative studies of antiadhesive cyclic and acyclic RGD peptides

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Thrombosis and atherosclerosis: Regulatory role of interactions among blood components and endothelium

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Solid-phase parallel synthesis applied to lead optimization: Discovery of potent analogues of the GPIIb/IIIa antagonist RWJ-50042

inferredcites →https://doi.org/10.1016/s0021-9258(17)31981-6openalex-snapshot

Selective recognition of cyclic RGD peptides of NMR defined conformation by alpha IIb beta 3, alpha V beta 3, and alpha 5 beta 1 integrins.

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The tetrapeptide analogue of the cell attachment site of fibronectin inhibits platelet aggregation and fibrinogen binding to activated platelets.

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A novel method for generation of enolizable N-trimethylsilylaldimines and application to β-lactam synthesis

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Development of the new potent non-peptide gpIIb/IIIa antagonist NSL-95301 by utilizing combinatorial technique

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Development of new non-peptide GPIIb/IIIa antagonists, NSL-95315 and NSL-95317, isosteres of NSL-95300

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1-Hydroxy-7-azabenzotriazole. An efficient peptide coupling additive

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Biological analogs. Nature of the binding sites of copper-containing proteins

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Investigation of conformational specificity at GPIIb/IIIa: evaluation of conformationally constrained RGD peptides

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Conformational restriction of the phenylalanine residue in a cyclic opioid peptide analog: effects on receptor selectivity and stereospecificity

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Requisite cation complexation for the reduction of 2,6-pyrido-18-crown-6 N-oxide and an analog by potassium tri-sec-butylborohydride. Evidence for a single electron transfer mechanism

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Notes- A Convenient Synthesis of Water-Soluble Carbodiimides.

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Notes- Reduction of Phenols to Aromatic Hydrocarbons

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Platelets and Thrombolytic Therapy

inferredcites →https://doi.org/10.1073/pnas.83.15.5708openalex-snapshot

Inhibition of platelet function with synthetic peptides designed to be high-affinity antagonists of fibrinogen binding to platelets.

inferredcites →https://doi.org/10.1074/jbc.272.12.7720openalex-snapshot

A Novel Peptide Motif for Platelet Fibrinogen Receptor Recognition

inferredcites →https://doi.org/10.1126/science.2420006openalex-snapshot

Platelet Membrane Glycoprotein IIb/IIIa: Member of a Family of Arg-Gly-Asp—Specific Adhesion Receptors

inferredcites →https://doi.org/10.1126/science.2821619openalex-snapshot

New Perspectives in Cell Adhesion: RGD and Integrins

inferredcites →https://doi.org/10.1126/science.3513310openalex-snapshot

Distribution of Protein and RNA in the 30 S Ribosomal Subunit

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Unstable angina with fatal outcome: dynamic coronary thrombosis leading to infarction and/or sudden death. Autopsy evidence of recurrent mural thrombosis with peripheral embolization culminating in total vascular occlusion.

inferredcites →https://doi.org/10.1161/01.cir.91.2.403openalex-snapshot

SC-54684A: An Orally Active Inhibitor of Platelet Aggregation

inferredcites →https://doi.org/10.1182/blood.v71.4.831.831openalex-snapshot

The platelet membrane glycoprotein IIb-IIIa complex

inferredcites →https://doi.org/10.1242/jcs.97.4.585openalex-snapshot

The molecular basis and specificity of integrin-ligand interactions

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Cobalt(Ii) Catalyzed Michael-Type Hydroarylamination of Activated Olefins

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Construction of β ‐Phenylalanine Derivatives through Pd‐Catalyzed, C(sp 2 )−H ( ortho ) Functionalization

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Integrin Ligands with α/β‐Hybrid Peptide Structure: Design, Bioactivity, and Conformational Aspects

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Active site mapping of trypsin, thrombin and matriptase-2 by sulfamoyl benzamidines

