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Hydroxypropyl Methylcellulose Acetate Succinate-Based Spray-Dried Dispersions: An Overview

https://doi.org/10.1021/mp8000793
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Physical and biological considerations for the use of nonaqueous solvents in oral bioavailability enhancement
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Role of Thermodynamic, Molecular, and Kinetic Factors in Crystallization from the Amorphous State
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Solubilizing Vehicles for Oral Formulation Development
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The Vitreous State
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The Glass Transition
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Polymer alloys and blends: Thermodynamics and rheology
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Salt formation to improve drug solubility
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Cyclodextrins as pharmaceutical solubilizers
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Lipid-based systems for the enhanced delivery of poorly water soluble drugs
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Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs
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Current strategies for engineering drug nanoparticles
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Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs
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Co-solubilization of poorly soluble drugs by micellization and complexation
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Use of a screening method to determine excipients which optimize the extent and stability of supersaturated drug solutions and application of this system to solid formulation design
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The utility of cyclodextrins for enhancing oral bioavailability
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Crystal nucleation and growth in glass-forming melts: Experiment and theory
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Places of emulsions in drug delivery
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
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X-Ray powder diffraction determination of the relative amount of crystalline acetaminophen in solid dispersions with polyvinylpyrrolidone
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Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and ‘self-microemulsifying’ drug delivery systems
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Improving drug solubility for oral delivery using solid dispersions
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Drug-like properties and the causes of poor solubility and poor permeability
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Application of formulation technologies in lead candidate selection and optimization
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The Nature of the Glassy State and the Behavior of Liquids at Low Temperatures.
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Evaluation of a Targeted Prodrug Strategy to Enhance Oral Absorption of Poorly Water-Soluble Compounds
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Nanosuspensions in drug delivery
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Drugs as materials: valuing physical form in drug discovery
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Cyclodextrin-based pharmaceutics: past, present and future
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Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs
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Prodrugs: design and clinical applications
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Thermodynamic and kinetic properties of glasses
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Improving the Dissolution Rate of Poorly Water Soluble Drug by Solid Dispersion and Solid Solution—Pros and Cons
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Overcoming Roadblocks in Lead Optimization: A Thermodynamic Perspective
inferredcites →https://doi.org/10.1142/9781860949074_0026openalex-snapshot
Polymeric Nanoparticles for Delivery in the Gastro-Intestinal Tract
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Drug Nanoparticles: Formulating Poorly Water-Soluble Compounds
