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Design of Experiments (DoE) and Process Optimization. A Review of Recent Publications
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Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1016/j.tet.2008.10.056openalex-snapshot
Practical and versatile oxidation of alcohol using novel Na2WO4–H2O2 system under neutral conditions
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Reactivity of pyridinium poly(hydrogen fluoride) towards silicon tetrachloride, trichlorosilane and tris(amino)silanes
inferredcites →https://doi.org/10.1016/s0922-3487(08)x7011-xopenalex-snapshot
Design and Optimization in Organic Synthesis
inferredcites →https://doi.org/10.1021/bk-2004-0870.ch006openalex-snapshot
Design of Experiments in Pharmaceutical Process Research and Development
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Statistical Method Makes A Comeback
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GREEN CHEMISTRY PROGRESS REPORT
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Crystallization-Induced Diastereomer Transformations
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A Reassessment of the Transition-Metal Free Suzuki-Type Coupling Methodology
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Homeopathic Ligand-Free Palladium as a Catalyst in the Heck Reaction. A Comparison with a Palladacycle
inferredcites →https://doi.org/10.1021/op000025iopenalex-snapshot
DOE (Design of Experiments) in Development Chemistry: Potential Obstacles
inferredcites →https://doi.org/10.1021/op020065hopenalex-snapshot
A New Approach to Rapid Parallel Development of Four Neurokinin Antagonists. Part 2. Synthesis of ZD6021 Cyano Acid
inferredcites →https://doi.org/10.1021/op020075iopenalex-snapshot
Thorough Examination of a Wittig−Horner Reaction Using Reaction Calorimetry (RC-1), LabMax, and ReactIR
inferredcites →https://doi.org/10.1021/op025585ropenalex-snapshot
Industrially Viable Syntheses of Highly Enantiomerically Enriched 1-Aryl Alcohols via Asymmetric Hydrogenation
inferredcites →https://doi.org/10.1021/op030029yopenalex-snapshot
Optimisation of Ethyl(2-phthalimidoethoxy)acetate Synthesis with the Aid of DOE
inferredcites →https://doi.org/10.1021/op034018gopenalex-snapshot
Rapid Improvement of a Reductive Sulfonylation Using Design of Experiment Methods
inferredcites →https://doi.org/10.1021/op034033lopenalex-snapshot
Chemical Development on the Chiral Auxiliary (S)-4-(Phenylmethyl)-2-oxazolidinone Utilizing Automated Synthesis and DoE
inferredcites →https://doi.org/10.1021/op0341465openalex-snapshot
A New and Simplified Process for Preparing N -[4-(3,4-Dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]methanamine and a Telescoped Process for the Synthesis of (1 S - cis )-4-(3,4-Dichlorophenol)-1,2,3,4-tetrahydro- N -methyl-1-naphthalenamine Mandelate: Key Intermediates in the Synthesis of…
inferredcites →https://doi.org/10.1021/op040014fopenalex-snapshot
Synthetic Process Development and Scale-Up of the Oxidative Cleavage of a Double Bond Catalyzed by Ruthenium Trichloride
inferredcites →https://doi.org/10.1021/op040204qopenalex-snapshot
Use of DOE for Rapid Development of a Red-Al Reduction Process for the Synthesis of 3,4-Isopropylidenedioxypyrrolidine Hydrotosylate
inferredcites →https://doi.org/10.1021/op049803nopenalex-snapshot
Unification of Reaction Metrics for Green Chemistry: Applications to Reaction Analysis
inferredcites →https://doi.org/10.1021/op049809copenalex-snapshot
A Facile and Scaleable Synthesis of ABT-239, A Benzofuranoid H3 Antagonist
inferredcites →https://doi.org/10.1021/op049844jopenalex-snapshot
Practical Process for the Air Oxidation of Cresols: Part B. Evaluation of the Laboratory-Scale Oxidation Process
inferredcites →https://doi.org/10.1021/op049904lopenalex-snapshot
Using DOE to Achieve Reliable Drug Administration: A Case Study
inferredcites →https://doi.org/10.1021/op049908qopenalex-snapshot
Process Control Limits from a Laboratory Study on the Ni(0)-Mediated Coupling of Ethyl Acrylate with a C-22 Steroidal Iodide: A Case Study on the Role of Experimental Design in Highly Developed Processes
inferredcites →https://doi.org/10.1021/op050051mopenalex-snapshot
Synthesis of Methyl 1-(2,3,5-Tri-O-acetyl-β- l -ribofuranosyl)-1,2,4- triazole-3-carboxylate from l -Ribose: From a Laboratory Procedure to a Manufacturing Process
inferredcites →https://doi.org/10.1021/op050119yopenalex-snapshot
Developing Processes for Crystallization-Induced Asymmetric Transformation
inferredcites →https://doi.org/10.1021/op058013qopenalex-snapshot
Optimization of the Mizoroki−Heck Reaction Using Design of Experiment (DoE)
inferredcites →https://doi.org/10.1021/op060057ropenalex-snapshot
Development and Optimisation of an Unsymmetrical Hantzsch Reaction for Plant-Scale Manufacture
inferredcites →https://doi.org/10.1021/op060215eopenalex-snapshot
From High-Throughput Catalyst Screening to Reaction Optimization: Detailed Investigation of Regioselective Suzuki Coupling of 1,6-Naphthyridone Dichloride
inferredcites →https://doi.org/10.1021/op100010nopenalex-snapshot
Development of a Scaleable Process for the Synthesis of a Next-Generation Statin
inferredcites →https://doi.org/10.1021/op100026uopenalex-snapshot
Expedited Development through Parallel Reaction Screening: Application to PTC-Mediated Knoevenagel Condensation
inferredcites →https://doi.org/10.1021/op100053kopenalex-snapshot
Process Development of Selectively Benzoylated and Fluorinated Glycosyl Donors
