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Bicyclic Cyclohexenones as Inhibitors of NF-κB Signaling

https://doi.org/10.1021/ml300034a
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1 of the 37 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-21): 10.1038/nature10167 (notice 2018-07-25).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Immortalized and tumorigenic adult human prostatic epithelial cell lines: Characteristics and applications part I. Cell markers and immortalized nontumorigenic cell lines
inferredcites →https://doi.org/10.1002/anie.201005959openalex-snapshot
An NMR Spectroscopic Method to Identify and Classify Thiol‐Trapping Agents: Revival of Michael Acceptors for Drug Discovery?
inferredcites →https://doi.org/10.1002/pros.10082openalex-snapshot
Mechanisms of constitutive NF‐κB activation in human prostate cancer cells
inferredcites →https://doi.org/10.1016/0092-8674(86)90346-6openalex-snapshot
Multiple nuclear factors interact with the immunoglobulin enhancer sequences
inferredcites →https://doi.org/10.1016/j.bmc.2005.11.027openalex-snapshot
Sesquiterpene lactones as inhibitors of IL-8 expression in HeLa cells
inferredcites →https://doi.org/10.1016/j.bmcl.2008.12.089openalex-snapshot
Syntheses and potential anti-prostate cancer activities of ionone-based chalcones
inferredcites →https://doi.org/10.1016/j.ccr.2004.09.003openalex-snapshot
Nuclear factor-κB
inferredcites →https://doi.org/10.1016/j.cell.2008.01.020openalex-snapshot
Shared Principles in NF-κB Signaling
inferredcites →https://doi.org/10.1016/j.gde.2008.01.020openalex-snapshot
NF-κB and cancer — identifying targets and mechanisms
inferredcites →https://doi.org/10.1016/j.juro.2010.01.065openalex-snapshot
Cryptocaryone, a Natural Dihydrochalcone, Induces Apoptosis in Human Androgen Independent Prostate Cancer Cells by Death Receptor Clustering in Lipid Raft and Nonraft Compartments
inferredcites →https://doi.org/10.1016/j.tetlet.2010.01.101openalex-snapshot
The first asymmetric total syntheses of both enantiomers of cryptocaryone
inferredcites →https://doi.org/10.1016/s0040-4020(01)00596-8openalex-snapshot
New cytotoxic flavonoids from Cryptocarya infectoria
inferredcites →https://doi.org/10.1016/s0040-4039(01)80867-4openalex-snapshot
Crytocaryone: A revised structure
inferredcites →https://doi.org/10.1016/s0040-4039(01)94060-2openalex-snapshot
Cryptocaryone, a novel 5′,6′-dihydrochalcone, from gamb.
inferredcites →https://doi.org/10.1016/s0957-4166(00)00401-8openalex-snapshot
Enantioselective catalytic cyclopropanation of styrenes by copper complexes with chiral pinene-[5,6]-bipyridine ligands
inferredcites →https://doi.org/10.1016/s0968-0896(99)00195-9openalex-snapshot
Inhibition of transcription factor NF-κB by sesquiterpene lactones: a proposed molecular mechanism of action
inferredcites →https://doi.org/10.1016/s1359-6101(01)00016-8openalex-snapshot
Interleukin-8 and human cancer biology
inferredcites →https://doi.org/10.1021/ml200020hopenalex-snapshot
Natural Product-Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as a New Antifungal Template
inferredcites →https://doi.org/10.1021/ml200036ropenalex-snapshot
Advent of Imidazo[1,2-a]pyridine-3-carboxamides with Potent Multi- and Extended Drug Resistant Antituberculosis Activity
inferredcites →https://doi.org/10.1021/np034072qopenalex-snapshot
Sesquiterpene Lactones from Montanoa hibiscifolia That Inhibit the Transcription Factor NF-κB
inferredcites →https://doi.org/10.1021/np070290yopenalex-snapshot
NF-κB-Inhibiting Naphthopyrones from the Fijian EchinodermComanthus parvicirrus
inferredcites →https://doi.org/10.1021/np800350xopenalex-snapshot
Inhibitors of the NF-κB Activation Pathway from Cryptocarya rugulosa
inferredcites →https://doi.org/10.1021/ol101588jopenalex-snapshot
Enantioselective Modular Synthesis of Cyclohexenones: Total Syntheses of (+)-Crypto- and (+)-Infectocaryone
inferredcites →https://doi.org/10.1021/ol901642wopenalex-snapshot