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Development of supersaturatable self-emulsifying drug delivery system formulations for improving the oral absorption of poorly soluble drugs
inferredcites →https://doi.org/10.1517/17425247.4.4.403openalex-snapshot
Drug delivery strategies for poorly water-soluble drugs
inferredcites →https://doi.org/10.1615/critrevtherdrugcarriersyst.v20.i23.40openalex-snapshot
Solid Dispersions: Revival with Greater Possibilities and Applications in Oral Drug Delivery
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Application of Nanoparticles in Oral Delivery of Immediate Release Formulations

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Overview of Drug Product Development
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Molecular Dynamics Simulations of Amorphous Systems
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SPRAY DRYING AND AMORPHOUS DISPERSIONS
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ACHIEVING A HOT MELT EXTRUSION DESIGN SPACE FOR THE PRODUCTION OF SOLID SOLUTIONS
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Oral Site‐Directed Drug Delivery and Influence on PK
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Dielectric Study of Equimolar Acetaminophen–Aspirin, Acetaminophen–Quinidine, and Benzoic Acid–Progesterone Molecular Alloys in the Glass and Ultraviscous States and Their Relevance to Solubility and Stability
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Molecular Dynamics Simulation of Amorphous Indomethacin-Poly(Vinylpyrrolidone) Glasses: Solubility and Hydrogen Bonding Interactions
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Development of Polyvinylpyrrolidone-Based Spray-Dried Solid Dispersions Using Response Surface Model and Ensemble Artificial Neural Network
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Engineered Multifunctional Albumin‐Decorated Porous Silicon Nanoparticles for FcRn Translocation of Insulin
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Optimizing the Formulation of Poorly Water-Soluble Drugs
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Solubilized Formulations
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Structured Development Approach for Amorphous Systems
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Melt Extrusion
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Formulation Development of Amorphous Solid Dispersions Prepared by Melt Extrusion
inferred← citeshttps://doi.org/10.1007/978-1-4614-8432-5_8openalex-snapshot
Nonsink In Vitro Dissolution Testing of Amorphous Solid Dispersions
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Performance and Characterization of Amorphous Solid Dispersions: An Overview
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Practical Considerations for Spray Dried Formulation and Process Development
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Discovery Formulations: Approaches and Practices in Early Preclinical Development
inferred← citeshttps://doi.org/10.1007/978-1-4939-1399-2_3openalex-snapshot
Enabling Discovery Through Leveraging and Miniaturizing Pharmaceutical Principles and Processes
inferred← citeshttps://doi.org/10.1007/978-1-4939-1399-2_4openalex-snapshot
Diagnosing Biopharmaceutical Limitations
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MBP Technology: Process Development and Scale-Up
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Dissolution of Amorphous Solid Dispersions: Theory and Practice
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KinetiSol®-Based Amorphous Solid Dispersions
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Overview of Amorphous Solid Dispersion Technologies
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Excipients for Amorphous Solid Dispersions
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Miniaturized Screening Tools for Polymer and Process Evaluation
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Design and Development of HPMCAS-Based Spray-Dried Dispersions
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Multiparticulate Technologies for Fixed-Dose Combinations
inferred← citeshttps://doi.org/10.1007/978-3-030-88719-3_10openalex-snapshot
Spray-Drying Technology
inferred← citeshttps://doi.org/10.1007/978-3-030-88719-3_2openalex-snapshot
Optimizing the Formulation of Poorly Water-Soluble Drugs
inferred← citeshttps://doi.org/10.1007/978-3-030-88719-3_5openalex-snapshot
Cosolvent and Complexation Systems
inferred← citeshttps://doi.org/10.1007/978-3-030-88719-3_8openalex-snapshot