inferredcites →https://doi.org/10.1021/op1000622openalex-snapshot
Application of the QbD Principles in the Development of the Casopitant Mesylate Manufacturing Process. Process Research Studies for the Definition of the Control Strategy of some Drug Substance-CQAs for Stages 2a, 2b, and 2c
inferredcites →https://doi.org/10.1021/op1000836openalex-snapshot
Development of a Control Strategy for a Defluorinated Analogue in the Manufacturing Process of Casopitant Mesylate
inferredcites →https://doi.org/10.1021/op100097copenalex-snapshot
The Synthesis of GV143253A: A Case Study for the Use of Analytical and Statistical Tools to Elucidate the Reaction Mechanism and to Optimize the Process
inferredcites →https://doi.org/10.1021/op100121sopenalex-snapshot
Development of a Dynamic Kinetic Resolution for the Isolation of an Intermediate in the Synthesis of Casopitant Mesylate: Application of QbD Principles in the Definition of the Parameter Ranges, Issues in the Scale-Up and Mitigation Strategies
inferredcites →https://doi.org/10.1021/op100150bopenalex-snapshot
Development of Drug Substances as Mixture of Polymorphs: Studies to Control Form 3 in Casopitant Mesylate
inferredcites →https://doi.org/10.1021/op100176uopenalex-snapshot
A Mechanistic Insight into a Simple C−N Bond Formation via SN2 Displacement: A Synergistic Kinetics and Design of Experiment Approach
inferredcites →https://doi.org/10.1021/op100225gopenalex-snapshot
Kilogram Synthesis of a Second-Generation LFA-1/ICAM Inhibitor
inferredcites →https://doi.org/10.1021/op100257ropenalex-snapshot
Development of a Second-Generation, Highly Efficient Manufacturing Route for the HIV Integrase Inhibitor Raltegravir Potassium
inferredcites →https://doi.org/10.1021/op100266sopenalex-snapshot
A Scalable Oxidation for the Final Stage of Synthesis of Cathepsin K Inhibitor SB-462795
inferredcites →https://doi.org/10.1021/op1002825openalex-snapshot
Current Practices of Process Validation for Drug Substances and Intermediates
inferredcites →https://doi.org/10.1021/op100315kopenalex-snapshot
Direct Hydrolysis of O,O′-Dibenzoyltartaric Anhydride - An Alternative Method for Manufacture of the same Acid: Tartaric Acid and Its O-Acyl Derivatives. Part 9
inferredcites →https://doi.org/10.1021/op100335qopenalex-snapshot
A Safe and Efficient Synthetic Route to a 2,5-Dimethyl-1-aryl-1 H -imidazole Intermediate
inferredcites →https://doi.org/10.1021/op100338zopenalex-snapshot
Fast Scale-Up Using Microreactors: Pyrrole Synthesis from Micro to Production Scale
inferredcites →https://doi.org/10.1021/op200056jopenalex-snapshot
Statistical Optimization of Reaction Parameters for the Synthesis of 2,4,6,8,10,12-Hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane
inferredcites →https://doi.org/10.1021/op200079gopenalex-snapshot
A Simplified Process for the Manufacture of AZD0530, a Potent SRC Kinase Inhibitor
inferredcites →https://doi.org/10.1021/op200093bopenalex-snapshot
Determination of Accurate Specific Heat Capacities of Liquids in a Reaction Calorimeter, by Statistical Design
inferredcites →https://doi.org/10.1021/op200107gopenalex-snapshot
The Lactol Route to Fesoterodine: An Amine-Promoted Friedel–Crafts Alkylation on Commercial Scale
inferredcites →https://doi.org/10.1021/op200132yopenalex-snapshot
Lipase-Catalyzed Monostearin Synthesis under Continuous Flow Conditions
inferredcites →https://doi.org/10.1021/op200145jopenalex-snapshot
Work-Up Optimization en Route to an Improved Process To Prepare a Progesterone Receptor Antagonist
inferredcites →https://doi.org/10.1021/op200312mopenalex-snapshot
A New Efficient Synthetic Route for the Synthesis of the Antiallergic Drug, Olopatadine Hydrochloride, via Stereospecific Palladium-Catalyzed Reaction
inferredcites →https://doi.org/10.1021/op200329xopenalex-snapshot
Development of a Robust Procedure for the Copper-catalyzed Ring-Opening of Epoxides with Grignard Reagents
inferredcites →https://doi.org/10.1021/op200346gopenalex-snapshot
Development of an Improved Process for Doxercalciferol via a Continuous Photochemical Reaction
inferredcites →https://doi.org/10.1021/op200347kopenalex-snapshot
Using Continuous Processes to Increase Production
inferredcites →https://doi.org/10.1021/op3000493openalex-snapshot
Synthesis of Phenylboronic Acids in Continuous Flow by Means of a Multijet Oscillating Disc Reactor System Operating at Cryogenic Temperatures
inferredcites →https://doi.org/10.1021/op300063fopenalex-snapshot
Kinetic Resolution of 1,3,6-Tri-O-benzyl-myo-Inositol by Novozym 435: Optimization and Enzyme Reuse
inferredcites →https://doi.org/10.1021/op3000916openalex-snapshot
Process Development and Optimization for Production of a Potassium Ion Channel Blocker, ICA-17043
inferredcites →https://doi.org/10.1021/op300113wopenalex-snapshot
Formation of Aromatic Amidoximes with Hydroxylamine using Microreactor Technology
inferredcites →https://doi.org/10.1021/op300131eopenalex-snapshot
Development of a Practical and Convergent Process for the Preparation of Sulopenem
inferredcites →https://doi.org/10.1021/op300162dopenalex-snapshot
Optimization of Reductive Debenzylation of Hexabenzylhexaazaisowurtzitane (the Key Step for Synthesis of HNIW) Using Response Surface Methodology
inferredcites →https://doi.org/10.1021/op300190sopenalex-snapshot
Lewis Acid-Catalyzed Synthesis of 4-Aminopyrimidines: A Scalable Industrial Process
inferredcites →https://doi.org/10.1021/op300210jopenalex-snapshot
Demonstration on Pilot-Plant Scale of the Utility of 1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD) as a Catalyst in the Efficient Amidation of an Unactivated Methyl Ester
