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Serine Protease Inhibition by a Silanediol Peptidomimetic

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Reduction of Carbonyl Compounds with Chiral Oxazaborolidine Catalysts: A New Paradigm for Enantioselective Catalysis and a Powerful New Synthetic Method
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Polysilanols
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Sila‐Pharmaka, 371) Darstellung und Eigenschaften der Enantiomere der Antimuskarinika Sila‐Procyclidin und Sila‐Tricyclamol‐iodid: Optisch aktive Silanole mit Silicium als Chiralitätszentrum2)
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Silanediol Protease Inhibitors: From Conception to Validation
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Crystal Structure of the Boronic Acid-Based Proteasome Inhibitor Bortezomib in Complex with the Yeast 20S Proteasome
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A sensitive new substrate for chymotrypsin
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On the size of the active site in proteases. I. Papain
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Synthèses et réactivités comparées de sila- et germacyclopentanes fonctionnellement β-substitués
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Inhibition of aspartic proteases by pepstatin and 3-methylstatine derivatives of pepstatin. Evidence for collected-substrate enzyme inhibition
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Inhibition of serine proteases by peptidyl fluoromethyl ketones
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Design of potent competitive inhibitors of angiotensin-converting enzyme. Carboxyalkanoyl and mercaptoalkanoyl amino acids
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Structure and Mechanism of the Pepsin-Like Family of Aspartic Peptidases
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Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
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Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design
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3D-QSAR of angiotensin-converting enzyme and thermolysin inhibitors: a comparison of CoMFA models based on deduced and experimentally determined active site geometries
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New Method for the Synthesis of Silaheterocycles and the First Pentacoordinate Silanol
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Synthesis of Silyl and Germyl Ketones
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Synthesis of α-Silyl Ketones via 1,3-Dithianes
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Silicon-Based Metalloprotease Inhibitors: Synthesis and Evaluation of Silanol and Silanediol Peptide Analogues as Inhibitors of Angiotensin-Converting Enzyme1
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Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design
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Protease Inhibitors: Current Status and Future Prospects
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Synthetic studies on (2R,4'R,8'R)-.alpha.-tocopherol. An approach utilizing side chain synthons of microbiological origin
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Synthesis and Evaluation of Macrocyclic Transition State Analogue Inhibitors for α-Chymotrypsin
inferredcites →https://doi.org/10.1021/jo048121vopenalex-snapshot
Silanediol Inhibitors of Angiotensin-Converting Enzyme. Synthesis and Evaluation of Four Diastereomers of Phe[Si]Ala Dipeptide Analogues1
inferredcites →https://doi.org/10.1021/jo049929iopenalex-snapshot
A Silanediol Inhibitor of the Metalloprotease Thermolysin: Synthesis and Comparison with a Phosphinic Acid Inhibitor1
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Further Studies toward the Stereocontrolled Synthesis of Silicon-Containing Peptide Mimics
inferredcites →https://doi.org/10.1021/ol7021559openalex-snapshot
Efficient Asymmetric Synthesis of Silanediol Precursors from 1,5-Dihydrosiloles
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Triggers, targets and treatments for thrombosis
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Targeting proteases: successes, failures and future prospects
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The pharmacological landscape and therapeutic potential of serine hydrolases
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Matrix metalloproteinases and the regulation of tissue remodelling
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The X-ray structure of a protonated hypervalent silanol
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Novel mechanism of inhibition of human angiotensin-I-converting enzyme (ACE) by a highly specific phosphinic tripeptide
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The specificity of chymotrypsin
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Kinetics and mechanism of the hydrolysis and alcoholysis of alkoxysilanes
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Phosphinic Acid Compounds in Biochemistry, Biology and Medicine
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Aspartic Proteases in Drug Discovery
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Recent Developments in the Design of Mechanism-based and Alternate Substrate Inhibitors of Serine Proteases
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Systematic Review: Comparative Effectiveness of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers for Treating Essential Hypertension

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Advances and Properties of Silanol‐Based Materials
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Drug Targets
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The Corey–Bakshi–Shibata Reduction: Mechanistic and Synthetic Considerations – Bifunctional Lewis Base Catalysis with Dual Activation
inferred← citeshttps://doi.org/10.1002/9783527809080.cataz14968openalex-snapshot
serine protease
inferred← citeshttps://doi.org/10.1002/9783527828166.ch4openalex-snapshot
Miscellaneous Reactions
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Organocatalytic Enantioselective Michael Addition of Pyrazol‐5‐ones to β‐Silylmethylene Malonates: Synthesis of Chiral Organosilanes Under Metal‐ free Conditions
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Iron‐Catalyzed Intermolecular 1,2‐Difunctionalization of Styrenes and Conjugated Alkenes with Silanes and Nucleophiles
inferred← citeshttps://doi.org/10.1002/ange.202109252openalex-snapshot
Direct Access to α‐Aminosilanes Enabled by Visible‐Light‐Mediated Multicomponent Radical Cross‐Coupling
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Construction of Si‐Stereogenic Silanols by Palladium‐Catalyzed Enantioselective C−H Alkenylation
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Iron‐Catalyzed Intermolecular 1,2‐Difunctionalization of Styrenes and Conjugated Alkenes with Silanes and Nucleophiles