Structured Development Approach for Amorphous Systems
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Melt Extrusion
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Applications of Spray-Dried Vaccines
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Preformulation in Drug Product Design
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Downstream Processing of Amorphous Solid Dispersions of Drugs
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Excipients That Facilitate Amorphous Drug Stabilization
inferred← citeshttps://doi.org/10.1007/978-3-319-29454-4_10openalex-snapshot
Application of Maleic Anhydride-Based Materials
inferred← citeshttps://doi.org/10.1007/978-3-319-42609-9_10openalex-snapshot
Spray-Drying Technology
inferred← citeshttps://doi.org/10.1007/978-3-319-42609-9_2openalex-snapshot
Optimizing the Formulation of Poorly Water-Soluble Drugs
inferred← citeshttps://doi.org/10.1007/978-3-319-42609-9_5openalex-snapshot
Co-solvent and Complexation Systems
inferred← citeshttps://doi.org/10.1007/978-3-319-42609-9_8openalex-snapshot
Structured Development Approach for Amorphous Systems
inferred← citeshttps://doi.org/10.1007/978-3-319-42609-9_9openalex-snapshot
Melt Extrusion
inferred← citeshttps://doi.org/10.1007/978-3-319-50042-3_7openalex-snapshot
Developability Assessment of Clinical Candidates
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inferred← citeshttps://doi.org/10.1007/s00289-026-06309-5openalex-snapshot
Role of polymeric carriers in amorphous solid dispersions: comprehensive review of stabilization mechanisms, dissolution behavior, and FDA-approved formulations
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Direct synthesis of cellulose adipate derivatives using adipic anhydride
inferred← citeshttps://doi.org/10.1007/s10570-013-9889-3openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s10570-013-9970-yopenalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11095-011-0465-yopenalex-snapshot
Design of Dry Nanosuspension with Highly Spontaneous Dispersible Characteristics to Develop Solubilized Formulation for Poorly Water-Soluble Drugs
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inferred← citeshttps://doi.org/10.1007/s11095-011-0505-7openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11095-012-0695-7openalex-snapshot
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Formulating Weakly Basic HCl Salts: Relative Ability of Common Excipients to Induce Disproportionation and the Unique Deleterious Effects of Magnesium Stearate
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inferred← citeshttps://doi.org/10.1007/s11095-015-1725-zopenalex-snapshot
Using Environment-Sensitive Fluorescent Probes to Characterize Liquid-Liquid Phase Separation in Supersaturated Solutions of Poorly Water Soluble Compounds
inferred← citeshttps://doi.org/10.1007/s11095-015-1771-6openalex-snapshot
Novel Gefitinib Formulation with Improved Oral Bioavailability in Treatment of A431 Skin Carcinoma
inferred← citeshttps://doi.org/10.1007/s11095-016-1969-2openalex-snapshot
Initial Drug Dissolution from Amorphous Solid Dispersions Controlled by Polymer Dissolution and Drug-Polymer Interaction
inferred← citeshttps://doi.org/10.1007/s11095-017-2296-yopenalex-snapshot
Impact of Drug-Polymer Miscibility on Enthalpy Relaxation of Irbesartan Amorphous Solid Dispersions
inferred← citeshttps://doi.org/10.1007/s11095-018-2345-1openalex-snapshot
Surface Enrichment and Depletion of the Active Ingredient in Spray Dried Amorphous Solid Dispersions
inferred← citeshttps://doi.org/10.1007/s11095-019-2632-5openalex-snapshot
A Single Hydrogen to Fluorine Substitution Reverses the Trend of Surface Composition Enrichment of Sorafenib Amorphous Solid Dispersion upon Moisture Exposure
inferred← citeshttps://doi.org/10.1007/s11095-020-02890-0openalex-snapshot
Solvent-Assisted Secondary Drying of Spray-Dried Polymers
inferred← citeshttps://doi.org/10.1007/s11095-020-02909-6openalex-snapshot
Characterization of Grades of HPMCAS Spray Dried Dispersions of Itraconazole Based on Supersaturation Kinetics and Molecular Interactions Impacting Formulation Performance
inferred← citeshttps://doi.org/10.1007/s11095-021-03040-wopenalex-snapshot
Solvent-Casted Films to Assist Polymer Selection for Amorphous Solid Dispersions During Preclinical Studies: In-vitro and In-vivo Exploration
inferred← citeshttps://doi.org/10.1007/s11095-021-03147-0openalex-snapshot
