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Mapping Microclimate pH Distribution inside Protein-Encapsulated PLGA Microspheres Using Confocal Laser Scanning Microscopy

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jps.10524openalex-snapshot
Determination of water‐soluble acid distribution in poly(lactide‐co‐glycolide)
inferredcites →https://doi.org/10.1007/bf00700871openalex-snapshot
Structure-property relationships in the case of the degradation of massive aliphatic poly-(?-hydroxy acids) in aqueous media
inferredcites →https://doi.org/10.1007/s11095-008-9594-3openalex-snapshot
Acidic Microclimate pH Distribution in PLGA Microspheres Monitored by Confocal Laser Scanning Microscopy
inferredcites →https://doi.org/10.1016/0168-3659(90)90018-oopenalex-snapshot
Biodegradable polymer systems for the sustained release of polypeptides
inferredcites →https://doi.org/10.1016/j.addr.2004.09.003openalex-snapshot
Biodegradable poly(lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens
inferredcites →https://doi.org/10.1016/j.ijpharm.2008.02.004openalex-snapshot
Stability of proteins encapsulated in injectable and biodegradable poly(lactide-co-glycolide)-glucose millicylinders
inferredcites →https://doi.org/10.1016/j.jconrel.2004.07.029openalex-snapshot
Mapping neutral microclimate pH in PLGA microspheres
inferredcites →https://doi.org/10.1016/s0065-3233(08)60065-0openalex-snapshot
Serum Albumin
inferredcites →https://doi.org/10.1016/s0142-9612(00)00178-2openalex-snapshot
Morphology, drug distribution, and in vitro release profiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method
inferredcites →https://doi.org/10.1016/s0142-9612(01)00101-6openalex-snapshot
Comparison of the effects of Mg(OH)2 and sucrose on the stability of bovine serum albumin encapsulated in injectable poly(d,l-lactide-co-glycolide) implants
inferredcites →https://doi.org/10.1016/s0168-3659(00)00227-3openalex-snapshot
Lysozyme distribution and conformation in a biodegradable polymer matrix as determined by FTIR techniques
inferredcites →https://doi.org/10.1016/s0169-409x(97)00050-1openalex-snapshot
One- and three-month release injectable microspheres of the LH-RH superagonist leuprorelin acetate
inferredcites →https://doi.org/10.1021/ja055287kopenalex-snapshot
Prediction of Microclimate pH in Poly(lactic-co-glycolic Acid) Films
inferredcites →https://doi.org/10.1021/ma021036+openalex-snapshot
Determination of Diffusion Coefficient of a Small Hydrophobic Probe in Poly(lactide-co-glycolide) Microparticles by Laser Scanning Confocal Microscopy
inferredcites →https://doi.org/10.1021/ma0481959openalex-snapshot
Potentiometric Method for Determination of Microclimate pH in Poly(lactic-co-glycolic acid) Films
inferredcites →https://doi.org/10.1021/mp800027fopenalex-snapshot
Stabilization of Tetanus Toxoid Encapsulated in PLGA Microspheres
inferredcites →https://doi.org/10.1023/a:1007513425337openalex-snapshot
Stabilization of Proteins Encapsulated in Cylindrical Poly(lactide-co-glycolide) Implants: Mechanism of Stabilization by Basic Additives
inferredcites →https://doi.org/10.1023/a:1007582911958openalex-snapshot
Visual Evidence of Acidic Environment Within Degrading Poly(lactic-co-glycolic acid) (PLGA) Microspheres
inferredcites →https://doi.org/10.1023/a:1015841715384openalex-snapshot
Controlled Delivery Systems for Proteins Based on Poly(Lactic/Glycolic Acid) Microspheres
inferredcites →https://doi.org/10.1023/a:1018822002353openalex-snapshot
pH and Osmotic Pressure Inside Biodegradable Microspheres During Erosion1
inferredcites →https://doi.org/10.1023/a:1018876308346openalex-snapshot
The Acidic Microclimate in Poly(lactide-co-glycolide) Microspheres Stabilizes Camptothecins
inferredcites →https://doi.org/10.1023/a:1026498209874openalex-snapshot
Protein Instability in Poly(Lactic-co-Glycolic Acid) Microparticles
inferredcites →https://doi.org/10.1038/71875openalex-snapshot
Protein stability in controlled-release systems
inferredcites →https://doi.org/10.1038/71916openalex-snapshot
Stabilization of proteins encapsulated in injectable poly (lactide- co-glycolide)
inferredcites →https://doi.org/10.1038/nbt0298-153openalex-snapshot
Improving protein therapeutics with sustained-release formulations
inferredcites →https://doi.org/10.1615/critrevtherdrugcarriersyst.v19.i1.20openalex-snapshot
Recent Advances in the Stabilization of Proteins Encapsulated in Injectable PLGA Delivery Systems

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1002/app.45464openalex-snapshot
Heterogeneous hydrolytic degradation of poly(lactic‐co‐glycolic acid) microspheres: Mathematical modeling
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Basic Salt Additives Modulate the Acidic Microenvironment Around In Situ Forming Implants
inferred← citeshttps://doi.org/10.1007/s11095-013-0975-xopenalex-snapshot
Rapid Vaccination Using an Acetalated Dextran Microparticulate Subunit Vaccine Confers Protection Against Triplicate Challenge by Bacillus Anthracis