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1-(2-Naphthyl)-1 H -pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 3: Design, synthesis and SAR of orally bioavailable benzamidine-P4 inhibitors

inferred← citeshttps://doi.org/10.1016/j.bmcl.2004.02.049openalex-snapshot

N,N-Dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)-benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines as potent factor Xa inhibitors

inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.02.114openalex-snapshot

Anthranilamide-based N,N-dialkylbenzamidines as potent and orally bioavailable factor Xa inhibitors: P4 SAR

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Stereoselective Mannich-type reaction of chlorotitanium α-phenylseleno esters enolates with aromatic aldimines

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Green, efficient and practical Michael addition of arylamines to α,β-unsaturated ketones

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(R)-(4-(Benzyloxycarbonylphenyl)-3-hydroxy-4,4-dimethyl-2-pyrrolidinone) acrylate derivative as a chiral dienophile for the synthesis of enantiopure 2-aminocyclohexane carboxylic acids

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Asymmetric Diels–Alder reaction using a new chiral β-nitroacrylate for enantiopure trans-β-norbornane amino acid preparation

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The iodolactone approach to enantiopure oxiranes of constrained chiral cyclic β-amino acids

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Boric acid: a novel and safe catalyst for aza-Michael reactions in water

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Synthesis of furan derivatives of cyclic β-amino acid cispentacin via intramolecular nitrile oxide cycloaddition

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Cyclic amino acid derivatives

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Chapter 10. Antiplatelet therapies

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Enantioselective synthetic approaches to cyclopropane and cyclobutane β-amino acids: synthesis and structural study of a conformationally constrained β-dipeptide

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1′-Azido- and 1′-amino-1,3-dioxolan-4-ones

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Stereoselective synthesis of (−)-(1R,2S)-2-aminocyclobutane-1-carboxylic acid, a conformationally constrained β-amino acid

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Three-Dimensional quantitative structure–Activity relationship analyses of RGD mimetics as fibrinogen receptor antagonists

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Symmetrical anhydride-type serine protease inhibitors: Structure-activity relationship studies of human chymase inhibitors

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Nonpeptide glycoprotein IIB/IIIA inhibitors. 19. A new design paradigm employing linearly minimized, centrally constrained, exosite inhibitors

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Natural-Products-Inspired Use of the gem -Dimethyl Group in Medicinal Chemistry

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Discovery of Novel 2,8-Diazaspiro[4.5]decanes as Orally Active Glycoprotein IIb-IIIa Antagonists

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Peptides Containing β-Amino Acid Patterns: Challenges and Successes in Medicinal Chemistry

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N -[2,2-Dimethyl-3-( N -(4-cyanobenzoyl)amino)nonanoyl]- l -phenylalanine Ethyl Ester as a Stable Ester-Type Inhibitor of Chymotrypsin-like Serine Proteases: Structural Requirements for Potent Inhibition of α -Chymotrypsin

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Nonapeptide Analogues Containing (R)-3-Hydroxybutanoate and β-Homoalanine Oligomers: Synthesis and Binding Affinity to a Class I Major Histocompatibility Complex Protein

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Conjugate Addition of Amines to α,β-Enones Promoted by CeCl3·7H2O−NaI System Supported in Silica Gel

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Stereoselective One-Pot Synthesis of Constrained N,O-Orthogonally ProtectedC-Glycosyl Norstatines [C(1‘)-Aminoglycosyl-1,3-dioxolan-4-ones]

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Process Optimization of Aldol-Type Reaction by Process Understanding Using in Situ IR

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On-water magnetic NiFe 2 O 4 nanoparticle-catalyzed Michael additions of active methylene compounds, aromatic/aliphatic amines, alcohols and thiols to conjugated alkenes

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Cobalt(II) catalyzed Michael-type hydroamination of activated olefins

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Synthesis and interest in medicinal chemistry of β-phenylalanine derivatives (β-PAD): an update (2010–2022)

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Backbone extension acyl rearrangements enable cellular synthesis of proteins with internal β 2 -peptide linkages

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Preparation of Optically Active β-Amino Acids from Microbial Polyester Polyhydroxyalkanoates

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