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Isolation of Dolastatin 10 from the Marine Cyanobacterium Symploca Species VP642 and Total Stereochemistry and Biological Evaluation of Its Analogue Symplostatin 1

https://doi.org/10.1021/np010049y
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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In Vivo Methods for Screening and Preclinical Testing
inferredcites →https://doi.org/10.1016/0040-4020(93)80003-copenalex-snapshot
Isolation of dolastatins 10–15 from the marine mollusc
inferredcites →https://doi.org/10.1016/0041-0101(83)90119-8openalex-snapshot
Progress in the chemistry of organic natural products
inferredcites →https://doi.org/10.1016/s0040-4020(97)00504-8openalex-snapshot
Isolation and stereostructure of dolastatin I, a cytotoxic cyclic hexapeptide from the Japanese sea hare Dolabella auricularia
inferredcites →https://doi.org/10.1021/ja9519086openalex-snapshot
Dolastatin H and Isodolastatin H, Potent Cytotoxic Peptides from the Sea Hare Dolabella auricularia: Isolation, Stereostructures, and Synthesis
inferredcites →https://doi.org/10.1021/np990310zopenalex-snapshot
Lyngbyastatin 2 and Norlyngbyastatin 2, Analogues of Dolastatin G and Nordolastatin G from the Marine Cyanobacterium Lyngbya majuscula
inferredcites →https://doi.org/10.1021/np990353fopenalex-snapshot
Dolastatin 3 and Two Novel Cyclic Peptides from a Palauan Collection of Lyngbya majuscula
inferredcites →https://doi.org/10.1080/10826079408013444openalex-snapshot
Procedures for the Analyses of Dolastatins 10 and 15 by High Performance Liquid Chromatography
inferredcites →https://doi.org/10.1093/jnci/82.13.1107openalex-snapshot
New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening
inferredcites →https://doi.org/10.1248/cpb.43.1706openalex-snapshot
Synthesis and Antitumor Activity of Novel Dolastatin 10 Analogs.

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Unconventional high-value products from microalgae: A review
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Bio-mining the microbial treasures of the ocean: New natural products
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2023.108235openalex-snapshot
Harmful and beneficial properties of cyanotoxins: Two sides of the same coin
inferred← citeshttps://doi.org/10.1016/j.bmc.2016.08.040openalex-snapshot
Synthesis and biological evaluation of santacruzamate A analogues for anti-proliferative and immunomodulatory activity
inferred← citeshttps://doi.org/10.1016/j.bmcl.2015.09.044openalex-snapshot
Identification of a molecular target of kurahyne, an apoptosis-inducing lipopeptide from marine cyanobacterial assemblages
inferred← citeshttps://doi.org/10.1016/j.bmcl.2018.04.067openalex-snapshot
Kakeromamide A, a new cyclic pentapeptide inducing astrocyte differentiation isolated from the marine cyanobacterium Moorea bouillonii
inferred← citeshttps://doi.org/10.1016/j.cellsig.2024.111411openalex-snapshot
Recent progress of protein kinase inhibitors derived from marine peptides for developing anticancer agents
inferred← citeshttps://doi.org/10.1016/j.chembiol.2009.06.012openalex-snapshot
Hoiamide A, a Sodium Channel Activator of Unusual Architecture from a Consortium of Two Papua New Guinea Cyanobacteria
inferred← citeshttps://doi.org/10.1016/j.chembiol.2011.12.014openalex-snapshot
