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MDCK (Madin-Darby Canine Kidney) Cells: A Tool for Membrane Permeability Screening
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/jps.2600740523openalex-snapshot
Absorption Potential: Estimating the Fraction Absorbed for Orally Administered Compounds
inferredcites →https://doi.org/10.1002/jps.2600790604openalex-snapshot
Epithelial Transport Of Drugs In Cell Culture. I: A Model For Studying The Passive Diffusion Of Drugs Over Intestinal Absorbtive (Caco-2) Cells
inferredcites →https://doi.org/10.1007/978-1-4899-1863-5openalex-snapshot
Models for Assessing Drug Absorption and Metabolism
inferredcites →https://doi.org/10.1007/978-1-4899-1863-5_3openalex-snapshot
Cultured Intestinal Epithelial Cell Models
inferredcites →https://doi.org/10.1016/0006-291x(91)91647-uopenalex-snapshot
Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
inferredcites →https://doi.org/10.1016/0167-4889(93)90069-2openalex-snapshot
Transepithelial secretion, cellular accumulation and cytotoxicity of vinblastine in defined MDCK cell strains
inferredcites →https://doi.org/10.1016/0168-3659(90)90118-dopenalex-snapshot
Transport and permeability properties of human Caco-2 cells: An in vitro model of the intestinal epithelial cell barrier
inferredcites →https://doi.org/10.1016/s0016-5085(89)80072-1openalex-snapshot
Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability
inferredcites →https://doi.org/10.1016/s0021-9258(18)63784-6openalex-snapshot
Transepithelial Transport of Drugs by the Multidrug Transporter in Cultured Madin-Darby Canine Kidney Cell Epithelia
inferredcites →https://doi.org/10.1016/s0169-409x(00)00128-9openalex-snapshot
Caco-2 monolayers in experimental and theoretical predictions of drug transport1PII of original article: S0169-409X(96)00415-2. The article was originally published in Advanced Drug Delivery Reviews 22 (1996) 67–84.1
inferredcites →https://doi.org/10.1016/s0169-409x(96)00415-2openalex-snapshot
Caco-2 monolayers in experimental and theoretical predictions of drug transport
inferredcites →https://doi.org/10.1021/ci980029aopenalex-snapshot
Prediction of Human Intestinal Absorption of Drug Compounds from Molecular Structure
inferredcites →https://doi.org/10.1023/a:1011953405272openalex-snapshot
MDCK Cell Cultures as an Epithelial In Vitro Model: Cytoskeleton and Tight Junctions as Indicators for the Definition of Age-Related Stages by Confocal Microscopy
inferredcites →https://doi.org/10.1023/a:1015802918845openalex-snapshot
Transepithelial Transport of Aliphatic Carboxylic Acids Studied in Madin Darby Canine Kidney (MDCK) Cell Monolayers
inferredcites →https://doi.org/10.1023/a:1015807904558openalex-snapshot
The Madin Darby Canine Kidney (MDCK) Epithelial Cell Monolayer as a Model Cellular Transport Barrier
inferredcites →https://doi.org/10.1023/a:1015927004752openalex-snapshot
Estimating Human Oral Fraction Dose Absorbed: A Correlation Using Rat Intestinal Membrane Permeability for Passive and Carrier-Mediated Compounds
inferredcites →https://doi.org/10.1023/a:1015937605100openalex-snapshot
Caco-2 Cell Monolayers as a Model for Drug Transport Across the Intestinal Mucosa
inferredcites →https://doi.org/10.1023/a:1016045820933openalex-snapshot
In Vitro Permeability Through Caco-2 Cells is not Quantitatively Predictive of in Vivo Absorption for Peptide-Like Drugs Absorbed via the Dipeptide Transporter System
inferredcites →https://doi.org/10.1023/a:1016207525186openalex-snapshot
Comparison of Intestinal Permeabilities Determined in Multiple in Vitro and in Situ Models: Relationship to Absorption in Humans
inferredcites →https://doi.org/10.1023/a:1018935704693openalex-snapshot
Mechanism and Kinetics of Transcellular Transport of a New β-Lactam Antibiotic Loracarbef Across an Intestinal Epithelial Membrane Model System (Caco-2)
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Comparison of the Permeability Characteristics of a Human Colonic Epithelial (Caco-2) Cell Line to Colon of Rabbit, Monkey, and Dog Intestine and Human Drug Absorption
inferredcites →https://doi.org/10.1023/a:1018947430018openalex-snapshot
Passive Transepithelial Absorption of Thyrotropin-Releasing Hormone (TRH) via a Paracellular Route in Cultured Intestinal and Renal Epithelial Cell Lines
inferredcites →https://doi.org/10.1023/a:1018965929419openalex-snapshot
Mechanism of Intestinal Absorption of Ranitidine and Ondansetron: Transport Across Caco-2 Cell Monolayers
inferredcites →https://doi.org/10.1038/ki.1986.7openalex-snapshot
Transport and metabolic functions in cultured renal tubule cells
inferredcites →https://doi.org/10.1073/pnas.73.4.1212openalex-snapshot
Transepithelial transport in cell culture.