inferredcites →https://doi.org/10.1021/op3002596openalex-snapshot
Improved One-Pot Synthesis of Citalopram Diol and Its Conversion to Citalopram
inferredcites →https://doi.org/10.1021/op3002855openalex-snapshot
The Large-Scale Synthesis of (S)-N-Boc-bis(4-fluorophenyl)alanine
inferredcites →https://doi.org/10.1021/op300292aopenalex-snapshot
Applying QbD Principles To Develop a Generic UHPLC Method Which Facilitates Continual Improvement and Innovation Throughout the Product Lifecycle for a Commercial API
inferredcites →https://doi.org/10.1021/op3002933openalex-snapshot
Development of Synthetic Routes, via a Tropinone Intermediate, to a Long-Acting Muscarinic Antagonist for the Treatment of Respiratory Disease
inferredcites →https://doi.org/10.1021/op300303popenalex-snapshot
An Efficient Process for the Large-Scale Synthesis of a 2,3,6-Trisubstituted Indole
inferredcites →https://doi.org/10.1021/op400010uopenalex-snapshot
Development and Scale-Up of an Optimized Route to the Peptide Boronic Acid, CEP-18770
inferredcites →https://doi.org/10.1021/op400179fopenalex-snapshot
Improved Continuous Flow Processing: Benzimidazole Ring Formation via Catalytic Hydrogenation of an Aromatic Nitro Compound
inferredcites →https://doi.org/10.1021/op400192hopenalex-snapshot
Seven Important Elements for an Effective Green Chemistry Program: An IQ Consortium Perspective
inferredcites →https://doi.org/10.1021/op600275gopenalex-snapshot
Development of a Scalable Process for the Synthesis of trans-2-Methylcyclopropanecarboxylic Acid
inferredcites →https://doi.org/10.1021/op700009topenalex-snapshot
An Efficient Synthesis of Dibenzo[c,f]-2,7-naphthyridine Ring System through Design of Experiments
inferredcites →https://doi.org/10.1021/op7001112openalex-snapshot
Process Research and Development and Scale-up of a 4,4-Difluoro-3,3-dimethylproline Derivative
inferredcites →https://doi.org/10.1021/op7002776openalex-snapshot
Development of a Scalable Synthetic Route to GSK369796 (N-tert-Butyl Isoquine), a Novel 4-Aminoquinoline Antimalarial Drug
inferredcites →https://doi.org/10.1021/op800105jopenalex-snapshot
Improved Process for the Preparation of 6-Chloro-5-(2-chloroethyl)oxindole
inferredcites →https://doi.org/10.1021/op800146dopenalex-snapshot
Synthesis of the NK1 Receptor Antagonist GW597599. Part 1: Development of a Scalable Route to a Key Chirally Pure Arylpiperazine
inferredcites →https://doi.org/10.1021/op800192aopenalex-snapshot
Mechanism and Processing Parameters Affecting the Formation of Methyl Methanesulfonate from Methanol and Methanesulfonic Acid: An Illustrative Example for Sulfonate Ester Impurity Formation
inferredcites →https://doi.org/10.1021/op800211copenalex-snapshot
Process Development and Scale-Up of a PPARγ Agonist: Selection of the Manufacture Route
inferredcites →https://doi.org/10.1021/op800238qopenalex-snapshot
Identification and Suppression of a Dimer Impurity in the Development of Delafloxacin
inferredcites →https://doi.org/10.1021/op8002486openalex-snapshot
The Role of New Technologies in Defining a Manufacturing Process for PPARα Agonist LY518674
inferredcites →https://doi.org/10.1021/op800255jopenalex-snapshot
Development of a Practical and Efficient Synthesis of CP-945,598-01, a CB1 Antagonist for the Treatment of Obesity
inferredcites →https://doi.org/10.1021/op8002739openalex-snapshot
Development of a Sequential Tetrahydropyran and Tertiary Butyl Deprotection: High-Throughput Experimentation, Mechanistic Analysis, and DOE Optimization
inferredcites →https://doi.org/10.1021/op8002823openalex-snapshot
Synthesis of the NK1 Receptor Antagonist GW597599. Part 2: Development of a Scalable Route to a Key Chirally Pure Arylpiperazine
inferredcites →https://doi.org/10.1021/op900078topenalex-snapshot
A Convenient and Stable Synthon for Ethyl Azide and Its Evaluation in a [3 + 2]-Cycloaddition Reaction under Continuous-Flow Conditions
inferredcites →https://doi.org/10.1021/op900104gopenalex-snapshot
Process Development for A Novel Pleuromutilin-Derived Antibiotic
inferredcites →https://doi.org/10.1021/op900139uopenalex-snapshot
Optimizing the Deprotection of the Amine Protecting p-Methoxyphenyl Group in an Automated Microreactor Platform
inferredcites →https://doi.org/10.1021/op9001824openalex-snapshot
Process Development and Scale Up of a Glycine Antagonist
inferredcites →https://doi.org/10.1021/op9002032openalex-snapshot
Synthesis of the NK1 Receptor Antagonist GW597599. Part 3: Development of a Scalable Route to a Key Chirally Pure Arylpiperazine Urea, A Happy End
inferredcites →https://doi.org/10.1021/op9002246openalex-snapshot
Development of a Practical Biocatalytic Process for ( R )-2-Methylpentanol
inferredcites →https://doi.org/10.1021/op900242xopenalex-snapshot
Application of Quality by Design Principles to Support Development of a Control Strategy for the Control of Genotoxic Impurities in the Manufacturing Process of a Drug Substance
inferredcites →https://doi.org/10.1021/op900265hopenalex-snapshot
Practical Application of Oxidation Using a Novel Na2WO4−H2O2System under Neutral Conditions for Scale-Up Manufacturing of 12α-Hydroxy-3-oxooleanano-28,13-lactone: Key Intermediate of Endothelin A Receptor Antagonist S-0139
inferredcites →https://doi.org/10.1021/op900286ropenalex-snapshot
Fit for Purpose Experimental Designs and Analyses in Chemical Development
inferredcites →https://doi.org/10.1021/op900301nopenalex-snapshot
