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An Integrated Process Analytical Technology (PAT) Approach for Pharmaceutical Crystallization Process Understanding to Ensure Product Quality and Safety: FDA Scientist’s Perspective
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Effects of Humidity and Temperature on In Vitro Dissolution of Carbamazepine Tablets
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Does conventional nucleation occur during phase separation in polymer blends?
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Prediction of the induction period of crystallization of naproxen in solid dispersion using differential scanning calorimetry
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Interpretation of crystallization induction periods
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Precipitation of barium sulfate: Induction time and the effect of an additive on nucleation and growth
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Kinetics of nucleation in solutions
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Analyses of precipitation processes of BIS(dimethylglyoximato)Ni(II) and related complexes
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Salting-out precipitation of potassium dihydrogen phosphate (KDP). I. Precipitation mechanism
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Applications of process analytical technology to crystallization processes
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Bulk video imaging based multivariate image analysis, process control chart and acoustic signal assisted nucleation detection
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Recent advances in the monitoring, modelling and control of crystallization systems
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Quality-by-Design (QbD): An integrated process analytical technology (PAT) approach for a dynamic pharmaceutical co-precipitation process characterization and process design space development☆
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Detection of phase shifts in batch fermentation via statistical analysis of the online measurements: A case study with rifamycin B fermentation
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Interpretation of the ultrasonic effect on induction time during BaSO4 homogeneous nucleation by a cluster coagulation model
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Physicochemical properties and bioavailability of carbamazepine polymorphs and dihydrate
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Effect of ultrasound on the induction time and the metastable zone widths of potassium sulphate
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Nucleation of Crystals from Solution: Classical and Two-Step Models
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Paracetamol Crystallization Using Laser Backscattering and ATR-FTIR Spectroscopy: Metastability, Agglomeration, and Control
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Development of an Experimental Method to Measure Nucleation Rates in Reactive Precipitation
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Influence of Additives on Nucleation of Vanillin: Experiments and Introductory Molecular Simulations
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Nucleation under Soft Confinement: Role of Polymer–Solute Interactions
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Nucleation of Butyl Paraben in Different Solvents
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Off-line Temporal Signal Comparison Using Singular Points Augmented Time Warping
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Online Temporal Signal Comparison Using Singular Points Augmented Time Warping
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Integrated Process Analytical Technology Approach for Nucleation Induction Time Measurement and Nucleation Mechanism Assessment for a Dynamic Multicomponent Pharmaceutical Antisolvent Crystallization System
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Direct Observation of Nucleus Structure and Nucleation Pathways in Apoferritin Crystallization
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Dealing with the Impact of Ritonavir Polymorphs on the Late Stages of Bulk Drug Process Development
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Correlation of Drug Substance Particle Size Distribution with Other Bulk Properties to Predict Critical Quality Attributes
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The Bioinequivalence of Carbamazepine Tablets with a History of Clinical Failures
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Elucidation of crystal form diversity of the HIV protease inhibitor ritonavir by high-throughput crystallization
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Confocal microscopy of colloids
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Heterogeneous nucleation and crystal growth on curved surfaces observed by real-space imaging
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Crystal Polymorphism in Chemical Process Development
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Quality by Design: Concepts for ANDAs
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Progress of Complex System Process Analysis Based on Modern Spectroscopy Combined With Chemometrics
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Selection of Design of PAT
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The integration of artificial intelligence through quality by digital design for sustainable pharmaceutical manufacturing
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Evaluation of a compact composite sensor array for concentration monitoring of solutions and suspensions via multivariate analysis
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Progress, problems, and potential of technology for measuring solution concentration in crystallization processes
inferred← citeshttps://doi.org/10.1016/j.powtec.2020.03.027openalex-snapshot
Process analytical technology-based (PAT) model simulations of a combined cooling, seeded and antisolvent crystallization of an active pharmaceutical ingredient (API)
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Current Trends in API Co-Processing: Spherical Crystallization and Co-Precipitation Techniques
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PAT-Facilitated Pharmaceutical Crystallization Development through Mechanistic Understanding
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Preferential Orientation Effect of Polymers on Paracetamol Crystallization: Experiments and Modeling
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Atomistic Simulation To Understand Anisotropic Growth Behavior of Naproxen Crystal in the Presence of Polymeric Additives
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Process Design for Antisolvent Crystallization of Erythromycin Ethylsuccinate in Oiling-out System
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Modeling Batch Crystallization under Uncertainty Using Physics-Informed Machine Learning
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Technoeconomic Optimization of Continuous Crystallization for Three Active Pharmaceutical Ingredients: Cyclosporine, Paracetamol, and Aliskiren
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Process Analytical Technology for Online Monitoring of Organic Reactions by Mass Spectrometry and UV–Vis Spectroscopy
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Robust Crystallization Process Development for the Metastable δ-form of Pyrazinamide
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Raman Spectroscopy for Monitoring the Continuous Crystallization of Carbamazepine
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Improved Understanding of Cefixime Trihydrate Reactive Crystallization and Process Scale-up with the Aid of PAT
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Process Design and Optimization for the Continuous Manufacturing of Nevirapine, an Active Pharmaceutical Ingredient for HIV Treatment
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Process Development and Control with Recent New FBRM, PVM, and IR
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Assessment of Recent Process Analytical Technology (PAT) Trends: A Multiauthor Review
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Development of an automated multi-stage continuous reactive crystallization system with in-line PATs for high viscosity process
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Evaluation of focused beam reflectance measurement (FBRM) for monitoring and predicting the crystal size of carbamazepine in crystallization processes
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Understanding the role of solvent in regulating the crystal habit
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Quality-by-Design (QbD) for Capsule Formulation and Process Development
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In-Situ Monitoring of Dissolution and Crystallization Processes of Carbamazepine Using Low-Frequency Raman Spectroscopy and Multivariate Analysis
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Application of PAT-Based Feedback Control Approaches in Pharmaceutical Crystallization
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Tuning the Crystal Habits of Organic Explosives by Antisolvent Crystallization: The Case Study of 2,6-dimaino-3,5-dinitropyrazine-1-oxid (LLM-105)
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