pH-Dependent supersaturation from amorphous solid dispersions of weakly basic drugs
inferred← citeshttps://doi.org/10.1007/s11095-022-03370-3openalex-snapshot
Predicting Spray Dried Dispersion Particle Size Via Machine Learning Regression Methods
inferred← citeshttps://doi.org/10.1007/s11095-022-03416-6openalex-snapshot
Densifying Co-Precipitated Amorphous Dispersions to Achieve Improved Bulk Powder Properties
inferred← citeshttps://doi.org/10.1007/s11095-025-03837-zopenalex-snapshot
In Vitro-In Vivo Correlation Of Amorphous Solid Dispersion Enabled Itraconazole Tablets
inferred← citeshttps://doi.org/10.1007/s11095-026-04137-wopenalex-snapshot
Colloidal Stability of Amorphous Nanoparticles in Solution: Impact of Stabilizer
inferred← citeshttps://doi.org/10.1007/s11814-014-0192-2openalex-snapshot
Process optimization and characterization of carvedilol solid dispersion with hydroxypropyl-β-cyclodextrin and tartaric acid
inferred← citeshttps://doi.org/10.1007/s11814-022-1280-3openalex-snapshot
Amorphous solid dispersions of tegoprazan and three different polymers: In vitro/in vivo evaluation of physicochemical properties
inferred← citeshttps://doi.org/10.1007/s12247-009-9064-4openalex-snapshot
A Model-Based Methodology for Spray-Drying Process Development
inferred← citeshttps://doi.org/10.1007/s12272-011-1111-2openalex-snapshot
Preparation and characterization of emulsified solid dispersions containing docetaxel
inferred← citeshttps://doi.org/10.1007/s13346-018-0494-8openalex-snapshot
Sustained-release amorphous solid dispersions
inferred← citeshttps://doi.org/10.1007/s13346-025-02018-0openalex-snapshot
Novel crystalline solid dispersions to improve the oral bioavailability and anti-liver cancer effect of Sorafenib
inferred← citeshttps://doi.org/10.1007/s13346-026-02134-5openalex-snapshot
Tabletting of single-screw hot melt extruded itraconazole: HPMC-AS amorphous solid dispersion by 3D printing and direct compression
inferred← citeshttps://doi.org/10.1007/s13346-026-02218-2openalex-snapshot
Spray drying-assisted development of hydroxypropyl methylcellulose acetate succinate microparticles for andrographolide delivery: an in-vivo study in experimental ulcerative colitis
inferred← citeshttps://doi.org/10.1007/s40005-017-0361-5openalex-snapshot
Characterization of amorphous solid dispersions
inferred← citeshttps://doi.org/10.1007/s40005-020-00498-5openalex-snapshot
Cellulose and its derivatives for application in 3D printing of pharmaceuticals
inferred← citeshttps://doi.org/10.1007/s40005-026-00827-0openalex-snapshot
Supersaturation dynamics of cocrystals, amorphous solid dispersions and co-amorphous systems: generation mechanisms, stability considerations, and basis of failure modes
inferred← citeshttps://doi.org/10.1016/b978-0-08-102553-6.00010-6openalex-snapshot
Polysaccharide-based amorphous solid dispersions (ASDs) for improving solubility and bioavailability of drugs
inferred← citeshttps://doi.org/10.1016/b978-0-12-802447-8.00030-3openalex-snapshot
Formulation, Process Development, and Scale-Up
inferred← citeshttps://doi.org/10.1016/b978-0-12-802447-8.00031-5openalex-snapshot
Process Development and Scale-Up
inferred← citeshttps://doi.org/10.1016/b978-0-12-811065-2.00008-4openalex-snapshot
Applications of Multivariate Analysis to Monitor and Predict Pharmaceutical Materials Properties
inferred← citeshttps://doi.org/10.1016/b978-0-323-90191-8.00006-3openalex-snapshot
Thermal analysis in studying the phase problem
inferred← citeshttps://doi.org/10.1016/b978-0-443-34156-4.00015-7openalex-snapshot
Process development and scale-up: twin screw extrusion
inferred← citeshttps://doi.org/10.1016/b978-0-443-34156-4.00022-4openalex-snapshot
Process development and scale-up: spray dried amorphous solid dispersions for insoluble drugs
inferred← citeshttps://doi.org/10.1016/b978-1-4160-3135-2.50014-8openalex-snapshot
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Modification of physicochemical characteristics of active pharmaceutical ingredients and application of supersaturatable dosage forms for improving bioavailability of poorly absorbed drugs
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Spray drying formulation of amorphous solid dispersions
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Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network
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Exploring the potential of porous silicas as a carrier system for dissolution rate enhancement of artemether