inferredcites →https://doi.org/10.1074/jbc.270.43.25672openalex-snapshot
Differential Recognition of β-Lactam Antibiotics by Intestinal and Renal Peptide Transporters, PEPT 1 and PEPT 2
inferredcites →https://doi.org/10.1083/jcb.77.3.853openalex-snapshot
Polarized monolayers formed by epithelial cells on a permeable and translucent support
inferredcites →https://doi.org/10.1128/aac.36.7.1374openalex-snapshot
Epithelial cells in culture as a model for the intestinal transport of antimicrobial agents
inferredcites →https://doi.org/10.1128/aac.40.3.652openalex-snapshot
Transport of the antibacterial agent oxazolidin-2-one and derivatives across intestinal (Caco-2) and renal (MDCK) epithelial cell lines
inferredcites →https://doi.org/10.1615/critrevtherdrugcarriersyst.v14.i3.20openalex-snapshot
A Human Colonic Cell Line Sharing Similarities With Enterocytes as a Model to Examine Oral Absorption: Advantages and Limitations of the Caco-2 Model
inferredcites →https://doi.org/10.2307/1402416openalex-snapshot
Statistics: A Biomedical Introduction
inferredcites →https://doi.org/10.2307/2344819openalex-snapshot
Statistics: A Biomedical Introduction.
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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inferred← citeshttps://doi.org/10.1007/978-3-031-46545-1_20openalex-snapshot
In Silico Design of Acetylcholinesterase and Glycogen Synthase Kinase-3β Multi-target Inhibitors
inferred← citeshttps://doi.org/10.1007/978-3-0348-7997-2openalex-snapshot
Modern Methods of Drug Discovery
inferred← citeshttps://doi.org/10.1007/978-3-0348-7997-2_12openalex-snapshot
Physicochemical concepts in drug design
inferred← citeshttps://doi.org/10.1007/978-3-319-04346-3_1openalex-snapshot
Tactical Applications of Fluorine in Drug Design and Development
inferred← citeshttps://doi.org/10.1007/978-3-319-56850-8_9openalex-snapshot
QSAR/QSPR Modeling in the Design of Drug Candidates with Balanced Pharmacodynamic and Pharmacokinetic Properties
inferred← citeshttps://doi.org/10.1007/978-3-540-49757-8_9openalex-snapshot
Computational approaches for modeling human intestinal absorption and permeability
inferred← citeshttps://doi.org/10.1007/978-3-642-25240-2_38openalex-snapshot
Distribution: Across Barriers
inferred← citeshttps://doi.org/10.1007/978-3-662-04383-7_3openalex-snapshot
Rapid Permeability Screening in Drug Discovery to Predict Human Intestinal Absorption
inferred← citeshttps://doi.org/10.1007/978-3-662-04383-7_4openalex-snapshot
Drug Metabolism Assays and Their Use in Drug Discovery
inferred← citeshttps://doi.org/10.1007/978-3-662-04383-7_9openalex-snapshot
Strategies in Lead Selection and Optimization: Application of a Graphical Model and Automated In Vitro ADME Screening
inferred← citeshttps://doi.org/10.1007/bf02980227openalex-snapshot
Peptide transporter substrate identification during permeability screening in drug discovery: Comparison of transfected MDCK-hPepT1 cells to caco-2 cells
inferred← citeshttps://doi.org/10.1007/bf03257371openalex-snapshot
Applied Pharmacokinetics in Drug Development
inferred← citeshttps://doi.org/10.1007/s00044-014-1266-8openalex-snapshot
Synthesis, in-vitro screening, and docking analysis of novel pyrrolidine and piperidine-substituted ethoxy chalcone as anticancer agents
inferred← citeshttps://doi.org/10.1007/s00044-016-1764-yopenalex-snapshot
Binding of anti-Trypanosoma natural products from African flora against selected drug targets: a docking study
inferred← citeshttps://doi.org/10.1007/s00044-017-1893-yopenalex-snapshot
Quantum chemical, ADMET and molecular docking studies of ferulic acid amide derivatives with a novel anticancer drug target
inferred← citeshttps://doi.org/10.1007/s00044-019-02387-5openalex-snapshot
Novel chromenes and benzochromenes bearing arylazo moiety: molecular docking, in-silico admet, in-vitro antimicrobial and anticancer screening
inferred← citeshttps://doi.org/10.1007/s00204-013-1066-9openalex-snapshot
