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Synthesis of Ultra-Short-Acting Neuromuscular Blocker GW 0430: A Remarkably Stereo- and Regioselective Synthesis of Mixed Tetrahydroisoquinolinium Chlorofumarates

https://doi.org/10.1021/ol9911573
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Synthesis and Absolute Configuration of Cryptostylines I, II, and III
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Nondepolarizing relaxants: new concepts and new drugs
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Comprehensive organic chemistry
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Neuromuscular blocking activity of cyclic and acyclic bis-quaternary ammonium analogues of mivacurium chloride in the cat
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Asymmetric Transfer Hydrogenation of Imines
inferredcites →https://doi.org/10.1021/jm990060jopenalex-snapshot
Bis- and Mixed-Tetrahydroisoquinolinium Chlorofumarates: New Ultra-Short-Acting Nondepolarizing Neuromuscular Blockers
inferredcites →https://doi.org/10.1021/jo01067a619openalex-snapshot
Notes- N-Methylation of Amino Alcohols and Amino Mercaptans
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Notes- Formation of Girard-T Derivatives
inferredcites →https://doi.org/10.1021/jo01088a021openalex-snapshot
Syntheses in the 1,2,4-Benzotriazine Series
inferredcites →https://doi.org/10.1111/j.1600-0773.1994.tb01065.xopenalex-snapshot
Newer Neuromuscular Blocking Agents

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Catalytic Asymmetric Hydrogenation of C N Functions
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Cholinergics/Anticholinergics
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Noyori Hydrogenation
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Transferhydrogenations
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Imino Reductions by Transfer Hydrogenation
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Chiral Amines from Transition‐Metal‐Mediated Hydrogenation and Transfer Hydrogenation
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Hydrogenation, Hydroformylation, and Other Reductions
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A General Methodology for the Enantioselective Synthesis of 1‐Substituted Tetrahydroisoquinoline Alkaloids
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Asymmetric Transfer Hydrogenation of 1‐Aryl‐3,4‐Dihydroisoquinolines Using a Cp*Ir(TsDPEN) Complex
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History of the development of antagonists for neuromuscular blocking agents
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Total synthesis of racemic 1-aryl-tetrahydroisoquinoline alkaloids
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Solid-Phase Synthesis and Catalytic Screening of Polystyrene Supported Diphosphines
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New Drug Developments for Neuromuscular Blockade and Reversal: Gantacurium, CW002, CW011, and Calabadion
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Imino Transfer Hydrogenation Reductions
inferred← citeshttps://doi.org/10.1016/j.bmcl.2024.129793openalex-snapshot
Design, synthesis, and biological evaluation of new bis-benzylisoquinoline-based analogues as potential neuromuscular blocking agents
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Fumarates: Unique nondepolarizing neuromuscular blocking agents that are antagonized by cysteine
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Enantioselective synthesis of some tetrahydroisoquinoline and tetrahydro-β-carboline alkaloids
inferred← citeshttps://doi.org/10.1016/j.tetasy.2012.11.012openalex-snapshot
Two optimized synthetic pathways toward a chiral precursor of Mivacurium chloride and other skeletal muscle relaxants
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Enantioselective catalysis. Part 143: Astonishingly high enantioselectivity in the transfer hydrogenation of acetophenone with 2-propanol using Ru complexes of the Schiff base derived from (S)-2-amino-2′-hydroxy-1,1′-binaphthyl (NOBIN) and 2-pyridinecarbaldehyde
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Concise Enantioselective Total Synthesis of Isopavine Alkaloids
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Asymmetric Transfer Hydrogenation of Unhindered and Non-Electron-Rich 1-Aryl Dihydroisoquinolines with High Enantioselectivity
inferred← citeshttps://doi.org/10.1021/cr040700copenalex-snapshot
Asymmetric Synthesis of Active Pharmaceutical Ingredients
inferred← citeshttps://doi.org/10.1021/cr800403ropenalex-snapshot
Hydrophilic Ligands and Their Application in Aqueous-Phase Metal-Catalyzed Reactions
inferred← citeshttps://doi.org/10.1021/jm020574+openalex-snapshot
Neuromuscular Blocking Activity and Therapeutic Potential of Mixed-Tetrahydroisoquinolinium Halofumarates and Halosuccinates in Rhesus Monkeys
inferred← citeshttps://doi.org/10.1021/jo010721wopenalex-snapshot
Metal−Ligand Bifunctional Catalysis: A Nonclassical Mechanism for Asymmetric Hydrogen Transfer between Alcohols and Carbonyl Compounds
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Synthesis of Nitrogenated Heterocycles by Asymmetric Transfer Hydrogenation of N-(tert-Butylsulfinyl)haloimines
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Remarkable Positive Effect of Silver Salts on Asymmetric Hydrogenation of Acyclic Imines with Cp*Ir Complexes Bearing Chiral N-Sulfonylated Diamine Ligands
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One-pot formation of nitrogen-containing heterocyclic ring systems using a deprotection–cyclisation–asymmetric reduction sequence
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inferred← citeshttps://doi.org/10.1093/bja/aer341openalex-snapshot
Development and potential clinical impact of ultra-short acting neuromuscular blocking agents
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Novel neuromuscular blocking drugs and antagonists
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The future of neuromuscular blocking agents
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Is there still a place for fast-acting neuromuscular blockade agents: fast onset or safe and prompt reversal?
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Dose–response and Cardiopulmonary Side Effects of the Novel Neuromuscular-blocking Drug CW002 in Man
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Physiology and Pharmacology of Neuromuscular Transmission
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Chemistry of Concerto Molecular Catalysis Based on the Metal/NH Bifunctionality
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Opportunities Offered by Chiral η6-Arene/N-Arylsulfonyl-diamine-RuII Catalysts in the Asymmetric Transfer Hydrogenation of Ketones and Imines
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Practical Aspects and Mechanism of Asymmetric Hydrogenation with Chiral Half-Sandwich Complexes
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Experimental and Theoretical Perspectives of the Noyori-Ikariya Asymmetric Transfer Hydrogenation of Imines
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Determination of Enantiomeric Composition of Substituted Tetrahydroisoquinolines Based on Derivatization with Menthyl Chloroformate
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