Lessons from the Past and Charting the Future of Marine Natural Products Drug Discovery and Chemical Biology
inferred← citeshttps://doi.org/10.1016/j.copbio.2010.09.013openalex-snapshot
The expanding role of marine microbes in pharmaceutical development
inferred← citeshttps://doi.org/10.1016/j.copbio.2024.103162openalex-snapshot
Something ‘Old, New, Borrowed, or Blue’, the Search for Mother Nature’s Bioactive Agents
inferred← citeshttps://doi.org/10.1016/j.crbiot.2023.100167openalex-snapshot
Dolastatins and their analogues present a compelling landscape of potential natural and synthetic anticancer drug candidates
inferred← citeshttps://doi.org/10.1016/j.drudis.2013.05.010openalex-snapshot
Pharmaceutical agents from filamentous marine cyanobacteria
inferred← citeshttps://doi.org/10.1016/j.ejmcr.2021.100023openalex-snapshot
A comprehensive review on chemistry and pharmacology of marine bioactives as antimetastatic agents
inferred← citeshttps://doi.org/10.1016/j.fitote.2025.107055openalex-snapshot
Uncovering chemical novelty from freshwater filamentous Cyanobacteria
inferred← citeshttps://doi.org/10.1016/j.foodres.2025.118240openalex-snapshot
Philippine marine macroalgae as sources of bioactive natural products and macronutrients for food applications
inferred← citeshttps://doi.org/10.1016/j.hal.2018.11.008openalex-snapshot
Cyanobacterial bioactive metabolites—A review of their chemistry and biology
inferred← citeshttps://doi.org/10.1016/j.hal.2019.05.001openalex-snapshot
Cyanobacterial bioactive metabolites—A review of their chemistry and biology
inferred← citeshttps://doi.org/10.1016/j.jacme.2015.02.004openalex-snapshot
Pharmaceutical applications of cyanobacteria—A review
inferred← citeshttps://doi.org/10.1016/j.mrfmmm.2014.03.005openalex-snapshot
Apoptosis inducing lead compounds isolated from marine organisms of potential relevance in cancer treatment
inferred← citeshttps://doi.org/10.1016/j.oceano.2017.11.003openalex-snapshot
Bioactive metabolites produced by Spirulina subsalsa from the Baltic Sea
inferred← citeshttps://doi.org/10.1016/j.peptides.2017.06.002openalex-snapshot
Structural diversity of marine cyclic peptides and their molecular mechanisms for anticancer, antibacterial, antifungal, and other clinical applications
inferred← citeshttps://doi.org/10.1016/j.phrs.2022.106076openalex-snapshot
Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review
inferred← citeshttps://doi.org/10.1016/j.phyplu.2023.100418openalex-snapshot
Understanding mechanistic aspects and therapeutic potential of natural substances as anticancer agents
inferred← citeshttps://doi.org/10.1016/j.phytol.2015.04.024openalex-snapshot
Ehrenasterol and biemnic acid; new bioactive compounds from the Red Sea sponge Biemna ehrenbergi
inferred← citeshttps://doi.org/10.1016/j.rser.2016.11.110openalex-snapshot
Cyanobacterial factories for the production of green energy and value-added products: An integrated approach for economic viability
inferred← citeshttps://doi.org/10.1016/j.syapm.2006.01.009openalex-snapshot
Single-stranded conformational polymorphism for separation of mixed rRNAS (rRNA-SSCP), a new method for profiling microbial communities
inferred← citeshttps://doi.org/10.1016/j.tet.2010.11.106openalex-snapshot
Revised structure and structure–activity relationship of bisebromoamide and structure of norbisebromoamide from the marine cyanobacterium Lyngbya sp.