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Biorelevant test for supersaturable formulation
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Influence of solvent mixtures on HPMCAS-celecoxib microparticles prepared by electrospraying
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Cellulose based polymers in development of amorphous solid dispersions
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Preparation and optimization of various parameters of enteric coated pellets using the Taguchi L9 orthogonal array design and their characterization
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Fundamental aspects of solid dispersion technology for poorly soluble drugs
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Crosslinked hydrogels—a promising class of insoluble solid molecular dispersion carriers for enhancing the delivery of poorly soluble drugs
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Unraveling approaches for cannabidiol delivery nanosystems: A patent review
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Discovery of N-benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]-N-isopropylacetamide, an orally active, gut-selective CCK1 receptor agonist for the potential treatment of obesity
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Pyrazolopyridine inhibitors of B-RafV600E. Part 3: An increase in aqueous solubility via the disruption of crystal packing
inferred← citeshttps://doi.org/10.1016/j.bmcl.2012.02.049openalex-snapshot
Discovery of new piperidine amide triazolobenzodiazepinones as intestinal-selective CCK1 receptor agonists
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Stability and solubility enhancement of ellagic acid in cellulose ester solid dispersions
inferred← citeshttps://doi.org/10.1016/j.carbpol.2012.11.049openalex-snapshot
Synthesis and structure–property evaluation of cellulose ω-carboxyesters for amorphous solid dispersions
inferred← citeshttps://doi.org/10.1016/j.carbpol.2012.11.073openalex-snapshot
Solid dispersion of quercetin in cellulose derivative matrices influences both solubility and stability
inferred← citeshttps://doi.org/10.1016/j.carbpol.2012.12.029openalex-snapshot
Synthesis of amphiphilic 6-carboxypullulan ethers
inferred← citeshttps://doi.org/10.1016/j.carbpol.2013.07.017openalex-snapshot
Both solubility and chemical stability of curcumin are enhanced by solid dispersion in cellulose derivative matrices
inferred← citeshttps://doi.org/10.1016/j.carbpol.2013.09.017openalex-snapshot
Stability assessment of hypromellose acetate succinate (HPMCAS) NF for application in hot melt extrusion (HME)
inferred← citeshttps://doi.org/10.1016/j.carbpol.2014.07.004openalex-snapshot
Synthesis and characterization of neutral and anionic cellulosic amphiphiles
inferred← citeshttps://doi.org/10.1016/j.carbpol.2017.02.025openalex-snapshot
Submicrometric hypromellose acetate succinate particles as carrier for soy isoflavones extract with improved skin penetration performance
inferred← citeshttps://doi.org/10.1016/j.carbpol.2020.115828openalex-snapshot
Hypromellose acetate succinate based amorphous solid dispersions via hot melt extrusion: Effect of drug physicochemical properties
inferred← citeshttps://doi.org/10.1016/j.carpta.2021.100137openalex-snapshot
Effect of Hypromellose Acetate Succinate Substituents on Miscibility Behavior of Spray-dried Amorphous Solid Dispersions: Flory–Huggins Parameter Prediction and Validation
inferred← citeshttps://doi.org/10.1016/j.chroma.2016.09.017openalex-snapshot
Application of finite inverse gas chromatography in hypromellose acetate succinate-water-acetone systems
inferred← citeshttps://doi.org/10.1016/j.colsurfa.2021.127268openalex-snapshot
Mixed Micellization of drug-excipients and its application to enhance the binding and encapsulation efficacy of ibuprofen in aqueous media
inferred← citeshttps://doi.org/10.1016/j.colsurfb.2018.08.030openalex-snapshot
Effect of HPMCAS on recrystallization inhibition of nimodipine solid dispersions prepared by hot-melt extrusion and dissolution enhancement of nimodipine tablets
inferred← citeshttps://doi.org/10.1016/j.compchemeng.2010.04.004openalex-snapshot
Pharmaceutical process/equipment design methodology case study: Cyclone design to optimize spray-dried-particle collection efficiency
inferred← citeshttps://doi.org/10.1016/j.drudis.2011.11.007openalex-snapshot
Bridging solubility between drug discovery and development
inferred← citeshttps://doi.org/10.1016/j.drudis.2022.103344openalex-snapshot
