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Synthesis, stability, and pharmacological evaluation of nipecotic acid prodrugs

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jps.2600711108openalex-snapshot
Esters of Nipecotic and Isonipecotic Acids as Potential Anticonvulsants
inferredcites →https://doi.org/10.1002/jps.2600820109openalex-snapshot
Determination of m-nitrophenol and nipecotic acid in mouse tissues by high-performance liquid chromatography after administration of the anticonvulsant m-nitrophenyl-3-piperidinecarboxylate hydrochloride
inferredcites →https://doi.org/10.1007/978-3-642-76894-1openalex-snapshot
Physiology and Pharmacology of the Blood-Brain Barrier
inferredcites →https://doi.org/10.1007/978-3-642-76894-1_11openalex-snapshot
Transport of Drugs
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Experimental Manipulation of the Blood-Brain ”and Blood-Retinal Barriers
inferredcites →https://doi.org/10.1016/0006-2952(92)90649-4openalex-snapshot
Intestinal active absorption of sugar-conjugated compounds by glucose transport system: implication of improvement of poorly absorbable drugs
inferredcites →https://doi.org/10.1016/0006-2952(93)90053-yopenalex-snapshot
Comparative study of active absorption by the intestine and disposition of anomers of sugar-conjugated compounds
inferredcites →https://doi.org/10.1016/0006-8993(95)01539-6openalex-snapshot
Arginine vasopressin reduces the blood-brain transfer of l-tyrosine and l-valine: further evidence of the effect of the peptide on the l-system transporter at the blood-brain barrier
inferredcites →https://doi.org/10.1016/0014-2999(79)90026-8openalex-snapshot
Convulsant and anticonvulsant actions in DBA/2 mice of compounds blocking the reuptake of GABA
inferredcites →https://doi.org/10.1016/0014-2999(95)00561-7openalex-snapshot
GYKI 52466 and related 2,3-benzodiazepines as anticonvulsant agents in DBA/2 mice
inferredcites →https://doi.org/10.1016/0028-3908(84)90121-7openalex-snapshot
Anticonvulsant activity of the nipecotic acid ester, (±)-m-nitrophenyl-3-piperidinecarboxylate
inferredcites →https://doi.org/10.1016/0028-3908(88)90129-3openalex-snapshot
A comparison of prodrug esters of nipecotic acid
inferredcites →https://doi.org/10.1016/0165-0173(89)90003-9openalex-snapshot
Animal models of the epilepsies
inferredcites →https://doi.org/10.1016/0165-6147(83)90308-5openalex-snapshot
Problems in GABA research
inferredcites →https://doi.org/10.1016/0196-9781(92)90138-sopenalex-snapshot
In vitro penetration of des-tyrosine1-D-phenylalanine3-β-casomorphin across the blood-brain barrier
inferredcites →https://doi.org/10.1016/0304-4165(94)90125-2openalex-snapshot
The β-anomeric and glucose preferences of glucose transport carrier for intestinal active absorption of monosaccharide conjugates
inferredcites →https://doi.org/10.1016/0378-5173(93)90080-yopenalex-snapshot
Naproxen 1-Alkylazacycloalkan-2-one esters as dermal prodrugs: in vitro evaluation
inferredcites →https://doi.org/10.1016/0378-5173(94)90191-0openalex-snapshot
Drug delivery via active transport at the blood-brain barrier: affinity of a prodrug of phosphonoformate for the large amino acid transporter
inferredcites →https://doi.org/10.1016/s0920-1211(97)00031-4openalex-snapshot
Comparison of the preclinical anticonvulsant profiles of tiagabine, lamotrigine, gabapentin and vigabatrin
inferredcites →https://doi.org/10.1021/jm00041a012openalex-snapshot
Design, Synthesis and Evaluation of Substituted Triarylnipecotic Acid Derivatives as GABA Uptake Inhibitors: Identification of a Ligand with Moderate Affinity and Selectivity for the Cloned Human GABA Transporter GAT-3
inferredcites →https://doi.org/10.1021/jm00094a018openalex-snapshot
Improved brain delivery of AZT using a glycosyl phosphotriester prodrug
inferredcites →https://doi.org/10.1021/jm00135a009openalex-snapshot
Esters of isoguvacine as potential prodrugs