inferred← citeshttps://doi.org/10.1016/j.tet.2012.05.038openalex-snapshot
Isolation and structures of biselyngbyasides B, C, and D from the marine cyanobacterium Lyngbya sp., and the biological activities of biselyngbyasides
inferred← citeshttps://doi.org/10.1016/j.tetlet.2006.03.082openalex-snapshot
Belamide A, a new antimitotic tetrapeptide from a Panamanian marine cyanobacterium
inferred← citeshttps://doi.org/10.1016/j.tetlet.2011.05.107openalex-snapshot
Asymmetric synthesis of (E)-dehydroapratoxin A
inferred← citeshttps://doi.org/10.1016/j.tetlet.2018.02.046openalex-snapshot
Caldorin, a new polyketide from the marine cyanobacterium Caldora penicillata
inferred← citeshttps://doi.org/10.1016/j.toxicon.2019.12.159openalex-snapshot
Portoamides A and B are mitochondrial toxins and induce cytotoxicity on the proliferative cell layer of in vitro microtumours
inferred← citeshttps://doi.org/10.1016/s0065-2164(06)61004-6openalex-snapshot
Biogenetic Diversity of Cyanobacterial Metabolites
inferred← citeshttps://doi.org/10.1016/s0968-0896(02)00014-7openalex-snapshot
New apratoxins of marine cyanobacterial origin from guam and palau
inferred← citeshttps://doi.org/10.1016/s1671-2927(08)60346-6openalex-snapshot
Molecular Evidences for the Biosynthesis of Pederin by Endosymbiont
inferred← citeshttps://doi.org/10.1021/acs.est.5b04415openalex-snapshot
Combined LC–MS/MS and Molecular Networking Approach Reveals New Cyanotoxins from the 2014 Cyanobacterial Bloom in Green Lake, Seattle
inferred← citeshttps://doi.org/10.1021/acs.estlett.5b00116openalex-snapshot
Isolation of Polycavernoside D from a Marine Cyanobacterium
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.0c00042openalex-snapshot
Irijimasides A–E, Macrolide Glycosides from an Okeania sp. Marine Cyanobacterium
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.0c00950openalex-snapshot
Biosynthesis of Chlorinated Lactylates in Sphaerospermopsis sp. LEGE 00249
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.1c00065openalex-snapshot
Natural Product Based Antibody Drug Conjugates: Clinical Status as of November 9, 2020
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.1c00334openalex-snapshot
Phormidepistatin from the Cyanobacterium UIC 10484: Assessing the Phylogenetic Distribution of the Statine Pharmacophore
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.1c00996openalex-snapshot
Triproamide and Pemukainalides, Cyclic Depsipeptides from the Marine Cyanobacterium Symploca hydnoides
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.1c01030openalex-snapshot
Aulosirazoles B and C from the Cyanobacterium Nostoc sp. UIC 10771: Analogues of an Isothiazolonaphthoquinone Scaffold that Activate Nuclear Transcription Factor FOXO3a in Ovarian Cancer Cells
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.1c01135openalex-snapshot
Discovery and Development of Dolastatin 10-Derived Antibody Drug Conjugate Anticancer Drugs
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.4c01051openalex-snapshot
Fatuamide A, a Hybrid PKS/NRPS Metallophore from a Leptolyngbya sp. Marine Cyanobacterium Collected in American Samoa
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.4c01445openalex-snapshot
Menominin A and B: Cytotoxic Cyclodepsipeptides from the Freshwater Sponge-Associated Cyanobacterium Nostoc sp. UIC 10607
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.5c00095openalex-snapshot
Hedopeptolide, a NO Production Inhibitor from the Marine Cyanobacterium Okeania sp.
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.5c00439openalex-snapshot
In Silico Design and Analysis of Cyanobacterial Pseudo Natural Products
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.5c00757openalex-snapshot
Structure Determination and Biosynthesis of Dapalides A–C, Glycosylated Kahalalide F Analogues from the Marine Cyanobacterium Dapis sp
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.6b00203openalex-snapshot
Caldoramide, a Modified Pentapeptide from the Marine Cyanobacterium Caldora penicillata
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.6b00907openalex-snapshot
Integrating Molecular Networking and Biological Assays To Target the Isolation of a Cytotoxic Cyclic Octapeptide, Samoamide A, from an American Samoan Marine Cyanobacterium
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.6c00312openalex-snapshot
Cytotoxic Irciniastatin Analogs and a New Thiazole Lipid from Sarcotragus spinosulus
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.6c00670openalex-snapshot
Tonakiamides A and B, Antitrypanosomal Lipopeptides Isolated from a Marine Okeania sp. Cyanobacterium
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.6c00688openalex-snapshot
Editorial Introducing the Collection in Honor of Valerie J. Paul
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.7b00137openalex-snapshot
Biseokeaniamides A, B, and C, Sterol O-Acyltransferase Inhibitors from an Okeania sp. Marine Cyanobacterium
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.7b00964openalex-snapshot
Marine Invertebrate Natural Products that Target Microtubules
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.8b00417openalex-snapshot
Izenamides A and B, Statine-Containing Depsipeptides, and an Analogue from a Marine Cyanobacterium
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