Palladium-Catalyzed Reactions of Cyclohexadienones: Regioselective Cyclizations Triggered by Alkyne Acetoxylation
inferredcites →https://doi.org/10.1038/nature04870openalex-snapshot
Nuclear factor-κB in cancer development and progression
inferredcites →https://doi.org/10.1038/nature10167openalex-snapshot
Selective killing of cancer cells by a small molecule targeting the stress response to ROS
inferredcites →https://doi.org/10.1038/ni.2055openalex-snapshot
Return to homeostasis: downregulation of NF-κB responses
inferredcites →https://doi.org/10.1038/nrd1279openalex-snapshot
The IKK NF-κB system: a treasure trove for drug development
inferredcites →https://doi.org/10.1038/nrd3410openalex-snapshot
The resurgence of covalent drugs
inferredcites →https://doi.org/10.1038/nri1703openalex-snapshot
NF-κB: linking inflammation and immunity to cancer development and progression
inferredcites →https://doi.org/10.1038/onc.2010.566openalex-snapshot
NF-κB addiction and its role in cancer: ‘one size does not fit all’
inferredcites →https://doi.org/10.1038/sj.onc.1203160openalex-snapshot
Constitutive activation of IκB kinase α and NF-κB in prostate cancer cells is inhibited by ibuprofen
inferredcites →https://doi.org/10.1093/carcin/18.6.1215openalex-snapshot
Androgen responsive adult human prostatic epithelial cell lines immortalized by human papillomavirus 18
inferredcites →https://doi.org/10.1128/mcb.13.10.6137-6146.1993openalex-snapshot
NF-κB Subunit-Specific Regulation of the Interleukin-8 Promoter
inferredcites →https://doi.org/10.1211/0022357021778637openalex-snapshot
Natural products as targeted modulators of the nuclear factor-κB pathway
inferredcites →https://doi.org/10.2174/138945011798109437openalex-snapshot
Perspectives on Sesquiterpene Lactones in Inflammation and Cancer
inferredcites →https://doi.org/10.2174/138955706777934937openalex-snapshot
Naturally Occurring NF-κB Inhibitors

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Diverse metabolites with anti-psoriasis potential from different fermentations of the fungicolous fungus Xylaria longipes HFG1018
inferred← citeshttps://doi.org/10.1002/ange.201300137openalex-snapshot
Rhodium‐Catalyzed Asymmetric Arylative Cyclization of meso‐1,6‐Dienynes Leading to Enantioenriched cis‐Hydrobenzofurans
inferred← citeshttps://doi.org/10.1002/ange.201307426openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/ange.201311172openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/ange.201407061openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/ange.201508022openalex-snapshot
Phosphine‐Catalyzed β,γ‐Umpolung Domino Reaction of Allenic Esters: Facile Synthesis of Tetrahydrobenzofuranones Bearing a Chiral Tetrasubstituted Stereogenic Carbon Center
inferred← citeshttps://doi.org/10.1002/ange.201802125openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/anie.201300137openalex-snapshot
Rhodium‐Catalyzed Asymmetric Arylative Cyclization of meso‐1,6‐Dienynes Leading to Enantioenriched cis‐Hydrobenzofurans
inferred← citeshttps://doi.org/10.1002/anie.201307426openalex-snapshot
Divergent Total Synthesis of Indoxamycins A, C, and F
inferred← citeshttps://doi.org/10.1002/anie.201311172openalex-snapshot
Palladium Enolate Umpolung: Cyclative Diacetoxylation of Alkynyl Cyclohexadienones Promoted by a Pd/SPRIX Catalyst
inferred← citeshttps://doi.org/10.1002/anie.201407061openalex-snapshot
Recognition of Nucleic Acid Junctions Using Triptycene‐Based Molecules
inferred← citeshttps://doi.org/10.1002/anie.201508022openalex-snapshot
Phosphine‐Catalyzed β,γ‐Umpolung Domino Reaction of Allenic Esters: Facile Synthesis of Tetrahydrobenzofuranones Bearing a Chiral Tetrasubstituted Stereogenic Carbon Center
inferred← citeshttps://doi.org/10.1002/anie.201802125openalex-snapshot
Bio‐inspired Domino oxa‐Michael/Diels–Alder/oxa‐Michael Dimerization of para‐Quinols
inferred← citeshttps://doi.org/10.1002/cjoc.70436openalex-snapshot