A Detailed Study of Sulfonate Ester Formation and Solvolysis Reaction Rates and Application toward Establishing Sulfonate Ester Control in Pharmaceutical Manufacturing Processes
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inferred← citeshttps://doi.org/10.1002/cmtd.202000044openalex-snapshot
A Machine Learning‐Enabled Autonomous Flow Chemistry Platform for Process Optimization of Multiple Reaction Metrics
inferred← citeshttps://doi.org/10.1002/cmtd.202100053openalex-snapshot
Rapid and Mild One‐Flow Synthetic Approach to Unsymmetrical Sulfamides Guided by Bayesian Optimization
inferred← citeshttps://doi.org/10.1002/cmtd.202600004openalex-snapshot
Democratizing AI‐Enhanced Experimental Optimization: An Accessible Workflow for Chemists
inferred← citeshttps://doi.org/10.1002/cssc.202402451openalex-snapshot
Eco‐Friendly and Ready‐To‐Market Polyurethanes: A Design of Experiment‐Guided Substitution of Toxic Catalyst and Fossil‐Based Isocyanate
inferred← citeshttps://doi.org/10.1002/dac.70283openalex-snapshot
Dynamically Adaptive RSUs in VANETs: An Approach Focused on Sustainability
inferred← citeshttps://doi.org/10.1002/ejoc.201700849openalex-snapshot
Environmentally Friendly Synthesis of Indoline Derivatives using Flow‐Chemistry Techniques
inferred← citeshttps://doi.org/10.1002/ejoc.201900220openalex-snapshot
Flow Synthesis of Iodonium Trifluoroacetates through Direct Oxidation of Iodoarenes by Oxone®
inferred← citeshttps://doi.org/10.1002/ejoc.202500649openalex-snapshot
Regiocontrolled Cleavage of Dialkyl Ethers Using Regenerative Borates as a Sustainable Alternative to Boron Trichloride
inferred← citeshttps://doi.org/10.1002/ep.13960openalex-snapshot
An overview of adsorptive desulfurization of liquid transportation fuels over various adsorbents including zeolites
inferred← citeshttps://doi.org/10.1002/hlca.202300023openalex-snapshot
Fit‐for‐Purpose Synthesis of CDK2 Inhibitor GNE‐140
inferred← citeshttps://doi.org/10.1002/hlca.202500120openalex-snapshot
Implementation of Large‐Scale Multi‐Reactor Automation for Process Development
inferred← citeshttps://doi.org/10.1002/ijch.201700148openalex-snapshot
The Art of Organic Synthesis in the Age of Automation
inferred← citeshttps://doi.org/10.1002/ijch.202300068openalex-snapshot
Electrochemical Oxidation of Alcohols Using Halogen Mediators
inferred← citeshttps://doi.org/10.1002/jssc.201701008openalex-snapshot
Determination of the clean‐up efficiency of the solid‐phase extraction of rosemary extracts: Application of full‐factorial design in hyphenation with Gaussian peak fit function
inferred← citeshttps://doi.org/10.1002/jssc.202001018openalex-snapshot
Development of a gel permeation chromatography method for analysing cellulose nitrate in museums
inferred← citeshttps://doi.org/10.1002/mren.201900044openalex-snapshot
Polypropylene Copolymers Designed for Fused Filament Fabrication 3D‐Printing
inferred← citeshttps://doi.org/10.1002/pc.24441openalex-snapshot
Ultrasonic mixing head for liquid composite molding: Process and material characteristics
inferred← citeshttps://doi.org/10.1002/qre.70037openalex-snapshot
Use of Split‐Plot Optimal Design for Optimization of a Constrained Two‐Step Chemical Reaction Process: A Case Study Example
inferred← citeshttps://doi.org/10.1002/rem.21749openalex-snapshot
Removal of fluoride from water using aluminum‐modified activated carbon prepared from khat (Catha edulis) stems
inferred← citeshttps://doi.org/10.1002/slct.202000061openalex-snapshot
Definitive Screening Design Optimization of Chemoenzymatic Process for (R)‐3‐(Carbamoylmethyl)‐5‐methylhexanoicacid: A Key Intermediate of Pregabalin
inferred← citeshttps://doi.org/10.1002/slct.202101394openalex-snapshot
One‐Pot Synthesis of Xanthone by Carbonylative Suzuki Coupling Reaction
inferred← citeshttps://doi.org/10.1002/tcr.201800048openalex-snapshot
Rapid Optimization of Reaction Conditions Based on Comprehensive Reaction Analysis Using a Continuous Flow Microwave Reactor
inferred← citeshttps://doi.org/10.1002/tcr.201800132openalex-snapshot
Practical and Scalable Organic Reactions with Flow Microwave Apparatus
inferred← citeshttps://doi.org/10.1002/wer.70215openalex-snapshot
Artificially Constructing Microbial Consortia for Bioaugmentation of Nitroglycerin Degradation
inferred← citeshttps://doi.org/10.1002/wfs2.1479openalex-snapshot
Analytical strategies for herbal Cannabis samples in forensic applications: A comprehensive review
inferred← citeshttps://doi.org/10.1007/3418_2015_152openalex-snapshot
Beyond Organometallic Flow Chemistry: The Principles Behind the Use of Continuous-Flow Reactors for Synthesis
inferred← citeshttps://doi.org/10.1007/978-3-030-86169-8_17openalex-snapshot
Biochemical Parameters and Their Optimization Strategies for Microbial Bioremediation of Wastewater
inferred← citeshttps://doi.org/10.1007/978-3-031-22039-5_18openalex-snapshot
Categorical-Continuous Bayesian Optimization Applied to Chemical Reactions
inferred← citeshttps://doi.org/10.1007/978-3-031-25662-2_12openalex-snapshot
Optimization of Performance the Waste in Treatment of Textile Wastewater Using Response Surface Methodology
inferred← citeshttps://doi.org/10.1007/978-3-031-78395-1_18openalex-snapshot
A Hyperparameter Optimization Method Based on Statistical Orthogonal Design for Neural Network Models
inferred← citeshttps://doi.org/10.1007/978-3-031-78736-2_6openalex-snapshot
Optimising Materials Properties with Minimal Data: Lessons from Vanadium Catalyst Modelling
inferred← citeshttps://doi.org/10.1007/978-3-032-18878-6_9openalex-snapshot
Model-Based Design and Design of Experiments Techniques Integration for Optimal Design of New Machines and Systems