Trends in oral small-molecule drug discovery and product development based on product launches before and after the Rule of Five
inferred← citeshttps://doi.org/10.1016/j.ejpb.2009.09.007openalex-snapshot
Fusion production of solid dispersions containing a heat-sensitive active ingredient by hot melt extrusion and Kinetisol® dispersing
inferred← citeshttps://doi.org/10.1016/j.ejpb.2010.04.009openalex-snapshot
Combined use of ordered mesoporous silica and precipitation inhibitors for improved oral absorption of the poorly soluble weak base itraconazole
inferred← citeshttps://doi.org/10.1016/j.ejpb.2011.04.010openalex-snapshot
Effect of the non-ionic surfactant Poloxamer 188 on passive permeability of poorly soluble drugs across Caco-2 cell monolayers
inferred← citeshttps://doi.org/10.1016/j.ejpb.2011.12.016openalex-snapshot
Enhanced kinetic solubility profiles of indomethacin amorphous solid dispersions in poly(2-hydroxyethyl methacrylate) hydrogels
inferred← citeshttps://doi.org/10.1016/j.ejpb.2012.06.016openalex-snapshot
Formulation and delivery of improved amorphous fenofibrate solid dispersions prepared by thin film freezing
inferred← citeshttps://doi.org/10.1016/j.ejpb.2012.07.012openalex-snapshot
Development of fully amorphous dispersions of a low Tg drug via co-spray drying with hydrophilic polymers
inferred← citeshttps://doi.org/10.1016/j.ejpb.2016.11.031openalex-snapshot
Glass-forming ability of compounds in marketed amorphous drug products
inferred← citeshttps://doi.org/10.1016/j.ejpb.2017.12.002openalex-snapshot
Physical stability of API/polymer-blend amorphous solid dispersions
inferred← citeshttps://doi.org/10.1016/j.ejpb.2017.12.016openalex-snapshot
Oral bioavailability enhancement of β-lapachone, a poorly soluble fast crystallizer, by cocrystal, amorphous solid dispersion, and crystalline solid dispersion
inferred← citeshttps://doi.org/10.1016/j.ejpb.2018.07.002openalex-snapshot
The role of the polymer matrix in solvent-free hot melt extrusion continuous process for mechanochemical synthesis of pharmaceutical cocrystal
inferred← citeshttps://doi.org/10.1016/j.ejpb.2020.01.006openalex-snapshot
Dissolution enhancement of carbamazepine using twin-screw melt granulation
inferred← citeshttps://doi.org/10.1016/j.ejpb.2021.08.014openalex-snapshot
Chrono modulated multiple unit particulate systems (MUPS) via a continuous hot melt double extrusion technique: Investigation of the formulation and process suitability
inferred← citeshttps://doi.org/10.1016/j.ejpb.2022.07.010openalex-snapshot
Hydroxypropyl methylcellulose acetate succinate as an exceptional polymer for amorphous solid dispersion formulations: A review from bench to clinic
inferred← citeshttps://doi.org/10.1016/j.ejpb.2022.07.011openalex-snapshot
Hydroxypropyl methyl cellulose derivatives stabilize fragment antibody against aggregation in spray dried formulations at elevated temperature and resist pH changes
inferred← citeshttps://doi.org/10.1016/j.ejpb.2025.114809openalex-snapshot
Synergistic approach of salt formation and polymer-mediated stabilization to enhance the biopharmaceutical performance of Mebendazole
inferred← citeshttps://doi.org/10.1016/j.ejps.2011.09.003openalex-snapshot
Characterization of thermal and rheological properties of zidovidine, lamivudine and plasticizer blends with ethyl cellulose to assess their suitability for hot melt extrusion
inferred← citeshttps://doi.org/10.1016/j.ejps.2013.07.011openalex-snapshot
Design of self-dispersible dry nanosuspension through wet milling and spray freeze-drying for poorly water-soluble drugs
inferred← citeshttps://doi.org/10.1016/j.ejps.2014.06.007openalex-snapshot
Inhibition mechanism of hydroxypropyl methylcellulose acetate succinate on drug crystallization in gastrointestinal fluid and drug permeability from a supersaturated solution
inferred← citeshttps://doi.org/10.1016/j.ejps.2015.05.027openalex-snapshot
In situ molecular elucidation of drug supersaturation achieved by nano-sizing and amorphization of poorly water-soluble drug
inferred← citeshttps://doi.org/10.1016/j.ejps.2015.12.008openalex-snapshot
Methodology of oral formulation selection in the pharmaceutical industry
inferred← citeshttps://doi.org/10.1016/j.ejps.2016.08.011openalex-snapshot
Production of nano-solid dispersions using a novel solvent-controlled precipitation process — Benchmarking their in vivo performance with an amorphous micro-sized solid dispersion produced by spray drying
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