Assessment of ABCG2-mediated transport of xenobiotics across the blood–milk barrier of dairy animals using a new MDCKII in vitro model
inferred← citeshttps://doi.org/10.1007/s00204-025-03992-7openalex-snapshot
Quantitative in vitro-to-in vivo extrapolation of human adrenergic and trace amine-associated receptor 1 potencies of pre-workout supplement ingredients using physiologically based kinetic modelling-based reverse dosimetry
inferred← citeshttps://doi.org/10.1007/s00216-022-03991-yopenalex-snapshot
Evaluation and optimization of PolyJet 3D-printed materials for cell culture studies
inferred← citeshttps://doi.org/10.1007/s00216-025-05783-6openalex-snapshot
Investigating drug-liposome interactions using liposomal electrokinetic chromatography
inferred← citeshttps://doi.org/10.1007/s00216-025-05958-1openalex-snapshot
Evaluation of fused deposition modeling (FDM)-printed devices for microfluidic-based cell culture studies
inferred← citeshttps://doi.org/10.1007/s00706-015-1453-4openalex-snapshot
Synthesis, characterization, and pharmacological evaluation of novel azolo- and azinothiazinones containing 2,4-dihydroxyphenyl substituent as anticancer agents
inferred← citeshttps://doi.org/10.1007/s00726-012-1393-9openalex-snapshot
Antioxidative peptides: enzymatic production, in vitro and in vivo antioxidant activity and potential applications of milk-derived antioxidative peptides
inferred← citeshttps://doi.org/10.1007/s00894-005-0065-zopenalex-snapshot
Computational approaches for modeling human intestinal absorption and permeability
inferred← citeshttps://doi.org/10.1007/s00894-014-2069-zopenalex-snapshot
How “drug-like” are naturally occurring anti-cancer compounds?
inferred← citeshttps://doi.org/10.1007/s10123-018-0029-7openalex-snapshot
Integration of virtual screening and susceptibility test to discover active-site subpocket-specific biogenic inhibitors of Helicobacter pylori shikimate dehydrogenase
inferred← citeshttps://doi.org/10.1007/s10337-015-3019-3openalex-snapshot
Development of an HPLC-FLD Method for Determination of Rhodamine-123 in Caco-2 Cell-Based Permeability Studies
inferred← citeshttps://doi.org/10.1007/s10534-022-00469-3openalex-snapshot
New Ni(II) and Pd(II) complexes bearing derived sulfa drug ligands: synthesis, characterization, DFT calculations, and in silico and in vitro biological activity studies
inferred← citeshttps://doi.org/10.1007/s10822-008-9194-7openalex-snapshot
Simulation-based cheminformatic analysis of organelle-targeted molecules: lysosomotropic monobasic amines
inferred← citeshttps://doi.org/10.1007/s10822-011-9475-4openalex-snapshot
Binding of novel fullerene inhibitors to HIV-1 protease: insight through molecular dynamics and molecular mechanics Poisson–Boltzmann surface area calculations
inferred← citeshttps://doi.org/10.1007/s10822-015-9855-2openalex-snapshot
The challenges of making decisions using uncertain data
inferred← citeshttps://doi.org/10.1007/s11030-005-1297-7openalex-snapshot
Rational selection of structurally diverse natural product scaffolds with favorable ADME properties for drug discovery
inferred← citeshttps://doi.org/10.1007/s11030-015-9650-yopenalex-snapshot
High-throughput screening against $$\sim $$ ∼ 6.1 million structurally diverse, lead-like compounds to discover novel ROCK inhibitors for cerebral injury recovery
inferred← citeshttps://doi.org/10.1007/s11030-023-10772-xopenalex-snapshot
Design and investigation of interactions of novel peptide conjugates of purine and pyrimidine derivatives with EGFR and its mutant T790M/L858R: an in silico and laboratory study
inferred← citeshttps://doi.org/10.1007/s11030-025-11172-zopenalex-snapshot
Computational screening for natural compounds as potential immune checkpoint inhibitors against TIGIT, a new avenue in cancer immunotherapy
inferred← citeshttps://doi.org/10.1007/s11030-025-11334-zopenalex-snapshot