inferred← citeshttps://doi.org/10.1007/978-3-032-22043-1_18openalex-snapshot
Quality by Design Methodology in Pharmaceutical Product Development
inferred← citeshttps://doi.org/10.1007/978-3-032-22043-1_21openalex-snapshot
Design of Experiments in Pharmaceutical Process Development: Application in Key Intermediate Synthesis of Olaparib
inferred← citeshttps://doi.org/10.1007/978-3-319-23497-7_4openalex-snapshot
Applying Design of Experiments Methodology to PEI Toxicity Assay on Neural Progenitor Cells
inferred← citeshttps://doi.org/10.1007/978-3-319-23497-7_5openalex-snapshot
A Design of Experiment Approach to Optimize an Image Analysis Protocol for Drug Screening
inferred← citeshttps://doi.org/10.1007/978-3-319-97816-1_19openalex-snapshot
Optimization of Energy Pile Conductance Using Finite Element and Fractional Factorial Design of Experiment
inferred← citeshttps://doi.org/10.1007/978-3-662-56434-9_11openalex-snapshot
Kinetische Modellierung in der Chemischen Reaktionstechnik
inferred← citeshttps://doi.org/10.1007/978-3-662-56444-8_11-1openalex-snapshot
Kinetische Modellierung in der Chemischen Reaktionstechnik
inferred← citeshttps://doi.org/10.1007/978-3-662-69921-8_7openalex-snapshot
Kinetic Modeling in Chemical Reaction Engineering
inferred← citeshttps://doi.org/10.1007/978-981-16-9232-1_18openalex-snapshot
QbD-Steered Systematic Development of Drug Delivery Nanoconstructs: Vital Precepts, Retrospect and Prospects
inferred← citeshttps://doi.org/10.1007/978-981-16-9427-1_36openalex-snapshot
Analysis and Investigation of the Effects of Particle Size and Concentration on Sand Screen Erosion Prediction and Modelling
inferred← citeshttps://doi.org/10.1007/978-981-19-3895-5_9openalex-snapshot
Optimization and Analysis of Abrasive Wear of Agro-waste Fiber Reinforced Composites by RSM Design Matrix
inferred← citeshttps://doi.org/10.1007/978-981-96-0771-6_9openalex-snapshot
Design and Analysis of a Multi-panel Solar Array with Struts
inferred← citeshttps://doi.org/10.1007/978-981-99-2598-8_20openalex-snapshot
Anthracene Removal from Wastewater Using Biotechnological Interventions
inferred← citeshttps://doi.org/10.1007/s00170-021-06617-2openalex-snapshot
Ultrasonic nanocrystalline surface modification of low strength aluminum alloy: trade-off between surface integrity and production rate aiming at desired fatigue life
inferred← citeshttps://doi.org/10.1007/s00170-021-06725-zopenalex-snapshot
Correction to: “Ultrasonic nanocrystalline surface modification of low strength aluminum alloy: trade-off between surface integrity and production rate aiming at desired fatigue life”
inferred← citeshttps://doi.org/10.1007/s00170-025-15407-zopenalex-snapshot
From automation to autonomy in smart manufacturing: a Bayesian optimization framework for modeling multi-objective experimentation and sequential decision making
inferred← citeshttps://doi.org/10.1007/s00348-015-1986-7openalex-snapshot
Autonomous spatially adaptive sampling in experiments based on curvature, statistical error and sample spacing with applications in LDA measurements
inferred← citeshttps://doi.org/10.1007/s00449-021-02529-3openalex-snapshot
Design of experiment (DOE) applied to artificial neural network architecture enables rapid bioprocess improvement
inferred← citeshttps://doi.org/10.1007/s00769-026-01701-0openalex-snapshot
The convergence of statistical design and computational intelligence: a systematic review of DOE-driven AI/ML in analytical method development and validation
inferred← citeshttps://doi.org/10.1007/s10337-022-04223-2openalex-snapshot
Evolution of Stability-Indicating Method in the Quantification of Related Substances and Degradation Products of Elagolix Sodium: Quality by Design-Driven Approach Utilizing Ultra-high Performance Liquid Chromatography
inferred← citeshttps://doi.org/10.1007/s10562-019-02716-8openalex-snapshot
Evaluation of Reverse Microemulsion Parameters Over the Catalytic Performance of Promoted Fe–Co Catalysts for the Production of Light Olefins from Syngas Using Box–Behnken Design
inferred← citeshttps://doi.org/10.1007/s10570-018-1957-2openalex-snapshot
Structural relationships and optimization of resin-finishing parameters using the Taguchi approach
inferred← citeshttps://doi.org/10.1007/s10570-020-03525-8openalex-snapshot
Effluent-free deep dyeing of cotton fabric with cacao husk extracts using the Taguchi optimization method
inferred← citeshttps://doi.org/10.1007/s10570-023-05535-8openalex-snapshot
Design of experiments in the optimization of all-cellulose composites
inferred← citeshttps://doi.org/10.1007/s10586-024-04973-8openalex-snapshot
Assessing the performance of a fault tolerant LoRaWAN architecture with a focus on the sensor layer and data retransmission strategy
inferred← citeshttps://doi.org/10.1007/s10616-023-00596-wopenalex-snapshot
Optimization of adaptation parameters from adhesion cell culture in serum-containing media to suspension in chemically defined media by superlative box design
inferred← citeshttps://doi.org/10.1007/s10847-020-01038-2openalex-snapshot
Design and optimization of cyclodextrin-based nanosponges of antimalarials using central composite design for dry suspension
inferred← citeshttps://doi.org/10.1007/s10853-023-08805-9openalex-snapshot
Investigating the role of graphite and reduced graphene oxide in the fabrication of microporous layers for proton exchange membrane fuel cells
inferred← citeshttps://doi.org/10.1007/s10854-018-8530-5openalex-snapshot