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Comparative Studies on the Influences of Primary Emulsion Preparation on Properties of Uniform-Sized Exenatide-Loaded PLGA Microspheres
inferred← citeshttps://doi.org/10.1007/s11095-015-1622-5openalex-snapshot
Microcosmic Mechanism of Dication for Inhibiting Acylation of Acidic Peptide
inferred← citeshttps://doi.org/10.1007/s11095-019-2640-5openalex-snapshot
Proton Oriented-“Smart Depot” for Responsive Release of Ca2+ to Inhibit Peptide Acylation in PLGA Microspheres
inferred← citeshttps://doi.org/10.1007/s11095-024-03682-6openalex-snapshot
Peptide Acylation in Aliphatic Polyesters: a Review of Mechanisms and Inhibition Strategies
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Quality by design prospects of pharmaceuticals application of double emulsion method for PLGA loaded nanoparticles
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Characterization methodologies for long-acting and implantable drug delivery systems
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Degradation, intra-articular retention and biocompatibility of monospheres composed of [PDLLA-PEG-PDLLA]-b-PLLA multi-block copolymers
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Monomer sequence in PLGA microparticles: Effects on acidic microclimates and in vivo inflammatory response
inferred← citeshttps://doi.org/10.1016/j.addr.2023.114857openalex-snapshot
Long-acting PLGA microspheres: Advances in excipient and product analysis toward improved product understanding
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Biologics-device combinations: Enabling prolonged therapies in the posterior segment ocular disease
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Novel synthesized microporous ionic polymer applications in transesterification of Jatropha curcas seed oil with short Chain alcohol
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Injectable microsphere-based delivery strategies for stem cells and their derivatives in tissue regeneration
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One-step fabrication of agent-loaded biodegradable microspheroids for drug delivery and imaging applications
inferred← citeshttps://doi.org/10.1016/j.ejpb.2012.11.006openalex-snapshot
Optimization of encapsulation of a synthetic long peptide in PLGA nanoparticles: Low-burst release is crucial for efficient CD8+ T cell activation
inferred← citeshttps://doi.org/10.1016/j.ejpb.2016.11.008openalex-snapshot
Mechanistic analysis of triamcinolone acetonide release from PLGA microspheres as a function of varying in vitro release conditions
inferred← citeshttps://doi.org/10.1016/j.ejpb.2020.10.008openalex-snapshot
Characterization of attributes and in vitro performance of exenatide-loaded PLGA long-acting release microspheres
inferred← citeshttps://doi.org/10.1016/j.ejpb.2022.07.011openalex-snapshot
Hydroxypropyl methyl cellulose derivatives stabilize fragment antibody against aggregation in spray dried formulations at elevated temperature and resist pH changes
inferred← citeshttps://doi.org/10.1016/j.ejps.2019.04.017openalex-snapshot
Effect of inner pH on peptide acylation within PLGA microspheres
inferred← citeshttps://doi.org/10.1016/j.eurpolymj.2025.114309openalex-snapshot
Highly statistical PLGAs based on L-methylglycolide: the impact of copolymer microstructure on hydrolytic degradation monitored by pH fluorescent sensor
inferred← citeshttps://doi.org/10.1016/j.foodchem.2021.131427openalex-snapshot
Co-encapsulation of (–)-epigallocatechin-3-gallate and quercetin in double emulsion hydrogel beads: Microstructures, functional properties, and digestion behaviors
inferred← citeshttps://doi.org/10.1016/j.foodhyd.2016.11.018openalex-snapshot
Confocal fluorescence mapping of pH profile inside hydrogel beads (microgels) with controllable internal pH values
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2018.01.026openalex-snapshot
Improving release completeness from PLGA-based implants for the acid-labile model protein ovalbumin
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The mechanism behind the biphasic pulsatile drug release from physically mixed poly(dl-lactic(-co-glycolic) acid)-based compacts
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Health care-associated infections: Controlled delivery of cationic antiseptics from polymeric excipients
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Novel double-layered PLGA microparticles-dissolving microneedle (MPs-DMN) system for peptide drugs sustained release by transdermal delivery
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Optimization of aqueous remote loading of leuprolide in poly(lactic-co-glycolic acid) microspheres
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Formation and degradation process of in situ forming implants – Attributes and impact on performance
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Polymeric systems for peptide and protein delivery: design principles, translational barriers, and future research directions