inferredcites →https://doi.org/10.1023/a:1016017832146openalex-snapshot
Transport of Alpha-Tocopherol and Its Derivatives Through Erythrocyte Membranes
inferredcites →https://doi.org/10.1023/a:1016084508097openalex-snapshot
Macromolecular Carrier Systems for Targeted Drug Delivery: Pharmacokinetic Considerations on Biodistribution
inferredcites →https://doi.org/10.1111/j.1471-4159.1975.tb04410.xopenalex-snapshot
INHIBITION OF GABA UPTAKE IN RAT BRAIN SLICES BY NIPECOTIC ACID, VARIOUS ISOXAZOLES AND RELATED COMPOUNDS
inferredcites →https://doi.org/10.1111/j.1471-4159.1982.tb07972.xopenalex-snapshot
γ‐Aminobutyric Acid and Benzodiazepine Binding Sites in Audiogenic Seizure‐Susceptible Mice
inferredcites →https://doi.org/10.1111/j.1471-4159.1986.tb01757.xopenalex-snapshot
Blood–Brain Transfer of Glucose and Glucose Analogs in Newborn Rats
inferredcites →https://doi.org/10.1111/j.1471-4159.1987.tb01039.xopenalex-snapshot
Kinetics of Neutral Amino Acid Transport Across the Blood‐Brain Barrier
inferredcites →https://doi.org/10.1111/j.1528-1157.1985.tb05398.xopenalex-snapshot
A Review of Mouse Mutants as Genetic Models of Epilepsy
inferredcites →https://doi.org/10.1111/j.1528-1157.1995.tb02576.xopenalex-snapshot
A Review of the Preclinical Pharmacology of Tiagabine: A Potent and Selective Anticonvulsant GABA Uptake Inhibitor

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Nipecotic Acid: Systemic Availability and Brain Delivery After Nasal Administration of Nipecotic Acid and n-Butyl Nipecotate to Rats
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Current Chemical, Biological, and Physiological Views in the Development of Successful Brain-Targeted Pharmaceutics
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Crossing the Blood–Brain Barrier: Recent Advances in Drug Delivery to the Brain
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Pharmacokinetics of Drug Delivery Past the Blood–Brain Barrier
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Anticonvulsant and anxiolytic activity of FrPbAII, a novel GABA uptake inhibitor isolated from the venom of the social spider Parawixia bistriata (Araneidae: Araneae)
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Glucose transport to the brain: A systems model
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Nipecotic acid as potential lead molecule for the development of GABA uptake inhibitors; structural insights and design strategies
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Lipophilicity-related inhibition of blood platelet aggregation by nipecotic acid anilides
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Ascorbic and 6-Br-ascorbic acid conjugates as a tool to increase the therapeutic effects of potentially central active drugs
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Structure–activity relationship study of compounds binding to large amino acid transporter 1 (LAT1) based on pharmacophore modeling and in situ rat brain perfusion
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Docking and pharmacodynamic studies on hGAT1 inhibition activity in the presence of selected neuronal and astrocytic inhibitors. Part I
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The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human β-amyloid precursor protein transgenic mice
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Development towards a novel screening method for nipecotic acid bioisosteres using molecular imprinted polymers (MIPs) as alternative to in vitro cellular uptake assays
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Investigation of platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids
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Phenylphenothiazine-Based Porous Organic Polymers as Visible-Light Heterogeneous Photocatalysts for Switchable Bromoalkylation and Cyclopropanation of Unactivated Terminal Alkenes
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