Enhanced solar cell performance by optimization of spray coated CZTS thin film using Taguchi and response surface method
inferred← citeshttps://doi.org/10.1007/s10953-026-01568-2openalex-snapshot
Optimization and Performance Evaluation of Ultrasound-Assisted Cooling Crystallization of Oxalic Acid via Response Surface Methodology
inferred← citeshttps://doi.org/10.1007/s10967-019-06952-5openalex-snapshot
Design of experiments in 241Am alpha source preparation by electrodeposition: an approach to process optimization
inferred← citeshttps://doi.org/10.1007/s10973-020-09557-3openalex-snapshot
Thermal behavior of oligo[(ε-caprolactone)-co-δ-gluconolactone] enzymatically synthesized in reaction conditions optimized by experimental design
inferred← citeshttps://doi.org/10.1007/s11094-026-03535-zopenalex-snapshot
Role of Artificial Intelligence in Advancing Chromatographic Techniques: A Comprehensive Review
inferred← citeshttps://doi.org/10.1007/s11696-020-01469-8openalex-snapshot
Effect of reduction and reaction conditions on the catalytic performance of Co–Ni/Al2O3 catalyst in CO hydrogenation: modeling of surface reaction rate
inferred← citeshttps://doi.org/10.1007/s11947-021-02679-yopenalex-snapshot
Tailoring the Properties of Pea-Enriched Soft Cakes Using a Multiobjective Model Based on Sensory-Relevant Instrumental Characterization
inferred← citeshttps://doi.org/10.1007/s12033-019-00218-xopenalex-snapshot
Design of Experiments As a Tool for Optimization in Recombinant Protein Biotechnology: From Constructs to Crystals
inferred← citeshttps://doi.org/10.1007/s12247-020-09468-8openalex-snapshot
Application of Simple Lattice Design and Desirability Function for Formulating and Optimizing SMEDDS of Clofazimine
inferred← citeshttps://doi.org/10.1007/s12247-025-09985-4openalex-snapshot
Enhanced Delivery of Posaconazole Using Novel Solid Self Nanoemulsifying Drug Delivery System: In Vitro Characterization and Pharmacokinetic Study in Wistar Rats
inferred← citeshttps://doi.org/10.1007/s12247-025-10077-6openalex-snapshot
Enhancing Flowability and Compactibility of Glutinous Rice Starch Through Co-Precipitation: A Central Composite Design Approach
inferred← citeshttps://doi.org/10.1007/s12633-020-00454-wopenalex-snapshot
Design, Facile Synthesis and Characterization of Porphyrin-Zirconium-Ferrite@SiO2 Core-Shell and Catalytic Application in Cyclohexane Oxidation
inferred← citeshttps://doi.org/10.1007/s13399-023-05205-6openalex-snapshot
Study of thermal stability and characterisation of novel bioplastic as a potential alternate for synthetic fibre replacement in polymer composite
inferred← citeshttps://doi.org/10.1007/s13399-024-06276-9openalex-snapshot
Exopolysaccharide pullulan production from enzymatic hydrolysate of quinoa stalks via citric acid–assisted hydrothermal pretreatment
inferred← citeshttps://doi.org/10.1007/s13738-021-02457-9openalex-snapshot
A simple and straightforward combination of surfactant-assisted magnetic dispersive micro-solid-phase extraction and hydride generation procedure to determine arsenic (III) species in environmental, biological, and fruit juice samples
inferred← citeshttps://doi.org/10.1007/s13738-025-03337-2openalex-snapshot
Milestones and opportunities for the optimization of dispersive liquid-liquid microextraction factors using design of experiments to analyze organic pollutants in environmental water samples using UHPLC–ESI–QTOF–MS: a critical review
inferred← citeshttps://doi.org/10.1007/s40145-018-0309-xopenalex-snapshot
TiO2/WO3 heterogeneous structures prepared by electrospinning and sintering steps: Characterization and analysis of the impedance variation to humidity
inferred← citeshttps://doi.org/10.1007/s40430-020-2209-6openalex-snapshot
Plugin energy penalty model and gypsum production for flue gas desulfurization prediction
inferred← citeshttps://doi.org/10.1007/s40684-026-00864-yopenalex-snapshot
Artificial Neural Network-assisted Statistical Modeling of Voronoi Lattices for Lightweight Crashworthy Structures
inferred← citeshttps://doi.org/10.1007/s40726-025-00346-wopenalex-snapshot
Towards Environmental Sustainability: Employing Adaptive Laboratory Evolution to Develop Elite Algae Strains for Industrial and Environmental Applications
inferred← citeshttps://doi.org/10.1007/s41981-020-00135-0openalex-snapshot
Flow chemistry for process optimisation using design of experiments
inferred← citeshttps://doi.org/10.1007/s41981-021-00163-4openalex-snapshot
3D printed ceramics as solid supports for enzyme immobilization: an automated DoE approach for applications in continuous flow
inferred← citeshttps://doi.org/10.1007/s41981-023-00293-xopenalex-snapshot
Asymmetric electrochemical synthesis in flow
inferred← citeshttps://doi.org/10.1007/s42398-022-00218-9openalex-snapshot
Butanol production by Clostridium acetobutylicum DSMZ 792 from cassava starch
inferred← citeshttps://doi.org/10.1007/s43207-020-00064-7openalex-snapshot
Optimized precipitation process for efficient and size-controlled synthesis of hydroxyapatite–chitosan nanocomposite
inferred← citeshttps://doi.org/10.1016/b978-0-12-820206-7.00111-6openalex-snapshot
High-Throughput Experimentation in Organometallic Chemistry and Catalysis
inferred← citeshttps://doi.org/10.1016/b978-0-323-85043-8.00014-3openalex-snapshot
Characterization of reactions and growth in automated continuous flow and bioreactor platforms—From linear DoE to model-based approaches
inferred← citeshttps://doi.org/10.1016/b978-0-443-28989-7.00019-5openalex-snapshot
Design of experiments and life cycle assessment as experimental tools for elastomer sustainability