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Non-invasive in vivo characterization of microclimate pH inside in situ forming PLGA implants using multispectral fluorescence imaging
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Injectable controlled release depots for large molecules
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Characterizing release mechanisms of leuprolide acetate-loaded PLGA microspheres for IVIVC development I: In vitro evaluation
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Mechanisms of in vivo release of triamcinolone acetonide from PLGA microspheres
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Imaging the porous structure in the core of degrading PLGA microparticles: The effect of molecular weight
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Controlling and quantifying the stability of amino acid-based cargo within polymeric delivery systems
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Mapping in vivo microclimate pH distribution in exenatide-encapsulated PLGA microspheres
inferred← citeshttps://doi.org/10.1016/j.jddst.2018.03.024openalex-snapshot
Effect of size on the in vitro / in vivo drug release and degradation of exenatide-loaded PLGA microspheres
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Drug Release Profile Study of Gentamicin Encapsulated Poly(lactic Acid) Microspheres for Drug Delivery
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Homogeneous hydrolytic degradation of poly(lactic-co-glycolic acid) microspheres: Mathematical modeling
inferred← citeshttps://doi.org/10.1016/j.xphs.2026.104167openalex-snapshot
Long-acting delivery of a model monoclonal antibody from ethylene vinyl acetate implants at a high loading: Drug release and protein stability
inferred← citeshttps://doi.org/10.1021/acs.iecr.1c01013openalex-snapshot
Modeling the Microenvironment-Dependent Degradation of Drug-Loaded Polylactic-co-glycolic Microparticles
inferred← citeshttps://doi.org/10.1021/acs.jafc.6b04644openalex-snapshot
Encapsulation of Pancreatic Lipase in Hydrogel Beads with Self-Regulating Internal pH Microenvironments: Retention of Lipase Activity after Exposure to Gastric Conditions
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Physical–Chemical Characterization of Octreotide Encapsulated in Commercial Glucose-Star PLGA Microspheres
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Patient-Centric Long-Acting Injectable and Implantable Platforms─An Industrial Perspective
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Effect of Particle Size on Drug Loading and Release Kinetics of Gefitinib-Loaded PLGA Microspheres
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Long-Acting Release Microspheres Containing Novel GLP-1 Analog as an Antidiabetic System
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Degradation, Intra-Articular Biocompatibility, Drug Release, and Bioactivity of Tacrolimus-Loaded Poly( d - l -lactide-PEG)-b-poly( l -lactide) Multiblock Copolymer-Based Monospheres
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Mechanistic Studies on the Degradation and Protein Release Characteristics of Poly(lactic- co -glycolic- co -hydroxymethylglycolic acid) Nanospheres
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Efficient Delivery of the Toll-like Receptor Agonists Polyinosinic:Polycytidylic Acid and CpG to Macrophages by Acetalated Dextran Microparticles
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Positive charge of “sticky” peptides and proteins impedes release from negatively charged PLGA matrices
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Injectable leonurine nanocrystal-loaded microspheres for long-term hyperlipidemia management
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Local Delivery of Neurotrophin-3 and Anti-NogoA Promotes Repair After Spinal Cord Injury
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Encapsulation-free controlled release: Electrostatic adsorption eliminates the need for protein encapsulation in PLGA nanoparticles
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Influence of Hydrophobic Ion Pairing on Formulation Performance of Liraglutide in PLGA Microspheres
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Characterization of nanostructured ureteral stent with gradient degradation in a porcine model
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Single-injection prime-boost vaccines based on biodegradable polymers
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Development of a Stable Respiratory Syncytial Virus Pre-Fusion Protein Powder Suitable for a Core-Shell Implant with a Delayed Release in Mice: A Proof of Concept Study
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Engineering Microenvironment of Biodegradable Polyester Systems for Drug Stability and Release Control
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Controlled Release of Strontium through Neutralization Reaction within a Methoxy(Polyethylene Glycol)-Polyesterc hydrogel
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