Structure-guided discovery of a novel BTK inhibitor inducing apoptosis and G1 phase arrest in tumor cells
inferred← citeshttps://doi.org/10.1007/s11033-020-05977-4openalex-snapshot
Renal proximal tubular epithelial cells: review of isolation, characterization, and culturing techniques
inferred← citeshttps://doi.org/10.1007/s11051-019-4628-9openalex-snapshot
Cellular uptake and cytotoxicity of unmodified Pr3+:LaF3 nanoparticles
inferred← citeshttps://doi.org/10.1007/s11051-021-05249-7openalex-snapshot
Transmission electron microscopy and flow cytometry study of cellular uptake of unmodified Pr3+:LaF3 nanoparticles in dynamic
inferred← citeshttps://doi.org/10.1007/s11095-006-0249-yopenalex-snapshot
Development of an in Vitro Rat Intestine Segmental Perfusion Model to Investigate Permeability and Predict Oral Fraction Absorbed
inferred← citeshttps://doi.org/10.1007/s11095-006-9122-2openalex-snapshot
Transport of Poly(Amidoamine) Dendrimers across Caco-2 Cell Monolayers: Influence of Size, Charge and Fluorescent Labeling
inferred← citeshttps://doi.org/10.1007/s11095-007-9236-1openalex-snapshot
Predicting Effect of Food on Extent of Drug Absorption Based on Physicochemical Properties
inferred← citeshttps://doi.org/10.1007/s11095-007-9397-yopenalex-snapshot
The Role of Permeability in Drug ADME/PK, Interactions and Toxicity—Presentation of a Permeability-Based Classification System (PCS) for Prediction of ADME/PK in Humans
inferred← citeshttps://doi.org/10.1007/s11095-010-0150-6openalex-snapshot
In Situ Artificial Membrane Permeation Assay under Hydrodynamic Control: Permeability-pH Profiles of Warfarin and Verapamil
inferred← citeshttps://doi.org/10.1007/s11095-012-0699-3openalex-snapshot
Sotalol Permeability in Cultured-Cell, Rat Intestine, and PAMPA System
inferred← citeshttps://doi.org/10.1007/s11095-013-1069-5openalex-snapshot
The Extracellular Microenvironment Explains Variations in Passive Drug Transport Across Different Airway Epithelial Cell Types
inferred← citeshttps://doi.org/10.1007/s11095-014-1430-3openalex-snapshot
Oral Delivery of Glucagon Like Peptide-1 by a Recombinant Lactococcus lactis
inferred← citeshttps://doi.org/10.1007/s11095-014-1599-5openalex-snapshot
Genomic Knockout of Endogenous Canine P-Glycoprotein in Wild-Type, Human P-Glycoprotein and Human BCRP Transfected MDCKII Cell Lines by Zinc Finger Nucleases
inferred← citeshttps://doi.org/10.1007/s11095-020-02824-wopenalex-snapshot
Metformin Transport in Native MDCK-Wt and MDCK-II Monolayers Unveils Functional Inter-Strains Differences Influencing Drug Permeability
inferred← citeshttps://doi.org/10.1007/s11671-008-9160-2openalex-snapshot
Comparison of In vitro Nanoparticles Uptake in Various Cell Lines and In vivo Pulmonary Cellular Transport in Intratracheally Dosed Rat Model
inferred← citeshttps://doi.org/10.1007/s12010-012-9646-3openalex-snapshot
The Bioflavonoid Galangin Suppresses the Growth of Ehrlich Ascites Carcinoma in Swiss Albino Mice: A Molecular Insight
inferred← citeshttps://doi.org/10.1007/s12010-013-0158-6openalex-snapshot
From Natural Products to Drugs for Epimutation Computer-Aided Drug Design
inferred← citeshttps://doi.org/10.1007/s12010-024-05110-2openalex-snapshot
Decoding Drug Discovery: Exploring A-to-Z In Silico Methods for Beginners
inferred← citeshttps://doi.org/10.1007/s12272-010-1116-2openalex-snapshot
Biowaiver extension potential and IVIVC for BCS Class II drugs by formulation design: Case study for cyclosporine self-microemulsifying formulation
inferred← citeshttps://doi.org/10.1007/s12272-015-0704-6openalex-snapshot
Functional and cytometric examination of different human lung epithelial cell types as drug transport barriers
inferred← citeshttps://doi.org/10.1007/s12539-013-0200-yopenalex-snapshot
In silico molecular docking, preclinical evaluation of spiroindimicins A-D, lynamicin A and D isolated from deep marine sea derived Streptomyces sp. SCSIO 03032
inferred← citeshttps://doi.org/10.1007/s12539-017-0215-xopenalex-snapshot