6‐Methoxypyridine‐Benzoxazole Ligand‐Directed Palladium‐Catalyzed Hydroacetoxylative Cyclization of Alkyne‐Tethered Cyclohexadienones
inferred← citeshttps://doi.org/10.1002/cmdc.201700752openalex-snapshot
Helenalin Analogues Targeting NF‐κB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles
inferred← citeshttps://doi.org/10.1016/j.apsb.2013.02.006openalex-snapshot
Cancer stem cells: therapeutic implications and perspectives in cancer therapy
inferred← citeshttps://doi.org/10.1016/j.bmc.2015.05.037openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bmcl.2013.10.003openalex-snapshot
Drug discovery considerations in the development of covalent inhibitors
inferred← citeshttps://doi.org/10.1016/j.sdentj.2019.05.010openalex-snapshot
Head and neck cancer management and cancer stem cells implication
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c01464openalex-snapshot
Synthesis of Guaianolide Analogues with a Tunable α-Methylene−γ-lactam Electrophile and Correlating Bioactivity with Thiol Reactivity
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c01481openalex-snapshot
A Chemical Strategy for Intracellular Arming of an Endogenous Broad-Spectrum Antiviral Nucleotide
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b00788openalex-snapshot
Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b01248openalex-snapshot
Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase–Bromodomain Inhibitor
inferred← citeshttps://doi.org/10.1021/acs.joc.1c00290openalex-snapshot
Lewis Acid-Driven Meyer–Schuster-Type Rearrangement of Yne-Dienone
inferred← citeshttps://doi.org/10.1021/acs.joc.2c02320openalex-snapshot
Sequential Cu(II)-Catalyzed Multicomponent C–N Coupling, Nucleophilic Addition, and Cyclization Cascade: A Diastereoselective Approach to Carboxamide-Embedded Hexahydrobenzofuran Core
inferred← citeshttps://doi.org/10.1021/acs.joc.7b00936openalex-snapshot
Tunable Diastereoselective Desymmetrization of Cyclohexadienones Triggered by Copper-Catalyzed Three-Component Coupling Reaction
inferred← citeshttps://doi.org/10.1021/acs.joc.9b01445openalex-snapshot
Thioarylative Radical Cyclization of Yne-Dienone
inferred← citeshttps://doi.org/10.1021/acs.joc.9b01660openalex-snapshot
Metal Free Domino β-Azidation/[3 + 2] Cycloaddition Reaction for the Synthesis of 1,2,3-Triazole-Fused Dihydrobenzoxazinones
inferred← citeshttps://doi.org/10.1021/acs.orglett.3c00305openalex-snapshot
Cp*Co(III)-Catalyzed C(8)-Nucleophilic Cascade Cyclization of Quinoline N-Oxide with 1,6-Enyne
inferred← citeshttps://doi.org/10.1021/acs.orglett.7b03175openalex-snapshot
Phosphine-Catalyzed [4 + 2] Annulation of Allenoate with Sulfamate-Derived Cyclic Imines: A Reaction Mode Involving γ′-Carbon of α-Substituted Allenoate
inferred← citeshttps://doi.org/10.1021/acs.orglett.8b00479openalex-snapshot
A Flexible and Divergent Strategy to Flavonoids with a Chiral A-Ring Featuring Intramolecular Michael Addition: Stereoselective Synthesis of (+)-Cryptocaryone, (+)-Cryptogione F, and (+)-Cryptocaryanones A and B, as Well as (+)-Cryptochinones A and C
inferred← citeshttps://doi.org/10.1021/acs.orglett.9b04191openalex-snapshot
Rh(III)-Catalyzed Coupling of Acrylic Acids and Ynenones via Olefinic C–H Activation and Michael Addition
inferred← citeshttps://doi.org/10.1021/acscatal.3c01163openalex-snapshot
Design and Synthesis of Planar-Chiral Oxazole–Pyridine N , N -Ligands: Application in Palladium-Catalyzed Asymmetric Acetoxylative Cyclization
inferred← citeshttps://doi.org/10.1021/acscatal.7b04054openalex-snapshot
Rhodium-Catalyzed Highly Regio- and Enantioselective Reductive Cyclization of Alkyne-Tethered Cyclohexadienones
inferred← citeshttps://doi.org/10.1021/acschembio.6b00130openalex-snapshot
Catch and Release DNA Decoys: Capture and Photochemical Dissociation of NF-κB Transcription Factors
inferred← citeshttps://doi.org/10.1021/acschembio.6b00751openalex-snapshot
Targeting NF-κB p65 with a Helenalin Inspired Bis-electrophile