inferred← citeshttps://doi.org/10.1002/anie.202109252openalex-snapshot
Direct Access to α‐Aminosilanes Enabled by Visible‐Light‐Mediated Multicomponent Radical Cross‐Coupling
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Construction of Si‐Stereogenic Silanols by Palladium‐Catalyzed Enantioselective C−H Alkenylation
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Recent Advances in the Synthesis of Acylsilanes
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Incorporation of β‐Silicon‐β3‐Amino Acids in the Antimicrobial Peptide Alamethicin Provides a 20‐Fold Increase in Membrane Permeabilization
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Chiral Silanols: Strategies and Tactics for Their Synthesis
inferred← citeshttps://doi.org/10.1002/cjoc.70099openalex-snapshot
Cobalt‐Catalyzed Silyldifluoromethylamination of Styrenes with TMSCF2H and Nitrogen Nucleophiles†
inferred← citeshttps://doi.org/10.1002/ejic.201500457openalex-snapshot
The Syntheses and Crystal Structures of the First Disiloxane‐1,3‐dithiol and Its Cadmium Complex
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Design Strategies for Enhanced Hydrogen‐Bond Donor Catalysts
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Stereoselective Synthesis of Highly Substituted α‐Silylamines from Silylmethyl Azides under Ru Catalysis
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Preparation and Catalytic Activity of BINOL‐Derived Silanediols
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Silicon Mimics of Unstable Carbon
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Hydroxymethylsilanetriol – A Simple Analog of Silicic Acid
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Synthesis of N-(Silylmethyl)amides of Carboxylic Acids and Related Compounds
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Design and expeditious synthesis of organosilanes as potent antivirals targeting multidrug-resistant influenza A viruses
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Silaproline-bearing nirmatrelvir derivatives are potent inhibitors of the SARS-CoV-2 main protease highlighting the value of silicon-derivatives in structure-activity-relationship studies
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Biomedical applications of mesoporous silica nanoparticles as a drug delivery carrier
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Functionalized mesoporous silica nanoparticles and biomedical applications
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Novel route to silanetriols and silanediols based on acetoxysilylalkoxides
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Quest for Novel Chemical Entities through Incorporation of Silicon in Drug Scaffolds
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α-Aminocarbene-Mediated Si–H Insertion: Deoxygenative Silylation of Aromatic Amides with Silanes
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NBE-Controlled Palladium-Catalyzed Intermolecular Selective C–H Silylation of Boronic Acids
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Construction of 2-Fluoroallylsilanes by Palladium-Catalyzed Ring-Opening Defluorinative Silylation of gem -Difluorocyclopropanes
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Stereospecific Synthesis of α-Amino Allylsilane Derivatives through a [3,3]-Allyl Cyanate Rearrangement. Mild Formation of Functionalized Disiloxanes
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Asymmetric Synthesis of Silanediol Inhibitors for the Serine Protease Coagulation Cascade Enzyme FXIa
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Copper-Catalyzed Synthesis of 3-Silyl-1-silacyclopent-2-enes via Regio- and anti -Selective Addition of Silylboronates to Silicon-Containing Internal Alkynes
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Synthesis of β-Silyl Amines via Merging Photoinduced Energy and Hydrogen Atom Transfer in Flow
inferred← citeshttps://doi.org/10.1021/acs.orglett.8b04073openalex-snapshot
Synthesis of Chiral α-Aminosilanes through Palladium-Catalyzed Asymmetric Hydrogenation of Silylimines
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NBE-Controlled Palladium-Catalyzed Interannular Selective C–H Silylation: Access to Divergent Silicon-Containing 1,1′-Biaryl-2-Acetamides
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Copper-Catalyzed Desymmetrization of Prochiral Silanediols to Silicon-Stereogenic Silanols
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Lanthanum Ate Amide-Catalyzed Regio- and Stereoselective Hydrosilylation of Internal Alkynes
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Environmental Chemistry of Organosiloxanes
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Synthesis, Reactivity, Functionalization, and ADMET Properties of Silicon-Containing Nitrogen Heterocycles
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Organosilicon Molecules with Medicinal Applications
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Asymmetric Modular Synthesis of a Semirigid Dipeptide Mimetic by Cascade Cycloaddition/Ring Rearrangement and Borohydride Reduction
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Stereospecific Si-C coupling and remote control of axial chirality by enantioselective palladium-catalyzed hydrosilylation of maleimides
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Acylsilanes: valuable organosilicon reagents in organic synthesis
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An access to 1,3-azasiline-fused quinolinones via oxidative heteroannulation involving silyl C(sp 3 )–H functionalization
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Copper-promoted difunctionalization of unactivated alkenes with silanes
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Selective Si–C(sp 3 ) bond cleavage of a silyl-bridged amido alkyl ligand in an yttrium complex
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4.4.28.17 α-Silyl Alcohols, Ethers, and Amines (Update 2020)
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GC-MS Profiling and Antifungal Activity of Secondary Metabolite from Endophytic Fungus of Giloy
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Construction of Si-Stereogenic Silanols via Enantioselective Pd-Catalyzed C–H Alkenylation
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On the Potential of Silicon as a Building Block for Life
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Recent advances in Cu-catalyzed C(sp 3 )–Si and C(sp 3 )–B bond formation
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Merging Electron Transfer Activation with 1,2-Metalate Migration: Deoxygenative Silylation of Amides
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Progress in [4+1] Cycloadditions of Conjugated Dienes
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Study and applications of [3,3] sigmatropic rearrangement of allyl cyanates for the synthesis of molecules of biological interest.
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