Novel Insight from Computational Virtual Screening Depict the Binding Potential of Selected Phytotherapeutics Against Probable Drug Targets of Clostridium difficile
inferred← citeshttps://doi.org/10.1007/s12975-012-0200-yopenalex-snapshot
Drug-Like Property Profiling of Novel Neuroprotective Compounds to Treat Acute Ischemic Stroke: Guidelines to Develop Pleiotropic Molecules
inferred← citeshttps://doi.org/10.1007/s13205-018-1303-2openalex-snapshot
Prediction of binding potential of natural leads against the prioritized drug targets of chikungunya and dengue viruses by computational screening
inferred← citeshttps://doi.org/10.1007/s13318-015-0310-5openalex-snapshot
Intestinal Permeability of β-Lapachone and Its Cyclodextrin Complexes and Physical Mixtures
inferred← citeshttps://doi.org/10.1007/s13346-017-0383-6openalex-snapshot
Incorporation of lipolysis in monolayer permeability studies of lipid-based oral drug delivery systems
inferred← citeshttps://doi.org/10.1007/s13577-026-01427-8openalex-snapshot
Cytotoxic and genotoxic effects of oxime β-lapachone in human cancer cells: selectivity toward NCI-H460 and insights from molecular docking
inferred← citeshttps://doi.org/10.1007/s13659-017-0125-yopenalex-snapshot
Antiparasitic Sesquiterpenes from the Cameroonian Spice Scleria striatinux and Preliminary In Vitro and In Silico DMPK Assessment
inferred← citeshttps://doi.org/10.1007/s40005-025-00788-wopenalex-snapshot
Hydrophobic ion pairing–loaded SNEDDS for leuprolide acetate: in vitro feasibility for enhanced lipophilicity, acidic dissolution control, and MDCK permeability
inferred← citeshttps://doi.org/10.1007/s40203-017-0029-xopenalex-snapshot
Exploration of 3,6-dihydroimidazo(4,5-d)pyrrolo(2,3-b)pyridin-2(1H)-one derivatives as JAK inhibitors using various in silico techniques
inferred← citeshttps://doi.org/10.1007/s40203-018-0040-xopenalex-snapshot
Molecular modeling of inhibitors against fructose bisphosphate aldolase from Candida albicans
inferred← citeshttps://doi.org/10.1007/s40203-024-00228-xopenalex-snapshot
Predicting phase-I metabolism of piceatannol: an in silico study
inferred← citeshttps://doi.org/10.1007/s40203-025-00378-6openalex-snapshot
Computational study of phytochemicals from Khaya grandifoliola (WELW) as potential inhibitors of the Plasmodium falciparum transketolase and putative antimalarial agents
inferred← citeshttps://doi.org/10.1007/s44371-026-00910-3openalex-snapshot
Discovering potent Onchocerca volvulus inhibitors from the ConMedNP library through virtual screening, MMGBSA, and molecular dynamics simulations
inferred← citeshttps://doi.org/10.1016/b0-08-045044-x/00126-7openalex-snapshot
Passive Permeability and Active Transport Models for the Prediction of Oral Absorption
inferred← citeshttps://doi.org/10.1016/b0-08-045044-x/00132-2openalex-snapshot
Progress in Bioanalytics and Automation Robotics for Absorption, Distribution, Metabolism, and Excretion Screening
inferred← citeshttps://doi.org/10.1016/b978-0-08-100094-6.00020-1openalex-snapshot
Correlation between cell- and tissue-based in vitro models for drug permeability screening with in vivo situation
inferred← citeshttps://doi.org/10.1016/b978-0-12-411508-8.00006-2openalex-snapshot
In vitro ADME and In vivo Pharmacokinetics
inferred← citeshttps://doi.org/10.1016/b978-0-12-801076-1.00026-5openalex-snapshot
Permeability Methods
inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.11532-6openalex-snapshot
In Silico ADME Modeling
inferred← citeshttps://doi.org/10.1016/b978-0-12-802447-8.00012-1openalex-snapshot
Oral Drug Absorption
inferred← citeshttps://doi.org/10.1016/b978-0-12-817214-8.00006-3openalex-snapshot
In vitro ADME and in vivo pharmacokinetics
inferred← citeshttps://doi.org/10.1016/b978-0-12-820018-6.00021-1openalex-snapshot
Advances in CRISPR technologies enable novel in vitro tools for ADME studies
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