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An Efficient and Practical Synthesis of the HIV Protease Inhibitor Atazanavir via a Highly Diastereoselective Reduction Approach

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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New Approaches to the Use of Amino Acids as Chiral Building Blocks in Organic Synthesis [New Synthetic Methods (85)]
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Diastereoselective reduction of N-phthaloyl α-amino ketones: synthesis of syn-3-amino-1,2-diol derivatives
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Synthetic studies towards amino alcohols. Diastereocontrolled reduction of α′-chiral α,β-enones.
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A concise synthesis of aza-dipeptide isosteres
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NEW DRUGS ON THE HORIZON
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Industrial Syntheses of the Central Core Molecules of HIV Protease Inhibitors
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New Aza-Dipeptide Analogues as Potent and Orally Absorbed HIV-1 Protease Inhibitors: Candidates for Clinical Development
inferredcites →https://doi.org/10.1021/jo010270fopenalex-snapshot
Highly Stereoselective Syntheses of syn- and anti-1,2-Amino Alcohols
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Diastereoselective Reduction of a Chiral N-Boc-Protected δ-Amino-α,β-unsaturated γ-Keto Ester Phe-Gly Dipeptidomimetic
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A Stereocontrolled, Convergent Synthesis of Hydroxyethylene Dipeptide Isosteres
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Process Research and Development for an Efficient Synthesis of the HIV Protease Inhibitor BMS-232632
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Results of a Phase 2 Clinical Trial at 48 Weeks (AI424-007): A Dose-Ranging, Safety, and Efficacy Comparative Trial of Atazanavir at Three Doses in Combination with Didanosine and Stavudine in Antiretroviral-Naive Subjects
inferredcites →https://doi.org/10.1128/aac.00098-06openalex-snapshot
Population Pharmacokinetics of Atazanavir in Patients with Human Immunodeficiency Virus Infection
inferredcites →https://doi.org/10.1517/13543784.11.9.1295openalex-snapshot
Atazanavir: a novel HIV-1 protease inhibitor

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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