inferred← citeshttps://doi.org/10.1016/b978-0-443-36522-5.00012-7openalex-snapshot
Process Optimization by Minimizing Impurities
inferred← citeshttps://doi.org/10.1016/b978-0-443-36542-3.00007-4openalex-snapshot
Organic synthesis: basic concepts, definitions, classification of synthetic steps, and retrosynthetic analysis
inferred← citeshttps://doi.org/10.1016/b978-0-443-36542-3.00011-6openalex-snapshot
Synthesis of optically active target molecules
inferred← citeshttps://doi.org/10.1016/j.addr.2025.115739openalex-snapshot
Guiding design and performance of nonviral nucleic acid delivery vehicles via machine learning
inferred← citeshttps://doi.org/10.1016/j.apenergy.2022.119305openalex-snapshot
Design of experiments applied to lithium-ion batteries: A literature review
inferred← citeshttps://doi.org/10.1016/j.apm.2022.03.015openalex-snapshot
A novel hybrid adaptive scheme for Kriging-based reliability estimation – A comparative study
inferred← citeshttps://doi.org/10.1016/j.apt.2024.104416openalex-snapshot
Optimizing reuse of Vanadis® 8 tool steel powders through multi-objective Lichtenberg algorithm: A powder metallurgy approach
inferred← citeshttps://doi.org/10.1016/j.aquaculture.2025.742545openalex-snapshot
Review of state-of-the-art improvements in recirculating aquaculture systems: Insights into design, operation, and statistical modeling approaches
inferred← citeshttps://doi.org/10.1016/j.arabjc.2023.104872openalex-snapshot
Acid assisted-hydrothermal carbonization of solid waste from essential oils industry: Optimization using I-optimal experimental design and removal dye application
inferred← citeshttps://doi.org/10.1016/j.arabjc.2024.105599openalex-snapshot
The effective adsorption of Ni(II) and nitrate from aquatic systems by superparamagnetic MoS2/γ-Fe2O3 nanocomposites: Optimization through RSM-CCD design
inferred← citeshttps://doi.org/10.1016/j.bbamem.2024.184335openalex-snapshot
Flow-based bioconjugation of coumarin phosphatidylethanolamine probes: Optimised synthesis and membrane molecular dynamics studies
inferred← citeshttps://doi.org/10.1016/j.bbrc.2025.151718openalex-snapshot
Prediction and control of the particle size of polyethylene glycol–free lipid nanoparticles using a design of experiment
inferred← citeshttps://doi.org/10.1016/j.bcp.2024.116078openalex-snapshot
Drug Mechanism: A bioinformatic update
inferred← citeshttps://doi.org/10.1016/j.buildenv.2022.109919openalex-snapshot
Personal thermal comfort models based on physiological measurements – A design of experiments based review
inferred← citeshttps://doi.org/10.1016/j.buildenv.2025.113415openalex-snapshot
Evaluating Personal Comfort Systems Performance – A Design of Experiments based Review
inferred← citeshttps://doi.org/10.1016/j.carres.2024.109289openalex-snapshot
Design of experiments optimization of N,N,N-trimethyl chitosan synthesis using N,N-diisopropylethylamine base
inferred← citeshttps://doi.org/10.1016/j.catcom.2021.106333openalex-snapshot
Aerobic iron-catalyzed site-selective C(sp3)–C(sp3) bond cleavage in N-heterocycles
inferred← citeshttps://doi.org/10.1016/j.cclet.2023.108877openalex-snapshot
Process analytical technologies and self-optimization algorithms in automated pharmaceutical continuous manufacturing
inferred← citeshttps://doi.org/10.1016/j.ccr.2025.217383openalex-snapshot
On the use of chemical bonding descriptors in machine learning
inferred← citeshttps://doi.org/10.1016/j.cep.2023.109638openalex-snapshot
Design and scale-up of a superb micromixer with fan-shaped obstacles for synthesis of Dolutegravir intermediate
inferred← citeshttps://doi.org/10.1016/j.ceramint.2022.12.175openalex-snapshot
Design of experiments optimization of fluorine-doped tin oxide films prepared by spray pyrolysis for photovoltaic applications
inferred← citeshttps://doi.org/10.1016/j.ces.2021.116511openalex-snapshot
Recent advances in heterogeneous micro-photoreactors for wastewater treatment application
inferred← citeshttps://doi.org/10.1016/j.ces.2024.120327openalex-snapshot
Guided experimental design for static nonparametric modeling
inferred← citeshttps://doi.org/10.1016/j.ces.2026.124255openalex-snapshot
Adaptive framework for data-driven probabilistic design space identification
inferred← citeshttps://doi.org/10.1016/j.chemolab.2020.104226openalex-snapshot
Adaptive design of experiments based on Gaussian mixture regression
inferred← citeshttps://doi.org/10.1016/j.chempr.2026.102952openalex-snapshot
Electrochemical self-optimization for the synthesis of densely functionalized molecules
inferred← citeshttps://doi.org/10.1016/j.cherd.2018.05.031openalex-snapshot
Continuous protein crystallisation platform and process: Case of lysozyme
inferred← citeshttps://doi.org/10.1016/j.cherd.2025.08.033openalex-snapshot
A comprehensive study of calcium dissolution kinetics from recycled concrete fines: Experimental and modeling insights
inferred← citeshttps://doi.org/10.1016/j.cirpj.2025.03.011openalex-snapshot
Surface topography and cross-section analysis of K340 cold work tool steel double-tracks deposited by directed energy deposition technique
inferred← citeshttps://doi.org/10.1016/j.cjche.2024.11.004openalex-snapshot
A parallel chemical reaction optimization method based on preference-based multi-objective expected improvement
inferred← citeshttps://doi.org/10.1016/j.clcb.2024.100095openalex-snapshot
Optimizing film mechanical and water contact angle properties via PLA/starch/lecithin concentrations
inferred← citeshttps://doi.org/10.1016/j.clet.2025.100988openalex-snapshot