inferred← citeshttps://doi.org/10.1021/acsomega.8b01787openalex-snapshot
New Strategy To Access Enantioenriched Cyclohexadienones: Kinetic Resolution of para -Quinols by Organocatalytic Thiol-Michael Addition Reactions
inferred← citeshttps://doi.org/10.1021/ja404593copenalex-snapshot
Cu-Catalyzed Asymmetric Borylative Cyclization of Cyclohexadienone-Containing 1,6-Enynes
inferred← citeshttps://doi.org/10.1021/jacs.6b00882openalex-snapshot
Intermolecular Homopropargyl Alcohol Addition to Alkyne and a Sequential 1,6-Enyne Cycloisomerization with Triazole-Gold Catalyst
inferred← citeshttps://doi.org/10.1021/ol400904yopenalex-snapshot
A Redox Economical Synthesis of Bioactive 6,12-Guaianolides
inferred← citeshttps://doi.org/10.1038/s41598-018-20192-9openalex-snapshot
Diversity Modification and Structure-Activity Relationships of Two Natural Products 1β-hydroxy Alantolactone and Ivangustin as Potent Cytotoxic Agents
inferred← citeshttps://doi.org/10.1038/s42004-024-01279-zopenalex-snapshot
Development of ketalized unsaturated saccharides as multifunctional cysteine-targeting covalent warheads
inferred← citeshttps://doi.org/10.1039/c2md20172kopenalex-snapshot
Amino-derivatives of the sesquiterpene lactone class of natural products as prodrugs
inferred← citeshttps://doi.org/10.1039/c3ob27491hopenalex-snapshot
Ligand and substrate effects during Pd-catalyzed cyclizations of alkyne-tethered cyclohexadienones
inferred← citeshttps://doi.org/10.1039/c5qo00334bopenalex-snapshot
Mechanism, chemoselectivity and enantioselectivity for the rhodium-catalyzed desymmetric synthesis of hydrobenzofurans: a theoretical study
inferred← citeshttps://doi.org/10.1039/c9cc05692kopenalex-snapshot
Ultrasensitive detection of transcription factors with a highly-efficient diaminoterephthalate fluorophore via an electrogenerated chemiluminescence strategy
inferred← citeshttps://doi.org/10.1039/d0cc00102copenalex-snapshot
Mn-catalyzed radical initiated domino transformation of alkynylated cyclohexadienones with TMSN 3 and O 2 to bicyclic azido alcohols
inferred← citeshttps://doi.org/10.1039/d0ob01550dopenalex-snapshot
Stereocontrolled transformations of cyclohexadienone derivatives to access stereochemically rich and natural product-inspired architectures
inferred← citeshttps://doi.org/10.1039/d1cc03071jopenalex-snapshot
Electrochemiluminescence platform for transcription factor diagnosis by using CRISPR–Cas12a trans -cleavage activity
inferred← citeshttps://doi.org/10.1039/d2qo00682kopenalex-snapshot
Mechanism and origin of regioselectivity in Rh-catalyzed desymmetric [2 + 2 + 2] cycloaddition: charge versus π–π stacking interaction
inferred← citeshttps://doi.org/10.1039/d4qo00105bopenalex-snapshot
Ru( ii )-catalyzed cascade cis carbohalogenation and cyclization of alkyne-tethered cyclohexadienones for synthesizing tetrasubstituted alkenes
inferred← citeshttps://doi.org/10.1039/d5ob00220fopenalex-snapshot
Rhodium( iii )-catalyzed asymmetric allylic cyclization of cyclohexadienone-tethered allenes
inferred← citeshttps://doi.org/10.1248/cpb.c23-00811openalex-snapshot
Antiproliferative Activities of Cynaropicrin and Related Compounds against Cancer Stem Cells
inferred← citeshttps://doi.org/10.2174/1385272824999201210193141openalex-snapshot
Synthetic Approaches for Building Tricyclic Cage-like Motifs Found in Indoxamycins
inferred← citeshttps://doi.org/10.3389/or.2024.1411736openalex-snapshot
Extracellular vesicles and cancer stem cells: a deadly duo in tumor progression
inferred← citeshttps://doi.org/10.3390/molecules28010365openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/molecules29174104openalex-snapshot
Diterpenoids with Potent Anti-Psoriasis Activity from Euphorbia helioscopia L.
inferred← citeshttps://doi.org/10.3923/ajava.2015.509.517openalex-snapshot
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inferred← citeshttps://doi.org/10.6023/cjoc202105029openalex-snapshot
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