Optimization of a chemical recycling process for epoxy-amine thermosets and their carbon fiber reinforced composites using a design of experiments approach
inferred← citeshttps://doi.org/10.1016/j.cogsc.2026.101088openalex-snapshot
Towards sustainable chemical and biocatalytic synthesis through machine learning-supported experimental decision-making
inferred← citeshttps://doi.org/10.1016/j.colsurfa.2023.132426openalex-snapshot
Reduced graphene oxide decorated with poly(diallyldimethylammonium chloride) for sensitive detection of acetaminophen in water and human urine samples
inferred← citeshttps://doi.org/10.1016/j.colsurfa.2024.133899openalex-snapshot
Box-Behnken design for the synthesis optimization of mesoporous sulfur-doped carbon-based materials from birch waste: Promising candidates for environmental and energy storage application
inferred← citeshttps://doi.org/10.1016/j.compositesa.2024.108510openalex-snapshot
Design of experiments investigation into the production of all cellulose composites using regenerated cellulosic textiles
inferred← citeshttps://doi.org/10.1016/j.compstruc.2023.107018openalex-snapshot
Multi-parameter identification of concrete dam using polynomial chaos expansion and slime mould algorithm
inferred← citeshttps://doi.org/10.1016/j.compstruct.2026.120934openalex-snapshot
Design and characterization of a novel beetle elytra inspired lattice structure: The effect of Gyroid topology and helical pillars
inferred← citeshttps://doi.org/10.1016/j.conbuildmat.2023.131354openalex-snapshot
Cement Pastes in Tertiary Colours: A Digital Approach for Colouration of Cement-Based Materials
inferred← citeshttps://doi.org/10.1016/j.ejps.2017.10.042openalex-snapshot
The application of Quality by Design framework in the pharmaceutical development of dry powder inhalers
inferred← citeshttps://doi.org/10.1016/j.foodchem.2022.134588openalex-snapshot
A novel quality-by-design optimized spectrofluorimetric method for the sensitive determination of ricinine alkaloid in edible oils
inferred← citeshttps://doi.org/10.1016/j.fuel.2022.124607openalex-snapshot
Application of statistical approaches in IC engine calibration to enhance the performance and emission Characteristics: A methodological review
inferred← citeshttps://doi.org/10.1016/j.fuel.2026.140996openalex-snapshot
Optimization of process variables for CO2/CH4 and CO2/N2 binary gas separation using dual-layer hollow fiber mixed-matrix membrane
inferred← citeshttps://doi.org/10.1016/j.gresc.2026.07.003openalex-snapshot
“Control from root design”: A proactive strategy for green and sustainable API process research and development
inferred← citeshttps://doi.org/10.1016/j.heliyon.2022.e10640openalex-snapshot
Optimization of the incubation parameters for biogenic synthesis of WO3 nanoparticles using Taguchi method
inferred← citeshttps://doi.org/10.1016/j.heliyon.2025.e42576openalex-snapshot
Biorefinery of sunflower by-products: Optimization of twin-screw extrusion for novel biostimulants
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2023.127916openalex-snapshot
Plant leaf mucilage/carrageenan/Eudragit® NE30D blended films: Optimization, characterization, and pharmaceutical application
inferred← citeshttps://doi.org/10.1016/j.ijhydene.2025.03.131openalex-snapshot
Hydrogen-rich syngas from model biogas steam reforming over a Ni–Pr/hydrotalcite-derived catalyst: An RSM-central composite rotational design
inferred← citeshttps://doi.org/10.1016/j.ijhydene.2026.155124openalex-snapshot
The Pathfinder: Adaptive learning for hydrogen storage material optimization
inferred← citeshttps://doi.org/10.1016/j.ijleo.2019.163970openalex-snapshot
Research on laser processing technology of instrument panel implicit weakening line based on neural network and genetic algorithm
inferred← citeshttps://doi.org/10.1016/j.ijlmm.2020.08.003openalex-snapshot
Optimization of ultrasonic nanocrystalline surface modification of copper and its influence on fatigue life
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2019.04.050openalex-snapshot
Comprehensive quality by design approach for stable nanocrystalline drug products
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2023.122620openalex-snapshot
Interpretable artificial neural networks for retrospective QbD of pharmaceutical tablet manufacturing based on a pilot-scale developmental dataset
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2024.124566openalex-snapshot
Quality by design steered approach for co-encapsulation of timolol maleate and dorzolamide hydrochloride in injectable liposomes
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2025.125422openalex-snapshot
The value of spray drying as stabilization process for proteins
inferred← citeshttps://doi.org/10.1016/j.ipha.2024.02.007openalex-snapshot
Optimization and characterization of xanthan gum based multiparticulate formulation for colon targeting
inferred← citeshttps://doi.org/10.1016/j.istruc.2022.09.091openalex-snapshot
Multiobjective design optimization of double arrowhead auxetic model using Lichtenberg algorithm based on metamodelling
inferred← citeshttps://doi.org/10.1016/j.jallcom.2018.01.163openalex-snapshot
Towards a consistent understanding of the metal hydride reaction kinetics: Measurement, modeling and data processing
inferred← citeshttps://doi.org/10.1016/j.jchromb.2018.02.003openalex-snapshot
Headspace solid-phase microextraction (HS-SPME) combined with GC–MS as a process analytical technology (PAT) tool for monitoring the cultivation of C. tetani
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